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三种截骨保膝方案治疗膝内侧间室骨关节炎的疗效比较

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中国中医骨伤科杂志 2024年第4期32卷 39-43页

作者：郭浩山谢晓音潘超马建李楠刘晓之聊城市中医医院山东聊城252000 聊城市退役军人医院莒南县人民医院

目的:对比单纯开放楔形胫骨高位截骨术、关节镜清理联合开放楔形胫骨高位截骨术、关节镜清理联合腓骨近端截骨术三种保膝方案治疗膝内侧间室骨关节炎的疗效。方法:自2016年1月至2022年8月,82例(82膝)内侧膝骨关节炎患者接受保膝手术治疗... 详细信息

目的:对比单纯开放楔形胫骨高位截骨术、关节镜清理联合开放楔形胫骨高位截骨术、关节镜清理联合腓骨近端截骨术三种保膝方案治疗膝内侧间室骨关节炎的疗效。方法:自2016年1月至2022年8月,82例(82膝)内侧膝骨关节炎患者接受保膝手术治疗,根据治疗方案的不同分为3组:A组单纯行开放楔形胫骨高位截骨术(23例),B组行关节镜清理联合开放楔形胫骨高位截骨术(30例),C组行关节镜清理联合腓骨近端截骨术(29例)。分别记录三组手术时间、围手术期出血量、术前及术后随访时美国特种外科医院(HSS)评分、视觉模拟量表(VAS)评分,进行疗效评价。结果:所有病例均获得随访,随访时间平均为(20.4±8.5)个月。A组和C组手术时间差异无统计学意义(P>0.05),均较B组短,差异有统计学意义(P0.05),均较C组多,差异有统计学意义(P0.05),均较C组改善更为明显,差异有统计学意义(P<0.05)。结论:三种保膝方案治疗膝内侧间室骨关节炎均起到良好效果,联合关节镜能够处理半月板损伤、软骨损伤等病变,但并没有显著提高胫骨高位截骨术的疗效,单纯进行胫骨高位截骨术即可取得令人满意的疗效,腓骨近端截骨术远期疗效逊于胫骨高位截骨术,但创伤小、花费少、术后可早期完全负重行走是其优点。

关键词：膝骨关节炎胫骨高位截骨术腓骨近端截骨术关节镜保膝

Thermal-history reconstruction of the Baiyun Sag in the deep-water area of the Pearl River Mouth Basin, northern South China Sea

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Frontiers of Earth Science 2018年第3期12卷 532-544页

作者： xiaoyin.TANG Shuchun YANG Shengbiao HU Geothermal and Environmental Research Laboratory Xi'an Jiaotong University Xi'an 710049 China CNOOC Research Institute Beijing 100027 China Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China

The Baiyun Sag, located in the deep-water area of the northern South China Sea, is the largest and deepest subbasin in the Pearl River Mouth Basin and one of the most important hydrocarbon-accumulation depression areas in China. Thermal history is widely thought to be of great importance in oil and gas potential assessment of a basin as it controls the timing of hydrocarbon generation and expulsion from the source rock. In order to unravel the paleo-heat flow of the Baiyun Sag, we first analyzed tectonic subsidence of 55 pseudo-wells constructed based on newly interpreted seismic profiles, along with three drilled wells. We then carried out thermal modeling using the multi-stage finite stretching method and calibrated the results using collected present-day vitrinite reflectance data and temperature data. Results indicate that the first and second heating of the Baiyun Sag after 49 ma ceased at 33.9 ma and 23 ma. Reconstructed average basal paleo- heat flow values at the end of the rifting periods are -57.7- 86.2 mW/m2 and -66.7-97.3 mW/m2, respectively. Following the last heating period at 23 ma, the study area has undergone a persistent thermal attenuation phase, and basal heat flow has cooled down to ～64.0-79.2 mW/m2 at present.

关键词： thermal history tectonic subsidence Baiyun Sag deep-water area South China Sea

1,8-cineole ameliorates colon injury by downregulating macrophage M1 polarization via inhibiting the HSP90-NLRP3-SGT1 complex

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Journal of Pharmaceutical Analysis 2023年第9期13卷 984-998页

作者： Shengsuo ma Bing Yang Yang Du Yiwen Lv Jiarong Liu Yucong Shi Ting Huang Huachong Xu Li Deng xiaoyin.Chen School of Traditional Chinese Medicine Jinan UniversityGuangzhou510632China Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine Jinan UniversityGuangzhou510632China

Ulcerative colitis(UC)is characterized by chronic relapsing intestinal ***,there is no effective treatment for the *** to our preliminary data,1,8-cineole,which is the main active compound of Amomum compactum *** maton volatile oil and an effective drug for the treatment of pneumonia,showed remarkable anti-inflammatory effects on colitis ***,its mechanism of action and direct targets remain *** study investigated the direct targets and mechanism through which 1,8-cineole exerts its anti-inflammatory effects using a dextran sulfate sodium salt-induced colitis mouse *** effects of 1,8-cineole on macrophage polarization were investigated using activated bone marrow-derived macrophages and RAW264.7 *** addition,1,8-cineole targets were revealed by drug affinity responsive target stability,thermal shift assay,cellular thermal shift assay,and heat shock protein 90(HSP90)adenosine triphosphatases(ATPase)activity *** results showed that 1,8-cineole exhibited powerful anti-inflammatory properties in vitro and in vivo by inhibiting the macrophage M1 polarization and protecting intestinal barrier ***,1,8-cineole directly interacted with HSP90 and decreased its ATPase activity,also inhibited nucleotide-binding and oligomerization domain-,leucine rich repeat-,and pyrin domain-containing 3(NLRP3)binding to HSP90 and suppressor of G-two allele of SKP1(SGT1)and suppressed NLRP3 inflammasome activation in *** results demonstrated that 1,8-cineole is a potential drug candidate for UC treatment.

关键词： 1,8-cineole Amomum compactum Sol.ex maton NLRP3 HSP90 Ulcerative colitis Intestinal barrier function

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儿童急性弛缓性脊髓炎4例临床特点分析

中华儿科杂志 2024年第7期62卷 676-680页

作者：葛绣山焦辉陈倩张宝元赵林清朱汝南李淑品马才惠张媛媛彭晓音首都儿科研究所附属儿童医院神经内科北京100020 首都儿科研究所附属儿童医院感染管理处北京100020 首都儿科研究所病毒学研究室北京100020

目的总结儿童急性弛缓性脊髓炎(AFM)的临床表现、诊治经验和预后。方法回顾性病例总结,对首都儿科研究所附属儿童医院神经内科2018年9月至2022年11月收治的4例临床诊断AFM患儿的病例资料进行临床特点分析。结果4例AFM患儿年龄分别为7岁... 详细信息

目的总结儿童急性弛缓性脊髓炎(AFM)的临床表现、诊治经验和预后。方法回顾性病例总结,对首都儿科研究所附属儿童医院神经内科2018年9月至2022年11月收治的4例临床诊断AFM患儿的病例资料进行临床特点分析。结果4例AFM患儿年龄分别为7岁、4岁3月龄、7岁1月龄、6岁5月龄,女2例、男2例。前驱呼吸道感染3例、消化道感染1例。以感染后出现不对称肢体无力为主要表现,受影响肢体范围从单一肢体到四肢。所有患儿均无脑病表现,1例患儿出现周围性面瘫。4例患儿脊髓磁共振成像均提示长节段长T1长T2信号,以灰质受累为主。2例患儿出现脑脊液细胞-蛋白分离现象。1例咽拭子病原体检出肠道病毒D68;1例患儿血液中腺病毒抗体IgM阳性;1例患儿血液中埃可病毒、柯萨奇B组病毒抗体IgG阳性。4例患儿经过糖皮质激素、人免疫球蛋白或单纯对症治疗,同时在后期康复训练下,肌力不同程度恢复,3例遗留有残疾。结论以感染后、急性、不对称肢体无力起病伴有磁共振成像脊髓中央区域异常信号的患儿需考虑AFM,目前有效治疗手段有限且预后不良。

关键词：儿童急性弛缓性脊髓炎急性弛缓性麻痹肠道病毒

Zircon U-Pb geochronology,Hf isotopes,and geochemistry constraints on the age and tectonic affinity of the basement granitoids from the Qiongdongnan Basin,northern South China Sea

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Acta Oceanologica Sinica 2023年第3期42卷 19-30页

作者： Lijun Mi xiaoyin.Tang Haizhang Yang Shuchun Yang Shuai Guo China National Offshore Oil Corporation(CNOOC)Research Center Beijing 100028China Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China Key Laboratory of Paleomagnetism and Tectonic Reconstruction Ministry of Natural ResourcesBeijing 100081China Key Laboratory of Petroleum Geomechanics China Geological SurveyBeijing 100081China

Studies in the northern South China Sea(SCS)basement remain important for understanding the evolution of the Southeast Asian continental *** to a thick cover of sediments and scarce borehole penetration,little is known about the age and tectonic affinity of this *** this study,an integrated study of zircon U-Pb geochronology,Hf isotopes,and whole-rock major and trace elements on seven basement granitoids from seven boreholes of Qiongdongnan Basin has been carried *** zircon U-Pb results for these granitoids present middle-late Permian((270.0±1.2)ma;(253±3.4)ma),middle to late Triassic((246.2±3.4)ma;(239.3±0.96)ma;(237.9±0.99)ma;(228.9±1.0)ma)and Late Cretaceous ages((120.6±0.6)ma).New data from this study,in combination with the previous dataset,indicates that granitoid ages in northern SCS basement vary from 270 ma to 70.5 ma,with three age groups of 270–196 ma,162–142 ma,and 137–71 ma,*** for the late Paleozoic-Mesozoic rocks in the basement of the northern SCS,a few old zircon grains with the age of(2708.1±17)ma to(2166.6±19)ma provide clues to the existence of the pre-Proterozoic *** geochemical signatures indicate that the middle Permian-early Cretaceous granitoids from the Qiongdongnan Basin are I-type granites formed in a volcanic arc environment,which were probably related to the subduction of the Paleo-Pacific Plate.

关键词： Qiongdongnan Basin basement granitoids geochemistry U-Pb and Hf isotopes Paleo-Pacific Plate subduction

Tectono-thermal evolution of the Liwan Sag, deepwater area in the Zhujiang River Mouth Basin, northern South China Sea

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Acta Oceanologica Sinica 2018年第2期37卷 66-75页

作者： TANG xiaoyin.HUANG Shaopeng YANG Shuchun JIANG Guangzheng JI Mo HU Shengbiao Geothermal and Environmental Research Laboratory Xi'an Jiaotong University Xi'an 710049 China State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100049 China CNOOC Research Institute Beijing 100027 China

The Liwan Sag, with an area of 4 000 km-2, is one of the deepwater sags in the Zhujiang River（Pearl River） Mouth Basin, northern South China Sea. Inspired by the exploration success in oil and gas resources in the deepwater sags worldwide, we conducted the thermal modeling to investigate the tectono-thermal history of the Liwan Sag,which has been widely thought to be important to understand tectonic activities as well as hydrocarbon potential of a basin. Using the multi-stage finite stretching model, the tectonic subsidence history and the thermal history have been obtained for 12 artificial wells, which were constructed on basis of one seismic profile newly acquired in the study area. Two stages of rifting during the time periods of 49–33.9 ma and 33.9–23 ma can be recognized from the tectonic subsidence pattern, and there are two phases of heating processes corresponding to the *** reconstructed average basal paleo-heat flow values at the end of the rifting events are -70.5 and -94.2 mW/m^2 respectively. Following the heating periods, the study area has undergone a persistent thermal attenuation phase since 23 ma and the basal heat flow cooled down to -71.8–82.5 mW/m^2 at present.

关键词： tectono-thermal evolution thermal history heat flow deepwater area Liwan Sag

Broadband high-efficiency polymerized liquid crystal metasurfaces with spin-multiplexed functionalities in the visible

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Photonics Research 2022年第6期10卷 1380-1393页

作者： XINJIAN LU xiaoyin.LI YINGHUI GUO MINGBO PU JIANGYU WANG YAXIN ZHANG XIONG LI XIAOLIANG ma XIANGANG LUO State Key Laboratory of Optical Technologies on Nano-Fabrication and Micro-Engineering Institute of Optics and ElectronicsChinese Academy of SciencesChengdu 610209China School of Optoelectronics University of Chinese Academy of SciencesBeijing 100049China Vector Light Field Research Center Institute of Optics and ElectronicsChinese Academy of SciencesChengdu 610209China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 610054China

Traditional optical components are usually designed for a single functionality and narrow operation band,leading to the limited practical *** date,it is still quite challenging to efficiently achieve multifunctional performances within broadband operating bandwidth via a single planar optical ***,a broadband high-efficiency polarization-multiplexing method based on a geometric phase polymerized liquid crystal metasurface is proposed to yield the polarization-switchable functionalities in the *** proofs of the concept,two broadband high-efficiency polymerized liquid crystal metalenses are designed to obtain the spin-controlled behavior from diffraction-limited focusing to sub-diffraction focusing or focusing vortex *** experimental results within a broadband range indicate the stable and excellent optical performance of the planar liquid crystal *** addition,low-cost polymerized liquid crystal metasurfaces possess unique superiority in large-scale patterning due to the straightforward processing technique rather than the point-by-point nanopatterning method with high cost and low *** high-efficiency liquid crystal metasurfaces also have unrivalled advantages benefiting from the characteristic with low waveguide *** proposed strategy paves the way toward multifunctional and high-integrity optical systems,showing great potential in mobile devices,optical imaging,robotics,chiral materials,and optical interconnections.

关键词： polarization interconnection waveguide

无晶状体眼二期前房型人工晶状体植入后的临床观察

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上海医学 2004年第9期27卷 666-669页

作者：吴强陈国辉马晓昀上海交通大学附属第六人民医院上海市第六人民医院眼科 200233

目的　探讨无晶状体眼二期植入弹性开放襻一体式前房型人工晶状体的有效性和安全性。方法　 37例 37眼白内障术后无晶状体眼在表面麻醉下经巩膜隧道式切口二期植入新型弹性开放襻一体式前房型人工晶状体 ,并联合周边虹膜切除术。术后随... 详细信息

目的　探讨无晶状体眼二期植入弹性开放襻一体式前房型人工晶状体的有效性和安全性。方法　 37例 37眼白内障术后无晶状体眼在表面麻醉下经巩膜隧道式切口二期植入新型弹性开放襻一体式前房型人工晶状体 ,并联合周边虹膜切除术。术后随访 5～ 2 8个月 ,平均 18.4个月。结果　 37只无晶状体眼均顺利植入新型弹性开放襻一体式前房型人工晶状体。术前矫正视力为 0 .1～ 0 .6 ,术后 3个月达 0 .2～ 0 .8,2 7眼≥ 0 .5(73.0 % ) ,35眼 (94 .6 % )达到术前最佳矫正视力以上。术前角膜内皮细胞计数平均为 (194 7± 5 81)个 /mm2 ,术后 3个月平均为 (1871± 4 6 2 )个 /mm2 ,手术前、后的差异无显著性 (P >0 .0 5 )。术后常见并发症为角膜水肿、葡萄膜炎、一过性高眼压。结论　无晶状体眼二期植入新型弹性开放襻一体式前房型人工晶状体是一种简便、安全。

关键词：无晶状体眼弹性开放襻前房型人工晶状体植入术前术后矫正视力平均安全性显著性

子痫前期上调lncRNA maLAT1对缺氧诱导的滋养细胞功能损伤的作用机制探究

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中国计划生育和妇产科 2024年第6期16卷 71-76,82页

作者：卢智健李晓茵卢倩瑜陈志萍叶旭彬东莞市人民医院妇产科广东东莞523000

目的探究子痫前期(PE)患者胎盘组织中长链非编码RNA maLAT1(lncRNA maLAT1)的表达,及其对缺氧诱导的滋养细胞功能损伤的作用。方法收集2020年5月至2022年10月东莞市人民医院20例PE患者(PE组)和20例健康对照(NP组)的胎盘组织,采用定量... 详细信息

目的探究子痫前期(PE)患者胎盘组织中长链非编码RNA maLAT1(lncRNA maLAT1)的表达,及其对缺氧诱导的滋养细胞功能损伤的作用。方法收集2020年5月至2022年10月东莞市人民医院20例PE患者(PE组)和20例健康对照(NP组)的胎盘组织,采用定量逆转录聚合酶链式反应(qRT-PCR)检测maLAT1和自噬相关基因LC3和Beclin-1 mRNA在两组胎盘组织中的表达差异。体外培养人滋养层细胞系HTR-8,采用瞬时转染技术将过表达maLAT1质粒(maLAT1)或其阴性对照(pc-NC)质粒转染入细胞中。低氧(Hyp)条件处理上述细胞,并将其分为4组:Control组,Hyp+pc-NC组,Hyp+maLAT1组和自噬抑制剂3-甲基腺嘌呤(3-ma)处理的Hyp+maLAT1+3-ma组。CCK-8法检测各组细胞的增殖活力,Transwell法检测各组细胞的侵袭能力,TUNEL染色法检测各组细胞的凋亡,Western blotting实验检测各组细胞中凋亡相关蛋白Bax、Bcl-2、cleved caspase-3的表达和自噬相关蛋白Beclin-1蛋白表达和LC3-Ⅱ/Ⅰ比值。结果与NP组相比,maLAT1、LC3和Beclin-1 mRNA在PE组中的表达均显著降低(PmaLAT1组和Hyp+maLAT1+3-ma组的细胞增殖活力、侵袭能力、Bcl-2与Beclin-1蛋白表达和LC3-Ⅱ/Ⅰ比值均显著降低(PmaLAT1组细胞增殖活力、侵袭能力、Bcl-2与Beclin-1蛋白表达和LC3-Ⅱ/Ⅰ比值均明显升高(PmaLAT1+3-ma组细胞增殖活力、侵袭能力、Bcl-2与Beclin-1蛋白表达和LC3-Ⅱ/Ⅰ比值均显著降低(PmaLAT1组相比,Hyp+maLAT1+3-ma组细胞增殖活力、侵袭能力、Bcl-2与Beclin-1蛋白表达和LC3-Ⅱ/Ⅰ比值均显著降低(PmaLAT1在PE患者胎盘组织中的表达显著降低,上调其表达可通过促进细胞自噬水平改善低氧诱导的滋养细胞增殖和侵袭能力损伤,并抑制细胞的凋亡。

关键词：子痫前期长链非编码RNA maLAT1 低氧自噬滋养细胞