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全科医学和初级保健横断面研究的基本设计和实施步骤

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中国全科医学 2024年第13期27卷 1584-1593页

作者：李雪迎康晓平迟春花王熙诚尚美霞周国鹏高畅潘子涵北京大学第一医院医学统计室北京市100034 北京大学公共卫生学院流行病学与卫生统计学系北京市100191 北京大学第一医院全科医学科北京市100034 University College London school of managementGower StreetLondon WC1E 6BT

横断面研究是经典的研究设计方法之一,在临床各个专业中均有广泛的应用。在全科医学研究中大量科学问题的解答采用了横断面研究设计。这其中不仅包括了对人群健康特征,疾病特征或卫生服务现状的调查研究,还包括了面向社区人群的疾病筛... 详细信息

横断面研究是经典的研究设计方法之一,在临床各个专业中均有广泛的应用。在全科医学研究中大量科学问题的解答采用了横断面研究设计。这其中不仅包括了对人群健康特征,疾病特征或卫生服务现状的调查研究,还包括了面向社区人群的疾病筛查诊断方法构建等多种研究场景。在全科医学领域中,横断面研究可以做现况描述和比较分析,关联因素分析以及社区筛查诊断方法探索。开展横断面研究应包括研究设计和研究实施两个阶段,研究设计包括准确提炼研究目标,明确研究人群,研究因素及结局指标等临床要素以及确定样本获取方式,明确样本量的确定依据及合理的统计分析策略等方法学要素。研究实施,则需要通过完备的研究方案和病例报告表呈现研究设计思路,在伦理批准的前提下开展数据收集工作,同时注重数据管理工作质量并严格执行方案中的统计分析方法,求证医学问题。横断面研究的特点是相比于随访观察研究所需要的研究周期相对较短,不同基础的研究团队都能找到适合的研究方向,通过了解健康医疗现状,从探讨关联因素创建筛查方法等角度,服务社区医疗。

关键词：全科医学初级卫生保健横断面研究调查研究关联性分析诊断能力评价研究设计

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Development of rapid nucleic acid assays based on the recombinant polymerase amplification for monkeypox virus

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Virologica Sinica 2023年第1期38卷 165-170页

作者： Yuchang Li Yanhong Gao Ying Tang Jing Li Sen Zhang Tao Jiang xiaoping kang State Key Laboratory of Pathogen and Biosecurity The Academy of Military Medical ScienceInstitute of Microbiology and EpidemiologyBeijing100071China Laboratory Department of the First Medical Center Chinese PLA General HospitalBeijing100850China

Dear Editor,Monkeypox virus(MPXV),an enveloped double-stranded DNA virus with 190 open-reading frames and a genome length of about 200 kb,belongs to the genus Orthomyxovirus(OPXV;subfamily Chordopoxvirinae,family Poxviridae),which causes a disease with symptoms similar to,but less severe than,*** is subdivided into two clades:clade I for the former Congo Basin clade and clade II for the former West African,and the clade I is more *** clade II consists two subclades,clade IIa and clade IIb,with the latter referring primarily to the group of variants largely circulating in the 2022 global outbreak(ICTV,2022;Bunge et al.,2022;Mauldin et al.,2022).

关键词： subdivided latter primarily

“双碳”背景下基于农业视角浅议都江堰灌区低碳发展模式

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四川水利 2024年第2期45卷 1-4页

作者：贾军容王君勤康小平周伍光四川省都江堰水利发展中心成都610081 四川省水利科学研究院成都610072

应对气候变化是人类目前共同面对的严峻挑战。中国作为碳排放大国,明确提出“2030碳达峰,2060碳中和”的“双碳”目标,为缓解气候变化的影响积极贡献中国力量。实现碳达峰,农业的减排固碳既是重要手段,又有巨大潜力。文章针对都江堰灌... 详细信息

应对气候变化是人类目前共同面对的严峻挑战。中国作为碳排放大国,明确提出“2030碳达峰,2060碳中和”的“双碳”目标,为缓解气候变化的影响积极贡献中国力量。实现碳达峰,农业的减排固碳既是重要手段,又有巨大潜力。文章针对都江堰灌区在“双碳”背景下的低碳发展模式进行了探讨,从灌区管理现状入手,基于农业视角分析都江堰灌区低碳化管理中存在的主要问题,提出了都江堰灌区实现低碳的改进措施。研究结果可为其他灌区的低碳发展提供借鉴和参考。

关键词：碳达峰碳中和低碳农业低碳灌区都江堰灌区

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OBE理念下的汽车理论课程思政建设与探索

汽车实用技术 2024年第3期49卷 125-128页

作者：杨淇康小平郜敏武志伟巩少鹏山西能源学院机电工程系山西晋中030604

新工科背景下,成果导向教育(OBE)理念和课程思政交叉融合于专业课程教学,对专业课教师提出了新的要求与挑战。文章以山西能源学院车辆工程专业基础课汽车理论为研究对象,基于OBE理念进行课程思政元素的挖掘与教学改革。以学生为中心,产... 详细信息

新工科背景下,成果导向教育(OBE)理念和课程思政交叉融合于专业课程教学,对专业课教师提出了新的要求与挑战。文章以山西能源学院车辆工程专业基础课汽车理论为研究对象,基于OBE理念进行课程思政元素的挖掘与教学改革。以学生为中心,产出为导向,进行反向教学设计。从课程目标、教学内容、教学方式、教学评价四个方面进行教学改革与思政建设,使课程思政与OBE理念协同作用于汽车理论教学全过程,全面提升以产出导向为原则的汽车理论教学质量。

关键词：汽车理论 OBE理念课程思政教学改革

代谢综合征组分异常人群PM_(2.5)长期暴露与慢性肾脏疾病的关联

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卫生研究 2024年第3期53卷 427-434页

作者：赵泽濛刘露露田雪罗丽丽罗会康晓平王肖南刘相佟郭秀花罗艳侠首都医科大学公共卫生学院首都医科大学临床流行病学北京市重点实验室北京100069 首都医科大学附属北京中医医院疾控处北京100010 北京小汤山医院北京102211

目的探究细颗粒物(fine particulate matter,PM_(2.5))长期暴露与代谢综合征(metabolism syndrome,MS)组分异常人群慢性肾脏疾病(chronic kidney disease,CKD)患病风险的关联。方法基于北京市某医院健康体检数据,采用回顾性队列研究方... 详细信息

目的探究细颗粒物(fine particulate matter,PM_(2.5))长期暴露与代谢综合征(metabolism syndrome,MS)组分异常人群慢性肾脏疾病(chronic kidney disease,CKD)患病风险的关联。方法基于北京市某医院健康体检数据,采用回顾性队列研究方法收集2013—2019年体检数据。问卷调查获取人口学特征和生活习惯信息,测量血压、身高、体重和腰围,检测甘油三酯(triglyceride,TG)、空腹血糖和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)等。同时根据研究对象的地址提取经纬度进行污染物暴露数据的估计。利用Logistic回归模型分析PM_(2.5)长期暴露对MS组分异常人群CKD患病风险的估计效应。建立双污染物和多污染物模型,检验上述结果稳定性。基于年龄、是否患有MS、MS单组分异常情况及MS双组分异常情况进行相应的亚组分析。结果研究共纳入1540名基线期MS组分异常人员,研究期间患CKD者206人,PM_(2.5)两年年均浓度[中位数(四分位间距)]为57.57(17.61)μg/m^(3)。PM_(2.5)长期暴露与MS组分异常人群CKD患病风险增加的关联有统计学意义,PM_(2.5)暴露每增加10μg/m^(3),CKD的患病风险增加2.26倍(OR=3.26,95%CI 2.72~3.90)。双污染物和多污染物模型结果提示,在控制同期其它空气污染物的混杂后,PM_(2.5)长期暴露与MS组分异常人群CKD患病风险增加的关联仍然稳定。亚组分析结果发现,年龄≥45岁,未患MS、TG<1.7 mmol/L、HDL-C≥1.04 mmol/L、未患高血压、患有中心性肥胖和高血糖的人群中PM_(2.5)与CKD相关健康影响更强。结论长期暴露于PM_(2.5)后,MS组分异常人群CKD患病风险增加。年龄≥45岁的中老年人,以及患有中心性肥胖和高血糖者应成为重点关注人群。

关键词：空气污染细颗粒物长期暴露慢性肾脏疾病代谢综合征组分

Identity-based searchable attribute signcryption in lattice for a blockchain-based medical system

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Frontiers of Information Technology & Electronic Engineering 2024年第3期25卷 461-471页

作者： Huifang YU xiaoping BAI School of Cyberspace Security Xi'an University of Posts&TelecommunicationsXi'an 710121China School of Information Engineering Qinghai Communications Technical CollegeXining 810003China

Electronic healthcare systems can offer convenience but face the risk of data forgery and information *** solve these issues,we propose an identity-based searchable attribute signcryption in lattice for a blockchain-based medical system(BCMS-LIDSASC).BCMS-LIDSASC achieves decentralization and anti-quantum security in the blockchain environment,and provides fine-grained access control and ***,smart contracts are used to replace traditional trusted third parties,and the interplanetary file system(IPFS)is used for ciphertext storage to alleviate storage pressure on the *** to other schemes,BCMS-LIDSASC requires smaller key size and less storage,and has lower computation *** contributes to secure and efficient management of medical data and can protect patient privacy and ensure the integrity of electronic healthcare systems.

关键词： Blockchain Identity-based searchable attribute signcryption Distributed storage NTRU lattice

Insights into the mechanism of multiple Cu-doped Co Fe_(2)O_(4)nanocatalyst activated peroxymonosulfate for efficient degradation of Rhodamine B

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Journal of Environmental Sciences 2024年第3期137卷 382-394页

作者： Yuanmin Mo xiaoping Zhang School of Environment&Energy South China University of TechnologyGuangzhou Higher Education Mega CentreGuangzhou 510006China The Key Laboratory of Pollution Control and Ecosystem Restoration in Industry Clusters of Ministry of Education Guangzhou 510006China Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and Recycling Guangzhou 510006China Guangdong Provincial Engineering and Technology Research Center for Environmental Risk Prevention and Emergency Disposal Guangzhou 510006China

The multiple metal catalyst as a promising nanomaterial has shown excellent activity in the peroxymonosulfate(PMS)activation for pollutant ***,the role of special sites and in-depth understanding of the PMS activation mechanism are not fully *** this study,a Cu-doped CoFe_(2)O_(4)nanocatalyst(0.5CCF)was synthesized by a sol-gel and calcination method,and used for PMS activation to remove Rhodamine B(RhB).The results showed that the Cu doping obviously enhanced the catalytic performance of CoFe_(2)O_(4),with 99.70%of RhB removed by 0.5CCF while 74.91%in the CoFe_(2)O_(4)within 15 *** on the X-ray photoelectron spectroscopy and electrochemical analysis,this could be ascribed to the more low valence of Co and Fe species generated on the 0.5CCF and faster electron transfers occurred in the 0.5CCF due to the Cu *** addition,Cu doping could provide more reaction sites for the 0.5CCF to activate PMS for RhB *** metal species and the surface hydroxyl were the reaction sites of PMS activation,and the surface hydroxyl played an important role in surface-bound reactive species *** the PMS activation,the Cu not only activated PMS to produce reactive oxygen species(ROS),but also regenerated Co^(2+)and Fe^(2+)to accelerate the PMS *** non-radical of ^(1)O_(2)was the main ROS with a 99.35%of contribution rate,and the SO_(5)^(·–)self-reaction was its major *** study provides a new insight to enhance the PMS activation performance of multiple metal catalysts by Cu doping in wastewater treatment.

关键词： Cu-doped CoFe_(2)O_(4)nanocatalyst PMS activation Mechanism Rhodamine B removal

An integrated rapid nucleic acid detection assay based on recombinant polymerase amplification for SARS-CoV-2

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Virologica Sinica 2022年第1期37卷 138-141页

作者： Ying Tang Yiqin Wang Yuchang Li Huai Zhao Sen Zhang Ying Zhang Jing Li Yuehong Chen Xiaoyan Wu Chengfeng Qin Tao Jiang xiaoping kang Department of Virology Beijing Institute of Microbiology and EpidemiologyAMMSBeijing 100071China State Key Laboratory of Pathogen and Biosecurity AMMSBeijing 100071China Beijing University of Chemical Technology Beijing 100029China Technology Center of Erenhot Customs Erenhot 011100China Lifereal Biotech.Inc. Hangzhou 311100China Anhui Medical University Hefei 230032China

Dear Editor,Severe acute respiratory syndrome coronavirus-2(SARS-Co V-2)is a novel coronavirus that causes the outbreak of coronavirus disease 2019(COVID-19)(Li et al.,2020a).Viral nucleic acid testing is the standard method for the laboratory diagnosis of COVID-19(Wu et al.,2020a;Zhu et al.,2020).Currently,a variety of qPCR-based detection kits are used for laboratory-based detection and confirmation of SARS-CoV-2 infection(Corman et al.,2020;Hussein et al.,2020;Ruhan et al.,2020;Veyer et al.,2020).Conventional qPCR involves virus inactivation,nucleic acid extraction,and qPCR amplification ***,the process is complicated,which usually takes longer than 2 h,and requires biosafety laboratories and professional ***,qPCR is not suitable for use in field or medical units.

关键词： al. diagnosis acute

A Comparison of Four Neural Networks Algorithms on Locomotion Intention Recognition of Lower Limb Exoskeleton Based on Multi-source Information

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Journal of Bionic Engineering 2024年第1期21卷 224-235页

作者： Duojin Wang xiaoping Gu Hongliu Yu Institute of Rehabilitation Engineering and Technology University of Shanghai for Science and Technology516 Jungong RoadShanghai 200093China Shanghai Engineering Research Center of Assistive Devices 516 Jungong RoadShanghai 200093China

Lower Limb Exoskeletons(LLEs)are receiving increasing attention for supporting activities of daily *** such active systems,an intelligent controller may be *** this paper,we proposed a locomotion intention recognition system based on time series data sets derived from human motion *** of input data and Deep Learning(DL)algorithms,this framework enables the detection and prediction of users’movement *** makes it possible to predict the detection of locomotion modes,allowing the LLEs to provide smooth and seamless *** pre-processed eight subjects were used as input to classify four scenes:Standing/Walking on Level Ground(S/WOLG),Up the Stairs(US),Down the Stairs(DS),and Walking on Grass(WOG).The result showed that the ResNet performed optimally compared to four algorithms(CNN,CNN-LSTM,ResNet,and ResNet-Att)with an approximate evaluation indicator of 100%.It is expected that the proposed locomotion intention system will significantly improve the safety and the effectiveness of LLE due to its high accuracy and predictive performance.

关键词： Lower limb exoskeletons(LLEs) Locomotion intention ResNet Multi-source