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Characteristics of brainstem auditory evoked potential of neonates with mild or moderate hyperbilirubinemia

Neural Regeneration Research 2007年第11期2卷 660-664页

作者： xiaoqing guo Xiuhong Pu Tao An Qian Li Meng Qiu Qiong Wu Yanlan Tan Department of Pediatrics the 309 Clinical Division General Hospital of Chinese PLA Beijing 100091 China

BACKGROUND： Brainstem auditory evoked potential （BAEP） has been widely used to evaluate the functional integrity and development of injured auditory system and brain, especially to objectively evaluate the function of auditory system and brain stem of very young babies, such as neonates and sick babies. OBJECTIVE： To observe the changes of BAEP of neonates with hyperbilirubinemia, and to investigate the relationship of bilirubin concentration and BAEP. DESIGN： An observation experiment. SETTING： Department of Pediatrics, the 309 Clinical Division, General Hospital of Chinese PLA. PARTICIPANTS： Fifty-eight neonates with mild or moderate hyperbilirubinemia exhibiting jaundice within 24 hours after born, who received the treatment in the Department of Pediatrics, the 309 Clinical Division, General Hospital of Chinese PLA between January 2004 and May 2007, were recruited in this study. The involved neonates, 31 boys and 27 girls, had gestational age of 37 to 46 weeks. They had no history of birth asphyxia, and were scored 8 to 10 points when born. Written informed consents of examination and treatment were obtained from the guardians of the neonates. This study was approved by the Hospital Ethics Committee. According to serum total bilirubin value, the neonates were assigned into 3 groups： low-concentration bilirubin group （n =16）, moderate-concentration bilirubin group （n =27） and high-concentration bilirubin group （n =15）. According to mean daily bilirubin increase, the subjects were sub-assigned into bilirubin rapid increase group （n =39） and bilirubin slow increase group （n = 19）. METHODS： After admission, all the neonates received drug treatment. Meanwhile, their 116 ears were examined with a myoelectricity evoked potential equipment （KEYPOINT） in latency, wave duration, amplitude and wave shape differentiation of each wave of BAEP. BAEP abnormal type was observed and abnormal rate of BAEP was calculated. MAIN OUTCOME MEASURES： ①Abnormal rate and abnorm

关键词： hyperbilirubinemia brainstem auditory evoked potential neonates

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Selenium deficiency induces spleen pathological changes in pigs by decreasing selenoprotein expression,evoking oxidative stress,and activating inflammation and apoptosis

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Journal of Animal Science and Biotechnology 2021年第4期12卷 1517-1529页

作者： Shuang Li Wenjuan Sun Kai Zhang Jiawei Zhu Xueting Jia xiaoqing guo Qingyu Zhao Chaohua Tang Jingdong Yin Junmin Zhang State Key Laboratory of Animal Nutrition Institute of Animal Sciences of Chinese Academy of Agricultural SciencesBeijing 100193China State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Scientific Observing and Experiment Station of Animal Genetic Resources and Nutrition in North China of Ministry of Agriculture and Rural Affairs Institute of Animal Sciences of Chinese Academy of Agricultural SciencesBeijing 100193China

Background:The immune system is one aspect of health that is affected by dietary selenium(Se)levels and selenoprotein *** is an important immune organ of the body,which is directly involved in cellular ***,there are limited reports on Se levels and spleen ***,this study established a Se-deficient pig model to investigate the mechanism of Se deficiency-induced splenic ***:Twenty-four pure line castrated male Yorkshire pigs(45 days old,12.50±1.32 kg,12 full-sibling pairs)were divided into two equal groups and fed Se-deficient diet(0.007 mg Se/kg)or Se-adequate diet(0.3 mg Se/kg)for 16 *** the end of the trial,blood and spleen were collected to assay for erythroid parameters,the osmotic fragility of erythrocytes,the spleen index,histology,terminal deoxynucleotidyl transferase nick-end labeling(TUNEL)staining,Se concentrations,the selenogenome,redox status,and signaling related inflammation and ***:Dietary Se deficiency decreased the erythroid parameters and increased the number of osmotically fragile erythrocytes(P<0.05).The spleen index did not change,but hematoxylin and eosin and TUNEL staining indicated that the white pulp decreased,the red pulp increased,and splenocyte apoptosis occurred in the Se deficient *** deficiency decreased the Se concentration and selenoprotein expression in the spleen(P<0.05),blocked the glutathione and thioredoxin antioxidant systems,and led to redox *** deficiency activated the NF-κB and HIF-1αtranscription factors,thus increasing pro-inflammatory cytokines(IL-1β,IL-6,IL-8,IL-17,and TNF-α),decreasing anti-inflammatory cytokines(IL-10,IL-13,and TGF-β)and increasing expression of the downstream genes COX-2 and iNOS(P<0.05),which in turn induced *** addition,Se-deficiency induced apoptosis through the mitochondrial pathway,upregulated apoptotic genes(Caspase3,Caspase8,and Bak),and downregulated antiapoptotic genes(Bcl-2)(P<0.05)at the mRNA

关键词： Apoptosis Inflammation Oxidative stress Pigs Selenium deficiency Spleen

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Targeting Hypoxic Tumors with Hybrid Nanobullets for Oxygen-Independent Synergistic Photothermal and Thermodynamic Therapy

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Nano-Micro Letters 2021年第6期13卷 311-331页

作者： Di Gao Ting Chen Shuojia Chen Xuechun Ren Yulong Han Yiwei Li Ying Wang xiaoqing guo Hao Wang Xing Chen Ming guo Yu Shrike Zhang guosong Hong Xingcai Zhang Zhongmin Tian Zhe Yang The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049People’s Republic of China Paulson School of Engineering and Applied Sciences John AHarvard UniversityCambridgeMA 02138USA School of Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA School of Public Health Guangxi Medical UniversityNanning 530000People’s Republic of China Division of Engineering in Medicine Department of MedicineBrigham and Womens HospitalHarvard Medical SchoolCambridgeMA 02139USA Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA

Hypoxia is a feature of solid tumors and it hinders the therapeutic efficacy of oxygen-dependent cancer ***,we have developed all-organic oxygen-independent hybrid nanobullets ZPA@HA-ACVA-AZ for the“precise strike”of hypoxic tumors through the dual-targeting effects from surface-modified hyaluronic acid(HA)and hypoxia-dependent factor carbonic anhydrase IX(CA IX)-inhibitor acetazolamide(AZ).The core of nanobullets is the special zinc(II)phthalocyanine aggregates(ZPA)which could heat the tumor tissues upon 808-nm laser irradiation for photothermal therapy(PTT),along with the alkyl chain-functionalized thermally decomposable radical initiator ACVA-HDA on the side chain of HA for providing oxygen-independent alkyl radicals for ablating hypoxic cancer cells by thermodynamic therapy(TDT).The results provide important evidence that the combination of reverse hypoxia hallmarks CA IX as targets for inhibition by AZ and synergistic PTT/TDT possess incomparable therapeutic advantages over traditional(reactive oxygen species(ROS)-mediated)cancer treatment for suppressing the growth of both hypoxic tumors and their metastasis.

关键词： Photothermal therapy(PTT) Thermodynamic therapy(TDT) Targeting hybrid nanobullet Hypoxia tumor Zinc phthalocyanine aggregate(ZPA)

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Immunogenic-cell-killing and immunosuppression-inhibiting nanomedicine

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Bioactive Materials 2021年第6期6卷 1513-1527页

作者： Ying Wang Di Gao Yan Liu xiaoqing guo Shuojia Chen Li Zeng Jinxuan Ma Xingcai Zhang Zhongmin Tian Zhe Yang The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’an710049China John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA02138United States School of Engineering Massachusetts Institute of TechnologyCambridgeMA02139United States

Combining chemo-therapeutics with immune checkpoint inhibitors facilitates killing cancer cells and activating the immune system through inhibiting immune ***,their treatment effects remain limited due to the compromised accumulation of both drugs and inhibitors in certain tumor ***,a new poly(acrylamide-co-acrylonitrile-co-vinylimidazole-co-bis(2-methacryloyl)oxyethyl disulfide)(PAAVB)polymer-based intelligent platform with controllable upper critical solution temperature(UCST)was used for the simultaneous delivery of paclitaxel(PTX)and curcumin(CUR).Additionally,a hyaluronic acid(HA)layer was coated on the surface of PAAVB NPs to target the CD44-overexpressed tumor *** proposed nanomedicine demonstrated a gratifying accumulation in tumor tissue and uptake by cancer ***,the acidic microenvironment and high level of glutathione(GSH)in cancer cells could spontaneously decrease the UCST of polymer,leading to the disassembly of the NPs and rapid drug release at body temperature without ***,the released PTX and CUR could induce the immunogenic cell death(ICD)to promote adaptive anti-tumor immunogenicity and inhibit immunosuppression through suppressing the activity of indoleamine 2,3-dioxygenase 1(IDO1)enzyme ***,the synergism of this intelligent nanomedicine can suppress primary breast tumor growth and inhibit their lung metastasis.

关键词： Controllable upper critical solution temperature(UCST) Immunogenic cell death(ICD) Indoleamine 2,3-dioxygenase 1(IDO1) Drug delivery Cancer chemoimmunotherapy

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An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing

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Bioactive Materials 2022年第10期7卷 162-172页

作者： Lin Jin xiaoqing guo Di Gao Yan Liu Jiahua Ni Zhiming Zhang Yiqiao Huang Guibin Xu Zhe Yang Xingcai Zhang Xianhan Jiang Department of Urology The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510700PR China International Joint Research Laboratory for Biomedical Nanomaterials of Henan Zhoukou Normal UniversityZhoukou466001PR China The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’an710049PR China School of Engineering and Applied Sciences Harvard UniversityCambridgeMA02138USA School of Engineering Massachusetts Institute of TechnologyCambridgeMA02139USA Research Institute of Xi’an Jiaotong University HangzhouZhejiang311200PR China

Moderately regulating vascularization and immune microenvironment of wound site is necessary to achieve scarless wound healing of the ***,we have prepared an angiogenesis-promoting and scar-preventing band-aid with a core-shell structure,that consists of MXene-loaded nanofibers(MNFs)as the core and dopamine-hyaluronic acid hydrogel(H)as the shell(MNFs@V-H@DA)to encapsulate a growth factor(vascular endothelial growth factor,VEGF,abbreviated as V)and H2S donor(diallyl trisulfide,DATS,abbreviated as DA).The continuous release of DA from this system produced H2S,which would successfully induce macrophages to polarize into M2-lile phenotype,regulating the immune microenvironment and inhibiting an excessive inflammatory response at the wound *** is conducive to the proliferation of skin cells,facilitating the wound *** addition,an appropriate amount of VEGF can be released from the MXene nanofibrous skeleton by adjusting the time of near-infrared(NIR)light exposure,preventing excessive neovascularization and extracellular matrix deposition at the wound ***,this NIR photothermal-responsive band-aid achieved scarless wound healing through gradient-controlled vascularization and a related immune sequential reaction of damaged skin tissue.

关键词： Angiogenesis promotion NIR response Hydrogel Nanofibers Scarless wound healing

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基于改进Multi-Scale AlexNet的番茄叶部病害图像识别

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农业工程学报 2019年第13期35卷 162-169页

作者：郭小清范涛杰舒欣南京农业大学信息科技学院

番茄同种病害在不同发病阶段表征差异明显,不同病害又表现出一定的相似性,传统模式识别方法不能体现病害病理表征的动态变化,实用性较差。针对该问题,基于卷积神经网络提出一种适用于移动平台的多尺度识别模型,并基于此模型开发了面向... 详细信息

番茄同种病害在不同发病阶段表征差异明显,不同病害又表现出一定的相似性,传统模式识别方法不能体现病害病理表征的动态变化,实用性较差。针对该问题,基于卷积神经网络提出一种适用于移动平台的多尺度识别模型,并基于此模型开发了面向农业生产人员的番茄叶部病害图像识别系统。该文详细描述了AlexNet的结构,分析其不足,结合番茄病害叶片图像特点,去除局部响应归一化层、修改全连接层、设置不同尺度卷积核提取特征,设计了基于AlexNet的多感受野识别模型,并基于Android实现了使用此模型的番茄叶部病害图像识别系统。Multi-ScaleAlexNet模型运行所耗内存为29.9MB,比原始AlexNet的内存需求652MB降低了95.4%,该模型对番茄叶部病害及每种病害早中晚期的平均识别准确率达到92.7%,基于此模型的Andriod端识别系统在田间的识别率达到89.2%,能够满足生产实践中移动平台下的病害图像识别需求。研究结果可为基于卷积神经网络的作物病害图像识别提供参考,为作物病害的自动化识别和工程化应用参考。

关键词：图像处理病害图像识别算法卷积神经网络番茄病害多尺度

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防止装配式板桥铰接联结裂纹的研究

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公路 2000年第11期45卷 34-35页

作者：过晓青陕西省公路局西安市710068

针对装配式板梁桥 ,企口混凝土铰处经行车运营后易开裂的弊病 ,对原企口的联结形式进行了改进。完善后的企口联结提高了抗剪强度 ,经 5年多座桥梁的使用验证 ,证明该企口强度高、不开裂、整体性好。改进后的企口构造合理、工艺简单。

关键词：装配式板桥企口铰接联结裂纹防止措施

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近十年国外图像检索研究论文定量分析

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图书馆 2008年第4期 56-57,62页

作者：郭小青邵阳学院湖南邵阳422000

本文以外文数据库Academic Research Library,ProQuest Education Journals,EB-SCOhost等几大数据库为统计工具,采用文献计量学方法对1997年至2007年西方国家中发表的关于网络图像检索的134篇研究论文进行了论文年度、主题、作者、核心... 详细信息

本文以外文数据库Academic Research Library,ProQuest Education Journals,EB-SCOhost等几大数据库为统计工具,采用文献计量学方法对1997年至2007年西方国家中发表的关于网络图像检索的134篇研究论文进行了论文年度、主题、作者、核心期刊分布统计分析,探讨了图像检索在西方各国的发展情况,并针对现状提出现在的问题及相应的解决措施。

关键词：图像检索定量分析

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基于凹点搜索的重叠果实定位检测算法研究

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农业机械学报 2011年第12期42卷 191-196页

作者：谢忠红姬长英郭小清朱淑鑫南京农业大学工学院南京210031 南京农业大学信息科学技术学院南京210095

为了能够快速准确地计算出生长状态为靠拢或重叠的成熟类圆果实的形心坐标和半径,提出了一种基于凹点搜索的快速定位和检测重叠果实目标的方法。利用色调分量的统计规律实现背景分离,采用链码跟踪法获得单像素果实轮廓,并按步长获取边... 详细信息

为了能够快速准确地计算出生长状态为靠拢或重叠的成熟类圆果实的形心坐标和半径,提出了一种基于凹点搜索的快速定位和检测重叠果实目标的方法。利用色调分量的统计规律实现背景分离,采用链码跟踪法获得单像素果实轮廓,并按步长获取边缘特征点;然后利用N点方向编码差获取边缘凹点,确定凹点群,根据阈值确定分割凹点;最后利用改进的Hough变换计算出多个重叠桃子的形心坐标和半径。研究结果表明,本文算法速度快,果实正确识别率最高可达90.0%,形心和半径误差均小于7%。

关键词：重叠果实 N点方向编码差边缘特征点凹点 Hough变换

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某偏置驾驶室自卸车车门下沉问题分析及改进

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汽车技术 2013年第7期 10-13页

作者：郭晓青中国第一汽车股份有限公司技术中心

针对某款偏置驾驶室宽体自卸车在矿区用户使用过程中出现的车门铰链变形、车门下沉等现象,结合车辆实际使用工况,通过CAE分析和台架试验等手段,对车门铰链刚度、车门焊接总成刚度进行了评价分析。结合分析结果对铰链和车门进行了结构改... 详细信息

针对某款偏置驾驶室宽体自卸车在矿区用户使用过程中出现的车门铰链变形、车门下沉等现象,结合车辆实际使用工况,通过CAE分析和台架试验等手段,对车门铰链刚度、车门焊接总成刚度进行了评价分析。结合分析结果对铰链和车门进行了结构改进,使得改进后的车门垂直刚度满足新加载工况的要求。

关键词：车门下沉垂直刚度 CAE分析台架试验

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