The virological impacts of SARS-CoV-2 D614G mutation
作者机构：Laboratory of Cell EngineeringInstitute of BiotechnologyResearch Unit of Cell Death MechanismChinese Academy of Medical ScienceBeijing 100071China
出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)
年 卷 期：2021年第13卷第10期
页 面：712-720页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学]
基 金：supported by the National Key Research&Development Program of China(2018YFA0900804) the National Natural Science Foundation of China(31970685)
主 题：SARS-CoV-2 COVID-19 D614G infectivity virus mutation
摘 要：The coronavirus diseases 2019(COVID-19)caused by the infection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged in December 2019 has caused more than 140 million infections worldwide by the end of April *** an enveloped single-stranded positive-sense RNA virus,SARS-CoV-2 underwent constant evolution that produced novel variants carrying mutation conferring fitness *** current prevalent D614G variant,with glycine substituted for aspartic acid at position 614 in the spike glycoprotein,is one of such variants that became the main circulating strain worldwide in a short period of *** the past year,intensive studies from all over the world had defined the epidemiological characteristics of this highly contagious variant and revealed the underlying *** review aims at presenting an overall picture of the impacts of D614G mutation on virus transmission,elucidating the underlying mechanisms of D614G in virus pathogenicity,and providing insights into the development of effective therapeutics.
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