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学术界 2015年第4期 318-322页

作者： Chen Weifeng qian xiaoping Business College Xi'an University

For Xi'an,the central city of the Silk Road Economic Belt,it is both the theoretical and practical problem to develop into an international metropolis,so how to develop into an international metropolis becomes the research focus. This paper firstly introduces the necessity,the current situation and the evaluation index system of the construction of the city Xi'an in the context of the Silk Road Economic Belt; then it analyzes the econom ic developm ent of the three old districts,the three new districts,the three suburban districts and the four counties; and finally it puts forward the development path for Xi'an in the context of the Silk Road Economic Belt — the development pattern of "five districts,one international harbor area and two bases""nine-grid-pattern "economic development and the function-oriented coordinated development of the regional economy.

关键词：国际化大都市丝绸之路经济带西安语境评价指标体系中心城市经济发展

Functional maturation of two murine medullary-type CD8SP thymocytes

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Chinese Science Bulletin 2001年第9期46卷 746-751页

作者： Tian Tian qian xiaoping Gao Ling Chen Weifeng Department of Immunology Bejing Medical UniversityBejing 100083China

TCRαβTCD4-CD8+ thymocytes are heterogeneity. They may undergo phenotypic and functional maturation within thymic medulla. Medullary-type CD8SP thymocytes were divided into seven subsets based on phenotypic analysis, and their precursor-progeny relationship along with the differential pathway was also delineated. To further testify the validity of the maturation pathway, we purified 6C10-CD69+ cells representing the early stage and 6C10-Qa-2+ cells representing the later stage among medullary-type CD8SP thymocytes and compared their functional maturation levels. CD8+ T cells of spleen were used as the control. It is shown that there is no obvious difference of proliferation ability among these three subsets; however, intracytoplasmic cytokine assay shows that there is a hierarchy of IFN-γ and TNFα secretion among these subsets, strikingly comparable to their phenotypic status among medullary type CD8SP thymocytes. The bioassays of IL-2 and IFN-γ in culture supernatant give the similar results.

关键词： CD4^(-)CD8^(+)thymocyte phenotype function

Analysis on the types of chemokines expressed by the murine thymic epithelial cell line MTEC1

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Chinese Science Bulletin 2000年第12期45卷 1098-1101页

作者： Laiping Xie xiaoping qian Sunyou Gong Weifeng Chen Beijing Med Univ Dept Immunol Beijing 100083 Peoples R China

Six kinds of chemokines including SDF-1α, IP-10, KG, RANTES, MCP-1 and Lymphotactin have been amplified using the primers designed by ourselves with RT-PCR from the total RNA of a medullary-type murine thymic epithelial cell line MTEC1 cells. The amplified cDNA fragments of the chemokines have been identified by nucleotide sequencing and Northern blot analysis. The results demonstrate that there are two different splicing forms of SDF-1 mRNA existing in MTEC1. The concentrated culture supernatant of MTEC1 shows an intermediate level of chemotaxis to CD4-CD8- thymocytes, which conforms to the biological function of SDF-1.

关键词： thymic epithelial cells chemokines analysis.

Analysis of the chemotactic activities of mouse chemokine MIP-2 to thymocyte subgroups

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Chinese Science Bulletin 2001年第20期46卷 1694-1698页

作者： Gong Shunyou Gao Ling qian xiaoping Tian Tian Chen Weifeng Peking Univ Hlth Sci Ctr Dept Immunol Beijing 100083 Peoples R China

A mouse chemokine MIP-2(macrophage in-flamatory protein 2) is constitutively expressed not only by peritoneal macrophages, but also by fresh thymic stromal cells, based on RT-PCR detection. Moreover, the specific receptor of MIP-2 is expressed at different levels among four main subgroups of murine thymocytes including DN, DP, CD4SP and CD8SP. By the chemotaxis assays with Boyden chamber, we proved that the recombinant mouse MIP-2 can chemoattract the four main subgroups of thymocytes in different degrees, it mainly chemoattract the DP and SP subgroups. We firstly reported that MIP-2 is involved in the regulation of the directional migration of developing thymocytes.

关键词： macrophage inflamatory protein 2 thymocytes chenio-tactic activity.

Functional analysis of three genetic disorder related PITX2 mutants

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Chinese Science Bulletin 2006年第2期51卷 164-169页

作者： WANG Guo LIU xiaoping PAN qian LIANG Desheng WU qianling DAI Heping ZHU Feizhou XIA Kun XIA Jiahui National Laboratory of Medical Genetics Central South University Changsha 410078 China

The autosome dominant disorders, ring dermoid of the cornea (RDC), iris hypolasia (IH) and Axenfeld-Rieger syndrome (ARS), are allelic disor- ders, as all three can result from mutations of the transcriptional factor PITX2. Among three disorder phenotypes, ARS is the most severe, IH is milder than ARS, and RDC is the mildest. Missense muta- tions of the PITX2 homeodomain identified in RDC (R62H), IH (R84W) and ARS patients (T68P) were introduced into PITX2 cDNA by site-directed mutagenesis. PITX2 mutant proteins expressed in eucaryotic cells were stable and localized to the nu- cleus. Analysis of these mutant PITX2 proteins by DNA-binding shift and transactivation studies dem- onstrated that the R62H had the most activity in both studies, and the R84W still retained somewhat func- tions, whereas the T68P proved to be non-functional. These results are consistent with previous hypothesis that varying amount of residual PITX2 mutant activity could underline the severity of these phenotypes.

关键词：常染色体显性等位基因遗传性障碍 PITX2突变体功能分析

基于随机规划的风光互补系统特性分析与准入功率极限计算

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太阳能学报 2018年第3期39卷 619-626页

作者：杨晓萍张倩西安理工大学水利水电学院

分析风、光及风光互补发电系统出力特性，针对风速、光照强度及负荷的随机性和互补性，提出一种基于随机规划的风光互补系统准入功率极限分析方法；建立含多个随机变量、多约束、非线性的机会约束随机规划模型，采用基于随机模拟技术的... 详细信息

分析风、光及风光互补发电系统出力特性，针对风速、光照强度及负荷的随机性和互补性，提出一种基于随机规划的风光互补系统准入功率极限分析方法；建立含多个随机变量、多约束、非线性的机会约束随机规划模型，采用基于随机模拟技术的改进粒子群优化算法求解，并于IEEE-30验证系统约束条件置信水平及不同季节条件等对风光互补系统准入功率极限的影响。结果表明该模型能全面考虑风光机组实时运行波动与互补特性，求解算法简单，操作方便，计算速度快，误差小。

关键词：风光互补系统准入功率极限随机规划随机模拟技术改进粒子群优化算法

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环境法益与环境犯罪司法解释之应然立场

社会科学 2014年第8期 96-105页

作者：钱小平华东政法大学东南大学

污染环境罪中"严重污染环境"之立法修正,使"环境"本身成为了犯罪的对象,标志着环境法益成为了中国环境刑法立法的基石。然而,2013年司法解释未能把握立法修正的核心变化,仍然混淆了环境法益与其他法益之关系,将解释立场定位于保护个人... 详细信息

污染环境罪中"严重污染环境"之立法修正,使"环境"本身成为了犯罪的对象,标志着环境法益成为了中国环境刑法立法的基石。然而,2013年司法解释未能把握立法修正的核心变化,仍然混淆了环境法益与其他法益之关系,将解释立场定位于保护个人法益及社会管理秩序,缺乏对环境法益的独立诉求,造成解释内容在合目的性、合理性及合法性上产生诸多问题。据此,有必要在保护环境法益的基本理念指导下,针对污染行为的宽严尺度、主观罪过类型、既遂判断标准及刑罚处罚幅度等问题进行重新解释。

关键词：污染环境罪环境法益问题与完善

监察追诉时效问题的再思考——兼与刘练军教授商榷

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法学论坛 2019年第5期34卷 153-160页

作者：钱小平东南大学法学院

追诉时效具有经过法定期间后公权力不得再对违法犯罪行为进行评价而导致行为人责任消灭的法律效果。监察委员会通过统一的调查程序对职务违法和职务犯罪进行追诉,产生"政务处分"和"移送检察院起诉"两种法律后果。"移送检察院起诉"属于... 详细信息

追诉时效具有经过法定期间后公权力不得再对违法犯罪行为进行评价而导致行为人责任消灭的法律效果。监察委员会通过统一的调查程序对职务违法和职务犯罪进行追诉,产生"政务处分"和"移送检察院起诉"两种法律后果。"移送检察院起诉"属于职务犯罪层面的程序性法律后果,直接适用刑法的追诉时效;"政务处分"属于职务违法层面的实体性法律后果,应当设置时效制度,对监察权予以必要限制,以体现法治反腐之实质价值。在即将制定的《政务处分法》中应当规定政务处分时效制度,具体时效宜设置为五年,违法行为在五年内未被发现或不及时处分的,不再给予政务处分。

关键词：监察委员会追诉时效政务处分时效

积极预防型社会治理模式下危险作业罪的认定与检视

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法律科学（西北政法大学学报） 2021年第6期39卷 113-123页

作者：钱小平东南大学法学院江苏南京211129

积极预防型社会治理模式将社会治理理念融入刑法观,促进了刑法观的更新与发展。以积极预防刑法立法观为导向而创设的危险作业罪,反映了当代中国社会治理与安全生产风险预防的客观需要。在该罪认定上,应贯彻实质理性的刑法解释观,对现实... 详细信息

积极预防型社会治理模式将社会治理理念融入刑法观,促进了刑法观的更新与发展。以积极预防刑法立法观为导向而创设的危险作业罪,反映了当代中国社会治理与安全生产风险预防的客观需要。在该罪认定上,应贯彻实质理性的刑法解释观,对现实危险、危险行为进行必要的限缩解释,将该罪罪过认定为故意具有实质的合理性;以协同治理的刑事一体观为导向,确立危险作业罪的附条件不起诉制度和行政合规制度,完善检察机关对行政执法机关的过程监督,实现对危险作业犯罪的妥当处罚,可以合理、有效地发挥刑法参与社会治理的积极功能。

关键词：积极预防社会治理危险作业罪司法认定

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监察管辖制度的适用问题及完善对策

南京师大学报（社会科学版） 2020年第1期 131-141页

作者：钱小平东南大学法学院

监察管辖具有与监察体制改革相适应的生成逻辑。在实践中,监察管辖出现了管辖范围泛化、管辖能力不足、管辖衔接错位等问题,反映了在监察体制改革过程中形成的监察优先主义存在的法治隐忧。为防止监察优先主义向监察中心主义的转化,应... 详细信息

监察管辖具有与监察体制改革相适应的生成逻辑。在实践中,监察管辖出现了管辖范围泛化、管辖能力不足、管辖衔接错位等问题,反映了在监察体制改革过程中形成的监察优先主义存在的法治隐忧。为防止监察优先主义向监察中心主义的转化,应当确立依法监察、程序协同、程序谦抑、职责区分、权利保障等原则,修正监察优先主义,并以此为导向,合理收缩监察机关的管辖罪名,建立职务违法犯罪的区分管辖模式,确立管辖权转移的具体规则,明确分案管辖的例外规则,严格并案管辖的适用条件,推动监察管辖制度的体系化完善。

关键词：监察管辖适用问题完善对策