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两个视锥-视杆细胞营养不良家系的AIPL1基因变异分析

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中华医学遗传学杂志 2019年第11期36卷 1081-1084页

作者：王犁明郝朋应铭韩瑞芳王玉川高娟苑晓勇李轩天津市眼科医院天津市眼科研究所天津市眼科学与视觉科学重点实验室天津医科大学眼科临床学院南开大学附属眼科医院天津300020

目的分析两个视锥-视杆细胞营养不良家系的基因变异情况,探索基因变异类型与临床表型的联系.方法对家系成员进行电生理、眼底照相等眼科临床检查.采集患者及其父母外周静脉血样提取基因组DNA,采用全外显子组测序筛选家系候选致病基因并... 详细信息

目的分析两个视锥-视杆细胞营养不良家系的基因变异情况,探索基因变异类型与临床表型的联系.方法对家系成员进行电生理、眼底照相等眼科临床检查.采集患者及其父母外周静脉血样提取基因组DNA,采用全外显子组测序筛选家系候选致病基因并进行分析.结果家系1患者检测出AIPL1基因错义变异c.923T>C(p.L308P)和无义变异c.421C>T(p.Q141X),其父亲携带p.Q141X变异,母亲携带p.L308P变异;家系2患者检测出AIPL1基因错义变异c.572T>C(p.L191P)和无义变异c.421C>T(p.Q141X),其父亲携带p.Q141X变异,母亲携带p.L191P变异.结论AIPL1基因新的p.L308P、p.L191P、p.Q141X复合杂合变异体尚未见报道,是导致两例视锥-视杆细胞营养不良患者发病的主要原因.全外显子组测序方法有助于对视锥视杆细胞营养不良进行分子鉴别诊断,并为患者遗传咨询提供依据.

关键词：视锥-视杆细胞营养不良 AIPL1基因基因变异全外显子组测序

Particle Swarm Optimization-Support Vector Machine Model for Machinery Fault Diagnoses in High-Voltage Circuit Breakers

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Chinese Journal of Mechanical Engineering 2020年第1期33卷 104-113页

作者： Xiaofeng Li Shijing Wu xiaoyong Li Hao yuan Deng Zhao School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China

According to statistic data,machinery faults contribute to largest proportion of High-voltage circuit breaker failures,and traditional maintenance methods exist some disadvantages for that ***,based on the wavelet packet decomposition approach and support vector machines,a new diagnosis model is proposed for such fault diagnoses in this *** vibration eigenvalue extraction is analyzed through wavelet packet decomposition,and a four-layer support vector machine is constituted as a fault *** Gaussian radial basis function is employed as the kernel function for the *** penalty parameter c and kernel parameterδof the support vector machine are vital for the diagnostic accuracy,and these parameters must be carefully ***,a particle swarm optimizationsupport vector machine model is developed in which the optimal parameters c andδfor the support vector machine in each layer are determined by the particle swarm *** validity of this fault diagnosis model is determined with a real dataset from the operation ***,comparative investigations of fault diagnosis experiments with a normal support vector machine and a particle swarm optimization back-propagation neural network are also *** results indicate that the proposed fault diagnosis model yields better accuracy and e-ciency than these other models.

关键词： High-voltage circuit breaker Machinery fault diagnosis Wavelet packet decomposition Support vector machine

Late Triassic–Cenozoic Thermochronology in the Southern Sanjiang Tethys, SW China, New Insights from Zircon Fission Track Analysis

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Journal of Earth Science 2019年第5期30卷 996-1004页

作者： Li Yang Wanming yuan xiaoyong Zhu Zhen Shi Science Research Institute China University of Geosciences

The Sanjiang Tethys orogenic belt is located in the southeast side of the Qinghai-Tibet Plateau. It has undergone the opening and closing movements in different periods of Tethys oceans, complex accretive orogeny and strong mineralization from Paleozoic to Mesozoic. Using zircon fission track(ZFT) thermochronology, this study reveals the Sanjiang Tethys has experienced multi-stage tectonic activities during the Late Triassic–Cenozoic. The 15 ZFT ages with their decomposition components obtained from Sanjiang Tethysian region range from 212 to 19 Ma, which not only shows 6 age groups of 212, 179–172, 156–133, 121–96, 84–70 and 50–19 Ma, but also constrains the age limit of the tectonothermal events. These age groups recorded the Paleo-Tethys main and branches ocean opening/closure time. The age-elevation plot indicates the Sanjiang region had differential uplifting and exhumation and fast uplifting times of ca. 133, 116 and 80 Ma, coinciding with the age groups mentioned above. These results show new geochronological evidences and viewpoints.

关键词： tectonic events zircon fission track analysis tethys evolution Sanjiang region Qinghai-Tibet Plateau thermochronology

Chaotic CS Encryption:An Efficient Image Encryption Algorithm Based on Chebyshev Chaotic System and Compressive Sensing

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Computers, Materials & Continua 2024年第5期79卷 2625-2646页

作者： Mingliang Sun Jie yuan xiaoyong Li Dongxiao Liu Key Laboratory of Trustworthy Distributed Computing and Service(BUPT) Ministry of EducationBeijing University of Posts and TelecommunicationsBeijing100876China

Images are the most important carrier of human information. Moreover, how to safely transmit digital imagesthrough public channels has become an urgent problem. In this paper, we propose a novel image encryptionalgorithm, called chaotic compressive sensing (CS) encryption (CCSE), which can not only improve the efficiencyof image transmission but also introduce the high security of the chaotic system. Specifically, the proposed CCSEcan fully leverage the advantages of the Chebyshev chaotic system and CS, enabling it to withstand various attacks,such as differential attacks, and exhibit robustness. First, we use a sparse trans-form to sparse the plaintext imageand then use theArnold transformto perturb the image pixels. After that,we elaborate aChebyshev Toeplitz chaoticsensing matrix for CCSE. By using this Toeplitz matrix, the perturbed image is compressed and sampled to reducethe transmission bandwidth and the amount of data. Finally, a bilateral diffusion operator and a chaotic encryptionoperator are used to perturb and expand the image pixels to change the pixel position and value of the compressedimage, and ultimately obtain an encrypted image. Experimental results show that our method can be resistant tovarious attacks, such as the statistical attack and noise attack, and can outperform its current competitors.

关键词： Image encryption chaotic system compressive sensing arnold transform

The Effect of Bi_2O_3 on the Structure and Microwave Dielectric Properties of Ba_(6-3x)Nd_(8+2x)Ti_(18)O_(54)System(x=2/3)

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Journal of Wuhan University of Technology(Materials Science) 2008年第2期23卷 143-146页

作者： LI yuan WU Shunhua SU Hao WANG xiaoyong Institute of Electronics and Information Engineering Tianjin University Tianjin 300072 China

The structures and dielectric properties of Ba6-3xNd8＋2xTi18O54 system（x=2/3） doped with different contents of Bi2O3, whose final molecular formula is Ba6-3x（Nd1-yBiy）8＋2xTi18O54 were investigated. It is indicated that the dielectric constant increases greatly whereas Q value（f0=4 GHz） decreases with the increase of Bi2O3 content. However, the temperature coefficient could be controlled below 0±30×10^-6/℃ in the experiment. These phenomena are related to the appearance of a new phase, Bi4Ti3O12, which has high dielectric constant. Also, that Bi^3＋（0.13 nm） substitutes for Nd^3＋（0.099 5 nm） will increase the unit cell volume, which will lead to the enlargement of the octahedron B site occupied by Ti^4＋. So the spontaneous polarization of Ti^4＋ ions will be strengthened. Besides, Bi^3＋ will fill up some vacancies which Ba^2＋ or Nd^3＋ ions leave in two A1 sites and four A2 sites. More positive ions polarize, which also contributes to higher dielectric constant. The samples got with the optimium properties are sintered at 1 200 ℃ for 4 h, when y=0.25, ε≈110, Q≈5 400（f0=4 GHz）, TCC=-4.7×10^-6/℃; When y=0.3, ε≈120, Q≈5 000（f0=4 GHz）, TCC=-24×10^-6/℃.

关键词： BNT Bi2O3 dielectric constant temperature coefficient Q value

Objective Identification and Climatic Characteristics of Heavy-Precipitation Northeastern China Cold Vortexes

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Advances in Atmospheric Sciences 2023年第2期40卷 305-316,I0009,I0010页

作者： Xu CHEN xiaoyong ZHUGE Xidi ZHANG yuan WANG Daokai XUE Key Laboratory of Mesoscale Severe Weather of Ministry of Education and School of Atmospheric SciencesNanjing UniversityNanjing 210023China Key Laboratory of Transportation Meteorology of China Meteorological Administration Nanjing Joint Institute for Atmospheric SciencesNanjing 210041China National Meteorological Center Beijing 100081China

The northeastern China cold vortex(NCCV)plays an important role in regional rainstorms over East *** the National Centers for Environmental Prediction Final reanalysis dataset and the Global Precipitation Measurement product,an objective algorithm for identifying heavy-precipitation NCCV(HPCV)events was designed,and the climatological features of 164 HPCV events from 2001 to 2019 were *** number of HPCV events showed an upward linear trend,with the highest frequency of occurrence in *** most active region of HPCV samples was the Northeast China Plain between 40°–55°*** HPCV events lasted 3–5 days and had radii ranging from 250 to 1000 *** duration of HPCV events with larger sizes was *** half of the HPCV events moved into(moved out of)the definition region(35°–60°N,115°–145°E),and half initiated(dissipated)within the *** initial position was close to the western boundary of the definition region,and the final position was mainly near the eastern *** locations associated with the precipitation were mostly concentrated within 2000 km southeast of the HPCV systems,and they were farther from the center in the cold season than in the warm season.

关键词： northeastern China cold vortex heavy precipitation objective identification climatological features

Multifunctional Fluorescent Magnetic Nanoparticles： Synthesis, Characterization and Targeted Cell Imaging Applications

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Chinese Journal of Chemistry 2017年第6期35卷 977-983页

作者： Lilin Zhou, xiaoyong Zhang Lei Liu Yen Wei Jinying yuan Key Lab of Organic Optoelectronic & Molecular Engineering Department of Chemistry Tsinghua University Beijing 100084 China

Multifunctional fluorescent magnetic nanoparticles （Fe3O4@SiO2-PLLA-RhB/FA） with cell recognition ability were synthesized through conjugation of magnetic nanoparticles with folic acid （FA） and Rhodamine B. To verity their potential biomedical applications, biocompatibility as well as cell imaging applications of the multifunctional nanoparticles were further investigated. Results showed that these fluorescent magnetic nanoparticles are well bio- compatible with NIH-3T3 cells and HeLa cells. More importantly, these nanoparticles could be selectively taken up by HeLa cells （FA receptor positive） as evidenced by laser scanning confocal microscopy, suggesting their potential for biological imaging applications. Given their excellent biocompatibility and multifunctional characteristics, weexpect that the fluorescent magnetic nanoparticles could be promising for various biomedical applications.

关键词： fluorescent magnetic particles biological imaging multifunctional biocompatibility

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通气减蚀挑坎水力学问题的试验研究

水利学报 1983年第3期 1-13页

作者：时启燧潘水波邵媖媖袁小勇水利水电科学研究院

本文仅对通气减蚀设施中应用较普遍、体型最简单的陡坡上微突挑坎进行了较系统的试验研究。文中就挑坎高度、坎后空腔的长度和轮廓,空腔末端断面水流掺气情况,底板承受的动水压力,沿壁射流底层的挟气能力等,按自模、相似原理进行了试验... 详细信息

本文仅对通气减蚀设施中应用较普遍、体型最简单的陡坡上微突挑坎进行了较系统的试验研究。文中就挑坎高度、坎后空腔的长度和轮廓,空腔末端断面水流掺气情况,底板承受的动水压力,沿壁射流底层的挟气能力等,按自模、相似原理进行了试验分析,给出了一系列经验性拟合方程。最后,根据沿壁水流掺气状况的演变资料,讨论了通气减蚀设施的防蚀保护范围,并提供了估算方法。

关键词：挑坎空腔掺气浓度高速水流水流动通气减蚀水力学流体力学

Synthesis,insecticidal activity and stability study of novel nitromethylene neonicotinoids with five-membered aromatic heterocycles

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Chinese Chemical Letters 2023年第6期34卷 391-394页

作者： Li Han Zihao yuan Xusheng Shao xiaoyong Xu Zhong Li Shanghai Key Laboratory of Chemical Biology School of PharmacyEast China University of Science and TechnologyShanghai 200237China Shanghai Collaborative Innovation Center for Biomanufacturing Technology Shanghai 200237China

Twenty-four novel neonicotinoid analogues with nitromethylene and five-membered aromatic heterocycles were designed and *** target molecular structures have been confirmed by analytical and spectral *** compounds exhibited notable insecticidal activities against aphid(Aphis medicaginis)and brown planthopper(Nilaparvata lugens).The aqueous stability test confirmed that the stabilities of those compounds were superior to the leading compound,and the photostability was even better than that of imidacloprid.

关键词： Nitromethylene Neonicotinoids Selective reduction Stability Insecticidal activity