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Editing of eIF(iso)4E.c confers resistance against Turnip mosaic virus in Brassica rapa

Horticultural Plant Journal 2024年第4期10卷 1020-1034页

作者： Yujia Liu xiaoyun Xin Peirong Li Weihong Wang Yangjun Yu Xiuyun Zhao Deshuang Zhang Jiao Wang Fenglan Zhang Shujiang Zhang Shuancang Yu Tongbing Su State Key Laboratory of Vegetable Biobreeding Beijing Vegetable Research CenterBeijing Academy of Agriculture and Forestry ScienceBeijing 100097China National Engineering Research Center for Vegetables Beijing Key Laboratory of Vegetable Germplasms ImprovementKey Laboratory of Biology and Genetics Improvement of Horticultural Crops(North China)Key Laboratory of Urban Agriculture(North)of Ministry of AgricultureBeijing Vegetable Research CenterBeijing Academy of Agriculture and Forestry ScienceBeijing 100097China Institute of Vegetables and Flowers Chinese Academy of Agricultural SciencesBeijing 100081China

Turnip mosaic virus(TuMV)constitutes one of the primary diseases affecting Brassica rapa,severely impacting its production and resulting in crop failures in various regions *** research has demonstrated the significance of plant translation initiation factors,specifically the eIF4E and eIF4G family genes,as essential recessive disease resistance *** our study,we conducted evolutionary and gene expression studies,leading us to identify e IF(iso)4E.c as a potential TuMV-resistant *** CRISPR/Cas9 technology,we obtained mutant *** plants with edited eIF(iso)4E.c *** confirmed eIF(iso)4E.c confers resistance against TuMV through phenotypic observations and virus content ***,we employed ribosome profiling assays on eif(iso)4e.c mutant seedlings to unravel the translation landscape in response to ***,we observed a moderate correlation between the fold changes in gene expression at the transcriptional and translational levels(R^(2)=0.729).Comparative analysis of ribosome profiling and RNA-seq data revealed that plant-pathogen interaction,and MAPK signaling pathway-plant pathways were involved in eIF(iso)4E.c-mediated TuMV *** analysis revealed that sequence features,coding sequence length,and normalized minimal free energy,influenced the translation efficiency of *** study highlights that the loss of e IF(iso)4E.c can result in a highly intricate translation mechanism,acting synergistically with transcription to confer resistance against TuMV.

关键词： Brassica rapa eIF(iso)4E.c TuMV Ribo-seq

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Resolving controversies surrounding carbon sinks from carbonate weathering

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Science China Earth Sciences 2024年第9期67卷 2705-2717页

作者： Xiaoyong BAI Sirui ZHANG Pete SMITH Chaojun LI Lian XIONG Chaochao DU Yingying XUE Zilin LI Mingkang LONG Minghui LI xiaoyun ZHANG Shu YANG Qing LUO Xiaoqian SHEN State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China Institute of Biological and Environmental Sciences University of AberdeenAberdeen AB243UUUK College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China School of Geography and Environmental Sciences Guizhou Normal UniversityGuiyang 550025China CAS Center for Excellence in Quaternary Science and Global Change Xi’an 710061China

The importance of carbonate weathering carbon sinks(CCSs)is almost equal to that of vegetation photosynthesis in the global carbon ***,CCSs have become controversial in formulating carbon neutral policies to deal with global climate problems in various countries,since the carbonate dissolution is *** order to address these controversies,we reviewed recent advances in understanding CCSs and examined the outstanding controversies surrounding *** have analyzed the five controversies,revealing the existence of CCSs,quantifying their magnitude,clarifying their spatiotemporal pattern,and documenting how they have increased and how they evolved under the background of global *** addressing these five controversies,we help to bring clarity to the role of CCSs in the carbon cycle of global terrestrial ecosystems.

关键词： Carbon sink Carbonate weathering Carbon cycle Climate change Anthropogenic driver

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Moderate red wine alleviates high-fat diet-induced atherosclerosis in ApoEmice via modulations of liver metabolism through gut microbiota remodeling

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Food Science and Human Wellness 2024年

作者： Xuanxuan Chen Hong Yang Kaikai Li Jianhong Cao xiaoyun Xu Siyi Pan Erhu Li College of Food Science and Technology， Huazhong Agricultural University Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University)， Ministry of Education Hubei Key Laboratory of Fruit & Vegetable Processing & Quality Control (Huazhong Agricultural University) Shangri-la Winery Co.， Ltd.

Red wine has a good potential for alleviating atherosclerosis， but the mechanisms related to hepatointestinal circulation remain to be elucidated. This study showed that administration of a high-polyphenol red wine (1. mL/kg/day) for 1. weeks significantly reduced the atherosclerotic lesion in high-fat diet-fed ApoE-/-mice. The total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels of plasma were lowered by 1..54% and 1..98%. The pro-inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor (TNF-α) levels were decreased by 27.59% and 31.92%. Red wine also reduced triglyceride (TG) level and lipid deposition in the liver， and increased the concentration of total bile acids (TBA). Untargeted metabolomics analysis indicated that red wine modulated the disorder of liver metabolism by regulating sphingolipid signaling pathway， sphingolipid metabolism， glycerophosphlipid metabolism， choline metabolism and bile secretion. 1.S rRNA sequencing revealed that red wine increased the abundance of Akkermansia and Bifidobacterium and reduced the abundance of Mucispirillum， Romboutsia， Lactobacillu， Bilophila and Blautia， along with the increased concentrations of short-chain fatty acids (SCFAs) in feces. These findings indicated that red wine could exert anti-atherosclerotic effect by regulating gut microbiota， restoring SCFAs， alleviating liver metabolic disorders.

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Computing-aware network (CAN): a systematic design of computing and network convergence

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Frontiers of Information Technology & Electronic Engineering 2024年第5期25卷 633-644页

作者： xiaoyun WANG Xiaodong DUAN Kehan YAO Tao SUN Peng LIU Hongwei YANG Zhiqiang LI China Mobile Communications Corporation Beijing 100032China China Mobile Research Institute Beijing 100053China

The coverage of network resources is increasingly extensive,and computing resources have likewise gradually become fundamental infrastructures,providing ubiquitous computing ***,in wide area networks(WANs),the underlying network and computing resources are not closely investigated or co-designed,and there are still problems reflected in slow computing service scheduling,inflexible data distribution,and inefficient data transmission.

关键词： computing network service

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Sulforaphane ameliorates non-alcoholic steatohepatitis by KLF4-mediated macrophage M2 polarization

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Food Science and Human Wellness 2024年第5期13卷 2727-2740页

作者： Xianghui Huang Jia Xu Ye Xu Bingxin Huangfu Feng Zhang Yanzhou Hu Ruxin Gao Xinxin Ren Boyang Zhang Kunlun Huang xiaoyun He Key Laboratory of Precision Nutrition and Food Quality Key Laboratory of Functional DairyMinistry of EducationCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Key Laboratory of Safety Assessment of Genetically Modified Organism(Food Safety) the Ministry of Agriculture and Rural Affairs of the P.R.ChinaBeijing 100083China

Non-alcoholic fatty liver disease (NAFLD) has become a global issue and a severe threat to public ***, to date, no approved therapeutic drugs have been developed. Dietary interventions with naturalproducts have shown promise in preventing and treating NAFLD. Sulforaphane (SFN) is a phytocompoundwith antioxidant and anti-inflammatory properties, and previous research has demonstrated that SFN canameliorate hepatic lipid accumulation and inflammation. However, the molecular mechanisms underlying thesebeneficial effects remain unclear. In this study, we confirmed the protective effects of SFN on excessive lipidaccumulation and inflammatory injury in a high-fat, high-fructose diet-induced non-alcoholic steatohepatitis(NASH) mouse model. We found that SFN attenuates the inflammatory injury in a macrophage cell line andthe liver of NASH mice, owing to the promotion of M1.type macrophage polarization toward the M2-type andthe regulation of inflammatory mediators. Further analysis demonstrated that this SFN-induced macrophageM2-type polarization occurs in a Krüppel-like factor 4 (KLF4)-dependent manner. In summary, we uncovereda new mechanism of action underlying SFN activity and provide evidence that dietary intervention with SFNmight be protective against NASH.

关键词： Non-alcoholic steatohepatitis(NASH) Krüppel-like factor 4 Nuclear translocation Chemokine Lipid metabolism

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Diagnostic Value of the Padua Score Combined with Thrombotic Biomarker Tissue Plasminogen Activator Inhibitor-1.(tPAI-1. Detection for the Risk of Deep Vein Thrombosis in Patients with Pulmonary Heart Disease

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Journal of Clinical and Nursing Research 2024年第8期8卷 137-144页

作者： xiaoyun Zhang Xinlong Xi Wenming Bian Qiang Liu Department of Cardiovascular Medicine People’s Hospital of PengzhouPengzhou 611930Sichuan ProvinceChina

This study explores the diagnostic value of combining the Padua score with the thrombotic biomarker tissue plasminogen activator inhibitor-1.tPAI-1.for assessing the risk of deep vein thrombosis(DVT)in patients with pulmonary heart *** patients often exhibit symptoms similar to venous thrombosis,such as dyspnea and bilateral lower limb swelling,complicating differential *** Padua Prediction Score assesses the risk of venous thromboembolism(VTE)in hospitalized patients,while tPAI-1.a key fibrinolytic system inhibitor,indicates a hypercoagulable *** data from hospitalized patients with cor pulmonale were retrospectively *** curves compared the diagnostic value of the Padua score,tPAI-1.levels,and their combined model for predicting DVT *** showed that tPAI-1.levels were significantly higher in DVT patients compared to non-DVT *** Padua score demonstrated a sensitivity of 82.61.and a specificity of 55.26%at a cutoff value of *** combined model had a significantly higher AUC than the Padua score alone,indicating better discriminatory ability in diagnosing DVT *** combination of the Padua score and tPAI-1.detection significantly improves the accuracy of diagnosing DVT risk in patients with pulmonary heart disease,reducing missed and incorrect *** study provides a comprehensive assessment tool for clinicians,enhancing the diagnosis and treatment of patients with cor pulmonale complicated by *** research should validate these findings in larger samples and explore additional thrombotic biomarkers to optimize the predictive model.

关键词： Padua prediction score Tissue plasminogen activator inhibitor-1.tPAI-1.detection Deep vein thrombosis(DVT) Pulmonary heart disease(cor pulmonale) Diagnostic accuracy

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Application of Bayesian Analysis Based on Neural Network and Deep Learning in Data Visualization

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Journal of Electronic Research and Application 2024年第4期8卷 88-93页

作者： Jiying Yang Qi Long xiaoyun Zhu Yuan Yang Yunnan Open University Kunming 650224Yunnan ProvinceChina

This study aims to explore the application of Bayesian analysis based on neural networks and deep learning in data *** research background is that with the increasing amount and complexity of data,traditional data analysis methods have been unable to meet the *** methods include building neural networks and deep learning models,optimizing and improving them through Bayesian analysis,and applying them to the visualization of large-scale data *** results show that the neural network combined with Bayesian analysis and deep learning method can effectively improve the accuracy and efficiency of data visualization,and enhance the intuitiveness and depth of data *** significance of the research is that it provides a new solution for data visualization in the big data environment and helps to further promote the development and application of data science.

关键词： Neural network Deep learning Bayesian analysis Data visualization Big data environment

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Low-frequency Stimulation at the Subiculum Prevents Extensive Secondary Epileptogenesis in Temporal Lobe Epilepsy

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Neuroscience Bulletin 2024年第5期40卷 564-576页

作者： Yujia Shen Yiwei Gong Xiaoli Da Shajing Gao Shuo Zhang Minjuan Sun Yuanzhi Yang xiaoyun Qiu Menghan Li Yang Zheng Fan Fei Yi Wang Zhong Chen Cenglin Xu Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou310053China Institute of Pharmacology and Toxicology NHC and CAMS Key Laboratory of Medical NeurobiologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China Department of Neurology First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310003China Department of Pharmacy The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310003China

Secondary epileptogenesis is characterized by increased epileptic susceptibility and a tendency to generate epileptiform activities outside the primary *** is one of the major resultants of pharmacoresistance and failure of surgical outcomes in epilepsy,but still lacks effective ***,we aimed to test the effects of low-frequency stimulation(LFS)at the subiculum for secondary epileptogenesis in a mouse ***,secondary epileptogenesis was simulated at regions both contralateral and ipsilateral to the primary focus by applying successive kindling *** kindled at the right CA3 showed higher seizure susceptibilities at both the contralateral CA3 and the ipsilateral entorhinal cortex and had accelerated kindling processes compared with naive *** at the ipsilateral subiculum during the primary kindling progress at the right CA3 effectively prevented secondary epileptogenesis at both the contralateral CA3 and the ipsilateral entorhinal cortex,characterized by decreased seizure susceptibilities and a retarded kindling process at those secondary *** application along with the primary epileptogenesis was ***,the effects of LFS on secondary epileptogenesis were associated with its inhibitory effect at the secondary focus through interfering with the enhancement of synaptic connections between the primary and secondary *** results imply that LFS at the subiculum is an effective preventive strategy for extensive secondary epileptogenesis in temporal lobe epilepsy and present the subiculum as a target with potential translational importance.

关键词： Secondary epileptogenesis Low-frequency stimulation Subiculum Temporal lobe epilepsy

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Targeted anti-cancer therapy: Co-delivery of VEGF siRNA and Phenethyl isothiocyanate (PEITC) via cRGD-modified lipid nanoparticles for enhanced anti-angiogenic efficacy

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 170-187页

作者： Bao Li Haoran Niu xiaoyun Zhao Xiaoyu Huang Yu Ding Ke Dang Tianzhi Yang Yongfeng Chen Jizhuang Ma Xiaohong Liu Keda Zhang Huichao Xie Pingtian Ding School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China School of Life Science and Biopharmaceutics Shenyang Pharmaceutical University Shenyang 1.001. China Department of Basic Pharmaceutical Sciences School of Pharmacy Husson University Bangor ME 04401USA College of Pharmacy Shenzhen Technology UniversityShenzhen 518118China

Anti-tumor angiogenesis therapy, targeting the suppression of blood vessel growth in tumors, presents a potent approach in the battle against cancer. Traditional therapies have primarily concentrated on single-target techniques, with a specific emphasis on targeting the vascular endothelial growth factor, but have not reached ideal therapeutic efficacy. In response to this issue, our study introduced a novel nanoparticle system known as CS-siRNA/PEITC&L-cRGD NPs. These chitosan-based nanoparticles have been recognized for their excellent biocompatibility and ability to deliver genes. To enhance their targeted delivery capability, they were combined with a cyclic RGD peptide (cRGD). Targeted co-delivery of gene and chemotherapeutic agents was achieved through the use of a negatively charged lipid shell and cRGD, which possesses high affinity for integrin αvβ3 overexpressed in tumor cells and neovasculature. In this multifaceted approach, co-delivery of VEGF siRNA and phenethyl isothiocyanate (PEITC) was employed to target both tumor vascular endothelial cells and tumor cells simultaneously. The co-delivery of VEGF siRNA and PEITC could achieve precise silencing of VEGF, inhibit the accumulation of HIF-1. under hypoxic conditions, and induce apoptosis in tumor cells. In summary, we have successfully developed a nanoparticle delivery platform that utilizes a dual mechanism of action of anti-tumor angiogenesis and pro-tumor apoptosis, which provides a robust and potent strategy for the delivery of anti-cancer therapeutics.

关键词： Anti-angiogenesis Tumor apoptosis Nanoparticles VEGF siRNA Hypoxia inducible factor(HIF)-1.protein Phenethyl isothi ocyanate(PEITC)

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包含有界切换增益的空间惯性传感器输出调节积分模型参考自适应控制

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中国科学：技术科学 2024年第3期54卷 490-500页

作者：孙笑云吴树范沈强上海交通大学航空航天学院上海200240 上海市引力波探测前沿科学研究基地上海200240

基于输出调节的多变量模型参考自适应控制(model reference adaptive control,MRAC)用于解决系统状态不可直接获取时,多变量系统向参考系统的稳定输出跟踪问题.在空间引力波探测航天器内部惯性传感器静电悬浮控制中,考虑到其作为航天器... 详细信息

基于输出调节的多变量模型参考自适应控制(model reference adaptive control,MRAC)用于解决系统状态不可直接获取时,多变量系统向参考系统的稳定输出跟踪问题.在空间引力波探测航天器内部惯性传感器静电悬浮控制中,考虑到其作为航天器平台惯性基准的稳定需求,双质量块动力学中存在的不连续干扰影响,以及应对不同工作模式的瞬态切换,提出一种基于积分输出调节MRAC的静电悬浮控制方案,引入有界的切换自适应校正增益及自适应积分修正项,用于系统不连续情况下的抗输入饱和、瞬态抑制及惯性传感器非敏感轴各自由度向参考状态的稳定逼近.基于Filippov集与广义梯度的Lyapunov分析验证该方案下,不连续系统中各闭环信号的收敛性,数值仿真验证样例空间引力波探测航天器中,作为关键载荷的双质量块空间惯性传感器各非敏感轴自由度针对位移噪声及残余加速度及切换瞬态的良好抑制效果.

关键词：静电悬浮控制空间引力波探测惯性传感器模型参考自适应控制不连续系统有界切换增益

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