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The virological impacts of SARS-CoV-2 D614G mutation

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Journal of Molecular Cell Biology 2021年第10期13卷 712-720页

作者： Chenxi Wang You Zheng Zubiao Niu xiaoyi jiang Qiang Sun Laboratory of Cell Engineering Institute of BiotechnologyResearch Unit of Cell Death MechanismChinese Academy of Medical ScienceBeijing 100071China

The coronavirus diseases 2019(COVID-19)caused by the infection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged in December 2019 has caused more than 140 million infections worldwide by the end of April *** an enveloped single-stranded positive-sense RNA virus,SARS-CoV-2 underwent constant evolution that produced novel variants carrying mutation conferring fitness *** current prevalent D614G variant,with glycine substituted for aspartic acid at position 614 in the spike glycoprotein,is one of such variants that became the main circulating strain worldwide in a short period of *** the past year,intensive studies from all over the world had defined the epidemiological characteristics of this highly contagious variant and revealed the underlying *** review aims at presenting an overall picture of the impacts of D614G mutation on virus transmission,elucidating the underlying mechanisms of D614G in virus pathogenicity,and providing insights into the development of effective therapeutics.

关键词： SARS-CoV-2 COVID-19 D614G infectivity virus mutation

“Digital earth” in support of an online oceanic educational public service and popularization

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Acta Oceanologica Sinica 2013年第5期32卷 82-86页

作者： ZHANG Xin DONG Wen jiang xiaoyi SHI Suixiang CHI Tianhe Institute of Remote Sensing Applications Chinese Academy of Sciences National Marine Data & Information Service State Oceanic Administration

According to the initial vision of ＂digital earth＂（DE）, the public should constitute a significant proportion of its users. However, to date, most of the studies and applications have focused on science, the private sec- tor and government. A DE-supported online oceanic educational public service and popularization system, iOcean, is studied. First, the vision for the public＇s engagement with ＂digital ocean＂ is described： an analysis is presented from four aspects, i.e., the space dimension, the time dimension, the state dimension and its relationship with human beings. Second, the technical framework of iOcean is discussed, including data updating and model computing, the data, the function, and the application layers. Third, two key technolo- gies are studied in detail that will enable the construction of iOcean. More than half a million public viewers have used the current version＇s website. Practical demonstrations show that iOcean can bring virtual oceans to web browsers and desktops and construct a bridge between government departments and the general public.

关键词： "digital earth" "digital ocean" iOcean public service popularization

Simple electrode assembly engineering:Toward a multifunctional lead-acid battery

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Journal of Energy Chemistry 2024年第9期96卷 536-543页

作者： Xiaojuan Cao Xiaoyu Yan Kai Zhao Le Ke xiaoyi jiang Lingjiao Li Ning Yan Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education School of Physics and TechnologyWuhan UniversityWuhan 430072HubeiChina Shenzhen Research Institute of Wuhan University Shenzhen 518057GuangdongChina

Electrochemical energy storage is a promising technology for the integration of renewable ***-acid battery is perhaps among the most successful commercialized systems ever since thanks to its excellent cost-effectiveness and safety *** of 165 years of development,the low energy density as well as the coupled power and energy density scaling restrain its wider application in real *** address this challenge,we optimized the configuration of conventional Pb-acid battery to integrate two gas diffusion *** novel device can work as a Pb-air battery using ambient air,showing a peak power density of 183 mW cm^(−2),which was comparable with other state-of-the-art metal-O_(2)*** can also behave as a fuel cell,simultaneously converting H_(2)and air into electricity with a peak power density of 75 mW cm^(−2).Importantly,this device showed little performance degradation after 35 h of the longevity *** work shows the exciting potential of lead battery technology and demonstrates the importance of battery architecture optimization toward improved energy storage capacity.

关键词： Lead-acid battery Decoupled electrode reaction Energy storage Discharge capacity Fuel cell

First Total Synthesis of the Proposed Structures of Orisuaveolines A and B

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Chinese Journal of Chemistry 2013年第1期31卷 123-126页

作者： Jie Zhang Shijun Da Xiaolin Feng xiaoyi Chen Jianhui jiang Ying Li State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering Lanzhou University Lanzhou Gansu 730000 China

First total synthesis of the proposed structures of β-indoloquinazoline alkaloids orisuaveolines A and B is re- ported. The key steps of the synthesis included a Pictet-Spengler reaction to build a six-member lactam which fur- ther transformed into target molecular by a one-pot condensation. This synthesis provided an access to the proposed structures of orisuaveolines A and B in a short and convenient manner from inexpensive, commercially available starting materials. The structures of our synthesized products were confirmed by 2D-NMR experiments.

关键词： orisuaveolines A and B indoloquinazoline alkaloids Pictet-Spengler reaction one-pot condensation

Bimodular effects of D614G mutation on the spike glycoprotein of SARS-CoV-2 enhance protein processing,membrane fusion,and viral infectivity

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Signal Transduction and Targeted Therapy 2020年第1期5卷 249-251页

作者： xiaoyi jiang Zhengrong Zhang Chenxi Wang Hongguang Ren Lihua Gao Haoran Peng Zubiao Niu He Ren Hongyan Huang Qiang Sun Beijing Institute of Biotechnology 20 Dongda StreetBeijing 100071China Department of Oncology Beijing Shijitan Hospital of Capital Medical University10 TIEYI RoadBeijing 100038China Department of Microbiology Second Military Medical UniversityShanghai 200433China

Dear Editor,By the end of June 2020,the pandemic of coronavirus diseases 2019(COVID-19)had resulted in more than 10 million individuals,all over the world,being infected with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).1 The high contagiousness of SARS-CoV-2 virus was largely attributed to the relatively unique sequence composition in its spike(S)glycoprotein,which is in charge of the host entry by interacting with its cellular receptor angiotensin-converting enzyme 2(ACE2).2,3 The S glycoprotein can be processed into an N terminal S1 fragment that is responsible for receptor binding,and a C terminal S2 fragment that functions to promote membrane fusion.4 SARS-CoV-2 is a type of single-stranded positive-sense ribonucleic acid(RNA)virus,and an increasing number of mutations were identified across the SARS-CoV-2 genome,including the region encoding S ***,the functional implications of these mutations remain largely unknown,we here reported the mutation analysis of S gene and a functional exploration of the dominant D614G mutation.

关键词： glycoprotein acute respiratory

应对海平面上升海岸实体保护国家实践的国际法律问题及启示

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中国软科学 2023年第4期 1-10页

作者：蒋小翼刘季昀武汉大学中国边界与海洋研究院湖北武汉430072

气候变化引起的海平面上升可能导致海岸受侵蚀、海洋地物被淹没等情况。各国采用硬工程建设、基础设施改造、沉积物保护、红树林等生态系统修复、填海造陆和人工岛屿建设等措施保护海岸,以此积极应对海平面上升导致的基线和沿海国海区... 详细信息

气候变化引起的海平面上升可能导致海岸受侵蚀、海洋地物被淹没等情况。各国采用硬工程建设、基础设施改造、沉积物保护、红树林等生态系统修复、填海造陆和人工岛屿建设等措施保护海岸,以此积极应对海平面上升导致的基线和沿海国海区界限发生的变化。根据国际法相关规定,人工保护海岸线是公认的做法,但沿海国在具体实践中也要注意国际法律原则和义务,确保在合法合理地维护本国海洋权利的同时,不损害他国利益。我国在应对海平面上升时,应利用合法有效的人工海岸保护措施维护海洋权益,合理利用填海造陆方式,合法开展岛礁建设和保护活动,建立和完善红树林修复保障体系,妥善处理海平面上升对海洋边界的影响,以及加强应对海平面上升的国际合作。

关键词：海平面上升海岸实体保护国家实践国际法启示

可持续发展目标导向下的主权债务与自然互换:发展趋势、演变动因及运用建议

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湖北社会科学 2024年第6期 121-129页

作者：蒋小翼曹昊武汉大学中国边界与海洋研究院湖北武汉430072

主权债务与自然互换是一种债务互换机制,债权人通过减免部分债务换取债务国当地的环境保护项目。伴随可持续发展目标的影响,该机制呈现出法律关系复杂、互换合意难度降低、债务减免和环保金额增加等特点。发展中国家主权债务不可持续问... 详细信息

主权债务与自然互换是一种债务互换机制,债权人通过减免部分债务换取债务国当地的环境保护项目。伴随可持续发展目标的影响,该机制呈现出法律关系复杂、互换合意难度降低、债务减免和环保金额增加等特点。发展中国家主权债务不可持续问题、可持续发展目标的资金需求、主权债务重组规则的变化以及国际绿(蓝)色金融原则的发展对该机制的演变会产生影响。主权债务与自然互换面临着透明度建设、规则的双重适用和提升主权债券评级的风险等挑战。中国应以构建人类命运共同体为指导思想,推动国际债务治理规则更新,助力绿(蓝)色金融规则的国际化,并寻求主权债务与自然互换的改进,以妥善实现可持续发展目标。

关键词：主权债务与自然互换可持续发展目标集体行动条款绿(蓝)色金融原则

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南极微塑料污染防治的国际法挑战与应对

中国软科学 2024年第9期 1-11页

作者：蒋小翼李佳宁武汉大学中国边界与海洋研究院湖北武汉430072

微塑料作为一种新污染物,已经给南极生态环境、人类健康和气候变化带来了极大的损害与威胁。南极条约体系、《联合国海洋法公约》及其执行协定和其他专门性环境条约为防治南极微塑料污染提供了国际法依据。但目前,南极微塑料的污染防治... 详细信息

微塑料作为一种新污染物,已经给南极生态环境、人类健康和气候变化带来了极大的损害与威胁。南极条约体系、《联合国海洋法公约》及其执行协定和其他专门性环境条约为防治南极微塑料污染提供了国际法依据。但目前,南极微塑料的污染防治仍面临针对性南极微塑料污染防治规范供给不足、条约在南极海域的适用存在重叠和争议、部分南极微塑料污染活动处于执法真空、南极微塑料污染责任制度存在缺陷等国际法挑战。为了应对南极微塑料的污染防治困境,应明确现有国际法规则的适用关系,注重发挥国际环境法基本原则的作用,在南极条约体系中完善并创新污染防治制度,在全球塑料公约框架下探索与构建有效防治机制。

关键词：南极微塑料污染南极条约体系南极环境保护国际法

Oxaliplatin combined with 5-fluorouracil, leucovorin regimen for patients with advanced colorectal cancer

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The Chinese-German Journal of Clinical Oncology 2007年第3期6卷 225-227页

作者： Suyi Li Lin Liu xiaoyi Gu Zao jiang Cailian Wang Tumor Center of the Affiliated Zhongda Hospital of Eastsouth University Nanjing 210009 China

Objective： To observe the efficacy and tolerability of continuously infusing 5-fluorouracil （5-FU） / folic acid combined with oxaliplatin （L-OHP/5-FU/LV regimen） as first line treatment in advanced colorectal cancer. Methods： 23 patients of advanced colorectal cancer were treated with 5-FU 500 mg/d, civ, d 1-d5, d8-d12, leucovorin 100 mg/d, iv gtt, d1, d8, folic acid tablet 60 mg/d, po, d2-d5, d9-d12, and oxaliplatin 65 mg/（m^2·d）, iv gtt, dl, d8, repeated every 21 days （one cycle）. The effect was evaluated after two cycles. Results： Complete response in 2 cases and partial response in 10 cases were observed with an overall response rate of 47.18%. Adverse effects were mainly grade 1-2, including nausea, vomiting, diarrhea, dental ulcer, peripheral neuritis and myelosuppression. Conclusion： L-OHP/5-FU/LV regimen is an effective and better tolerated alternative treatment in advanced colorectal cancer and yields promising clinical application.

关键词： advanced colorectal cancer oxaliplatin 5-fluorouracil leucovorin combination chemotherapy