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Meta-analysis and Trial Sequential Analysis of Compound Qingdai Capsule in the Treatment of Psoriasis

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Medicinal Plant 2022年第6期13卷 49-54页

作者： Songling YAO xiaoning yan Wanling CAI The First Clinical Medical College of Shaanxi University of Chinese Medicine Xianyang 712046China Shaanxi Provincial Hospital of Traditional Chinese Medicine Xi'an 710003China

[Objectives]To analyze the efficacy of Compound Qingdai Capsule in the treatment of psoriasis and conduct a systematic evaluation.[Methods]The clinical total effective rate,PASI index score,IL-17 level,IL-23 level,TNF-level,and adverse reactions were *** 0.9 software was used to conduct sequential analysis of the total effective rate,and subgroup analysis was performed according to the average age of the experimental group.[Results]Single application of Compound Qingdai Capsule or in combination with other methods in the treatment of psoriasis was superior to non-Compound Qingdai Capsule group,and the side effects were less than non-Compound Qingdai Capsule group;the n≥40 year-old group had certain heterogeneity,suggesting that the difference was statistically significant,and the effective rate was higher than that of the control *** funnel plot showed that the graph was asymmetrical,and there may be publication bias or the possibility of low-quality *** TSA results indicated that the actual sample size was far lower than the expected sample size,and the cumulative Z value did not reach the TSA cut-off value and more trials need to be included to confirm the efficacy.[Conclusions]Compound Qingdai Capsule has a clear curative effect on psoriasis,and its safety is *** study can provide relevant evidence for the effectiveness of Chinese patent drugs(CPD)in treating psoriasis.

关键词： Psoriasis Compound Qingdai Capsule Meta-analysis Randomized controlled trial(RCT) Sequential analysis

Effects of connective tissue growth factor and collagen type Ⅰ scleroderma

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Journal of Nanjing Medical University 2007年第3期21卷 175-179页

作者： xiaoning yan Jie Feng Bingjun Shi Department of Dermatology the Second Affiliated Hospital of Xi＇an Jiaotong University Xi＇an 710004 China

Objective： To investigate the effects of connective tissue growth factor（CTGF） and collagen type I（COL-I） on the pathogenesis of scleroderma and explore the relationship between the level of COL-I and CTGF. Methods： 12 mice model of scleroderma was established by the injection of Bleomycin. The level of CTGF and COL-I were detected by immunohistochemical method. The relationship was analyzed between CTGF and COL-I level. As control group, 12 healthy mice were selected. Results： The levels of CTGF and COL-I in sclerotic models were higher than in normal controls （P 〈 0.05）. It was found that there was a correlation between the level of CTGF and COL-I. Conclusion： CTGF and COL-I played an important role in the hardening process of the skin lesions of the mice model, which may be involved in the pathogenesis of scleroderma.

关键词： connective tissue growth factor collagen type I scleroderma

Zhenxin Anshen formula(镇心安神方)ameliorates atopic der-matitis-like skin dysfunction in mice and in vitro via regulation of transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 in Neural pathways

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Journal of Traditional Chinese Medicine 2023年第5期43卷 887-896页

作者： ZHAO Yiding yan xiaoning JIANG Shanshan LIU Yong DONG Chun CHI Huiyan MAO Chaoyi Department of Dermatology Shaanxi Provincial Hospital of traditional Chinese MedicineXi’an 710003China Department of Dermatology Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing 100193China Department of Education Management China Academy of Chinese Medical SciencesBeijing 100700China

OBJECTIVE:To investigate the efficacy of Zhenxin Anshen formula(镇心安神方,ZXAS)on atopic dermatitis(AD)by transient receptor potential vanilloid 1(TRPV1)and transient receptor potential ankyrin 1(TRPA1)signalling pathway in mice and in ***:AD-like lesions were induced by 1-chloro-2,4-dinitrobenzene(DNCB)to the shaved dorsal skin of BALB/c ***/c mice were divided into five groups:normal control,model control,cetirizine,low-,medium-,and high-dose of *** ZXAS in-tervention,the skin lesions and blood samples were collected for hematoxylin and eosin-stained and measuring the concentrations of inflammatory *** E(IgE),interleukin(IL)-4,IL-5,IL-13,and thymic stromal lymphopoietin(TSLP)were de-tected by Enzyme-linked immunosorbent assay(ELISA).The spinal cords were collected for measuring the expression of gastrin-releasing peptide receptor(GRPR),TRPV1,and TRPA1 by using immunohistochemistry,western blotting,and quantitative real-time polymerase chain reaction(qR T-PCR)*** addition,3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide(MTT)assay,flow cytometry,ELISA,and Western blotting were conducted for analysis of primary dorsal root ganglia(DRG)neurons in ***:ZXAS treatment improved DNCB-induced AD-like lesions through reducing dermatitis score,number of scratching and epidermal thickness,accompanied by the de-creased IgE and Th2 inflammatory *** also supressed the mRNA and protein expression of GRPR,TRPV1,and TRPA1 in the spinal *** medicated sera of ZXAS decreased capsaicin-induced Ca^(2+)influx and downregulated the expression of TRPV1,TRPA1,and phospholipase C in DRG ***:The therapeutic effect of ZXAS on AD may be related to the regulation of TRPV1 and TRPA1 and inhibition of Ca^(2+)signals in neurons.

关键词： dermatitis atopic pruritus neural pathways transient receptor potential vanil-loid 1 transient receptor potential ankyrin 1 Zhenxin Anshen formula

Evaluating the Impact of Trichoderma brevicompactum 31636 on Root Rot of Atractylodes macrocephala and the Fungal Community in the Rhizosphere Soil

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Clinical Complementary Medicine and Pharmacology 2022年第4期2卷 39-43页

作者： Xingge Huang xiaoning yan Yunjia Tang Xiaofeng Yuan College of Life Science Zhejiang Chinese Medical UniversityHangzhou 310053ZhejiangChina Academy of Chinese Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053ZhejiangChina

Background:Trichoderma brevicompactum can control of plant diseases,but there are few studies about the control of root rot by *** 31636 and its biocontrol ***:To explore the impact of *** 31636 on root rot and the structure of fungal communities of rhizosphere ***:The effect of *** 31636 on controlling root rot was assessed,the growth of plants was observed by pot experiments,and the fungal structure was detected by high-throughput sequencing ***:Compared with the CK(healthy plants)group,the plant height,fresh weight,and dry weight increased by 55.3%,48.55%and 57.8%,*** the concentration of atractylenolideⅠ,Ⅱ,Ⅲ,and atractylone increased by 19.35%,16.96%,89.42%and 89.32%,*** results of pot experiments indicated that *** 31636 could significantly improve the survival rate of Atractylodes *** results of principal coordinates analysis(PCoA)showed that the sample of CK and Fo+Th(adding Fusdrium oxysporum before *** 31636)group on one side,and samples of Th and Fo group on the ***,among the top 20 dominant fungi detected,the fungal genus with 1%increase of relative abundance included Trichoderma(1%),Sordariomycetes(1.5%),Mortierella(1.3%),Penicillium(1%),meanwhile the fungal genus with 1%decrease of relative abundance included Fusarium(30%)and Pleosporales(1%).Conclusion:In summary,*** 31636 can control the root rot of *** by regulating of the soil fungal community and inhibiting pathogen.

关键词： Rhizosphere soil Fungi High-throughput sequencing A.macrocephala T.brevicompactum 31636 Atractylenolide

Effects of Oxymatrine on the NF-kappa B expression of HaCaT cells

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Journal of Nanjing Medical University 2008年第3期22卷 178-182页

作者： Caiqing Zhang Jie Feng xiaoning yan Wenbing Li Gang Hu Department of Dermatology the Second Affiliated Hospital of Xi＇ an Jiaotong University Xi＇ an 710004 Shanxi Province China

Objective： To study the effect of oxymatrine on the expression of nuclear factor-kappa B（NF-K B） of Human benign epidermal keratinocytes line（HaCaT cells）. Methods：HaCaT cells were cultured with different concentration of Oxymatrine（10 μ g/ml, 50 μ g/ ml and 100 μg/ml） for 24 h, then 10.5 mol/L Substance P was added to the cells. After 30 min, NF-K B expression in the cells was observed by immunocytochemistry, NF-K B P65 protein expression was evaluated by Western blot, and the mRNA expression of NF-K B P65 was evaluated by reverse transcription polymerase chain reaction（RT-PCR）. The 10.5 mol/L Substance P and culture medium were added to the Substance P group and control group, respectively. Results：In control group, expression rate of positive cells, the expressions of protein and mRNA of NF-K B were all low. In Substance P group, when 10μ mol/L Substance P was added, the expressions were all increased（P 〈 0.05）. But in Oxymatrine groups, the expression rate of positive cells, the expressions of protein and mRNA were all descended in a concentration-dependent manner（P 〈 0.05 or P 〈 0.01）. Conclusion：Oxymatrine can down-regulate the expression of NF-K B of the HaCaT cells and may play an important role in regulating anti-inflammation and immunity.

关键词： Oxymatrine NF-κ B HaCaT cells Substance P

The expression of P63 protein in some keratinocyte original tissues and cells

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Journal of Nanjing Medical University 2007年第6期21卷 402-407页

作者： Rong Cui Jie Feng Xin Zhang Xi Zhou Haozhe Cao xiaoning yan Department of Dermatology the Second Affiliated Hospital Medical School of Xi＇ an Jiaotong University Xi＇ an 710004 Shanxi Province China Cancer Stem Cell Research Center Xi＇an Jiaotong University Xi＇an 710061 Shanxi Province China

Objective： To examine the expression patterns of p63 in tissues of particular keratinocyte original hyperproliferate diseases and variety cell types for determining if P63 is the marker of proliferative potential keratinocytes. Methods： P63 protein was detected and analyzed by immunoreactivity method and Western blot in biopsy specimens of keratinocyte original disorders including squamous cell carcinomas SCC, basal cell carcinomas BCC, Bowen＇ s disease and other tissues or cells, such as psoriasis vulgaris, normal skin tissues, primary cultured keratinocytes, immortal HaCaT cells, and epidermoid carcinoma cells A431. Results： P63 protein was expressed in the nuclei of basal and suprabasal layer of the epidermis, germinative cells of sebaceous glands in normal epidermal. P63 was strongly and diffusely detected in the majority of tumor cells in BCC and poorly-differentiated SCC. In Bowen＇ s disease, p63 expresses are remarkable in all cell layers. In the psoriasis plaque epidermal, p63 expressed mainly in basal cells and part of spinous cells. P63 expressed more strongly in primary cultured keratinocytes than in A431 cells or HaCaT cells. Conclusion： P63 is a nuclei marker of undifferentiated keratinocytes with the proliferative potential and may disrupt the terminal differentiation. The overexpression of p63 reflects immaturity of the tumor cells. The immunohistochemical staining of p63 may be useful for investigating the origin and differentiation of tumor cells.

关键词： protein keratinocyte carcinoma, skin psoriasis

柴达木盆地胜利区块中下侏罗统烃源岩控制因素与发育特征

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油气地质与采收率 2011年第3期18卷 36-38,113页

作者：颜小宁中国石化股份胜利油田分公司西部新区研究中心山东东营257015

烃源岩是新区油气勘探面对的首要问题,中下侏罗统是柴达木盆地东部胜利区块发育的主力烃源岩层系之一。野外地质调查发现,研究区主要发育深湖—半深湖相油页岩以及湖沼相煤系烃源岩2种类型烃源岩。烃源岩分布较广,但横向残留厚度及埋藏... 详细信息

烃源岩是新区油气勘探面对的首要问题,中下侏罗统是柴达木盆地东部胜利区块发育的主力烃源岩层系之一。野外地质调查发现,研究区主要发育深湖—半深湖相油页岩以及湖沼相煤系烃源岩2种类型烃源岩。烃源岩分布较广,但横向残留厚度及埋藏深度差异较大,主要受侏罗纪原型盆地发育与后期构造运动的双重影响。地化分析结果表明,深湖—半深湖相油页岩为好烃源岩,湖沼相煤系烃源岩为中等—好烃源岩。在研究区东部烃源岩厚度较大且已进入成熟阶段,是成熟油气有利勘探区;在中西部厚度较薄且只进入低熟阶段,是低熟油气勘探区。

关键词：烃源岩控制因素发育特征中下侏罗统胜利区块柴达木盆地

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慢阻肺急性加重期的辨证施护策略分析

中国中医药现代远程教育 2016年第7期14卷 121-122页

作者：鄢小宁四川省遂宁市中医院心病肺病科遂宁629000

目的对慢性阻塞性肺疾病急性加重期患者实施中医辨证辩护的策略进行探讨分析。方法随机将我院87例慢阻肺急性加重期患者分为对照组(42例)与观察组(45例),分别实施常规西医护理与中医辨证施护。结果观察组喘息症状积分明显低于对照组,观... 详细信息

目的对慢性阻塞性肺疾病急性加重期患者实施中医辨证辩护的策略进行探讨分析。方法随机将我院87例慢阻肺急性加重期患者分为对照组(42例)与观察组(45例),分别实施常规西医护理与中医辨证施护。结果观察组喘息症状积分明显低于对照组,观察组住院时间明显短于对照组,对比(P<0.05)。结论对慢阻肺急性加重期患者实施中医辨证施护,可显著改善患者临床症状,缩短住院时间。

关键词：慢阻肺急性加重期辨证施护肺胀咳喘

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针灸止痒的机理及辨证选穴

中国医学文摘（皮肤科学） 2015年第6期32卷 633-637页

作者：闫小宁陕西省中医医院皮肤科陕西西安710002

瘙痒是很多皮肤病及系统性疾病的常见临床表现,发生机制复杂,临床上缺乏有效的治疗手段。中医认为瘙痒与风、湿、热、瘀、虚等有关,随着针灸治疗在皮肤科的广泛应用,通过辨证取穴及针灸治疗的衍生疗法,使瘙痒有了新的治疗途径。

关键词：瘙痒针灸辨证取穴