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The intestinal microbiome of an Indo-Pacific humpback dolphin(Sousa chinensis)stranded near the Pearl River Estuary,China

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Integrative Zoology 2021年第3期16卷 287-299页

作者： xiaoling wan Jia LI Zhaolong CHENG Mengxue AO Renmao TIAN Richard William MCLAUGHLIN Jinsong ZHENG Ding wanG The Key Laboratory of Aquatic Biodiversity and Conservation of the Chinese Academy of Sciences Institute of HydrobiologyChinese Academy of SciencesWuhanChina University of Chinese Academy of Sciences BeijingChina Yellow Sea Fisheries Research Institute Chinese Academy of Fishery SciencesQingdaoChina Institute for Environmental Genomics Department of Microbiology and Plant BiologySchool of Civil Engineering and Environmental SciencesUniversity of OklahomaNormanOklahomaUSA Institute for Food Safety and Health Illinois Institute of TechnologyBedford ParkIllinoisUSA General Studies Gateway Technical CollegeKenoshaWisconsinUSA

The mammalian intestinal microbiome is critical for host health and disease ***,the cetacean intestinal microbiota remains relatively *** using high-throughput 16S rRNA gene sequencing,we analyzed intestinal bacterial samples from an Indo-pacific humpback dolphin(Sousa chinensis)stranded near the Pearl River Estuary in *** samples included 3 anatomical regions(foregut,midgut,and rectum)and 2 anatomical locations(content and mucus).Our analyses revealed that the dolphin intestinal bacteria contained 139 operational taxonomic units(OTUs),dominated at the phyla level by Firmicutes(47.05%in the content;94.77%in the mucus),followed by Bacteroidetes(23.63%in the content;1.58%in the mucus)and Gammaproteobacteria(14.82%in the content;2.05%in the mucus).The intestinal bacteria had a small core community(15 OTUs,accounting for 99.74%of the reads),some of which could be potentially pathogenic to both human and *** an alternative to sampling the dolphin intestinal bacteria,fecal sampling could be ***,function potentials such as,xenobiotics biodegradation,beta-lactam resistance,and human disease-related pathways,were detected in the dolphin intestinal *** findings provide the first baseline knowledge of the intestinal microbiome of the Indo-Pacific humpback dolphin,which may offer new insights into cetacean conservation by using microbial surveillance.

关键词： 16S rRNA gene high-throughput sequencing anthropogenic impact cetacean indo-pacific humpback dolphin intestinal microbiota

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Record of a juvenile Omura's whale live stranded in Hainan Island:Evidence of a potential breeding ground in the South China Sea?

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Water Biology and Security 2022年第3期1卷 51-55页

作者： Ruilin He xiaoling wan Minmin Chen Fei Fan Ding wang Jinsong Zheng The Key Laboratory of Aquatic Biodiversity and Conservation of the Chinese Academy of Sciences Institute of HydrobiologyChinese Academy of SciencesWuhan430072China University of Chinese Academy of Sciences Beijing100049China National Aquatic Biological Resource Center Wuhan430072China The Research Center of Aquatic Organism Conservation and Water Ecosystem Restoration in Anhui Province College of Life ScienceAnqing Normal UniversityAnqing 246133China

On January 12,2011,a very young juvenile Bryde's-like baleen whale was found stranded alive on the east coast of Hainan Island,in the South China ***,it died the next *** baleen whale showed some unique external morphology and skull features of the Omura's whale(Balaenoptera omurai).Subsequently,it was genetically identified as an Omura's whale using two different mitochondrial DNA *** study documents the first confirmed live stranding of a juvenile Omura's whale on Hainan Island,*** findings expand the known distribution range of this species in Chinese waters and may indicate that waters around Hainan Island in the South China Sea could be a potential breeding ground for the Omura's whale.

关键词： Omura's Whale Balaenoptera omurai Species identification Distribution Breeding ground South China Sea

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A tunable genome editing system of the prime editor mediated by dihydrofolate reductase

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Journal of Genetics and Genomics 2023年第3期50卷 204-207页

作者： Shu Liu Xiaoyue Duan Feng Peng Yafang wang Yang Liu xiaoling wan Jingfa Zhang Xiaosa Li Xiaodong Sun Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghai 200080China Department of Ophthalmology Shanghai Changhai HospitalShanghai 200043China Shanghai Key Laboratory of Ocular Fundus Diseases 100 Haining RoadShanghai 200080China

The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(CRISPR/Cas)system was discovered in bacteria and archaea as an adaptive immunity system to protect against exogenous DNA(Barrangou et al.,2007).This system has been developed into a powerful gene editing tool for eukaryotic genome manipulation that has therapeutic opportunities against hereditary diseases(Cong et al.,2013),especially monogenic diseases.

关键词： CRISPR/Cas genome system

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METTL3-mediated m^(6)A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial-mesenchymal transition

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Journal of Molecular Cell Biology 2023年第3期15卷 1-17页

作者： Yuwei wang Yuhong Chen Jian Liang Mei Jiang Ting Zhang xiaoling wan Jiahui Wu Xiaomeng Li Jieqiong Chen Junran Sun Yifan Hu Peirong Huang Jingyang Feng Te Liu Xiaodong Sun Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Shanghai Key Laboratory of Ocular Fundus Diseases Shanghai 200080China Shanghai Geriatric Institute of Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 200031China National Clinical Research Center for Eye Diseases Shanghai 200080China Shanghai Engineering Center for Visual Science and Photomedicine Shanghai 200080China

Subretinal fibrosis is a major cause of the poor visual prognosis for patients with neovascular age-related macular degeneration(nAMD).Myofibroblasts originated from retinal pigment epithelial(RPE)cells through epithelial-mesenchymal transition(EMT)contribute to the fibrosis formation.N^(6)-Methyladenosine(m^(6)A)modification has been implicated in the EMT process and multiple fibrotic *** role of m^(6)A modification in EMT-related subretinal fibrosis has not yet been *** this study,we found that during subretinal fibrosis in the mouse model of laser-induced choroidal neovascularization,METTL3 was upregulated in RPE *** m^(6)A epitranscriptomic microarray and further verification,high-mobility group AT-hook 2(HMGA2)was identified as thekey downstream target of METTL3,subsequently activating potent EMT-inducing transcription factor ***,by subretinal injections of adeno-associated virus vectors,we confirmed that METTL3 deficiency in RPE cells could efficiently attenuate subretinal fibrosis in *** conclusion,our present research identified an epigenetic mechanism of METTL3-m^(6)A-HMGA2 in subretinal fibrosis and EMT of RPE cells,providing a novel therapeutic target for subretinal fibrosis secondary to nAMD.

关键词： METTL3 N^(6)-methyladenosine epithelial-mesenchymal transition subretinal fibrosis HMGA2

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考虑绿色证书交易的电力市场均衡模型

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广东化工 2018年第9期45卷 79-81,76页

作者：万小玲新疆电力建设调试所有限责任公司综合服务中心新疆乌鲁木齐830011

近年来,我国积极推进电力工业市场化建设,加紧电力体制改革,绿色证书交易政策受到越来越多的关注。在此背景下,针对电力市场中发电商的竞价策略问题,考虑输电线路容量约束、机组出力约束和可再生能源发电配额约束等条件,提出了发电商竞... 详细信息

近年来,我国积极推进电力工业市场化建设,加紧电力体制改革,绿色证书交易政策受到越来越多的关注。在此背景下,针对电力市场中发电商的竞价策略问题,考虑输电线路容量约束、机组出力约束和可再生能源发电配额约束等条件,提出了发电商竞价行为的具有均衡约束的数学规划(EPEC)模型。模型下层为追求社会福利最大化的市场出清模型,上层为发电商利用策略性报价追求利润最大化模型。算例仿真分析结果表明,所构建模型既可促进可再生能源消纳,又可显著提高发电商收益。

关键词：绿色证书电力市场均衡模型纳什均衡 EPEC模型

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持续性护理在老年股骨粗隆间骨折患者中的应用效果

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中国伤残医学 2024年第4期32卷 105-108页

作者：万小玲南昌县中医院江西南昌330205

目的:探讨持续性护理在老年股骨粗隆间骨折患者中的应用效果.方法:选取该院2021年1月-2023年6月收治的60例老年股骨粗隆间骨折患者为研究对象,按随机数字表法将其分为对照组与观察组,各30例.对照组采用常规护理,观察组采用持续性护理.对... 详细信息

目的:探讨持续性护理在老年股骨粗隆间骨折患者中的应用效果.方法:选取该院2021年1月-2023年6月收治的60例老年股骨粗隆间骨折患者为研究对象,按随机数字表法将其分为对照组与观察组,各30例.对照组采用常规护理,观察组采用持续性护理.对比2组疼痛程度、髋关节功能、生活自理能力、并发症发生情况、社会支持情况.结果:观察组视觉模拟评分低于对照组,差异有统计学意义(P<0.05).观察组髋关节功能优于对照组,差异有统计学意义(P<0.05).术后6周、3、6个月,观察组Barthel指数高于对照组,差异有统计学意义(P<0.05).观察组并发症总发生率为6.67%,低于对照组的20.00%,差异有统计学意义(P<0.05).观察组社会支持情况优于对照组,差异有统计学意义(P<0.05).结论:老年股骨粗隆间骨折患者实施持续性护理效果显著,有助于缓解患者疼痛,改善髋关节功能,具有应用价值.

关键词：老年股骨粗隆间骨折持续性护理髋关节功能

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排舞流行于全民健身中的成因分析

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湖北体育科技 2013年第11期32卷 1038-1040页

作者：万小玲湖北省体操运动管理中心湖北武汉430205

排舞的动作优美流畅,风格特点鲜明,音乐节奏突出,队形变化多样有趣,其形式上的简单易学,内容上的兼容并收,高雅与流行的完美统一,使不同年龄层次的一般人都能很快融入其中进行练习。因此,大力推广排舞,丰富人们的业余文化生活,对于人们... 详细信息

排舞的动作优美流畅,风格特点鲜明,音乐节奏突出,队形变化多样有趣,其形式上的简单易学,内容上的兼容并收,高雅与流行的完美统一,使不同年龄层次的一般人都能很快融入其中进行练习。因此,大力推广排舞,丰富人们的业余文化生活,对于人们宣泄压力、缓解心情、营造和谐的社会关系将会起到重要的作用。

关键词：排舞流行健身价值成因

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The inhibitory effect of CORM-2 on inflammatory response in intracerebral hemorrhage rats and its mechanism

The inhibitory effect of CORM-2 on inflammatory response in ...

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江西省中西医结合学会神经科专业委员会第八次学术交流会

作者： Chen zhiying Zhang huiyan Li dongling Bao bing wang zhigang Yin min Zhou Jun wan xiaoling ’Yin xiaoping Department of Neurology Affiliated Hospital of Jiujiang University

Objective and background:Intracerebral hemorrhage(ICH) was a commom and often fatal type of *** perihematoma inflammatory injury after ICH was *** monoxide(CO) was accepted as a signalling molecule,being considered a *** administration of low levels of CO(as CORM-2) had been shown anti-inflammatory effect in many inflammatory *** aim of this study was to explore anti-inflammatory effect of CORM-2 in regulating the nuclear factor κb(NF-κB) signaling pathway in ***:Autologous femoral arterial blood injection method was employed to establish intracerebral hemorrhage model,SD rats were randomly divided into the following four groups,include control group,simple ICH group,CORM-2 treatment group and iCORM-2 treatment *** neurological scores were evaluated for the four groups at different time *** staining was utilized to observe the activation of microglia,the number of the cells co-expressed with *** blot assay was used to detect the heme oxygenase 1(HO-1)、inhibitor of IκB kinases β(IKKβ)、NF-κB and TNF-a proteins in each ***:The neurological scores of ICH group decreased at each time points compared with control group,and the lowest was at 48 hours(P 0.05).Conclusion:The IKK/NF-κB signaling pa

关键词： Intracerebral hemorrhage Carbon monoxide releasing molecule-2 IKK/NF-κB signaling pathway Anti-inflammatory effect

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合同制护士工作满意度调查分析及管理对策

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中国护理管理 2008年第7期8卷 60-62页

作者：万筱玲东莞市万江医院护理部广东省523050

目的:了解东莞市合同制护士工作满意度的整体状况,寻求并采取合理的合同制护士管理对策。方法:对东莞市合同制护士随机抽样进行问卷调查,问卷内容包括护士基本情况、工作满意度等。结果:不同学历、婚姻状况及职称的合同制护士工作满意... 详细信息

目的:了解东莞市合同制护士工作满意度的整体状况,寻求并采取合理的合同制护士管理对策。方法:对东莞市合同制护士随机抽样进行问卷调查,问卷内容包括护士基本情况、工作满意度等。结果:不同学历、婚姻状况及职称的合同制护士工作满意度有差别,不同职称的合同制护士在收入、工作任务、职业地位方面满意度均数之间的差异都有统计学意义。结论:有效提高合同制护士的工作满意度、稳定合同制护士队伍是提高医院护理质量的关键。

关键词：合同制护士工作满意度护理管理

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YSm750型压滤机头板轮的改进

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机械管理开发 2002年第5期17卷 22-23页

作者：万孝玲山西焦煤公司马兰矿选煤厂山西古交030205

论述头板轮易损的原因及机械改进措施。

关键词： YSm750型压滤机头板轮改进选矿厂

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