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BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period

Protein & Cell 2024年第1期15卷 21-35页

作者： Zhenmeiyu li Guoping liu {2. yang Mengge Sun Zhuangzhi Zhang Zhejun Xu Yanjing Gao Xin Jiang Zihao Su xiaosu li zhengang yang state Key laboratory of {2. neurobiology and MOE Frontiers Center for brain science Institutes of Brain Scienceand Department of NeurologyZhongshan HospitalFudan UniversityShanghai 200433China

The seat of human intelligence is the human cerebral cortex,which is responsible for our exceptional cognitive *** principles that lead to the development of the large-sized human cerebral cortex will shed light on what makes the human {2. and species so *** remarkable increase in the number of human cortical pyramidal neurons and the size of the human cerebral cortex is mainly because human cortical radial glial cells,primary neural stem cells in the cortex,generate cortical pyramidal neurons for more than 130 days,whereas the same process takes only about 7 days in *** molecular mechanisms underlying this difference are largely ***,we found that bone morphogenic protein 7(BMP7)is expressed by increasing the number of corti-cal radial glial cells during mammalian evolution(mouse,ferret,monkey,and human).BMP7 expression in cortical radial glial cells promotes neurogenesis,inhibits gliogenesis,and thereby increases the length of the neurogenic period,whereas Sonic Hedgehog(SHH)signaling promotes cortical *** demonstrate that BMP7 sign-aling and SHH signaling mutually inhibit each other through regulation of Gli3 repressor *** propose that BMP7 drives the evolutionary expansion of the mammalian cortex by increasing the length of the neurogenic period.

关键词： radial glia cortical neurogenesis cortical gliogenesis cortical evolution BMP7 SHH

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Overexpression of the transcription factor Sp8 induces ectopic motor neurons in the p3 domain of chick spinal cord

Overexpression of the transcription factor Sp8 induces ectop...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： xiaosu li~1,chao lin~1,{2. song~2.zhengang yang~(1,*) 1 institutes of brain science and state Key laboratory of medical {{12.,fudan university,{12.,hua zhong agricultural university,wuhan 436700,china

＜正＞During the period of neurogenesis in the spinal cord,particular types of neurons are generated from specific progenitor cells located in different dorsoventral（DV） regions of the ventricular *** graded morphogens along the DV axis of the neural tube confer positional information to the progenitor *** achieve through induction or inhibition of a set of transcription factors expression in a concentration dependent *** combinatorial expression of distinct transcription factors,the DV axis of the neural tube can be divided into multiple domains and cross-repressive interactions between complementary pairs of transcription factors further refine and sharpen the boundaries between adjacent *** action of these transcription factors directs different progenitor populations to generate particular subtypes of ***8 is a zinc finger transcription factors belonging to specificity protein（Sp） family and expression of Sp8 in the basal plate of spinal cord has been *** there is no study addressing the function role of Sp8 during spinal cord *** the present study,we first confirmed Sp8 expression in the spinal cord using *** neurogenesis in the spinal cord,Sp8 expression shares the same ventral limit with O1ig2.and is complementary to Nkx2.2.O1ig2. domain and Nkx2.2. domain are neighboring with each other,and give rise to Isll+ motor neurons and Siml+ V3 interneurons respectively. When mouse Sp8 was overexpressed in the chick spinal cord using either retrovirus or in ovo electroporation,we found that ectopic motor neurons were induced in the Nkx2.2. p3 ***,Nkx2.2.expression was cellautonomously repressed by Sp8 *** suggests that Sp8 participates in patterning the ventral spinal cord.

关键词： Sp8 motor neuron Nkx2.2 dorsoventral patterning spinal cord

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Developmental Origins of Human Cortical Oligodendrocytes and Astrocytes

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Neuroscience Bulletin 2022年第1期38卷 47-68页

作者： lin yang Zhenmeiyu {2. Guoping {2.u xiaosu {2. zhengang yang state Key laboratory of {2. neurobiology and MOE Frontiers Center for brain science Institutes of Brain ScienceInstitute for Translational Brain Researchand Department of NeurologyZhongshan HospitalFudan UniversityShanghai200032China

Human cortical radial glial cells are primary neural stem cells that give rise to cortical glutaminergic projection pyramidal neurons, glial cells (oligodendrocytes and astrocytes) and olfactory bulb GABAergic interneurons. One of prominent features of the human cortex is enriched with glial cells, but there are major gaps in understanding how these glial cells are generated. Herein, by integrating analysis of published human cortical single-cell RNA-Seq datasets with our immunohistochemistical analyses, we show that around gestational week 18, EGFR-expressing human cortical truncated radial glial cells (tRGs) give rise to basal multipotent intermediate progenitors (bMIPCs) that express EGFR, ASCL1, OliG2.and OliG1. These bMIPCs undergo several rounds of mitosis and generate cortical oligodendrocytes, astrocytes and olfactory bulb interneurons. We also characterized molecular features of the cortical tRG. Integration of our findings suggests a general picture of the lineage progression of cortical radial glial cells, a fundamental process of the developing human cerebral cortex.

关键词： Radial glial cell Intermediate progenitor cell EGFR HOPX Oligodendrocyte Astrocyte Olfactory bulb interneuron Cerebral cortex Human

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Decoding Cortical Glial Cell Development

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Neuroscience Bulletin 2021年第4期37卷 440-460页

作者： xiaosu li Guoping liu lin yang Zhenmeiyu li Zhuangzhi Zhang Zhejun Xu Yuqun Cai Heng Du Zihao Su Ziwu Wang yangyang Duan Haotian Chen Zicong Shang Yan You Qi Zhang Miao He Bin Chen zhengang yang state Key laboratory of {2. neurobiology Institutes of Brain ScienceMOE Frontiers Center for Brain ScienceDepartment of NeurologyInstitute for Translational Brain ResearchZhongshan HospitalFudan UniversityShanghai 200032China Department of Molecular Cell and Developmental BiologyUniversity of California Santa CruzSanta CruzCA 95064USA

Mouse cortical radial glial cells(RGCs)are primary neural stem cells that give rise to cortical oligodendrocytes,astrocytes,and olfactory bulb(OB)GABAergic interneurons in late *** are fundamental gaps in understanding how these diverse cell subtypes are ***,by combining single-cell RNA-Seq with intersectional {2.eage analyses,we show that beginning at around E16.5,neocortical RGCs start to generate ASCL1^(+)EGFR^(+)apical multipotent intermediate progenitors(MIPCs),which then differentiate into basal MIPCs that express ASCL1,EGFR,OliG2.and *** basal MIPCs undergo several rounds of divisions to generate most of the cortical oligodendrocytes and astrocytes and a subpopulation of OB ***,single-cell ATAC-Seq supported our model for the genetic logic underlying the specification and differentiation of cortical glial cells and OB *** together,this work reveals the process of cortical radial glial cell {2.eage progression and the developmental origins of cortical astrocytes and oligodendrocytes.

关键词： Radial glial cell Intermediate progenitor cell ASCL1 EGFR OliG2 Oligodendrocyte Astrocyte Olfactory bulb interneuron Cerebral cortex

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