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Angiogenic peptide hydrogels for treatment of traumatic brain injury

Bioactive materials 2020年第1期5卷 124-132页

作者： Xiaotang Ma Agnieszka Agas Zain Siddiqui KaKyung Kim Patricia Iglesias-Montoro Jagathi Kalluru Vivek Kumar James Haorah Department of Biomedical Engineering Center for Injury Bio-MechanicsMaterials and MedicineNew Jersey Institute of TechnologyNewarkNJ07102USA Department of Chemical and materials Engineering New Jersey Institute of TechnologyNewarkNJ07102USA Department of Restorative Dentistry Rutgers School of Dental MedicineNewarkNJUSA

Traumatic brain injury(TBI)impacts over 3.17 million Americans.management of hemorrhage and coagulation caused by vascular disruption after TBI is critical for the recovery of patients.Cerebrovascular pathologies play an important role in the underlying mechanisms of TBI.The objective of this study is to evaluate a novel regenerative medicine for the injured tissue after brain injury.We utilized a recently described synthetic growth factor with angiogenic potential to facilitate vascular growth in situ at the injury site.Previous work has shown how this injectable self-assembling peptide-based hydrogel(SAPH)creates a regenerative microenvironment for neovascularization at the injury site.Supramolecular assembly allows for thixotropy;the injectable drug delivery system provides sustained in vivo efficacy.In this study,a moderate blunt injury model was used to cause physical vascular damage and hemorrhage.The angiogenic SAPH was then applied directly on the injured rat brain.At day 7 post-TBI,significantly more blood vessels were observed than the sham and injury control group,as well as activation of VEGF-receptor 2,demonstrating the robust angiogenic response elicited by the angiogenic SAPH.Vascular markers von-Willebrand factor(vWF)andα-smooth muscle actin(α-Sma)showed a concomitant increase with blood vessel density in response to the angiogenic SAPH.Moreover,blood brain barrier integrity and blood coagulation were also examined as the parameters to indicate wound recovery post TBI.Neuronal rescue examination by NeuN and myelin basic protein staining showed that the angiogenic SAPH may provide and neuroprotective benefit in the long-term recovery.

关键词： Traumatic brain injury Cerebrovascular injury Regenerative medicine Angiogenesis Self-assembling peptide hydrogels

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Circulating endothelial microvesicles and their carried miR-125a 5p:potential biomarkers for ischaemic stroke

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Stroke & Vascular Neurology 2023年第2期8卷 89-102页

作者： Xiaotang Ma Xiaorong Liao Jiehong Liu Yan Wang Xiang Wang Yanfang Chen Xiaojian Yin Qunwen Pan Department of Neurology Affiliated Hospital of Guangdong Medical UniversityZhanjiangChina Pharmacology and Toxicology Wright State University Boonshoft School of MedicineDaytonOhioUSA

Background Endothelial microvesicles(EMVs)are closely associated with the status of endothelial cells(ECs).Our earlier study has shown that EMVs could exert protective roles in ECs by transferring their carried miR-125a 5p.However,whether circulating EMVs and their carried miR-125a 5p can be used as biomarkers in ischaemic stroke(IS)are remain unknown.Methods We recruited 72 subjects with IS,60 subjects with high stroke risk and 56 age-matched controls.The circulating EMVs and their carried miR-125a 5p(EMV-miR 125a 5p)levels were detected.We used microRNA(miR)array to study expression changes of miRs in plasma EMVs samples of three IS patients and three matched healthy controls.Transient middle cerebral artery occlusion(tMCAO)was used to establish IS mouse model.Results EMVs level was obviously elevated in IS patients,with the highest level in acute stage,and was positively related to carotid plaque,carotid intima-media thickness(IMT),National Institutes of Health Stroke Scale(NIHSS),infarct volume.On the contrary,we observed that EMV-miR 125a 5p level was obviously reduced in IS,with the lowest level in acute stage,and was negatively correlated with carotid plaque,IMT,NIHSS scores,infarct volume.EMVs and EMV-miR 125a 5p levels were closely related with large artery atherosclerosis subgroup.Importantly,EMVs and EMV-miR 125a 5p levels could serve as independent risk factors,and receiver operating characteristic curve achieved an area under curve(AUC)of 0.720 and 0.832 for IS,respectively,and elevated to 0.881 after their combination.In IS mouse model,control EMVs or n-EMVs administration could decrease the infarct volume and neurological deficit score,while increase the cerebral blood flow of IS mice compared with vehicle group,while IS EMVs or oxygen and glucose deprivation(OGD)-EMVs administration aggravated the tMCAO induced ischaemic injury.In addition,we observed that OGD EMVmiR-125a 5p could partially ameliorate the OGD EMVs induced brain injury after IS.Conclusions These findings demonstrate that circulatin

关键词： miR elevated protective

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Simultaneous, hybrid single-molecule method by optical tweezers and fluorescence

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Nanotechnology and Precision Engineering 2019年第4期2卷 145-156页

作者： Guoteng ma Chunguang Hu Shuai Li Xiaoqin Gao Hongbin Li xiaotang Hu State Key Laboratory of Precision Measuring Technology and Instruments Tianjin University300072China Nanchang Institute for Microtechnology of Tianjin University Tianjin 300072China Department of Chemistry University of British ColumbiaVancouverBC V6T 1Z1Canada

As studies on life sciences progress toward the single-molecule level,new experiments have put forward more requirements for simultaneously displaying the mechanical properties and conformational changes of biomolecules.Optical tweezers and fluorescence microscopy have been combined to solve this problem.The combination of instruments forms a new generation of hybrid single-molecule technology that breaks through the limitations of traditional biochemical analysis.Powerfulmanipulation and fluorescence visualization have beenwidely used,and these techniques provide new possibilities for studying complex biochemical reactions at the singlemolecule level.This paper explains the features of this combined technique,including the application characteristics of single-trap and dual-traps,the anti-bleaching method,and optical tweezers combined with epifluorescence,confocal fluorescence,total internal reflection fluorescence,and other fluorescence methods.Using typical experiments,we analyze technical solutions and explain the factors and principles that instrument designers should consider.This review aims to give an introduction to this novel fusion technology process and describe important biological results.

关键词： Single-molecule Optical tweezers Confocal fluorescence FRET TIRF

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A Sustainable Dual Cross‑Linked Cellulose Hydrogel Electrolyte for High‑Performance Zinc‑Metal Batteries

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Nano-Micro Letters 2024年第6期16卷 63-75页

作者： Haodong Zhang xiaotang Gan Yuyang Yan Jinping Zhou Hubei Engineering Center of Natural Polymers‑Based Medical materials Key Laboratory of Biomedical Polymers of Ministry of EducationCollege of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072People’s Republic of China Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan UniversityTransplant Center of Wuhan UniversityWuhan 430072People’s Republic of China

Aqueous rechargeable Zn-metal batteries(ARZBs)are considered one of the most promising candidates for grid-scale energy storage.However,their widespread commercial application is largely plagued by three major challenges:The uncontrollable Zn dendrites,notorious parasitic side reactions,and sluggish Zn^(2+) ion transfer.To address these issues,we design a sustainable dual crosslinked cellulose hydrogel electrolyte,which has excellent mechanical strength to inhibit dendrite formation,high Zn^(2+) ions binding capacity to suppress side reaction,and abundant porous structure to facilitate Zn^(2+) ions migration.Consequently,the Zn||Zn cell with the hydrogel electrolyte can cycle stably for more than 400 h under a high current density of 10 ma cm^(−2).Moreover,the hydrogel electrolyte also enables the Zn||polyaniline cell to achieve high-rate and long-term cycling performance(>2000 cycles at 2000 ma g^(−1)).Remarkably,the hydrogel electrolyte is easily accessible and biodegradable,making the ARZBs attractive in terms of scalability and sustainability.

关键词： Cellulose Dual cross-linked Aqueous rechargeable Zn-metal batteries Hydrogel electrolyte

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Small-molecule organic electrode materials for rechargeable batteries

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Science China Chemistry 2023年第11期66卷 3070-3104页

作者： xiaotang Gan Zhiping Song Hubei Key Lab of Electrochemical Power Sources College of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China

Small-molecule organic electrode materials(SMOEMs)have shown tremendous potential as cathodes or anodes for various rechargeable batteries including lithium and sodium batteries,due to their easy material availability,high structure designability,attractive theoretical capacity,and wide adaptability to counterions.However,they suffer from the severe dissolution problem and the subsequent shuttle effect in nonaqueous electrolytes,which cause the poor cycling stability and Coulombic efficiency.To satisfy the demands on the energy density and cycling stability simultaneously,the molecular structures of SMOEMs need to be rationally designed,and extrinsic approaches including electrode engineering and electrolyte optimizations can be further conducted.In this review,we summarize the fundamental knowledge about SMOEMs,including their working principles and applications,structure classifications,molecular structure design methods,and extrinsic optimization strategies.Moreover,we also provide some original insights aiming at guiding the research and development of SMOEMs in a more scientific and practical way.In brief,SMOEMs are facing huge opportunities and challenges as candidates to enable the next-generation of efficient,sustainable,and green rechargeable batteries.

关键词： organic electrode materials small-molecule organic batteries lithium batteries dissolution problem molecular structure design

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Recent Advance in Polymer Coatings Combating Bacterial Adhesion and Biofilm Formation

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Chinese Journal of Chemistry 2022年第24期40卷 2988-3000页

作者： xiaotang Chu Fangping Yang Haoyu Tang Institute of Functional Nano&Soft materials(FUNSOM) Collaborative Innovation Center of Suzhou Nano Science&TechnologySoochow UniversitySuzhouJiangsu215123 China

Implantable medical device-associated infections (DAIs) originating from bacterial adhesion and biofilm formation have threatened to the health and life of patients. Antibacterial polymer coatings with antifouling and/or bactericidal properties have showed great potentials to combat DAI issues. In this review, we report recent advances in antibacterial polymer coatings fighting bacterial adhesion and biofilm formation on implantable biomaterial surfaces. We summarize the mechanisms of bacterial adhesion and biofilm formation, which provides guidance for the design of antibacterial coatings. We describe the polymer and coating preparation methods and discuss the structure-property relationships of antibacterial polymer coatings. Applications of these polymer coatings in medical catheters, orthopaedic implants, and other applications are elaborated. Future challenges and prospects associated with antibacterial polymer coatings for implantable medical devices are discussed.

关键词： Polymers Structure-activity relationships Peptides Antibacterial coatings Biofilm

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本科院校书院制分析及对高职院校建设的启示

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深圳信息职业技术学院学报 2019年第4期17卷 62-67页

作者：李晓堂马超深圳信息职业技术学院智能制造与装备学院

高职院校书院制建设是学生管理模式的崭新尝试,目前仍处在摸索阶段。通过梳理本科院校书院建设的现状并进行分析思考,为高职院校书院建设提供借鉴。在此基础上,提出符合高职院校特点和实际情况的书院制建设建议。

关键词：高职院校书院制建设

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“双高”配电网下变电站并联电容器灵活投切

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电力系统及其自动化学报 2023年第2期35卷 132-139页

作者：李建文杨瑞卿李戎马小棠华北电力大学电气与电子工程学院保定071003

针对目前变电站并联电容器组投切方案存在的设备利用率低和易受双高配电网宽频谐波影响而损坏的问题,提出一种考虑谐波宽频特性的并联电容器组灵活投切策略。首先,建立10 kV配电网并联补偿模型和电容器组投切方案集合。然后,运用模态分... 详细信息

针对目前变电站并联电容器组投切方案存在的设备利用率低和易受双高配电网宽频谐波影响而损坏的问题,提出一种考虑谐波宽频特性的并联电容器组灵活投切策略。首先,建立10 kV配电网并联补偿模型和电容器组投切方案集合。然后,运用模态分析法确定投切方案网络谐振点。最后,从并联补偿方案的谐波谐振机理出发,设计程序计算谐波电流放大倍数,确定并联补偿方案基本可行域,筛选出最优投切组合。算例仿真表明,该投切策略能在实现原有无功补偿的功能上,提高设备总体利用率,避免并联电容器组投入后产生的谐波谐振和谐波电流放大。

关键词：配电网并联电容器模态分析电容器组投切谐波抑制

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结合数字延时补偿的并网逆变器阻抗重塑方法

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太阳能学报 2023年第4期44卷 316-323页

作者：李建文马小棠吴滨源李戎杨瑞卿新能源电力系统国家重点实验室(华北电力大学) 保定071003

首先建立并网逆变器阻抗模型,探究数字延时导致系统稳定性降低的原因,然后提出一种结合数字延时补偿的并网逆变器阻抗重塑方法,包括牛顿插值预测的延时补偿策略和逆变器阻抗重塑策略。该方法可有效削弱数字延时对逆变器输出阻抗的不利影... 详细信息

首先建立并网逆变器阻抗模型,探究数字延时导致系统稳定性降低的原因,然后提出一种结合数字延时补偿的并网逆变器阻抗重塑方法,包括牛顿插值预测的延时补偿策略和逆变器阻抗重塑策略。该方法可有效削弱数字延时对逆变器输出阻抗的不利影响,提高阻抗相交点频率处的相位裕度,拓宽并网系统适应电网阻抗变化的范围。最后,基于半实物仿真平台RT-LAB,搭建并网逆变器模型进行实验,验证该方法的有效性。

关键词： LCL型并网逆变器弱电网并网控制稳定性延时

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专门性语码倾向、技术接受度与在线英语学习投入度的结构分析

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外语研究 2022年第5期39卷 63-70,112页

作者：李正伟马晓雷高霄胡小棠国防科技大学军政基础教育学院湖南长沙410074 华北电力大学英语系河北保定071003

本研究基于合法化语码理论、技术接受模型理论和学习投入度理论,探讨中国英语学习者的在线学习行为特点。通过对4所高校527名学生的问卷调查数据进行结构方程模型分析,揭示学习者的英语语码倾向、技术接受度与在线学习投入度之间的复杂... 详细信息

本研究基于合法化语码理论、技术接受模型理论和学习投入度理论,探讨中国英语学习者的在线学习行为特点。通过对4所高校527名学生的问卷调查数据进行结构方程模型分析,揭示学习者的英语语码倾向、技术接受度与在线学习投入度之间的复杂结构关系。研究表明,学习者秉持的英语学习理念同在线教学的潜在要求之间可能存在语码冲突,这种错位可能是导致学习者产生挫败感、焦躁感和疏离感的主要原因。消解语码冲突、促进语码匹配应成为提高在线英语教学质量的重要课题。

关键词：合法化语码理论技术接受模型学习投入度中国英语学习者

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