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Acta Pharmaceutica Sinica B 2024年第2期14卷 517-532页

作者： Shuang Xiang xiaoyun Lu International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education(MOE) Guangdong Provincial Key Laboratory of New Drug Design and EvaluationGuangzhou City Key Laboratory of Precision Chemical Drug DevelopmentSchool of PharmacyJinan UniversityGuangzhou 510632China

Neurotrophic receptor kinase(NTRK) fusions are actionable oncogenic drivers of multiple pediatric and adult solid tumors,and tropomyosin receptor kinase(TRK) has been considered as an attractive therapeutic target for "pan-cancer" harboring these ***,two generations TRK inhibitors have been *** representative second-generation inhibitors selitrectinib and repotrectinib were designed to overcome clinic acquired resistance of the first-generation inhibitors larotrectinib or entrectinib resulted from solvent-front and gatekeeper on-target ***,xDFG(TRKAG667C/A/S,homologous TRKCG696C/A/S) and some double mutations still confer resistance to selitrectinib and repotrectinib,and overcoming these resistances represents a major unmet clinical *** this review,we summarize the acquired resistance mechanism of the first-and second-generation TRK inhibitors,and firstly put forward the emerging selective type Ⅱ TRK inhibitors to overcome xDFG mutations mediated ***,we concluded our perspectives on new challenges and future directions in this field.

关键词： NTRK fusions TRK kinase Clinical resistance xDFG mutations Selective type II inhibitors

Performance evaluation of HY-2 series satellites in marine gravity field recovery

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Geodesy and Geodynamics 2024年第4期15卷 397-403页

作者： Ruijie Hao xiaoyun Wan Keyan Zhang School of Land Science and Technology China University of Geosciences(Beijing)Beijing100083China School of Geospatial Engineering and Science Sun Yat-Sen UniversityZhuhai519082China

China has successfully launched four Haiyang-2(HY-2)series altimetry ***-2A has attracted significant attention in gravity field recovery,but the performance of other HY-2 series satellites,including HY-2B/C/D,is seldom *** study evaluated the performance of all the HY-2 series satellites in recovering marine gravity ***,the crossover discrepancies in sea surface height of the four satellites,HY-2A,HY-2B,HY-2C,and HY-2D,were analyzed to assess their altimetry *** was found that HY-2B had the best altimetry quality,followed by ***,different combina-tions of altimetry data were used to calculate vertical deflections and gravity anomalies in the South China Sea(1.2°E-1.9°E,1.°N-20°N).The results showed that combining data from HY-2B,HY-2C,and HY-2D improved the inversion accuracy of gravity anomalies by 0.3 mGal compared to using HY-2A data ***-2C and HY-2D contributed to enhancing the accuracy of the east component of vertical deflections.

关键词： Satellite altimetry HY-2 Sea surfaceheight Marinegravityfield

Light quarkonium and charmonium mass shifts in an unquenched quark model

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Chinese Physics C 2024年第9期48卷 96-106页

作者： xiaoyun Chen Yue Tan College of Science Jinling Institute of TechnologyNanjing 211169China Department of Physics Yancheng Institute of TechnologyYancheng 224000China

The unquenched quark model for the light quarkonium and charmonium states is explored in this *** quark-pair creation operator in the^(3)P_(0) model,which combines the two-quark and four-quark components,is modified by considering the effects of the created quark pair's ***,the separation between the created quark pair and valence quark pair is *** the wave functions,including those for the mesons and the relative motion between two mesons,are obtained by solving the corresponding Schrodinger equation using the Gaussian expansion *** aim of this study is to find a new set of parameters that can accurately describe the mass spectrum of low-lying light quarkonium and charmonium ***,certain exotic states,such as X(3872),can be described well in the unquenched quark model.

关键词： the unquenched quark model Gaussian expansion method light quarkonium and charmonium states

The fast method and convergence analysis of the fractional magnetohydrodynamic coupled flow and heat transfer model for the generalized second-grade fluid

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Science China Mathematics 2024年第4期67卷 919-950页

作者： Xiaoqing Chi Hui Zhang xiaoyun Jiang School of Mathematics and Statistics Shandong UniversityWeihai 264209China School of Mathematics Shandong UniversityJinan 250100China

In this paper,we first establish a new fractional magnetohydrodynamic(MHD)coupled flow and heat transfer model for a generalized second-grade *** coupled model consists of a fractional momentum equation and a heat conduction equation with a generalized form of Fourier *** second-order fractional backward difference formula is applied to the temporal discretization and the Legendre spectral method is used for the spatial *** fully discrete scheme is proved to be stable and convergent with an accuracy of O(τ^(2)+N-r),whereτis the time step-size and N is the polynomial *** reduce the memory requirements and computational cost,a fast method is developed,which is based on a globally uniform approximation of the trapezoidal rule for integrals on the real *** strict convergence of the numerical scheme with this fast method is *** present the results of several numerical experiments to verify the effectiveness of the proposed ***,we simulate the unsteady fractional MHD flow and heat transfer of the generalized second-grade fluid through a porous *** effects of the relevant parameters on the velocity and temperature are presented and analyzed in detail.

关键词： fractional MHD coupled flow and heat transfer model generalized second-grade fuid fast method convergence analysis numerical simulation

Factor Price Distortion,Technological Innovation,and High-Quality Economic Development

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2024年第1期19卷 91-105页

作者： WANG xiaoyun School of Accounting Dongbei University of Finance and EconomicsDalian 116025China School of Accounting Dalian University of Finance and EconomicsDalian 116622China

The entropy method is used to measure the high-quality economic development levels of 30 provinces(autonomous regions,municipalities)in China from 201. to 2020,and the impacts of factor price distortion,technological innovation,and their interaction terms on high-quality economic development are analyzed based on Tobit *** results show that highquality economic development of 30 provinces(autonomous regions,municipalities)in China is on the rise;factor price distortion has an inhibitory effect on high-quality economic development,while technological innovation has a promoting effect on high-quality economic development,and both of them have a lag effect;technological innovation level can help alleviate the negative impact of factor price distortion on high-quality economic development;and sub-regional research shows that the inhibitory effect of factor price distortion on highquality economic development in the east is significantly higher than that in the central and western regions,but the positive effect of technological innovation and the interaction terms between the two on high-quality economic development is significantly lower than that in the central and western ***,it is proposed to optimize top-level design for the two-wheel drive for high-quality economic development,strengthen the primary role of enterprises in innovation to promote high-quality economic development,and optimize the market-oriented allocation of factors to improve the efficiency of resource allocation.

关键词： factor price distortion technological innovation high-quality economic development entropymethod

A lightweight semantic segmentation algorithm integrating CA and ECA-Net modules

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Optoelectronics Letters 2024年第9期20卷 568-576页

作者： GUO Zhihao MA Dongmei LUO xiaoyun School of Physics and Electronic Engineering Northwest Normal UniversityLanzhou 730070China

Aiming at the existing semantic segmentation process due to the loss of pixel features and the complexity of calculating too many parameters,which leads to unsatisfactory segmentation results and too long time,this paper proposes a lightweight semantic segmentation algorithm based on the fusion of multiple *** algorithm is based on the pyramid scene parsing network(PSPNet).Firstly,Mobile Net V2 network is chosen as the feature extraction network to construct the lightweight network structure.

关键词： Net network algorithm

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Does Chinese Environmental Policy Affect Income Inequality? Evidence from the Central Environmental Protection Inspection

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China & World Economy 2024年第3期32卷 130-161页

作者： xiaoyun Wei Chuanmin Zhao China Academy for Rural Development and School of Public Affairs Zhejiang UniversityChina China Investment Corporation China

This paper investigates the effect of environmental policy on income *** focuses on the central environmental protection inspection led by the central government in *** a diference-in-diferences approach,it finds evidence that environmental regulation decreased the per capita income and enlarged the gap between urban and rural income while showing an insignificant effect on *** the policy can reduce pollution levels and bring environmental benefits in aggregate,the findings of this study suggest that the regulations appear to have reduced the proportion of manufacturing industry and hindered general innovation and investment from entrepreneurs,which resulted in greater *** residents suffered more from environmental regulation due to relatively high migration costs and their disadvantaged human resources on the aspects of health,education level,and *** local government's execution incentive can also play a key role in the effectiveness of environmental *** with lower GDP growth targets and younger government leaders were affected significantly with regard to the income growth of local residents and the urban-rural income gap.

关键词： central environmental protection inspection income inequality promotion incentive top-down policy urban-rural gap

Photonic neuromorphic architecture for tens-of-task lifelong learning

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Light(Science & Applications) 2024年第3期13卷 519-530页

作者： Yuan Cheng Jianing Zhang Tiankuang Zhou Yuyan Wang Zhihao Xu xiaoyun Yuan Lu Fang Sigma Laboratory Department of Electronic EngineeringTsinghua UniversityBeijing 100084China Beijing National Research Center for Information Science and Technology(BNRist) Beijing 100084China Institute for Brain and Cognitive Science Tsinghua University(THUIBCS)Beijing 100084China

Scalable,high-capacity,and low-power computing architecture is the primary assurance for increasingly manifold and large-scale machine learning *** electronic artificial agents by conventional power-hungry processors have faced the issues of energy and scaling walls,hindering them from the sustainable performance improvement and iterative multi-task *** to another modality of light,photonic computing has been progressively applied in high-efficient neuromorphic ***,we innovate a reconfigurable lifelong-learning optical neural network(L2 ONN),for highly-integrated tens-of-task machine intelligence with elaborated algorithm-hardware *** from the inherent sparsity and parallelism in massive photonic connections,L2 ONN learns each single task by adaptively activating sparse photonic neuron connections in the coherent light field,while incrementally acquiring expertise on various tasks by gradually enlarging the *** multi-task optical features are parallelly processed by multi-spectrum representations allocated with different *** evaluations on freespace and on-chip architectures confirm that for the first time,L2 ONN avoided the catastrophic forgetting issue of photonic computing,owning versatile skills on challenging tens-of-tasks(vision classification,voice recognition,medical diagnosis,etc.)with a single ***,L2 ONN achieves more than an order of magnitude higher efficiency than the representative electronic artificial neural networks,and 1.×larger capacity than existing optical neural networks while maintaining competitive performance on each individual *** proposed photonic neuromorphic architecture points out a new form of lifelong learning scheme,permitting terminal/edge AI systems with light-speed efficiency and unprecedented scalability.

关键词： life neural versatile

A combination of straw incorporation and polymer-coated urea offsets soil ammonia and nitrous oxide emissions in winter wheat fields

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Journal of Integrative Agriculture 2024年第5期23卷 1718-1736页

作者： xiaoyun Wang Yajie Tian Qianhui Zhang Zhengxin Zhao Rui Wang Huanjie Cai Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid Areas of Ministry of Education Northwest A&F UniversityYangling712100China College of Water Resources and Architectural Engineering Northwest A&F UniversityYangling 712100China

The combined effects of straw incorporation(SI)and polymer-coated urea(PCU)application on soil ammonia(NH_(3))and nitrous oxide(N_(2)O)emissions from agricultural fields have not been comprehensively evaluated in Northwest *** conducted a two-year field experiment to assess the effects of combining SI with either uncoated urea(U)or PCU on soil NH_(3)emissions,N_(2)O emissions,winter wheat yields,yield-scaled NH_(3)(/NH_(3)),and yield-scaled N_(2)O(/N_(2)O).Five treatments were investigated,no nitrogen(N)fertilizer(N_(0)),U application at 1.0 kg N ha-1.with and without SI(SI+U and S_(0)+U),and PCU application at 1.0 kg N ha^(-1. with and without SI(SI+PCU and S_(0)+PCU).The results showed that the NH_(3);emissions increased by 20.98-34.35%following Sl compared to straw removal,mainly due to increases in soil ammonium(NH_(4)^(+)-N)content and water-flled pore space(WFPS).SI resulted in higher N_(2)O emissions than under the So scenario by 1..31.49.23%due to increases in soil inorganic N(SIN)contents,WFPS,and soil microbial *** contrast,the PCU application reduced the SIN contents compared to the U application,reducing the NH_(3)and N_(2)O emissions by 45.99-58.07 and 1..08-53.04%,***,no significant positive effects of the SI or PCU applications on the winter wheat yield were *** lowest /NH_(3) and /N_(2)O values were observed under the S_(0)+PCU and SI+PCU *** results suggest that single PCU applications and their combination with straw are the optimal agricultural strategies for mitigating gaseous N emissions and maintaining optimal winter wheat yields in Northwest China.

关键词： straw incorporation polymer-coated urea NH_(3)and N_(2)O emissions winter wheat yields

Characterization of mulberry leaf instant tea and evaluation of its hypolipidemia effect via regulation of intestinal microbiota

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Food Science and Human Wellness 2024年第3期13卷 1348-1357页

作者： xiaoyun Han Yunlong Bai Xiaoxin Feng Baochang Du Baojiang Zheng Qingshen Sun Engineering Research Center of Agricultural Microbiology Technology Ministry of Education&Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold RegionKey Laboratory of Molecular Biology&Key Laboratory of MicrobiologyCollege of Heilongjiang Province&School of Life SciencesHeilongjiang UniversityHarbin 150080China Gannan Forest Farm Qiqihaer 162100China College of Life Sciences Northeast Forestry UniversityHarbin 150040China

The purpose of this study was to characterize mulberry leaf instant tea(MLIT)powder prepared from the'Longsang No.1.(Morus abla *** 1.mulberry leaves in Heilongjiang Province(China)and assess its obesity-preventing/relieving effects.A total of 1.4 compounds including quercetin,chlorogenic acid,1.deoxyecomycin(1.DNJ)related to antihyperlipidemia effects were identified from the MLIT *** treatment reversed the Lee's index,fat coefficient,and serum biochemical parameters in both the obesity relieving and obesity preventing mice fed with high-fat *** the obesity relieving experiment,the relative abundance of Desulfovibrio in mouse feces decreased after both 0.5%and 1.MLIT *** obesity preventing experiments,mouse with different amount of MLIT treatments showed increased relative abundance of Akkermansia,Bifidobacterium and Lactobacillus,while Deferribacteres,Desulfobacterota *** beneficial bacteria in the intestinal tract of mice treated with MLIT *** study proved that MLIT had antihyperlipidemia potential via modulating intestinal microbiota in mice.

关键词： Mulberry leaf instant tea Liquid chromatography-mass spectrometry(LC-MS) Antihyperlipidemia Intestinal microbiota