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Gradient layered m.ene/Fe3O4@CNTs/TOCNF ultrathin nanocom.osite paper exhibiting effective electrom.gnetic shielding and m.ltifunctionality

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Nano Research 2024年第9期17卷 8233-8242页

作者： Zhengkun m. Jingzong He Shilin Liu xiaoxuan Qie m.iheng Gan Ruonan Cheng Qilin Wu m.lcolm.Xing State Key Laboratory for m.dification of Chem.cal Fibers and Polym.r m.terials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China College of Chem.stry and Chem.cal Engineering Donghua UniversityShanghai 201620China Departm.nt of m.chanical Engineering University of ManitobaWinnipegMB R3T 2N2Canada

As wearable electronic devices are rapidly developing,there is an urgent need for lightweight,flexible,and ultrathin m.ltifunctional electrom.gnetic interference(Em.)shielding ***,the flexible ultrathin paper that com.ines efficient shielding and m.ltifunctional integration rem.ins a considerable ***,a novel m.ene/Fe_(3)O_(4)@CNTs/TOCNF(m.T,m.ene=transition m.tal carbide/carbonitride,CNTs=carbon nanotubes,TOCNF=TEm.O-oxidized cellulose nanofiber,TEm.O=2,2,6,6-tetram.thylpiperidine-1-oxyl radical)nanocom.osite paper with a m.ltilayer electrom.gnetic gradient structure and electrom.gnetic dual losses was successfully prepared by a sim.le filtration *** from.effective gradient design and adjusting the proportion of TOCNF,the com.osite paper(only 18μm.exhibits outstanding shielding effectiveness(SE)of 66 dB in the X-band,ultrahigh thickness-specific SE and surface-specific SE values of 3300 dB·m.-1 and 31,428 dB·cm.(2)·g^(-1)***,dehydroxylation treatm.nt im.roves m.T paper's hydrophobicity,environm.ntal stability,and m.chanical strength,expanding its range of ***,the highly efficient Joule heating properties and hydrophobicity provide m.T additional de-icing *** also sim.lated the electrom.gnetic shielding effects of m.T com.osite paper,which was applied in *** study docum.nts an innovative and intriguing m.terial com.ination,providing a sim.le and effective m.nufacturing strategy for developing Em. shielding *** paper is highly suitable for outdoor portable or wearable electronic devices and has significant application potential in hum.d/severe cold environm.nts.

关键词： cellulose fiber thin papers nanocom.osites electrom.gnetic interference(Em.)shielding

Echinatin inhibits tum.r growth and synergizes with chem.therapeutic agents against hum.n bladder cancer cells by activating p38 and suppressing Wnt/β-catenin pathways

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Genes & Diseases 2024年第2期11卷 1050-1065页

作者： xiaoxuan Wang Lijuan Luo Jingtao Xu Qiuping Lu Haichao Xia Yanran Huang Lulu Zhang Liping Xie Habu Jiwa Shiqiong Liang Xiaoji Luo Jinyong Luo Key Laboratory of Diagnostic m.dicine Designated By the Chinese m.nistry of Education School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Departm.nt of Orthopedics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China

Bladder cancer (BC) is one of the m.st com.on m.lignant tum.rs in the urinary *** to the poor prognosis and high m.rtality rate of the disease,it is urgent to develop new drugs with high efficacy and low toxicity to treat *** (Ecn) is a bioactive natural flavonoid oflicorice that has attracted special attention for its prom.sing anti-tum.r ***,we explored the inhibitory effects of Echinatin on BC cells and probed the possible m.lecular *** found that Ecnin vitro inhibited the proliferation,m.gration,and invasion,arrested the cell cycle at the G2/m.phase,and prom.ted apoptosis in BC ***,Ecn had no notable cytotoxicity towards hum.n norm.l *** subsequently confirm.d that Ecn restrained xenograft tum.r growth and m.tastasis of BC cells in vivo .m.chanistically,Ecn activated the p38 signaling pathway but inactivated the Wnt/β-catenin signaling pathway,while over-expression of β-catenin and the p38 inhibitor both attenuated the inhibitory effects of Ecn on BC ***,Ecn com.ined with cisplatin (DDP) or gem.itabine (Gem. had synergistic inhibitory effects on BC *** sum.ary,our results validate that Ecn inhibits the tum.r growth of hum.n BC cells via p38 and Wnt/β-catenin signaling *** m.aningfully,our results suggest a potential strategy to enhance DDP- or Gem.induced inhibitory effects on BC cells by com.ining with Ecn.

关键词： Bladder cancer Com.ination chem.therapy Echinatin p38 Wnt/β-catenin

Sim.ltaneous detection of 22 m.cotoxins in grape by QuEChERS and ultra-high-perform.nce liquid chrom.tography coupled with quadrupole/orbitrap high-resolution m.ss spectrom.try

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Journal of Future Foods 2024年第4期4卷 369-375页

作者： m.irong Cao Jing Wang m.ngtian Wang xiaoxuan Yuan Xu Zhang Junzhan m. Yan Zhang Qiang Li Hebei Food Safety Key Laboratory Key Laboratory of Special Food Supervision Technology for State Market RegulationHebei Engineering Research Center for Special Food Safety and HealthHebei Food Inspection and Research InstituteShijiazhuang 050227China Hebei Key Laboratory of Forensic m.dicine College of Forensic MedicineHebei Medical UniversityShijiazhuang 050017China

To effectively assess the extent of the m.cotoxin contam.nation of grapes,a m.thod was developed to analyze 22 m.cotoxins by ultra-high-perform.nce liquid chrom.tography coupled with quadrupole/orbitrap high-resolution m.ss spectrom.try(UPLC-Q-Orbitrap HRm.).Sam.les were extracted and purified using the QuEChERS(quick,easy,cheap,effective,rugged,and safe)*** extracts were separated on a BEH Shield C18 colum.(100 m.×2.1 m.,1.7μm.,using m.thanol and water with 0.1%form.c acid solution and 2 m.ol/L am.onium.acetate as the m.bile *** quantification was perform.d according to a m.trix-m.tched external standard *** was a good linear relationship within the respective m.ss concentration ranges of 22 m.cotoxins;the correlation coefficients were not less than *** lim.t of quantification was 0.3-10.0μg/*** recovery ranged from.68.6%to 109.0%,with a relative standard deviation of 1.28%-12.80%.The m.thod is sim.le,rapid,highly sensitive,and accurate,m.king it useful for screening grapes for com.on and em.rging m.cotoxins.

关键词： m.cotoxins Ultra-high-perform.nce liquid chrom.tography-quadrupole/orbitrap high-resolution m.ss spectrom.try Grape

Transform.ng growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian Li Xueer Liu Zelin Zhang xiaoxuan Chen Weiqiang Chen Kangsheng Li Jiangtao Sheng Departm.nt of m.crobiology and Im.unology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Departm.nt of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transform.ng growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system.*** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas m.y depend on the pathological process and cell types ***-gated sodium.channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons rem.in *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in prim.ry cortical neurons from.*** found that TGF-β1 increased VGSC current density in a dose-and tim.-dependent m.nner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of m.togen-activated protein kinase kinase(PD98059),p38 m.togen-activated protein kinase(SB203580),and Jun NH2-term.nal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-m.PK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transform.ng growth factor-beta 1 traum.tic brain injury voltage-gated sodium.currents

Efficacy and safety of anlotinib com.ined with the STUPP regim.n in patients with newly diagnosed glioblastom.: a m.lticenter, single-arm. phase Ⅱ trial

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Cancer Biology & m.dicine 2024年第5期21卷 433-444页

作者： Shuzhen Lai Peijing Li Xiaohui Liu Guihong Liu Tiem.ng Xie Xing Zhang xiaoxuan Wang Jing Huang Yiqiang Tang Zhigang Liu Guoping Shen Chaom.ng Li Fangxiao Lu Lei Wang Fagui Jiang Caixing Sun Yuanyuan Chen m.ng Chen Departm.nt of Radiation Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000China Departm.nt of Radiation Oncology Yuebei People’s Hospital Affiliated to the Medical College of Shantou UniversityShaoguan 512026China Chinese Academy of SciencesHangzhou 310022China Departm.nt of Radiation Oncology The Second Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhou 311403China Departm.nt of Radiation Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221004China Chinese Academy of SciencesHangzhou 310022China State Key Laboratory of Translational m.dicine and Innovative Drug Developm.nt Jiangsu Simcere Diagnostics Co.LtdNanjing 210000China Departm.nt of Radiation Oncology The Affiliated Huai’an First People’s Hospital of Nanjing Medical UniversityHuai’an 223399China Departm.nt of Radiation Oncology Jiangxi Cancer Hospital of Nanchang UniversityNanchang 330029China Departm.nt of Radiotherapy Dongguan Institute of Clinical Cancer ResearchDongguan Key Laboratory of Precision Diagnosis and Treatment for TumorsAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523059China The Cancer Center The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai 519000China Departm.nt of Radiation Oncology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Departm.nt of Oncology Maoming People’s HospitalMaoming 525000China Departm.nt of Radiation Oncology Kecheng District People’s HospitalQuzhou 324003China Chinese Academy of SciencesHangzhou 310022China Departm.nt of Radiation Oncology State Key Laboratory of Oncology in South ChinaSun Yat-sen University Cancer CenterGuangzhou 510060China United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University&Chinese Academ. of Sciences Ion m.dical Technology Co. LtdGuangzhou 510060China

Objective:Glioblastom.s are highly vascularized m.lignant *** determ.ned the efficacy and safety of the anti-angiogenic m.lti-kinase inhibitor,anlotinib,for a newly diagnosed ***:This m.lticenter,single-arm.trial(NCT04119674)enrolled 33 treatm.nt-naïve patients with histologically proven glioblastom.s between m.rch 2019 and Novem.er *** underwent treatm.nt with the standard STUPP regim.n[fractionated focal irradiation in daily fractions of 1.8-2 Gy given 5 d/w×6 w(total=54-60 Gy)]or radiotherapy plus continuous daily tem.zolom.de(Tm.)(75 m./m.(2)of body surface area/d,7 d/w from.the first to the last day of radiotherapy),followed by 6 cycles of adjuvant Tm.(150-200 m./m.(2)×5 d during each 28-d cycle)plus anlotinib(8 m./d on d 1-14 of each 3-w cycle for 2 cycles during concom.tant chem.radiotherapy,8 m.xim.l cycles as adjuvant therapy,followed by m.intenance at 8 m./*** prim.ry endpoint was progression-free survival(PFS).Secondary endpoints included overall survival(OS)and adverse events(AEs).Results:Thirty-three patients received the planned *** m.dian PFS was 10.9 m.nths(95%CI,9.9-18.7 m.nths)and the 12-m.nth PFS rate was 48.5%.The m.dian OS was 17.4 m.nths(95%CI,14.5-21.1 m.nths)and the 12-m.nth OS rate was 81.8%.The m.st com.on AEs included hypertriglyceridem.a[58%(n=19)],hypoalbum.nem.a[46%(n=15)],and hypercholesterolem.a[46%(n=15)]during concurrent chem.radiotherapy and leukopenia[73%(n=24)],hypertriglyceridem.a[67%(n=22)],and neutropenia[52%(n=17)]during adjuvant *** patients discontinued treatm.nt due to ***1(HR,5.6;95%CI,1.3-23.7;P=0.021)and RP1L1 alterations(HR,11.1;95%CI,2.2-57.2;P=0.004)were associated with a significantly shorter ***:Anlotinib plus the STUPP regim.n has prom.sing anti-tum.r activity against glioblastom. and m.nageable ***1 and RP1L1 alterations m.ght be novel predictive biom.rkers of the response to anlotinib.

关键词： Glioblastom. anti-angiogenesis m.lti-kinase inhibitor anlotinib tem.zolom.de progression-free survival

3'-Sialyllactose regulates glucose and lipid m.tabolic disorders via the gut–liver axis in m.ce fed a high-fat die

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Food Science and Hum.n Wellness 2024年

作者： Wei Zhang m.izhen Zhu Kelsang Dekyi Linxi Zheng Yichen Zhang Youping Lv Dongbei Guo xiaoxuan Chen Lili Pan Xinyue Wang Hongwei Li State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biom.dicine Laboratory School of Public Health Xiam.n University State Key Laboratory of m.lecular Vaccinology and m.lecular Diagnostics National Innovation Platform.for Industry-Education Integration in Vaccine Research Xiam.n University Departm.nt of Nutrition Zhongshan Hospital (Xiam.n) Fudan University Xiam.n Clinical Research Center for Cancer Therapy

Recent research has indicated that sialic acid， such as free sialic acid (N-acetylneuram.nic acid， Neu5Ac) and bound sialic acid (3'-sialyllactose， 3'-SL)， can am.liorate disorders associated with glycolipid m.tabolism. although the underlying m.chanism. have yet to be determ.ned. We exam.ned the effects of 3'-SL on glycolipid m.tabolism.in m.ce fed a high-fat diet. m.le C57BL/6J m.ce were divided into six groups: two m.del control groups (norm.l and high-fat diets) and four intervention groups [Neu5Ac， and low-，m.derate-， and high-dose 3'-SL]. After 8 weeks of continuous gavage intervention， m.ce in the 3'-SL intervention groups had lower body weight and total fat content; reduced fasting blood glucose， triglycerides， low-density lipoproteins and oxidized-low-density lipoproteins; and increased high-density lipoproteins，but no dosage-dependent of 3'-SL intervention was found， 3’-SL＿m.intervention as optim.l for further exploration. 3'-SL intervention could increase respiratory exchange ratio， energy expenditure， and am.unt of exercise perform.d. 3'-SL increased the colonic abundances of Akkerm.nsia， Lactobacillus， and Bacteroides， and reduced those of Erysipelatoclostridium. Faecalibaculum. and Aldercreutzia. Changes were also observed in colonic m.tabolites， and liver gene transcript and m.tabolites， which were m.inly enriched in bile secretion， taurine and hypotaurine m.tabolism. and insulin resistance. Additionally， 3'-SL was observed to regulate genes associated with physiological rhythm.， including clock， per2， cry1， and bhihe41. Collectively， our findings indicate that 3'-SL can contribute to the prevention and control of disorders associated with glucose and lipid m.tabolism.caused by high-fat diets. Com.ared with Neu5Ac， 3'-SL intervention can am.liorate intestinal flora disorders， enhance bile acid circulation， increase tissue energy expenditure， and reduce lipid synthesis， thereby prom.ting lipid-lowering effects m.diated via the liver–gut axis， and can a

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地道桥下穿高速公路动态施工过程数值模拟

工程建设 2024年第4期56卷 25-30页

作者：陈孝轩中国建材地勘中心广东总队广东广州510403

地道桥顶推下穿是一种高效且经济的解决路线交叉问题的施工方案,明确施工时地道桥的受力机理有助于优化设计,因此有必要对地道桥下穿过程进行模拟研究。文章以湖南省某公路地道桥下穿G4高速为例,基于有限差分法,对下穿顶推施工过程进行... 详细信息

地道桥顶推下穿是一种高效且经济的解决路线交叉问题的施工方案,明确施工时地道桥的受力机理有助于优化设计,因此有必要对地道桥下穿过程进行模拟研究。文章以湖南省某公路地道桥下穿G4高速为例,基于有限差分法,对下穿顶推施工过程进行了数值模拟分析,研究得出地道桥盾构法动态施工过程应力场与位移场变化的规律。研究结果表明:随着顶推的进行,掌子面后方土层应力变化明显,影响范围在掌子面后6 m.右。同时,摩阻力系数与地层条件特别是土质情况联系密切,顶推施工时,箱涵底部产生的摩阻力占比超过总摩阻力的70%,计算结果明确了地道桥顶推过程中的受力特征与作用机理,能为类似的地道桥下穿施工提供合理的借鉴与参考。

关键词：顶推地道桥动态施工极限摩阻力极限顶力数值模拟

基于界面电荷极化特性的变压器油纸绝缘寿命预测方法研究

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电力系统保护与控制 2024年第7期52卷 138-148页

作者：邹阳陈啸轩张云霄林锦茄林昕亮福州大学电气工程与自动化学院福建福州350108

准确预测变压器油纸绝缘寿命对于保障电力系统安全稳定运行具有重要意义。根据微观介电响应机制剖析界面极化与油纸绝缘老化的内在机理联系,并基于混合极化模型——一种在扩展德拜模型基础上引入界面极化支路的等效电路拓扑,探究界面电... 详细信息

准确预测变压器油纸绝缘寿命对于保障电力系统安全稳定运行具有重要意义。根据微观介电响应机制剖析界面极化与油纸绝缘老化的内在机理联系,并基于混合极化模型——一种在扩展德拜模型基础上引入界面极化支路的等效电路拓扑,探究界面电荷极化特性在油纸绝缘寿命预测中的应用。首先,分析温升过程中频谱特性变化背后蕴含的普适弛豫极化规律,基于混合极化模型重构回复电压极化谱。结合温度对主时间常数和模型参数的影响规律,提出一种单一温度测试下的油纸绝缘活化能计算方法,通过界面极化电容构建出频温平移因子。其次,剖析介质损耗因数随老化加深的变化规律,探究损耗峰偏移现象与界面极化弛豫时间的内在联系,凝练全新表征油纸绝缘聚合度含量的频域特征参量——界面极化支路极点Ph2。最后,联合界面极化支路极点Ph2、频温平移因子和损失累积动力学方程构建油纸绝缘寿命预测模型,并将不同运行年限变压器现场实测数据代入模型验证实效性,为油纸绝缘寿命预测提供了一种新思路。

关键词：油纸绝缘活化能频域介电谱混合极化模型寿命预测

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物流柜与无人机协同配送最小完工时间问题

工业工程与管理 2024年第1期29卷 197-208页

作者：朱外明胡笑旋马华伟合肥工业大学管理学院安徽合肥230009 过程优化与智能决策教育部重点实验室安徽合肥230009

物流柜与无人机协同配送是一种“非接触”配送模式,自动化程度高,具有广阔的应用前景。本文研究了该模式下的最小完工时间调度问题,即如何制定无人机的飞行路线和物流柜上的服务顺序,使得配送任务在尽可能短的时间内被执行。该问题是一... 详细信息

物流柜与无人机协同配送是一种“非接触”配送模式,自动化程度高,具有广阔的应用前景。本文研究了该模式下的最小完工时间调度问题,即如何制定无人机的飞行路线和物流柜上的服务顺序,使得配送任务在尽可能短的时间内被执行。该问题是一个车辆路径与机器调度耦合的复杂优化问题,其建模和求解具有一定的难度。本文建立了问题的有向图逻辑模型,将原问题转变为有向图上的弧选择和时间确定问题,并建立了0-1混合整数线性规划数学模型,设计了对应的变邻域搜索算法,选取中国9座城市构造了高仿真算例,验证了模型和算法的有效性。

关键词：物流柜无人机调度完工时间变邻域搜索