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君子和而不同? 非国有股东委派董事与国有企业董事会异议

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管理评论 2024年第7期36卷 232-245页

作者：孔晓旭唐晓萌柳学信首都经济贸易大学经济学院北京100070 首都经济贸易大学工商管理学院北京100070

发展混合所有制经济是国有企业改革的重要突破口,而引入非国有资本是新时期深化国有企业混合所有制改革的主要模式,但现有研究缺少非国有股东委派董事如何影响董事会决策的内在机制研讨。本文以2008—2019年沪深A股国有上市公司为样本,... 详细信息

发展混合所有制经济是国有企业改革的重要突破口,而引入非国有资本是新时期深化国有企业混合所有制改革的主要模式,但现有研究缺少非国有股东委派董事如何影响董事会决策的内在机制研讨。本文以2008—2019年沪深A股国有上市公司为样本,考察非国有股东委派董事通过增加国有企业董事会异议影响治理绩效的作用机制。研究发现,非国有股东委派董事对国有企业董事会异议有显著的正向影响,且政府干预难度、行业竞争程度、企业内部控制水平发挥正向调节作用;并且非国有股东委派董事通过增加董事会异议提升国有企业治理绩效,从而实现“君子和而不同”的效果。本研究厘清国有企业混合所有制改革背景下董事会内部决策过程及影响机制,能够为进一步完善混合所有制企业治理机制提供参考。

关键词：国有企业混合所有制改革非国有股东委派董事董事会异议

血浆BNP、hsCRP水平与急性冠状动脉综合征患者GRACE评分的关系

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中国实用医刊 2024年第1期51卷 48-51页

作者：耿红亮李振唐晓萌安阳市人民医院心内科安阳455000

目的分析血浆B型钠尿肽(BNP)、超敏C反应蛋白(hsCRP)水平与急性冠状动脉综合征(ACS)患者急性冠状动脉事件注册系统(GRACE)评分的关系。方法观察性研究。抽取2019年1月至2021年12月安阳市人民医院收治的ACS患者112例为观察组,观察组按照G... 详细信息

目的分析血浆B型钠尿肽(BNP)、超敏C反应蛋白(hsCRP)水平与急性冠状动脉综合征(ACS)患者急性冠状动脉事件注册系统(GRACE)评分的关系。方法观察性研究。抽取2019年1月至2021年12月安阳市人民医院收治的ACS患者112例为观察组,观察组按照GRACE评分细分为低危组(41例)、中危组(38例)、高危组(33例),另抽取同期健康体检者112例为健康组。检测并比较各组血浆BNP、hsCRP水平及GRACE评分,分析不同GRACE评分的ACS患者病变血管状况,分析血浆BNP、hsCRP水平与ACS患者GRACE评分的相关性。结果观察组BNP、hsCRP水平及GRACE评分高于健康组,差异有统计学意义(P0.05);低危组单支血管病变者比例(51.22%,21/41)高于中危组(21.05%,8/38)、高危组(3.03%,1/33),且三支血管病变者比例(14.63%,6/41)低于中危组(42.11%,16/38)、高危组(54.55%,18/33),差异有统计学意义(P<0.05)。Pearson结果显示,血浆BNP、hsCRP水平与ACS患者GRACE评分呈正相关(r=0.51、0.63,P均<0.05)。结论血浆BNP、hsCRP水平可随着ACS患者病情加重而逐渐升高,且BNP、hsCRP水平与GRACE评分呈正相关。

关键词：急性冠状动脉综合征 B型钠尿肽超敏C反应蛋白急性冠状动脉事件注册系统评分

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翻白草不同部位提取物抗常见致病菌活性评价

中国医院药学杂志 2024年第11期44卷 1253-1259页

作者：苟军丽李刚路宗志唐晓梦徐婉琳王汉卿宁夏医科大学药学院宁夏医科大学总医院药剂科宁夏银川750004 宁夏特色中医药省部共建协同创新中心宁夏特色中医药工程技术中心宁夏银川750004 六盘山区域药用资源保护与开发利用教育部重点实验室宁夏银川750004

目的:通过研究翻白草不同部位提取物对常见致病菌的抗菌活性,筛选翻白草抗菌的活性部位,并揭示其发挥抗菌作用的活性成分。方法:采用溶剂萃取法获得翻白草不同部位提取物,采用微量稀释法开展抑菌活性研究,采用Spearman分析揭示各部位化... 详细信息

目的:通过研究翻白草不同部位提取物对常见致病菌的抗菌活性,筛选翻白草抗菌的活性部位,并揭示其发挥抗菌作用的活性成分。方法:采用溶剂萃取法获得翻白草不同部位提取物,采用微量稀释法开展抑菌活性研究,采用Spearman分析揭示各部位化学成分与抑菌活性的相关关系。结果:翻白草不同部位提取物中总黄酮和总酚含量差异显著,均以乙酸乙酯部位最高,正丁醇部位次之。抗菌活性结果表明,翻白草各部位提取物对受试菌株均具有抑菌效果,对革兰氏阳性细菌的抗菌效果优于革兰氏阴性细菌;不同部位提取物抗菌活性以乙酸乙酯部位最强,正丁醇部位次之,水部位最弱。相关性分析结果显示,总黄酮含量与所有受试菌株的抑菌活性呈显著相关,总酚含量仅与部分受试菌株的抑菌活性具有显著相关性。结论:翻白草不同部位提取物均具有一定的抗菌活性,其中以乙酸乙酯部位最强,且其发挥抑菌作用的活性成分为黄酮和酚类成分。研究结果为翻白草用于临床抗菌以及其药用价值的开发利用提供了理论依据。

关键词：翻白草提取物抗菌抑菌

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Plant-derived nanovesicles: Further exploration of biomedical function and application potential

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Acta Pharmaceutica Sinica B 2023年第8期13卷 3300-3320页

作者： Aixue Li Dan Li Yongwei Gu Rongmei Liu xiaomeng tang Yunan Zhao Fu Qi Jifu Wei Jiyong Liu College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China Department of Pharmacy Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Pharmacy Jiangsu Cancer HospitalNanjing 210009China Jiangsu Institute of Cancer Research Nanjing 210009China The Affiliated Cancer Hospital of Nanjing Medical University Nanjing 210009China Department of Pharmacy Shanghai Proton and Heavy Ion CenterShanghai 201315China

Extracellular vesicles(EVs)are phospholipid bilayer vesicles actively secreted by cells,that contain a variety of functional nucleic acids,proteins,and lipids,and are important mediums of intercellular *** on their natural properties,EVs can not only retain the pharmacological effects of their source cells but also serve as natural delivery *** them,plant-derived nanovesicles(PNVs)are characterized as natural disease therapeutics with many advantages such as simplicity,safety,eco-friendliness,low cost,and low toxicity due to their abundant resources,large yield,and low risk of immunogenicity in *** review systematically introduces the biogenesis,isolation methods,physical characterization,and components of PNVs,and describes their administration and cellular uptake as therapeutic *** highlight the therapeutic potential of PNVs as therapeutic agents and drug delivery carriers,including anti-inflammatory,anticancer,wound healing,regeneration,and antiaging properties as well as their potential use in the treatment of liver disease and ***,the toxicity and immunogenicity,the current clinical application,and the possible challenges in the future development of PNVs were *** expect the functions of PNVs to be further explored to promote clinical translation,thereby facilitating the development of a new framework for the treatment of human diseases.

关键词： Plant-derived nanovesicles Extracellular vesicles Therapeutic agents Drugdelivery systems Clinical application

IPv6网络攻击事件溯源中的攻击树节点特征定位

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计算技术与自动化 2024年第2期43卷 145-150页

作者：唐晓萌任凯滕俐军汪敦全梁鼎铭福建华电可门发电有限公司福建福州350500 华电电力科学研究院有限公司浙江杭州310000 深圳融安网络科技有限公司广东深圳518000

在网络普及的现代,各类网络协议层出不穷,而在当下最为普遍的便是IPv6网络协议,其虽然优化解决了前网络协议中存在的部分问题,但是依旧存在各类安全隐患,为了能更好地预防并构建网络防御系统,需要对过往攻击事件中的攻击树节点特征实施... 详细信息

在网络普及的现代,各类网络协议层出不穷,而在当下最为普遍的便是IPv6网络协议,其虽然优化解决了前网络协议中存在的部分问题,但是依旧存在各类安全隐患,为了能更好地预防并构建网络防御系统,需要对过往攻击事件中的攻击树节点特征实施提取。为此,提出了IPv6网络攻击事件溯源中的攻击树节点特征定位。该方法首先利用攻击类型实施扩展,得到攻击树模型,并以此展开计算,之后结合深度学习网络对攻击树的节点特征实施提取,最后利用DV-Hop方法对提取到的攻击树节点特征实施定位。所提方法在定位过程中不仅能耗低,而且误差小,不易受环境干扰,定位稳定性较好,定位效率较高,可以更有效地为改进网络防御系统提供数据支持。

关键词： IPv6网络攻击树节点特征特征定位事件溯源

Effects of surfactants on the combined toxicity of TiO_2 nanoparticles and cadmium to Escherichia coli

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Journal of Environmental Sciences 2018年第12期30卷 126-133页

作者： Mei Li Jianchuan Pei xiaomeng tang Xiaoli Guo School of Environmental and Resource Sciences Zhejiang A & F University

The combined ecological toxicity of TiO2 nanoparticles（nano-TiO2） and heavy metals has been paid more attention. As the common pollutants in water environment, surfactants could affect the properties of nanoparticles and heavy metals, and thus further influence the combined toxicity of nano-TiO2 and heavy metals. In this study, the effects of sodium dodecyl benzene sulfonate（SDBS） and Tween 80 on the single and combined toxicities of Cd2＋ and nano-TiO2 to Escherichia coli（E. coli） were examined, and the underlying influence mechanism was further discussed. The results showed both SDBS and Tween 80 enhanced the toxicity of Cd2＋ to E. coli in varying degrees. The reaction of SDBS and Cd2＋ could increase the outer membrane permeability and the bioavailability of Cd, while Tween 80 itself could enhance the outer membrane permeability. The combined toxicity of nano-TiO2 and Cd2＋ to E. coli in absence of surfactant was antagonistic because of the adsorption of Cd2＋ to nanoTiO2 particles. However, in the presence of SDBS, both SDBS and nano-TiO2 influenced the toxicity of Cd2＋ , and also SDBS could adsorb to nano-TiO2 by binding to Cd2＋ . The combined toxicity was reduced at Cd2＋ lower than 4 mg/L and enhanced at Cd2＋ higher than 4 mg/L under multiple interactions. Tween 80 enhanced the combined toxicity of nano-TiO2 and Cd2＋ by increasing the outer membrane permeability. Our study firstly elucidated the effects of surfactants on the combined toxicity of nano-TiO2 and Cd2＋ to bacteria, and the underlying influencing mechanism was proposed.

关键词： Nano-TiO2 Heavy metal Surfactant Combined toxicity Bacteria

Activating transcription factor 4 protects mice against sepsis-induced intestinal injury by regulating gut-resident macrophages differentiation

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Chinese Medical Journal 2022年第21期135卷 2585-2595页

作者： Zhenliang Wen Xi Xiong Dechang Chen Lujing Shao xiaomeng tang Xuan Shen Sheng Zhang Sisi Huang Lidi Zhang Yizhu Chen Yucai Zhang Chunxia Wang Jiao Liu Department of Critical Care Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Critical Care Medicine Shanghai Children’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200062China Institute of Pediatric Infection Immunityand Critical Care MedicineShanghai Children’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200062China Institute of Pediatric Critical Care Shanghai Jiao Tong UniversityShanghai 200062China

Background: Gut-resident macrophages (gMacs) supplemented by monocytes-to-gMacs differentiation play a critical role in maintaining intestinal homeostasis. Activating transcription factor 4 (ATF4) is involved in immune cell differentiation. We therefore set out to investigate the role of ATF4-regulated monocytes-to-gMacs differentiation in sepsis-induced intestinal ***: Sepsis was induced in C57BL/6 wild type (WT) mice andAtf4-knockdown (Atf4+/-) mice by cecal ligation and puncture or administration of lipopolysaccharide (LPS). Colon, peripheral blood mononuclear cells, sera, lung, liver, and mesenteric lymph nodes were collected for flow cytometry, hematoxylin and eosin staining, immunohistochemistry, quantitative reverse transcription polymerase chain reaction, and enzyme-linked immunosorbent assay, ***: CD64, CD11b, Ly6C, major histocompatibility complex-II (MHC-II), CX3CR1, Ly6G, and SSC were identified as optimal primary markers for detecting the process of monocytes-to-gMacs differentiation in the colon of WT mice. Monocytes-to-gMacs differentiation was impaired in the colon during sepsis and was associated with decreased expression of ATF4 in P1 (Ly6Chi monocytes), the precursor cells of ***4 knockdown exacerbated the impairment of monocytes-to-gMacs differentiation in response to LPS, resulting in a significant reduction of gMacs in the colon. Furthermore, compared with WT mice,Atf4+/- mice exhibited higher pathology scores, increased expression of inflammatory factor genes (TNF-α, IL-1β), suppressed expression of CD31 and vascular endothelial-cadherin in the colon, and increased translocation of intestinal bacteria to lymph nodes and lungs following exposure to LPS. However, the aggravation of sepsis-induced intestinal injury resulting fromAtf4 knockdown was not caused by the enhanced inflammatory effect of Ly6Chi monocytes and ***: ATF4, as a novel regulator of monocytes-to-gMacs differentiation, plays a criti

关键词： Activating transcription factor 4 Mice Lipopolysaccharides Monocytes Leukocytes,mononuclear Cell differentiation Macrophages Sepsis Homeostasis gMacs Intestinal injury

Semi-volatile organic compounds in a museum in China:A non-targeted screening approach

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Science China(Technological Sciences) 2024年第9期67卷 2693-2705页

作者： SONG ZiDong NIAN LuYing SHI Meng REN XiaoPeng tang Ming SHI AnMei HAN Ying LIU Min WANG LuYang ZHANG YinPing XU Ying FENG xiaomeng Department of Building Science Tsinghua UniversityBeijing 100084China Beijing Key Laboratory of Indoor Air Quality Evaluation and Control Beijing 100084China National Museum of China Beijing 100006China Department of Endocrinology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China

Non-targeted analysis(NTA)was conducted to identify semi-volatile organic compounds(SVOCs)in a museum in China using the gas chromatography(GC)-Orbitrap-mass spectrometer(MS).Approximately 160 SVOCs were detected,of which 93 had not been reported in previous studies of museum *** of the detected SVOCs were found to be associated with the chemical agents applied in conservation treatment and the materials used in *** results of hierarchical cluster analysis(HCA)indicated a spatial variation of SVOCs in the indoor air in the museum,but there were no obvious temporal differences of SVOCs observed in indoor ***'s correlation analysis showed that several classes of SVOCs were well correlated,suggesting their common *** and plasticizers were found to be the primary sources of SVOC pollution detected in the *** with compounds in outdoor air,indoor SVOCs had a lower level of unsaturation and more portions of chemically reduced *** study is the first of its kind to comprehensively characterize SVOCs in a museum using an automated NTA approach with *** SVOCs identified in the current study are likely to be present in other similar museums;therefore,further examination of their potential impacts on cultural heritage artifacts,museum personnel,and visitors may be warranted.

关键词： non-target analysis high-resolution mass spectrometry semi-volatile organic compounds museum environment air pollutants

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植物RNA修饰的功能及分析方法

高等学校化学学报 2023年第3期44卷 142-155页

作者：唐潇萌袁必锋冯钰锜武汉大学公共卫生学院武汉430071 武汉大学化学与分子科学学院武汉430072

除经典碱基外,RNA中还包含许多化学修饰.迄今,已经在生命体的三域系统中鉴定出超过150种RNA修饰类型.这些RNA修饰不改变RNA的序列,但会改变其结构和生化特性,从而调节基因的时空表达.RNA修饰作为表观遗传学研究的一个重要领域,在调控植... 详细信息

除经典碱基外,RNA中还包含许多化学修饰.迄今,已经在生命体的三域系统中鉴定出超过150种RNA修饰类型.这些RNA修饰不改变RNA的序列,但会改变其结构和生化特性,从而调节基因的时空表达.RNA修饰作为表观遗传学研究的一个重要领域,在调控植物的生长发育和胁迫应激中起到至关重要的作用.近年来,随着分析技术,特别是RNA修饰测序技术的不断进步,对植物RNA修饰的功能和机制获得了深入的认识.本文主要介绍了植物RNA修饰的功能,总结了针对这些植物中RNA修饰的分析方法,以便为今后系统地开展植物中RNA修饰的研究提供参考.

关键词：植物 RNA修饰功能分析方法测序