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Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment

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Bioactive Materials 2024年第11期41卷 440-454页

作者： Xiaoting Zhang Boguang Yang Lu Feng xiayi xu Chenmin Wang Yuk-wai Lee Ming Wang xuan Lu Ling Qin Sien Lin Liming Bian Gang Li Musculoskeletal Research Laboratory Department of Orthopaedics&TraumatologyThe Chinese University of Hong KongPrince of Wales HospitalHong KongChina Stem Cells and Regenerative Medicine Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongPrince of Wales HospitalHong KongChina The CUHK-ACC Space Medicine Centre on Health Maintenance of Musculoskeletal System The Chinese University of Hong Kong Shenzhen Research InstituteShenzhenPR China SH Ho Scoliosis Research Laboratory Department of Orthopaedics and TraumatologyThe Chinese University of Hong KongHong KongChina Joint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing University The Chinese University of Hong KongHong KongChina Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongChina School of Biomedical Sciences and Engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou511442PR China Department of Orthopaedics and Traumatology The University of Hong KongHong KongChina

Osteoporotic bone defects pose a significant challenge for bone regeneration as they exhibit impaired healing capacity and delayed healing *** address this issue,this study introduces a hydrogel that creates a rejuvenating microenvironment,thereby facilitating efficient bone repair during the initial two weeks following bone defect *** hydrogel,named GelHFS,was created through host-guest polymerization of gelatin and acrylatedβ-*** of the human fetal mesenchymal stem cell secretome(HFS)formed GelHFS hydrogel aimed at mimicking a rejuvenated stem cell *** results demonstrated that GelHFS hydrogel promotes cell stellate spreading and osteogenic differentiation via integrinβ1-induced focal adhesion *** of GelHFS hydrogel in an osteoporotic bone defect rat model recruited endogenous integrinβ1-expressing cells and enhanced new bone formation and bone *** findings reveal that GelHFS hydrogel provides a rejuvenating niche for endogenous MSCs and enhances bone regeneration in osteoporotic bone *** findings highlight the potential of GelHFS hydrogel as an effective therapeutic strategy for addressing challenging bone healing such as osteoporotic bone regeneration.

关键词： Osteoporotic bone defects Bone regeneration Rejuvenating microenvironment Secretome Focal adhesion pathway

Preparation of ZrSiO4/C Inclusion Pigments by Nonhydrolytic Sol-gel Methed Combined with the Process of Carbon Black Modification

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Preparation of ZrSiO4/C Inclusion Pigments by Nonhydrolytic ...

基于活态传承模式的陶瓷美育文化融入高校思政育人的逻辑机理及实践路径研究

中国材料大会2012

作者： Weihui Jiang Yong Feng Jianmin Liu Qingxia Zhu xiayi xu School of Material Science and Engineering Jingdezhen Ceramic Institute Jiangxi Key Laboratory of Advanced Ceramic Materials

ISBN: (纸本)9783037856079

Inclusion pigments of ZrSiO4 /C were prepared by nonhydrolytic sol-gel （NHSG） method combined with the process of carbon black modification. The crystalline phases, microstructure, functional groups on the surface of carbon black and chromatic value of the pigments were characterized by XRD, TEM, FTIR and Colorimeter, respectively. The surface structural changes of the carbon black modified by nitric acid and the influences of process parameters on the chromatic value of the pigments were also investigated. The results show that the process of carbon black modification enhances the affinity and binding force between carbon black and ZrCl4 sol, which contributes to improve the effect of carbon black wrapped by ZrSiO4 . The ZrSiO4/C inclusion pigment were obtained after calcining at 1000 ℃ for 8 h, and the L*, a* and b* value is 53.88, 0.74, and 1.88, respectively.

关键词： Nonhydrolytic sol-gel method The process of carbon black modification Zirconium silicate Carbon black Inclusion pigment.

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景德镇陶瓷 2024年第4期52卷 70-73页

作者：魏媛鹤徐夏怡景德镇学院

陶瓷文化作为中华优秀传统文化的重要组成部分,具有深厚的历史底蕴和独特的艺术魅力。本文基于活态传承模式,探讨如何将陶瓷美育文化融入高校思想政治教育中。本文分析陶瓷美育文化的内涵和特征,并结合高校思想政治教育的目标和需求,提... 详细信息

陶瓷文化作为中华优秀传统文化的重要组成部分,具有深厚的历史底蕴和独特的艺术魅力。本文基于活态传承模式,探讨如何将陶瓷美育文化融入高校思想政治教育中。本文分析陶瓷美育文化的内涵和特征,并结合高校思想政治教育的目标和需求,提出在课程设计、实践活动和文化体验等方面的具体融合方案。研究发现,陶瓷美育文化不仅能够丰富高校思政教育的内容,还能增强学生的文化自信和爱国情怀,对培养全面发展的高素质人才具有重要的实践意义。本文从理论与实践两个层面,深入探讨陶瓷美育文化融入高校思政教育的可行性和有效性,为推动中华优秀传统文化的现代传承和创新提供新的思路和方法。

关键词：活态传承陶瓷文化高校思政育人

Enantio-divergent C–H borylation with two different ligands from a single chiral source

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Science China Chemistry 2025年第1期68卷 226-232页

作者： Rongrong Du Senmiao xu State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of Education Hangzhou Normal University University of Chinese Academy of Sciences

Reported here is an iridium-catalyzed enantio-divergent C（sp3）–H borylation of α-gem-dimethyl groups of trifluoromethyl ketone-derived hydrazones to construct a series of acyclic all-carbon quaternary stereocenters with a high level of chiral induction. Two different chiral bidentate boryl ligands from a common chiral source not only can switch the enantioselectivity but also are complementary in terms of the substrate scope.

关键词： asymmetric catalysis C–H borylation all-carbon quaternary stereocenters synthetic methods

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远程工作研究综述与展望

经济研究导刊 2023年第1期 147-150页

作者：徐灿徐夏怡张雨涛南京邮电大学南京210000

新冠肺炎疫情的暴发使得许多企业由在线下办公转为线上远程工作,远程工作开始大规模应用,但相关的研究还不够全面和深入,并缺乏系统性梳理。基于此,在回顾国内外相关文献的基础上,对远程工作的概念、发展以及研究视角进行梳理,分析现有... 详细信息

新冠肺炎疫情的暴发使得许多企业由在线下办公转为线上远程工作,远程工作开始大规模应用,但相关的研究还不够全面和深入,并缺乏系统性梳理。基于此,在回顾国内外相关文献的基础上,对远程工作的概念、发展以及研究视角进行梳理,分析现有研究的不足与缺陷,归纳远程工作的积极与消极影响,总结研究的发展趋势并指出未来研究的方向,以期为进一步开展该主题的相关研究和管理实践提供参考。

关键词：远程工作研究综述研究展望

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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li xu Huiming xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

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Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： Guo-Fu xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi xu Junqiu Jia Rui Mao Xiang Cao Yun xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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Applications of in-situ solid-state nuclear magnetic resonance in methanol to olefins reaction

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Science China Chemistry 2025年第1期68卷 134-151页

作者： Jing Niu Shutao xu Yingxu Wei Zhongmin Liu National Engineering Research Center of Lower-Carbon Catalysis Technology Dalian Institute of Chemical PhysicsChinese Academy of Sciences State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

The methanol-to-olefins（MTO） reaction offers an alternative pathway for the production of low-carbon olefins from non-oil feedstocks. Fundamental research has been impeded by a lack of comprehensive understanding of its underlying mechanism,despite the significant progress made in industry. In-situ solid-state nuclear magnetic resonance（ss NMR） spectroscopy has emerged as a pivotal tool, offering crucial insights into key species under real-time operando conditions. Furthermore, the host–guest interaction between zeolites or surface species residing on zeolites and the reactant/active intermediates is revealed by the combination of in-situ13C MAS NMR and 2D correlation spectroscopy. Moreover, recent technological advancements in hyperpolarization（HP） methods, including HP129Xe NMR and dynamic nuclear polarization（DNP）, have significantly improved the sensitivity of ss NMR, enabling detailed structural and kinetic analysis as well as the detection of trace species. In this feature article, we summarized recent advancements in（in-situ） ss NMR spectroscopy applied to MTO reaction processes,encompassing mechanistic investigations at various stages and the intricate host–guest interactions. These theoretical insights into the dynamic evolution of MTO reactions lay a solid foundation for the optimization of catalytic processes and the development of efficient catalysts, thereby advancing the techniques towards more sustainable and economical production route for olefins.

关键词： MTO zeolites in-situ ssNMR reactive intermediates reaction mechanism