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A robust implicit high-order discontinuous Galerkin method for solving compressible Navier-Stokes equations on arbitrary grids

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Acta Mechanica Sinica 2024年第8期40卷 96-119页

作者： Jia Yan xiaoquan yang Peifen Weng Shanghai Institute of Applied Mathematics and Mechanics Shanghai Key Laboratory of Mechanics in Energy EngineeringSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai200072China College of Energy and Mechanical Engineering Shanghai University of Electric PowerShanghai200090China

The primary impediments impeding the implementation of high-order methods in simulating viscous flow over complex configurations are robustness and *** challenges impose significant constraints on computational efficiency,particularly in the domain of engineering *** address these concerns,this paper proposes a robust implicit high-order discontinuous Galerkin(DG)method for solving compressible Navier-Stokes(NS)equations on arbitrary *** method achieves a favorable equilibrium between computational stability and *** solve the linear system,an exact Jacobian matrix solving strategy is employed for preconditioning and matrix-vector generation in the generalized minimal residual(GMRES)*** approach mitigates numerical errors in Jacobian solution during implicit calculations and facilitates the implementation of an adaptive Courant-Friedrichs-Lewy(CFL)number increasing strategy,with the aim of improving convergence and *** further enhance the applicability of the proposed method for intricate grid distortions,all simulations are performed in the reference *** practice significantly improves the reversibility of the mass matrix in implicit calculations.A comprehensive analysis of various parameters influencing computational stability and efficiency is conducted,including CFL number,Krylov subspace size,and GMRES convergence *** computed results from a series of numerical test cases demonstrate the promising results achieved by combining the DG method,GMRES solver,exact Jacobian matrix,adaptive CFL number,and reference domain calculations in terms of robustness,convergence,and *** analysis results can serve as a reference for implicit computation in high-order calculations.

关键词： Discontinuous Galerkin method Exact Jacobian matrix GMRES solver Adaptive CFL number Reference domain High-order

A robust compact least-squares reconstruction method for compressible turbulent flow simulations of complex configurations

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Chinese Journal of Aeronautics 2023年第12期36卷 113-138页

作者： Jia YAN Zhengyu NIU xiaoquan yang Jue DING Xiaolong TANG Peifeng WENG Shanghai Institute of Applied Mathematics and Mechanics Shanghai UniversityShanghai 200072China School of Mechanics and Engineering Science Shanghai UniversityShanghai 200072China Shanghai University of Electric Power Shanghai 200090China

For the second-order finite volume method,implicit schemes and reconstruction methods are two main algorithms which influence the robustness and efficiency of the numerical simulations of compressible turbulent *** this paper,a compact least-squares reconstruction method is proposed to calculate the gradients for the distribution of flow field variables *** compactness of the new reconstruction method is reflected in the gradient calculation *** geometries of the face-neighboring elements are no longer utilized,and the weighted average values at the centroid of the interfaces are used to calculate the gradients instead of the values at the centroid of the face-neighboring ***,an exact Jacobian solving strategy is developed for implicit temporal *** accurate processing of Jacobian matrix can extensively improve the invertibility of the Jacobian matrix and avoid introducing extra numerical *** addition,a modified Venkatakrishnan limiter is applied to deal with the shock which may appear in transonic flows and the applicability of the mentioned methods is enhanced *** combination of the proposed methods makes the numerical simulations of turbulent flow converge rapidly and steadily with an adaptive increasing CFL *** numerical results of several benchmarks indicate that the proposed methods perform well in terms of robustness,efficiency and accuracy,and have good application potential in turbulent flow simulations of complex configurations.

关键词： Compact least-squares reconstruction method Exact Jacobian matrix Finite volume method Implicit schemes Turbulent flow

Noise control for high subsonic jet flows by inner wall treatment

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Advances in Aerodynamics 2023年第1期5卷 332-361页

作者： Huyue Mao Xiaolong Tang xiaoquan yang Jue Ding Peifen Weng Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai UniversityShanghai 200444China Shanghai University of Electric Power Shanghai 200090China

Subsonic jet nozzles,commonly used in passenger aircrafts,generate significant noise that travels both downstream and upstream due to large-scale or fine-scale turbulence in the jet *** reduce jet noise,a novel wall treatment method,termed the wavy inner wall(WIW),is *** this method,the smooth inner wall near the exit of the nozzle is replaced by treated walls that carry small wavy *** simulations were conducted to investigate the effects of the WIW *** eddy simulations(LES)were used to predict the unsteady flow field and the far-field noise,followed by the analogy method proposed by Ffowcs Williams and *** better understand the mechanism behind the noise reduction achieved by the WIW treatment,the shear-layer instability,radial and azimuthal auto-correlation functions,turbulent kinetic energy,and acoustic source term from the Tam-Auriault(TA)jet-noise model were *** indicated that the WIW treatment advances the onset of jet flow instability in the shear-layer,leading to the early breakdown of jet shear-layer and production of different scales of downstream turbulent *** a result,the distribution and production of turbulent kinetic energy are affected,and the genera-tion and emission of jet noise are *** WIW treatment enables the control of fine scale turbulence,resulting in the reduction of mid-to high-frequency noise in the far field,while ensuring a low thrust *** feature makes the WIW method a promis-ing approach for jet noise control.

关键词： Jet noise Wavy inner wall Noise control Large eddy simulation

Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles

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Light(Science & Applications) 2020年第1期9卷 450-465页

作者： Yanfeng Dai Xiang Yu Jianshuang Wei Fanxin Zeng Yiran Li xiaoquan yang Qingming Luo Zhihong Zhang Britton Chance Center and MOE Key Laboratory for Biomedical Photonics School of Engineering SciencesWuhan National Laboratory for Optoelectronics–Huazhong University of Science and TechnologyWuhanHubei 430074China School of Biomedical Engineering Hainan UniversityHaikouHainan 570228China

Detection of sentinel lymph nodes(SLNs)is critical to guide the treatment of breast ***,distinguishing metastatic SLNs from normal and inflamed lymph nodes(LNs)during surgical resection remains a ***,we report a CD44 and scavenger receptor class B1 dual-targeting hyaluronic acid nanoparticle(5K-HA-HPPS)loaded with the near-infra-red fluorescent dye DiR-BOA for SLN imaging in breast *** small sized(~40 nm)self-assembled 5K-HA-HPPSs accumulated rapidly in the SLNs after intradermal *** with normal popliteal LNs(N-LN),there were ~3.2-fold and ~2.4-fold increases in fluorescence intensity in tumour metastatic SLNs(T-MLN)and inflamed LNs(Inf-LN),respectively,6 h after nanoparticle *** importantly,photoacoustic microscopy(PAM)of 5KHA-HPPS showed a significantly distinct distribution in T-MLN compared with N-LN and *** were mainly distributed at the centre of T-MLN but at the periphery of N-LN and *** ratio of PA intensity(R)at the centre of the LNs compared with that at the periphery was 5.93±0.75 for T-MLNs of the 5K-HA-HPPS group,which was much higher than that for the Inf-LNs(R=0.2±0.07)and N-LNs(R=0.45±0.09).These results suggest that 5K-HA-HPPS injection combined with PAM provides a powerful tool for distinguishing metastatic SLNs from pLNs and inflamed LNs,thus guiding the removal of SLNs during breast cancer surgery.

关键词： breast injection cancer

Targeting cancer-associated fibroblasts with hydroxyethyl starch nanomedicine boosts cancer therapy

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Nano Research 2023年第5期16卷 7323-7336页

作者： Chong Wang Huimin Wang Hai yang Chen Xu Qiang Wang Zheng Li Zhijie Zhang Jiankun Guan Ximiao Yu xiaoquan yang Xiangliang yang Zifu Li National Engineering Research Center for Nanomedicine College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China GBA Research Innovation Institute for Nanotechnology Guangzhou 510530China Key Laboratory of Biomedical Photonics(HUST) Ministry of EducationHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medical Huazhong University of Science and TechnologyWuhan 430074China Hubei Engineering Research Center for Biomaterials and Medical Protective Materials Huazhong University of Science and TechnologyWuhan 430074China Hubei Bioinformatics and Molecular Imaging Key Laboratory College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China

Cancer-associated fibroblasts(CAFs)play an important role in facilitating the progression of triple-negative breast cancer(TNBC)by deteriorating the tumor mechanical microenvironment(TMME).Herein,we designed a CAFs-targeting nanomedicine by conjugating doxorubicin(DOX)-loaded hydroxyethyl starch-IR780 nanoparticles(NPs)with Cys-Arg-Glu-Lys-Ala(CREKA)peptide,which had a special affinity for fibronectin overexpressed on *** systemic administration,the NPs efficiently targeted CAFs and generated hyperthermia upon light irradiation,decreasing CAFs through the combination of chemo-and ***,a series of changes in TMME were achieved by reducing CAFs,which further disrupted the niche of cancer stem cells(CSCs)to affect their *** a result,the tumor growth was significantly inhibited in 4T1 *** strategy of TMME modulation and CSCs elimination through targeting and depleting CAFs provides a novel therapeutic treatment for desmoplastic solid tumors.

关键词： hydroxyethyl starch cancer-associated fibroblasts tumor mechanical microenvironment cancer stem cells combination therapy

Effect of lipid peroxidation on the allergenicity and functional properties of soybeanβ-conglycinin(7S)and glycinin(11S)

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Food Science and Human Wellness 2023年第3期12卷 895-902页

作者： Liying Ye Liangtao Lv Xiao Lin Kan He xiaoquan yang Zhili Wan Lizhong Liu Haiqian Wu Shaojun Xing Xuli Wu School of Public Health Health Science CenterShenzhen UniversityShenzhen 518060China School of Food Science and Technology South China University of TechnologyGuangzhou 510640China School of Basic Medical Science Health Science CenterShenzhen UniversityShenzhen 518060China

This study aimed to analyze the effect of lipid peroxidation on the allergenicity and functional properties of soybeanβ-conglycinin(7 S)and glycinin(11 S).Oxidation complexes were determined using the lipid peroxidation *** properties were analyzed based on emulsifying and foaming *** potential allergenicity was evaluated by in vitro and in vivo *** results found that oxidation altered structures of the proteins and resulted in the formation of cross-linked protein *** emulsion and foaming properties of the proteins were improved after *** IgE-binding capacity of 7 S and11 S reduced after ***812 cell assays showed that both histamine and IL-4 release decreased after oxidation treatment.A mouse model showed that oxidation reduced the IgE,IgG,and IgG1 levels,as well as reduced histamine and mMCP-1 release in serum,which might suppress the allergic *** conclusion,the lipid peroxidation treatment likely causes changes to the functional properties of soybean,decreasing the potential allergenicity of 7 S and 11 S.

关键词： β-Conglycinin Glycinin Lipid peroxidation Allergenicity Functional properties

Observing single cells in whole organs with optical imaging

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Journal of Innovative Optical Health Sciences 2023年第1期16卷 115-140页

作者： xiaoquan yang Tao Jiang Lirui Liu Xiaojun Zhao Ximiao Yu Minjun yang Guangcai Liu Qingming Luo Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics MoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology Wuhan 430074 P.R.China HUST-Suzhou Institute for Brainsmatics JITRI Suzhou 215123P.R.China School of Biomedical Engineering Hainan University Haikou 570228 P.R.China

Cells are the basic unit of human organs that are not fully *** revolutionary advancements of optical imaging alowed us to observe single cells in whole organs,revealing the complicated composition of cells with spatial ***,in this review,we revisit the principles of optical contrast related to those biomolecules and the optical techniques that transform optical contrast into detectable optical ***,we describe optical imaging to achieve threedimensional spatial discrimination for biological *** to the milky appearance of tissues,the spatial information burred deep in the whole ***,strategies developed in the last decade could circumvent this issue and lead us into a new era of investigation of the cells with their original spatial information.

关键词： Single cell observation whole organ optical imaging

一种强耦合Spalart-Allmaras湍流模型的RANS方程的高效数值计算方法

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航空学报 2013年第9期34卷 2007-2018页

作者：杨小权杨爱明孙刚上海飞机设计研究院上海201210 复旦大学力学与工程科学系上海200433

在工程实际中,一方程湍流模型或两方程湍流模型的求解通常和雷诺平均Navier-Stockes(RANS)方程的求解是解耦的,也称之为松耦合求解。在松耦合求解过程中,RANS方程和湍流模型方程通常采用不同的数值方法异步求解。这种求解方式很容易产... 详细信息

在工程实际中,一方程湍流模型或两方程湍流模型的求解通常和雷诺平均Navier-Stockes(RANS)方程的求解是解耦的,也称之为松耦合求解。在松耦合求解过程中,RANS方程和湍流模型方程通常采用不同的数值方法异步求解。这种求解方式很容易产生因两者计算精度不一致而引起的额外数值耗散。为了消除这种耗散,将RANS方程与Spalart-Allmaras模型方程耦合成一个系统方程——强耦合RANS方程,并发展了一种用于求解该系统方程的高效强耦合算法,其中对流项离散采用了Roe格式,时间项的离散采用了隐式LU-SGS(Lower-Upper Symmetric Gauss-Seidel)格式,为了提高计算效率,采用了三层V循环多重网格方法。通过翼型/机翼和振荡翼型/机翼等算例验证了本文发展的强耦合算法不仅具有较好的收敛性,而且计算精度明显优于松耦合算法,特别对于阻力的预测,强耦合算法更加准确。

关键词： Spalart—Allmaras湍流模型 RANS方程强耦合算法多重网格方法双时间方法

High-resolution photoacoustic microscope for rat brain imaging in vivo

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Chinese Optics Letters 2010年第6期8卷 609-611页

作者：杨孝全蔡鑫 Konstantin Maslov 汪立宏骆清铭 Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology Optical Imaging Laboratory Department of Biomedical EngineeringWashington University in Saint LouisSaint Louis63130-4899USA

A reflection-mode photoacoustic microscope（PAM） for rat brain imaging in vivo is constructed.A pulsed laser is used as an excitation source,and a focused ultrasound transducer is adopted to collect the photoacoustic *** scanning is applied to acquire three-dimensional（3D） *** obtained measurements of the lateral and axial resolutions of the microscope are 45 and 15μm,*** imaging depth in the chicken breast tissue is 3.1 mm at a signal-to-noise ratio（SNR） of 20 dB without any signal *** imaging speed is 30 A-line/*** results in vivo demonstrate the capability of 3D imaging of the brain vessels of the rat after removing the skull.

关键词： Acoustic microscopes Laser excitation Photoacoustic effect Photoacoustic microscopy Pulsed laser applications Pulsed lasers Signal to noise ratio Ultrasonic transducers