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FRP-钢复合板剪力墙力学性能试验研究

土木工程学报 2023年第9期56卷 1-14页

作者：郝际平冯啸天于金光西安建筑科技大学陕西西安710055

为进一步提高钢板剪力墙的力学性能,文章将纤维增强复合材料(FRP)引入钢板剪力墙结构体系中,形成一种FRP-钢复合板剪力墙结构。复合板提升的拉力场效应,增加墙-框连接节点的设计难度,受剪墙板在框架-墙板连接节点部位容易发生局部破坏... 详细信息

为进一步提高钢板剪力墙的力学性能,文章将纤维增强复合材料(FRP)引入钢板剪力墙结构体系中,形成一种FRP-钢复合板剪力墙结构。复合板提升的拉力场效应,增加墙-框连接节点的设计难度,受剪墙板在框架-墙板连接节点部位容易发生局部破坏。为解决这一问题,提出增强复合板螺栓连接节点抗剪设计与构造方法,并通过9个复合板螺栓连接节点抗剪试验,探究复合板螺栓连接的破坏模式,验证设计方法的有效性。为验证采用增强复合板螺栓连接节点的FRP-钢复合板剪力墙的抗震性能,完成2个1/3缩尺的单层单跨钢板剪力墙试件的拟静力试验,墙板分别采用复合板和纯钢板,为充分发挥FRP的受拉承载能力,在钢板两侧沿对角度方向各粘贴一层单向CFRP纤维布,两层布的纤维相反方向布置,在墙-框节点连接区采用增强复合板螺栓连接节点,通过对比探究复合板剪力墙的抗震性能指标、破坏顺序和破坏模式。研究表明,墙-框复合板螺栓连接节点铺设CFRP能够提高节点抗剪承载能力,其中增设CFRP 90°铺层能够改善只有45°铺层复合板承载力的突降,提高节点的延性。复合板剪力墙表现出明显的三阶段受力特征:弹性阶段(阈值层间位移角0.4%),前期承载力由弹性模量控制,随后逐渐转变为屈曲强度控制,提升作用随位移增大逐渐降低;塑性阶段(阈值层间位移角1.5%),FRP对钢板的承载力和刚度实现明显的增强作用,呈现上升趋势,同时提升了钢板墙的耗能能力,控制了墙板的面外变形,承载力最大提升30%,刚度最大提升31%;破坏阶段(阈值层间位移角3%),FRP对钢板的承载力和刚度提升作用逐渐降低,随后FRP断裂,复合板剪力墙退化为纯钢板剪力墙结构。

关键词： FRP-钢复合板剪力墙螺栓连接节点抗剪承载力抗震性能设计方法

Clinical efficacy and identification of factors confer resistance to afatinib(tyrosine kinase inhibitor)in EGFR-overexpressing esophageal squamous cell carcinoma

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3130-3140页

作者： Yanni Wang Chang Liu Huan Chen Xi Jiao yujiao Wang Yanshuo Cao Jian Li xiaotian Zhang yu Sun Na Zhuo Fengxiao Dong Mengting Gao Fengyuan Wang Liyuan Dong Jifang Gong Tianqi Sun Wei Zhu Henghui Zhang Lin Shen Zhihao Lu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital and InstituteBeijingChina Genecast Biotechnology Co. LtdWuxiPR China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital and InstituteBeijingChina Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of PathologyPeking University Cancer Hospital and InstituteBeijingChina Precision Scientific(Beijing)Co. Ltd.BeijingChina Generulor Company Bio-X Lab ZhuhaiGuangdongChina Biomedical Innovation Center Beijing Shijitan HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory for Therapeutic Cancer Vaccines Beijing Shijitan HospitalCapital Medical UniversityBeijingChina

Epidermal growth factor receptor(EGFR)is reportedly overexpressed in most esophageal squamous cell carcinoma(ESCC)patients,but anti-EGFR treatments offer limited survival *** preclinical data showed the promising antitumor activity of afatinib in EGFR-overexpressing *** proof-of-concept,phase II trial assessed the efficacy and safety of afatinib in pretreated metastatic ESCC patients(n=41)with EGFR overexpression(NCT03940976).The study met its primary endpoint,with a confirmed objective response rate(ORR)of 39%in 38 efficacy-evaluable patients and a median overall survival of 7.8 months,with a manageable toxicity *** analysis of pretreatment tumors revealed that neurotrophic receptor tyrosine kinase 2(NTRK2)was negatively associated with afatinib sensitivity and might serve as a predictive biomarker,irrespective of EGFR ***,knocking down or inhibiting NTRK2 sensitized ESCC cells to afatinib *** study provides novel findings on the molecular factors underlying afatinib resistance and indicates that afatinib has the potential to become an important treatment for metastatic ESCC patients.

关键词： esophageal squamous expressing

Predicting gastric cancer response to anti-HER2 therapy or anti-HER2 combined immunotherapy based on multimodal data

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Signal Transduction and Targeted Therapy 2024年第9期9卷 4137-4148页

作者： Zifan Chen Yang Chen yu Sun Lei Tang Li Zhang Yajie Hu Meng He Zhiwei Li Siyuan Cheng Jiajia yuan Zhenghang Wang Yakun Wang Jie Zhao Jifang Gong Liying Zhao Baoshan Cao Guoxin Li xiaotian Zhang Bin Dong Lin Shen Center for Data Science Peking UniversityBeijingChina Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital and InstituteBeijingChina Department of Pathology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital and InstituteBeijingChina Department of Radiology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital and InstituteBeijingChina National Biomedical Imaging Center Peking UniversityBeijingChina Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor GuangzhouChina Department of Medical Oncology and Radiation Sickness Peking University Third HospitalBeijingChina National Engineering Laboratory for Big Data Analysis and Applications Peking UniversityBeijingChina Beijing International Center for Mathematical Research(BICMR) Peking UniversityBeijingChina Center for Machine Learning Research Peking UniversityBeijingChina

The sole use of single modality data often fails to capture the complex heterogeneity among patients,including the variability in resistance to anti-HER2 therapy and outcomes of combined treatment regimens,for the treatment of HER2-positive gastric cancer(GC).This modality deficit has not been fully considered in many ***,the application of artificial intelligence in predicting the treatment response,particularly in complex diseases such as GC,is still in its ***,this study aimed to use a comprehensive analytic approach to accurately predict treatment responses to anti-HER2 therapy or anti-HER2 combined immunotherapy in patients with HER2-positive *** collected multi-modal data,comprising radiology,pathology,and clinical information from a cohort of 429 patients:310 treated with anti-HER2 therapy and 119 treated with a combination of anti-HER2 and anti-PD-1/PD-L1 inhibitors *** introduced a deep learning model,called the Multi-Modal model(MuMo),that integrates these data to make precise treatment response *** achieved an area under the curve score of 0.821 for anti-HER2 therapy and 0.914 for combined ***,patients classified as low-risk by MuMo exhibited significantly prolonged progression-free survival and overall survival(log-rank test,P<0.05).These findings not only highlight the significance of multi-modal data analysis in enhancing treatment evaluation and personalized medicine for HER2-positive gastric cancer,but also the potential and clinical value of our model.

关键词： immunotherapy HER2 cancer

Reducing the mode-mismatch noises in atom–light interactions via optimization of the temporal waveform

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Photonics Research 2020年第11期8卷 1697-1702页

作者： xiaotian Feng Zhifei yu Bing Chen Shuying Chen yuan Wu Donghui Fan Chun-Hua yuan L.Q.Chen Z.Y.Ou Weiping Zhang State Key Laboratory of Precision Spectroscopy Quantum Institute for Light and AtomsDepartment of PhysicsEast China Normal UniversityShanghai 200062China School of Electronic Science and Applied Physics Hefei University of TechnologyHefei 230009China Department of Physics Indiana University-Purdue University IndianapolisIndianapolisIndiana 46202USA School of Physics and Astronomy and Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai 200240China

Atom–light interface is at the core of quantum metrology and quantum information *** noises during interaction processes are always inevitable and *** this paper,we perform the stimulated Raman scattering(SRS)in a hot Rb 87 vapor cell and demonstrate the reduction of related noises originated from mode mismatch via optimizing the temporal waveform of the input *** using the seed with the optimized mode,the intensity fluctuation of the signal field generated in atom–light interaction is decreased by 4.3 ***,the fluctuation of the intensity difference between the signal and atomic spin wave is reduced by 3.1 *** a temporal mode-cleaning method can be applied to improve the precision of atom interferometry using SRS and should be helpful for quantum information processing based on an atom–light correlated system.

关键词： quantum optimization interferometry

The Mechanism of N-O Bond Cleavage in Rhodium-Catalyzed C-H Bond Functionalization of Quinoline N-oxides with Alkynes:A Computational Study

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The Mechanism of N-O Bond Cleavage in Rhodium-Catalyzed C-H ...

Non-small cell lung cancers(NSCLCs)oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors

中国化学会第九届全国有机化学学术会议

作者： Yingzi Li Song Liu Zisong Qi xiaotian Qi Xingwei Li yu Lan School of Chemistry and Chemical Engineering Chongqing University Dalian Institute of Chemical Physics Chinese Academy of Sciences

＜正＞The mechanism and regioselectivity of the[RhⅢCl2Cp*]2-catalyzed C-H bond functionalization and N-O bond cleavage of quinoline N-oxide with alkynes were studied by using

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Signal Transduction and Targeted Therapy 2023年第10期8卷 5069-5084页

作者： Bopei Cui Lifang Song Qian Wang Kelei Li Qian He Xing Wu Fan Gao Mingchen Liu Chaoqiang An Qiushuang Gao Chaoying Hu xiaotian Hao Fangyu Dong Jiuyue Zhou Dong Liu Ziyang Song Xujia Yan Jialu Zhang yu Bai Qunying Mao Xiaoming Yang Zhenglun Liang Division of Hepatitis and Enterovirus Vaccines NHC Key Laboratory of Research on Quality and Standardization of Biotech ProductsNMPA Key Laboratory for Quality Research and Evaluation of Biological ProductsInstitute of Biological ProductsNational Institutes for Food and Drug ControlBejingChina National Engineering Technology Research Center for Combined Vaccines WuhanChina Beijing Minhai Biotechnology Co LtdBeijingChina Taibang Biologic Group BeijingChina Changchun Institute of Biological Products Co. LtdChangchunChina Shanghai Institute of Biological Products Co LtdShanghaiChina China National Biotec Group Company Limited BeijingChina

With the continuous in-depth study of the interaction mechanism between viruses and hosts,the virus has become a promising tool in cancer *** fact,many oncolytic viruses with selectivity and effectiveness have been used in cancer *** enterovirus is one of the most convenient sources to generate oncolytic viruses,however,the high seroprevalence of some enteroviruses limits its application which urges to exploit more oncolytic enteroviruses.

关键词： damage enterovirus cancer

Platelet count and mean platelet volume as predictive markers of preeclampsia

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Platelet count and mean platelet volume as predictive marker...

国有企业推进关键核心技术突破对协同创新网络竞合关系的治理机制——基于“华龙一号”核电技术案例研究

2019长三角围产医学学术会议暨浙江省围产医学学术大会

作者： Shouling Luo Jiangnan Pei Yi yu Chengjie Wang xiaotian Li Weirong Gu The Department of Obstetrics Obstetrics and Gynecology Hospital of Fudan University

Introduction: To evaluate the predictive utilization of Platelet count, mean platelet volume(MPV) and the platelet distribution width(PDW) in preeclamptic women. Methods: demographic characteristics and laboratory results were collected and compared from 5556 pregnancies pregnancy who received continuous prenatal care and bore in our hospital between 1964 and *** enrolls met the standards were divided into two subgroups depending on the week they had their first antenatal care. The first trimester group who had their first antenatal care before the 14 th week included 175 controls and 73 pregnancies who later developed preeclampsia(PE), and the second trimester group who had their first antenatal care between the 14 th week and the 28 th week included 135 controls and 112 pregnancies who later developed preeclampsia. Their platelet counts, MPV and PDW were measured when they had their first antenatal care. Result: There was no significant difference in age and the basic blood pressure between the study groups. The platelet count( 232.4±3.9 vs 238.9±6.5, p=0.52), MPV(10.3±0.06 vs 10.44±0.10,p=0.84) and PDW(12.0±0.14 vs 12.16±0.24 p=0.45)of the first trimester group had no difference, the PDW(12.02±0.18 vs 12.43±0.21 p=0.60)of the second trimester group had no difference neither, while the platelet count(221.6±4.22 vs 216.3±5.54 p=0.049) was significantly decreased in the PE group compared to the controls, and the MPV(10.25±0.08 vs 10.61±0.13 p<0.0001)was significantly elevated in the PE group compared to the controls. Conclusion: the platelet was significantly decreased and MPV is significantly elevated in the second half of pregnancy in women who later develop PE and might therefore be implemented in combination with other parameters in a PE prediction model.

关键词： preeclampsia platelet platelet indices prediction

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科技进步与对策 2024年第21期41卷 142-150页

作者：杨筱恬关月于淼大连理工大学经济管理学院辽宁大连116024

国有企业是科技创新的主力军,在“卡脖子”关键核心技术突破中如何对创新网络多主体竞合关系进行有效治理是推进科技创新的关键。选取中核工程作为案例研究对象,基于竞合关系与利益相关者视角探究国有企业作为核心企业对创新网络竞合关... 详细信息

国有企业是科技创新的主力军,在“卡脖子”关键核心技术突破中如何对创新网络多主体竞合关系进行有效治理是推进科技创新的关键。选取中核工程作为案例研究对象,基于竞合关系与利益相关者视角探究国有企业作为核心企业对创新网络竞合关系的治理机制。研究发现:①国有企业对协同创新网络主体存在行政要素驱动、技术要素驱动和利益要素驱动3类竞合关系;②针对不同类型竞合关系,分别采取行政协调、柔性治理与规范合作3种细分机制,促进创新网络主体良性合作,同时对价值创造与分配中存在的竞合关系进行有效治理。研究结论有助于丰富国有企业情境下的关键核心技术突破研究,为国有企业管理协同创新网络主体提供参考。

关键词：核心企业国有企业关键核心技术突破协同创新竞合关系治理

米格列奈钙与牛血清白蛋白相互作用的光谱研究

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光学学报 2017年第11期37卷 367-373页

作者：张啸天张林朱卫华俞波河海大学理学院江苏南京211100 南京航空航天大学理学院江苏南京210016

采用荧光光谱法、紫外可见吸收光谱法以及同步荧光光谱法研究了米格列奈钙与牛血清白蛋白(BSA)之间的相互作用。实验结果表明,米格列奈钙对牛血清白蛋白的荧光有较为明显的猝灭作用,其猝灭机制为动态猝灭,遵循Stern-Volmer方程;根据F9rs... 详细信息

采用荧光光谱法、紫外可见吸收光谱法以及同步荧光光谱法研究了米格列奈钙与牛血清白蛋白(BSA)之间的相互作用。实验结果表明,米格列奈钙对牛血清白蛋白的荧光有较为明显的猝灭作用,其猝灭机制为动态猝灭,遵循Stern-Volmer方程;根据F9rster的非辐射能量转移理论,计算出米格列奈钙分子与牛血清白蛋白分子的结合距离为5.461nm;用同步荧光光谱技术探究了米格列奈钙对BSA构象的影响,结果发现,当激发和发射波长差为60nm时,荧光峰位发生了微小的蓝移,说明BSA色氨酸残基附近的外围微环境受到了米格列奈钙分子的影响,极性减弱,BSA的疏水性增强。

关键词：光谱学光学荧光猝灭荧光光谱米格列奈钙牛血清白蛋白蛋白质构象