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One-step cell biomanufacturing platform:porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo

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Neural Regeneration Research 2024年第2期19卷 458-464页

作者： Lin Feng Da Li Yao Tian Chengshun Zhao Yun Sun xiaolong Kou Jun Wu Liu Wang Qi gu Wei Li Jie Hao Baoyang Hu Yukai Wang State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Institute for Stem Cell and Regenerative Medicine Chinese Academy of SciencesBeijingChina National Stem Cell Resource Center Chinese Academy of SciencesBeijingChina Savaid Medical School University of Chinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina

Numerous studies have shown that cell replacement therapy can replenish lost cells and rebuild neural circuitry in animal models of Parkinson’s disease.Transplantation of midbrain dopaminergic progenitor cells is a promising treatment for Parkinson’s disease.However,transplanted cells can be injured by mechanical damage during handling and by changes in the transplantation niche.Here,we developed a one-step biomanufacturing platform that uses small-aperture gelatin microcarriers to produce beads carrying midbrain dopaminergic progenitor cells.These beads allow midbrain dopaminergic progenitor cell differentiation and cryopreservation without digestion,effectively maintaining axonal integrity in vitro.Importantly,midbrain dopaminergic progenitor cell bead grafts showed increased survival and only mild immunoreactivity in vivo compared with suspended midbrain dopaminergic progenitor cell grafts.Overall,our findings show that these midbrain dopaminergic progenitor cell beads enhance the effectiveness of neuronal cell transplantation.

关键词： axonal integrity cell cryopreservation cellular environment cellular niche cell replacement therapy dopaminergic progenitors human pluripotent stem cell mechanical damage neuronal cell delivery Parkinson’s disease small-aperture gelatin microcarriers

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疏水膜、疏水性能评价及其自发脱水干燥

膜科学与技术 2024年第1期44卷 1-7页

作者：吕晓龙谷杰膜材料与膜应用国家重点实验室天津膜天膜科技股份有限公司天津300457 省部共建分离膜与膜过程国家重点实验室材料科学与工程学院生物化工研究所天津工业大学天津300387

介绍了多孔疏水膜的定义、临界润湿值的概念、疏水膜的透水压力值和临界润湿值测试方法。区别于通常的外力加热等方法,介绍了利用疏水膜材料自身特性来实现疏水膜干燥的两种疏水膜自脱水干燥的方法.一种方法是控制膜污染润湿进程,当膜... 详细信息

介绍了多孔疏水膜的定义、临界润湿值的概念、疏水膜的透水压力值和临界润湿值测试方法。区别于通常的外力加热等方法,介绍了利用疏水膜材料自身特性来实现疏水膜干燥的两种疏水膜自脱水干燥的方法.一种方法是控制膜污染润湿进程,当膜孔被润湿的深度小于该疏水膜材料的临界润湿值时,通过膜清洗实现疏水膜的自发脱水干燥.另一种方法是构建亲疏水双层复合疏水膜,当膜运行至产水电导率明显上升时,停机清洗,利用亲水材料与水之间的吸引力大于疏水材料与水之间的吸引力的特性使疏水膜孔自发脱水干燥.

关键词：疏水膜临界润湿值透水压力疏水膜干燥自发脱水

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股份回购与公司资金成本:财务风险视角

南京审计大学学报 2024年第3期21卷 50-61页

作者：顾小龙许紫薇广东财经大学智能财会管理学院广东广州510320 广东财经大学会计学院广东广州510320

以2005—2022年沪深A股上市公司股份回购数据为样本,考察回购前后资金成本变化情况,发现股份回购后企业资金成本呈上升趋势,其中,对于财务风险大的公司,回购导致资金成本上升的情况更加明显。进一步研究也表明,财务风险大的公司,在回购... 详细信息

以2005—2022年沪深A股上市公司股份回购数据为样本,考察回购前后资金成本变化情况,发现股份回购后企业资金成本呈上升趋势,其中,对于财务风险大的公司,回购导致资金成本上升的情况更加明显。进一步研究也表明,财务风险大的公司,在回购宣告后,其长期市场反应也更差。研究从资金成本角度解释了当前中国股份回购长期价值缺失的原因,揭示出股份回购的长期价值效应受企业内部条件的作用。

关键词：股份回购权益资金成本债务资金成本过度负债融资约束破产风险长期市场反应

Wetting Behaviors and Interfacial Reaction between Sn-10Sb-5Cu High Temperature Lead-free Solder and Cu Substrate

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Journal of Materials Science & Technology 2010年第2期26卷 156-162页

作者： Qiulian Zeng Jianjun guo xiaolong gu Xinbing Zhao Xiaogang Liu Zhejiang Province Key laboratory of Soldering &: Brazing Materials and Technology Zhejiang Metallurgical Research Institute Hangzhou 310011 China Department of Materials Science and Engineering Zhejiang University Hangzhou 310027 China

Sn-10Sb-5Cu lead-free solder was fabricated for high temperature application in electronic package. Wetting behaviors and interfacial reaction between such a high temperature lead-free solder and Cu substrate were investigated and compared with those of 95Pb-Sn solder. The results showed that the wetting properties of Sn-10Sb-SCu solder are superior to those of 95Pb-Sn solder in maximum wetting force, wetting time and wetting angle in the temperature range of 340-400℃. However, the surface of the Sn-10Sb-5Cu solder sample after wetting balance tests was rougher than that of 95Pb-Sn solder at the temperature lower than 360℃. In static liquid-state interracial reaction, the types and thickness of the intermetallic compounds （IMCs） of both solders were different from each other. The wetting kinetics in the Sn-10Sb-5Cu/Cu system was more rapid than that in 95Pb-Sn/Cu system, and the higher formation rate of IMCs in the former system was considered as the reason.

关键词： Wetting Interfacial reaction High temperature lead-free solder Sn-10Sb-5Cu solder

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江苏特色田园乡村:对乡村建设行动的启示

现代城市研究 2024年第5期39卷 23-29页

作者：王鹏罗小龙顾宗倪南京大学建筑与城市规划学院

江苏特色田园乡村建设是发达地区综合性乡村建设行动的地方典型实践。文章通过对江苏特色田园乡村建设历程和特征的梳理,从理念和机制层面总结江苏经验。在理念上江苏特色田园乡村建设是基于价值挖掘的乡村地域功能重塑和基于集成行动... 详细信息

江苏特色田园乡村建设是发达地区综合性乡村建设行动的地方典型实践。文章通过对江苏特色田园乡村建设历程和特征的梳理,从理念和机制层面总结江苏经验。在理念上江苏特色田园乡村建设是基于价值挖掘的乡村地域功能重塑和基于集成行动的乡村地域系统重构,准确把握了乡村振兴的要义。在机制上江苏特色田园乡村建设构建起“组织+制度”的管理运行机制、“专项+协同”的资金统筹机制、“规范+人才”的技术支撑机制以及“政府+市场”的主体参与机制,实现从要素叠加、维度累进到建设长效机制的结构性嵌入。基于江苏经验,认为乡村建设行动的要点在于塑造特色多元的乡村地域功能、构建系统高效的乡村建设体系、形成梯度有序的乡村建设格局。

关键词：乡村建设行动特色田园乡村经验启示江苏

Reputation repair and corporate donations:An investigation of responses to regulatory penalties

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China Journal of Accounting Research 2019年第3期12卷 293-313页

作者： Xue Xia Fei Teng xiaolong gu Center for Accounting Financeand InstitutionsBusiness SchoolSun Yat-sen UniversityChina Accounting School/International Business School Guangdong University of Finance and EconomicsChina Institute of Capital Market and Audit Governance Studies for the Great Bay Area(guangdong Hong-KongMacao)Guangdong University of Finance and EconomicsChina

According to the risk management and reputation insurance theory of corporate social responsibility, corporate donations can help a company to repair its reputation after a crisis.This study uses a propensity score matching–difference in difference(PSM + DID) methodology to investigate the charitable donation activities of companies that have been subject to regulatory penalties.The analysis of a sample of A-share listed companies in the 2004–2016 period shows that companies significantly increase their charitable donations after regulatory penalties, but this effect weakens over time.Further analysis reveals that non-state-owned companies, companies with higher ownership concentrations, and companies receiving severer penalties are more motivated to make donations after regulatory penalties.By studying the reputation repair behavior of companies that have been subject to regulatory penalties, this study offers further support for the risk management and reputation insurance theory of corporate social responsibility.It also enriches our understanding of companies’ active responses to regulatory penalties and provides insights into companies’ motives for making charitable donations.

关键词： Regulatory penalty Donation Reputation repair

Thermodynamic modeling and phase diagram prediction of salt lake brine systems.Ⅰ. Aqueous Mg^2+–Ca^2+–Cl^- binary and ternary systems

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Chinese Journal of Chemical Engineering 2020年第9期28卷 2391-2408页

作者： Huan Zhou xiaolong gu Yaping Dai Jingjing Tang Jian guo guangbi Li Xiaoqin Bai College of Chemical Engineering and Materials Science Tianjin Key Laboratory of Marine Resources and ChemistryTianjin University of Science and TechnologyTianjin 300457China

Salt lake brine is a complex salt-water system under natural environment.Although many models can express the thermodynamic properties and phase equilibrium of electrolyte aqueous solution,the multi-temperature characteristics and predictability are still the goals of model development.In this study,a comprehensive thermodynamic model system is re-established based on the eNRTL model and some improvements:(1) new expression of long-range electrostatic term with symmetrical reference state is proposed to handle the electrolyte solution covering entire concentration range;(2) the temperature dependence of the binary interaction parameters is formulated with a Gibbs Helmholtz expression containing three temperature coefficients,the liquid parameters,which associated with Gibbs energy,enthalpy,and heat capacity contribution;and(3) liquid parameters and solid species data are regressed from properties and solubility data at full temperature range.Together the activity coefficient model,property models and parameters of liquid and solid offer a comprehensive thermodynamic model system for the typical bittern of MgCl2-CaCl2-H2 O binary and ternary systems,and it shows excellent agreement with the literature data for the ternary and binary systems.The successful prediction of complete phase diagram of ternary system shows that the model has the ability to deal with high concentration and high non-idealitv system,and the ability to extrapolate the temperature.

关键词： Aqueous electrolytes Comprehensive thermodynamic model MgCl2-CaCl2-H2O Phase diagram Thermodynamic properties

“跨界合作园区热”:尺度重组与空间转型——以长江三角洲地区为例

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城市规划 2024年第2期48卷 20-30页

作者：杨凌凡罗小龙顾宗倪丁子尧南京大学建筑与城市规划学院中国城市规划学会

21世纪初以来,中国城市的增长经历了从竞争到合作的转变,“跨界合作园区热”接替“开发区热”成为转型期城市空间重构过程的集中展示。(1)研究立足长三角跨界合作园区的转型发展历程,探讨跨界合作园区历经的转移工业园、跨界新城到合作... 详细信息

21世纪初以来,中国城市的增长经历了从竞争到合作的转变,“跨界合作园区热”接替“开发区热”成为转型期城市空间重构过程的集中展示。(1)研究立足长三角跨界合作园区的转型发展历程,探讨跨界合作园区历经的转移工业园、跨界新城到合作创新区的政策发展历程,及其空间转型的基本趋势;(2)基于空间转型与合作主体尺度重组活动的紧密联系,进一步探讨空间转型背后尺度重组的动力机制,并提出尺度上推、尺度融合与尺度多元化3个重组阶段及其所形成的托管、合署与企业式3种治理模式;(3)研究建构了跨界合作园区尺度权力重组与空间转型的逻辑框架,并从动态引导的政策支撑体系、劳酬对等的利益协调机制、省-地监管的分层管控机制等方面提出政策建议。

关键词：城市合作飞地开发区空间尺度治理长三角

基于产权的社区渐进式更新困境解析与治理探索——以南京市小西湖街区为例

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现代城市研究 2024年第6期39卷 16-21页

作者：李杰罗小龙顾宗倪高尚民南京大学建筑与城市规划学院青岛市自然资源和规划局

作为存量规划背景下开展社区治理工作的重要路径,社区渐进式更新在实施过程中往往面临动力不足、阻力过多的问题。引入产权理论可以深化对于社区更新中空间关系与主体关系的认知,解释社区更新从启动到实施过程中的困境。文章结合南京市... 详细信息

作为存量规划背景下开展社区治理工作的重要路径,社区渐进式更新在实施过程中往往面临动力不足、阻力过多的问题。引入产权理论可以深化对于社区更新中空间关系与主体关系的认知,解释社区更新从启动到实施过程中的困境。文章结合南京市小西湖街区渐进式更新的实践探索,表明社区更新中对产权界定、整合与管理的制度创新能够有效地处理复杂的空间和主体关系。在此基础上,提出厘清产权的空间与功能边界、优化协商规模与规则、创建柔性规划管理制度等社区更新制度优化策略,以期推动城市更新行动的可持续发展。

关键词：产权社区渐进式更新制度创新社区治理南京小西湖街区