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Microstructure Modification and Ductility Improvement for TaMoNbZrTiAl Refractory High Entropy Alloys via Increasing Ti Content

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1186-1200页

作者： Yujing Zhou Siyi peng Yueling Guo xiaoxiang Wu Changmeng Liu Zhiming Li School of Mechanical Engineering Beijing Institute of TechnologyBeijing100081China Shagang School of Iron and Steel Soochow UniversitySuzhou215137China School of Materials Science and Engineering Central South UniversityChangsha410083China

Here, the composition of TaMoNbZrTiAl refractory high entropy alloy (RHEA) is optimized by increasing Ti content to improve its mechanical property especially the ductility, through comparing two RHEAs with different Ti content. The RHEAs contain two body-centered-cubic (BCC) phases. The BCC phase in the dendritic region is rich in Ta, Mo and Nb, and the BCC phase in the interdendritic region is enriched in Zr, Ti and Al. The as-cast RHEA with a higher Ti content remains dendritic microstructures, and Ti is mainly enriched in the interdendritic region. After annealing treatment at 1300 ℃ for 48 h, the dendritic microstructures change into equiaxed-grain morphology, accompanied by needle-like micron precipitates at grain boundaries in the RHEA with higher Ti content. For the as-cast RHEAs, the fracture strain increases by ~ 6.6% and the uniform plastic strain increases by ~ 5.9% at the compression test due to the increase of Ti content. Our work offers a reference for the composition design of RHEAs and makes a preliminary exploration of the optimization of the microstructures and mechanical properties.

关键词： Refractory high entropy alloys Solidification Grain morphology Microstructure Mechanical property

ON HOLOMORPHIC CURVES OF CONSTANT CURVATURE IN THE COMPLEX GRASSMANN MANIFOLD G(2,5)

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Acta Mathematica Scientia 2011年第1期31卷 237-248页

作者：焦晓祥彭家贵 Department of Mathematics Graduate University Chinese Academy of Sciences

In this article, it is proved that there doesn’t exist any nonsingular holomorphic sphere in complex Grassmann manifold G（2, 5） with constant curvature k = 4/7, 1/2, 4/9. Thus, from [7] it follows that if φ ： S2 ... 详细信息

关键词： Gauss curvature holomorphic curve complex Grassmann manifold

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奥扎格雷不同盐型注射剂药学特性的综合评价

中国医药工业杂志 2024年第3期55卷 417-422页

作者：刘家伟陈婧冯佳佳程虹秦海强章军建彭小祥胡欣武汉大学医院管理研究所湖北武汉430071 华中科技大学同济医学院附属同济医院药学部湖北武汉430030 武汉大学中南医院药学部湖北武汉430071 首都医科大学附属北京天坛医院神经病学中心北京100075 武汉大学中南医院神经内科湖北武汉430071 湖北省第三人民医院湖北省脑卒中防治中心湖北武汉430033 北京医院药学部国家老年医学中心中国医学科学院老年医学研究院北京市药物临床风险与个体化应用评价重点实验室(北京医院)北京100730

奥扎格雷是临床上用于抗血栓形成的一线用药。为了给临床合理用药提供参考依据,该研究对奥扎格雷不同盐型注射剂的药学特性维度,如成分结构、药理和毒理作用、药代动力学、药物相互作用和药品质量等进行了综合评价。结果显示,已上市的2... 详细信息

奥扎格雷是临床上用于抗血栓形成的一线用药。为了给临床合理用药提供参考依据,该研究对奥扎格雷不同盐型注射剂的药学特性维度,如成分结构、药理和毒理作用、药代动力学、药物相互作用和药品质量等进行了综合评价。结果显示,已上市的2种奥扎格雷盐型注射剂,奥扎格雷钠和奥扎格雷氨丁三醇的代谢过程和药理毒理作用相同,但奥扎格雷氨丁三醇注射剂的pH值近中性,溶解度更高、包材相容性更好。药品抽检结果显示,奥扎格雷钠注射剂的部分批次存在可见异物问题,尚无奥扎格雷氨丁三醇注射剂的全国抽检通告。上述结果说明奥扎格雷钠注射剂的药品质量控制有待提高,而奥扎格雷氨丁三醇注射剂的质量控制具有一定优势,可降低临床使用的安全性风险。

关键词：奥扎格雷钠奥扎格雷氨丁三醇药学特性综合评价

基于OBE理念“临床微生物学与检验”数字化教学改革

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医学教育研究与实践 2024年第4期32卷 468-474页

作者：陈瑶何欣雨袁廷勋彭效祥乔晋娟惠丽霞赵莉高伟李倩山东第二医科大学山东潍坊261053

信息技术的创新和发展引领了教育教学改革新浪潮。丰富的教学资源、多样的教学形式,已经成为推动教育数字化转型发展、改革创新的重要动力。目前,各高校各学科纷纷对教学模式的数字化转型做出积极的探索。本研究基于OBE理念,开展“两线... 详细信息

信息技术的创新和发展引领了教育教学改革新浪潮。丰富的教学资源、多样的教学形式,已经成为推动教育数字化转型发展、改革创新的重要动力。目前,各高校各学科纷纷对教学模式的数字化转型做出积极的探索。本研究基于OBE理念,开展“两线四点”数字化课程教学改革模式,并在“临床微生物学与检验”课程教学和评价中进行实践研究。研究从人才培养标准和学生学情出发,综合制定课程教学目标和计划,采用雨课堂、小规模限制性在线课程(Small Private Online Course,SPOC)、虚拟仿真实验、无纸化考核等丰富多样的数字化教学方法,同时引入问题式学习(Problem-based Learning,PBL)、课程思政等多种形式的教学改革,让学生尽可能地全方位参与到课程学习中;同时制定相应的评价方案并及时反馈于教学,以推动课程教学的良性运行,努力培养具备扎实的理论知识、实践技能、终生学习及创新意识的应用型医学检验技术人才。

关键词： OBE 数字化临床微生物学与检验

Isolation and characterization of mpox virus from the first mpox case in Shenzhen,China

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Virologica Sinica 2024年第2期39卷 335-337页

作者： Lin Cheng Liuqing Yang Miao Wang Yabo peng Haiyan Wang xiaoxiang Yang Juanjuan Zhao Mingxia Zhang Fuxiang Wang Zheng Zhang Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalShenzhen518112China Department of Infectious Diseases Shenzhen Third People's HospitalShenzhen 518112China The Second Affiliated Hospital School of MedicineSouthern University of Science and TechnologyShenzhen 518112China

Dear Editor,Unlike previous outbreaks of the mpox(previously known as monkeypox),which were localized in Africa and resulted in small numbers of infections due to limited human-to-human transmission,the current outbreak beginning in May 2022,has spread rapidly primarily through human-to-human transmission in non-endemic countries(Gong et al.,2022).As of 27 Sep 2023,115 countries and regions have reported cases of mpox to the World Health Organization(WHO),bringing the total number of confirmed cases to 90,618 including 125 *** the number of new cases has decreased in most WHO regions in the second half of 2022,the curves reveal a long outbreak tail in different subregions of the *** worrying,106 mpox cases were reported in the mainland of China in June 2023.

关键词： mainland bringing

Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China

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Stroke & Vascular Neurology 2016年第2期1卷 44-51页

作者： Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang xiaoxiang peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators Department of Interventional Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Tiantan Clinical Trial and Research Center for StrokeBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Center of Stroke Beijing Institute for Brain DisordersBeijingChina Department of Neurosurgery Changzhou No 1 People’s HospitalChangzhouChina Department of Neurology Tangshan Gongren HospitalTangshanChina Department of Neurology Chongqing Sanxia Central HospitalChongqingChina Department of Neurology Daping HospitalChongqingChina Department of Neurology Baotou Central HospitalBaotouChina Department of Neurology Hubei Zhongshan HospitalWuhanChina Department of Neurology Liaocheng Third People’s HospitalLiaochengChina Department of Neurology Luoyang Central Hospital affiliated to Zhengzhou UniversityChina Department of Neurology People’s Hospital of Linyi CityChina Department of Neurology Tianjin TEDA HospitalChina Department of Neurology Chifeng Municipal HospitalChina Department of Neurology Fuzhou PLA General HospitalChina Department of Neurology Affiliated Hospital of Guiyang Medical CollegeChina Department of Neurology Qilu Hospital of Shandong UniversityChina Department of Neurology Yantai Hill HospitalChina Department of Neurology The First Affiliated Hospital of Jinan UniversityChina Department of Neurology Xinan HospitalChina Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease BeijingChina Neuro-intensive Care Unit Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina 不详

Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior *** study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial *** and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse *** with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this *** primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift *** procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study *** primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours *** and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating *** registration number:NCT02350283.

关键词： prospective centre occlusion

可磷酸化短肽偶联壳聚糖介导兔关节软骨损伤修复的基因治疗

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中国修复重建外科杂志 2014年第11期28卷 1346-1352页

作者：赵荣兰彭效祥楚海荣宋伟刘庆潍坊医学院医学检验学系山东省临床检验诊断学重点实验室山东潍坊261053 潍坊市第二人民医院康复科

目的探讨可磷酸化短肽（phosphorylatable short peptide,pSP）偶联壳聚糖（chitosan,CS）（pSP-CS）,携载IGF-1和IL-1受体拮抗剂（IL-1 receptor antagonist,IL-1Ra）基因,局部转染促进关节软骨损伤修复的作用。方法构建pBudCE4.1-IL-1Ra、pBudCE4.1-IGF-1及pBudCE4.1-IL-1Ra＋IGF-1质粒,以pSP偶联CS形成pSP-CS,将以上重组质粒分别与其复合形成pSP-CS/质粒DNA（pDNA）复合物。取3月龄健康雄性新西兰大耳白兔30只,体重2.0-2.5 kg,双侧后肢随机分为5组（n=12）。假手术组（A组）仅暴露股骨外侧髁关节面,pSP-CS/pBudCE4.1干预组（B组）、pSP-CS/pBudCE4.1-IL-1Ra干预组（C组）、pSP-CS/pBudCE4.1-IGF-1干预组（D组）、pSP-CS/pBudCE4.1-IL-1Ra＋IGF-1干预组（E组）制备膝关节外侧髁软骨缺损模型。术后1周,各干预组给予对应pSP-CS/pDNA复合物,共7周;A组注射等量生理盐水。术后观察动物一般情况,8周时处死实验动物,取关节腔灌洗液ELISA分析IL-1Ra及IGF-1含量;实时荧光定量PCR检测缺损区软骨组织聚集蛋白聚糖（Aggrecan）、基质金属蛋白酶3（matrix metalloproteinase 3,MMP-3）、MMP抑制剂1（MMP inhibitor 1,TIMP-1）mRNA表达;阿尔辛蓝-过碘酸雪夫（alcian blue-periodic acid/schiff,ABPAS）染色及Aggrecan免疫组织化学染色鉴定损伤区新生细胞的软骨细胞表型,分析Aggrecan染色吸光度（A）值。结果实验动物术后无感染及死亡。各干预组关节腔灌洗液中检测到大量外源蛋白IGF-1和IL-1Ra,其中D、E组IGF-1含量以及C、E组IL-1Ra含量显著高于A组（P〈0.05）。E组Aggrecan和TIMP-1 mRNA表达上调,MMP-3 mRNA表达下调,明显优于C、D组（P〈0.05）。C、D、E组缺损处出现不同程度软骨性修复,AB-PAS染色及Aggrecan免疫组织化学染色均为阳性,且E组作用明显优于C、D组（P〈0.05）;B组缺损处仅被大量纤维组织增生和炎性细胞浸润,未见明显软骨性修复。结论 pSP-CS是一种较理想的基因载体,可携载治疗基因有效进入兔关节软骨组织;IL-1Ra与IGF-1协同作用明显促进损伤软骨修复。

关键词：可磷酸化短肽壳聚糖软骨损伤基因治疗 IGF-1 IL-1受体拮抗剂兔

老年男性癫痫患者生活质量的影响因素分析及干预对策

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中国实用神经疾病杂志 2015年第20期18卷 1-2页

作者：林力彭小祥武汉市中山医院神经内科武汉430033

目的分析影响老年男性癫痫患者生活质量的各个因素及相应干预对策。方法选取我院神经内科收治的52例门诊及住院癫痫患者为研究对象,以癫痫患者生活质量量表-89作为评分标准,对比分析婚姻状况、受教育程度、病程、发作类型、服药种类等... 详细信息

目的分析影响老年男性癫痫患者生活质量的各个因素及相应干预对策。方法选取我院神经内科收治的52例门诊及住院癫痫患者为研究对象,以癫痫患者生活质量量表-89作为评分标准,对比分析婚姻状况、受教育程度、病程、发作类型、服药种类等对老年男性癫痫患者的生活质量的影响。结果已婚患者在药物影响、社会功能及生活质量总分方均面明显高于未婚患者(P<0.05);受教育程度对担心发作、认知水平药物影响、社会功能及生活质量总分均有影响(P<0.05);发作病程≥20a患者的生活质量明显低于病程<20a患者(P<0.05);发作类型、服药种类对生活质量均有显著影响(P<0.05)。结论婚姻状况、受教育程度、病程、发作类型、服药种类等均对患者的生活质量存在不同程度的影响,需引起医护人员的足够重视。

关键词：癫痫生活质量影响因素干预对策老年

CBL联合TBL教学模式在临床检验技能学教学中的应用

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科教导刊 2023年第34期 152-154页

作者：彭效祥赵荣兰潍坊医学院医学检验学院山东潍坊261053

自2013年五年制医学检验专业改为四年制医学检验技术专业后,对学生应用能力的培养尤为重要。要想把学生培养成为合格的应用型医学检验技术人才,现行的教学内容和教学方法已不能满足人才培养目标的要求,因此对教学内容和教学方法的改革... 详细信息

自2013年五年制医学检验专业改为四年制医学检验技术专业后,对学生应用能力的培养尤为重要。要想把学生培养成为合格的应用型医学检验技术人才,现行的教学内容和教学方法已不能满足人才培养目标的要求,因此对教学内容和教学方法的改革势在必行。研究团队在对医学检验技术专业学生的培养中增加了临床检验技能学这门课程,并针对部分章节实施了CBL联合TBL教学模式的改革,旨在培养合格的应用型医学检验技术人才,也为以后开设这门课的学校或其他相似课程的教学提供参考和借鉴。

关键词：临床检验技能学教学模式 CBL TBL

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