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Potential of Antibody-Dependent Cellular Cytotoxicity in Acute and Recovery Phases of SARS-CoV-2 Infection

Infectious Diseases & Immunity 2022年第2期2卷 74-82页

作者： Tingting Cui Mingzhu Huang xiaoling su Zhengfang Lin Jiaying Zhong Xiaoyun Yang Zhongfang Wang The State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510180China

Background:Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has caused a global pandemic that has resulted in millions of *** researchers have reported the existence of neutralizing antibodies and viral T cell immunity against SARS-CoV-2,little is known about the presence of antibody-dependent cellular cytotoxicity(ADCC)and its role in combating SARS-CoV-2 ***:Nineteen acute COVID-19 patients at the First Affiliated Hospital of Guangzhou Medical University from January to February,2020 and 55 recovery COVID-19 patients at the Second Peoples Hospital of Changde City from February,2020 to February,2021 were recruited in this *** plasma samples were collected.A virus-specific ADCC assay was performed to study the COVID-19 plasma *** correlations between ADCC and total IgG titer,including anti-RBD,anti-N,and neutralizing antibody titer were ***:A high level of ADCC with 0.86%of IFN-g+CD107a+NK cells induced by anti RBD antibodies and with 0.54%of IFN-g+CD107a+NK cells induced by anti N antibodies was *** activity peaked at 3 weeks after disease onset with 1.16%and 0.63%of IFN-g+CD107a+NK cells induced by anti RBD and anti N antibodies respectively,declined to 0.32%and 0.32%of IFN-g+CD107a+NK cells respectively after more than 2 months,and persisted for 12 months after disease *** ADCC did not aggravate the severity of COVID-19 in terms of sequential organ failure assessment,although ADCC decreased with the age of COVID-19 ***,ADCC response is not correlated with neutralizing antibody titer or total IgG titers against S protein RBD and N protein in acute *** in recovered patients showed a significant correlation with anti RBD IgG titer(R2=0.33,Psults provide evidence that vaccination should not only foc

关键词： Antibody-dependent cell cytotoxicity Aged immunity Anti-viral immunity SARS-CoV-2 Severity

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Mass Spectrometry Analysis of SARS-CoV-2 Nucleocapsid Protein Reveals Camouflaging Glycans and Unique Post-Translational Modifications

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Infectious Microbes & Diseases 2021年第3期3卷 149-157页

作者： Zeyu sun Xiaoqin Zheng Feiyang Ji Menghao Zhou xiaoling su Keyi Ren Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina

The devastating coronavirus disease 2019(COVID-19)pandemic has prompted worldwide efforts to study structural biological traits of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its viral *** to the Spike protein,which is the primary target for currently available vaccines or antibodies,knowledge about other virion structural components is *** high-resolution mass spectrometry,we report a comprehensive post-translational modification(PTM)analysis of nucleocapsid phosphoprotein(NCP),the most abundant structural component of the SARS-CoV-2 *** addition to phosphoryl groups,we show that the SARS-CoV-2 NCP is decorated with a variety of PTMs,including N-glycans and *** on newly identified PTMs,refined protein structural models of SARS-CoV-2 NCP were proposed and potential immune recognition epitopes of NCP were aligned with *** data can facilitate the design of novel vaccines or therapeutics targeting NCP,as valuable alternatives to the current vaccination and treatment paradigm that is under threat of the ever-mutating SARS-CoV-2 Spike protein.

关键词： glycosylation mass spectrometry nucleocapsid protein post-translational modification SARS-CoV-2

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基于LMDI的灌溉需水量变化影响因素分解

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农业工程学报 2017年第7期33卷 123-131页

作者：谢娟粟晓玲西北农林科技大学水利与建筑工程学院旱区农业水土工程教育部重点实验室杨凌712100

为研究灌溉需水量的驱动因素,该文以甘肃省武威市为研究区,基于扩展的Kaya恒等式构建灌溉需水量因素分解模型,利用对数平均迪氏指数分解法(logarithmic mean Divisia index,LMDI)对武威市1995—2012年总体及不同时段灌溉需水量驱动因子... 详细信息

为研究灌溉需水量的驱动因素,该文以甘肃省武威市为研究区,基于扩展的Kaya恒等式构建灌溉需水量因素分解模型,利用对数平均迪氏指数分解法(logarithmic mean Divisia index,LMDI)对武威市1995—2012年总体及不同时段灌溉需水量驱动因子进行因素分解,并计算灌溉需水量的影响因素的效应值。结果表明:近18 a来,武威市各行政区以节水高效为目的对武威种植结构进行了大幅调整,减少了高耗水作物小麦的种植面积,增加了耐旱的玉米、棉花等作物的种植面积;在1995—2012年间,武威市灌溉需水量减少了5.023×108 m^3,种植规模效应、种植结构效应、气候变化效应、节水工程效应分别为2.435×108 m^3、?3.994×108 m^3、?1.286×108 m^3、?2.178×108 m^3;不同作物对灌溉需水量增长的效应不同,其中小麦抑制灌溉需水量增长,是灌溉需水量减少的最主要影响因子;4个分解效应在不同时段对武威市各区县灌溉需水量作用不同,但除在2000—2005年对凉州区灌溉需水量增加有微弱的促进作用外,种植结构效应在不同时段均表现为抑制灌溉需水量增长的作用。研究结果为合理调控农业发展规模,制定武威市灌溉用水规划提供参考。

关键词：灌溉气候变化蒸发蒸腾量需水量因素分解 LMDI 武威市

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基于三维视角的农业干旱对气象干旱的时空响应关系

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农业工程学报 2020年第8期36卷 103-113页

作者：冯凯粟晓玲西北农林科技大学水利与建筑工程学院杨凌712100 西北农林科技大学旱区农业水土工程教育部重点实验室杨凌712100

气象干旱是农业干旱的驱动因素,研究农业干旱对气象干旱的响应特征对理解干旱演变机制具有重要作用,而以往研究大多忽略了干旱的时空连续特征。该研究以SPEI和aSPI分别表征气象干旱和农业干旱,基于三维干旱识别方法提取2类干旱的历时、... 详细信息

气象干旱是农业干旱的驱动因素,研究农业干旱对气象干旱的响应特征对理解干旱演变机制具有重要作用,而以往研究大多忽略了干旱的时空连续特征。该研究以SPEI和aSPI分别表征气象干旱和农业干旱,基于三维干旱识别方法提取2类干旱的历时、面积、烈度、强度、中心以及迁移距离6个干旱特征,分析黑河流域1961-2014年干旱时空连续动态演变特征;提出时空尺度干旱事件匹配准则,确定存在时空联系的气象-农业干旱事件,探讨气象、农业干旱时空响应特征并建立干旱特征响应模型。结果表明:1)从三维视角可准确全面地认识干旱事件时空动态演变过程及区域干旱发展规律,研究区秋冬春连旱一般起源于中游中部,沿东南方向逐渐向上游迁移并消亡,且干旱迁移速率在上游相对较快;2)基于时空尺度的干旱事件对匹配结果能够保证时空尺度上气象、农业干旱的复杂关系更接近实际,为准确分析气象-农业干旱时空响应特征提供保障;3)研究区气象-农业干旱历时、干旱面积和干旱烈度的最优响应模型分别为二次多项式、指数函数和指数函数。该研究为准确评估干旱时空动态演变规律及干旱响应关系提供了新思路。

关键词：干旱气象农业动态演变干旱匹配

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石羊河流域多目标水资源配置模型及其应用

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农业工程学报 2009年第11期25卷 128-132页

作者：粟晓玲康绍忠西北农林科技大学水利与建筑工程学院杨凌712100 中国农业大学中国农业水问题研究中心北京100083

石羊河位于甘肃河西走廊内陆河流域,降雨稀少,生态环境脆弱,水是控制生态系统演变和限制社会经济发展的关键因子,水资源的合理配置是流域水资源持续利用的基础。遵循生态平衡原则、效率原则以及公平性原则,以流域生态需水满足度最大为... 详细信息

石羊河位于甘肃河西走廊内陆河流域,降雨稀少,生态环境脆弱,水是控制生态系统演变和限制社会经济发展的关键因子,水资源的合理配置是流域水资源持续利用的基础。遵循生态平衡原则、效率原则以及公平性原则,以流域生态需水满足度最大为生态目标、流域总的净效益最大为经济目标、流域内各计算单元人均净效益变率的均方差最小为社会公平目标,建立了水资源配置多目标评价函数。从供水、节水、结构调整、虚拟水等措施假设不同的水资源模拟配置情景,通过计算单元优化配置模型和水资源转化模拟模型的耦合模型得到各方案的配置结果,由多目标评价函数评价各方案的优劣,提出了流域水资源合理配置的方案。

关键词：水资源多目标优化模型配置石羊河流域

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农业水资源优化配置研究进展

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灌溉排水学报 2022年第7期41卷 1-7,34页

作者：粟晓玲西北农林科技大学旱区农业水土工程教育部重点实验室陕西杨凌712100 西北农林科技大学水利与建筑工程学院陕西杨凌712100

【目的】变化环境下我国水资源供需矛盾加剧,农业是我国主要用水部门,农业水资源优化配置是缓解缺水、提高水资源利用效率的有效途径。【方法】基于农业水资源的概念和优化配置内容,对作物灌溉制度优化、灌区种植结构与空间布局优化、... 详细信息

【目的】变化环境下我国水资源供需矛盾加剧,农业是我国主要用水部门,农业水资源优化配置是缓解缺水、提高水资源利用效率的有效途径。【方法】基于农业水资源的概念和优化配置内容,对作物灌溉制度优化、灌区种植结构与空间布局优化、灌区多水源联合调控、区域农业水资源承载力评价与优化配置、水-粮食-能源协同优化以及优化配置方法等方面的研究进展进行了系统综述。【结论】指出了农业水资源优化配置研究存在的问题与挑战,提出进一步对考虑气候变化、虚拟水贸易和水碳足迹的种植结构优化、基于二元水循环转化模拟的灌区多水源优化调控、水-粮食-能源-生态协同优化以及灌区适宜生态结构与耕地规模的研究。

关键词：农业水资源种植结构空间布局耕地规模水-粮食-能源-生态

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The Effects of Microwave Ablation and surgical Resection on Hematogenous Dissemination of Cancer Cells in Treating Patients with Small Primary Hepatocellular Carcinoma

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Chinese Journal of Clinical Oncology 2006年第4期3卷 277-282页

作者： Chaoyang Wen Boowei Dong Ping Liang xiaoling Yu Li su Dejiang Yu Honglian Xia Department of Ultrasound General Hospital of the PLA Beijing 100853China.

OBJECTIVE To conduct a comparative study of the effects of treatment using microwave ablation versus surgical resection on hematogenous dissemination of cancer cells, and on the level of immune cells of the peripheral blood in patients with small primary hepatocellular carcinoma (PHC,≤5 cm). METHODS Forty patients with small PHC (maximal diameter≤5 cm) were divided into a microwave group (19 cases) and a surgical operation group (21 cases). A real-time (RT) quantitative nested RT-PCR examination was performed for peripheral blood alpha-fetoprotein (AFP) mRNA. Studies were conducted to determine the level of CD3, CD4, CD8 and CD4/CD8 cells and for liver function at 30 min before, and 30 min,1 day and 3 days after the treatment. REsuLTS Compared to the value before ablation, no obvious changes of CD3, CD4, CD8 and CD4/CD8 cells were found in patients of the microwave group within 7 days after ablation, but CD3, CD4 and CD4/CD8 cells in the operation group were lower compared to that before operation. The copy number of AFP mRNA in the peripheral blood samples of the patients of the 2 groups before operation was determined in 67.5% of the patients (27/40). There was an rise in the expression after treatment but no statistical difference was found in comparing the 2 groups. Follow-up of the patients was conducted for 1 to 16 months. For patients with continuous expression of peripheral blood AFP mRNA, the possibility of relapse and metastasis was increased. CONCLUSION surgical resection or microwave ablation can cause more exfoliation of hepatoma carcinoma cells in the peripheral blood of patients with small PHC. The immune function of peripheral blood cells decreased in the patients after surgical resection, however, the immune function was better protected following microwave ablation. Microwave ablation causes minor reduction in liver function, and the treatment method presents a definite value for PHC therapy.

关键词： AFP mRNA hepatocellular carcinoma microwave ablation RT-fluorescent quantitative nested RT-PCR immune response.

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Study on Revision and Compilation of Rainstorm Intensity Formula in Liuzhou City and County

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Meteorological and Environmental Research 2018年第2期9卷 8-11页

作者： Xie Dong su xiaoling Li Yaqin Liuzhou Meteorological Bureau Liuzhou 545001 China

Rainstorm intensity formula,main basis of solving urban waterlogging,is the basis of scientifically and rationally making urban drainage professional planning and drainage engineering design. In this paper,compilation of rainstorm intensity formula in Luzhai County was taken as the case,revision and compilation techniques and research methods of rainstorm intensity formulas in municipal district and administrated county of Liuzhou were introduced. According to the Design Specification for Outdoor Drainage（ GB 50014-2006,2016） and the Technical Guidelines for Establishment of Intensity-Duration-Frequency Curve Design Rainstorm Profile,historical rainfall data at Luzhai National Weather Station were sampled by using annual maximum method,and sampling time was from1980 to 2016. The period with the maximum rainfall was divided into 11 time intervals： 5,10,15,20,30,45,60,90,120,150 and 180 min. Fitting adjust of rainstorm sample data was conducted by using Pearson-III distribution curve,rainstorm intensity formula was fitted by the least square method,and calculation accuracy test corresponded with the requirement of Design Specification for Outdoor Drainage（ GB 50014-2006,2016）. Conclusions and suggestions were as below： firstly,rainstorm intensity formula was compiled and calculated according to the recommended methods of the Design Specification for Outdoor Drainage（ GB 50014-2006,2016） and the Technical Guidelines for Establishment of Intensity-Duration-Frequency Curve Design Rainstorm Profile,calculation process was normative,and calculation result error met the requirement of the specification. Secondly,sampling by annual maximum method was more suitable for the expression of periodic hydrometeorological law by taking year as reappearance period,and could cause better randomness and independence of statistical sample,and the method was scientific and reliable. Thirdly,rainstorm intensity formula compiled by taking rainfall data in national weather stations of Liuzh

关键词： Liuzhou city and county Rainstorm intensity formula Revision Compilation Research

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概念性生态水文模型区分气候变化与土地利用变化的径流影响

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水力发电学报 2014年第3期33卷 36-41,117页

作者：郭静粟晓玲西北农林科技大学水利与建筑工程学院陕西杨凌712100

区分气候变化和人类活动对流域径流量的相对影响,对深入认识流域水资源形成和演变规律、合理开发利用水资源和保护生态环境具有重要的科学价值。采用由美国学者Tomer等提出的概念性生态水文模型,基于水量平衡和能量平衡原理,同时考虑气... 详细信息

区分气候变化和人类活动对流域径流量的相对影响,对深入认识流域水资源形成和演变规律、合理开发利用水资源和保护生态环境具有重要的科学价值。采用由美国学者Tomer等提出的概念性生态水文模型,基于水量平衡和能量平衡原理,同时考虑气候变化和人类活动的作用,定性区分气候变化和土地利用方式改变对径流变化的影响。应用于石羊河流域内出山口径流有减少趋势且存在变异的大靖河、古浪河、黄羊河、杂木河和金塔河5个子流域,结果表明在同一干旱期不同子流域径流变化的影响因素存在差异,在整个研究期气候变化为各河流出山口径流量变化的主要影响因子。

关键词：水文学气候变化土地利用方式概念性生态水文模型出山口径流石羊河流域

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SARS-CoV-2-specific CD4^(+)T cells are associated with long-term persistence of neutralizing antibodies

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1773-1782页

作者： Zhongfang Wang Xiaoyun Yang Xinyue Mei Yumin Zhou Zhiqiang Tang Guichang Li Jiaying Zhong Mengqiu Yu Mingzhu Huang xiaoling su Bijia Lin Pengxing Cao Ji Yang Pixin Ran State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina The Second People’s Hospital of Changde HunanChina School of mathematics and Statistics University of MelbourneMelbourneVICAustralia

Understanding the decay and maintenance of long-term SARS-CoV-2 neutralizing antibodies in infected or vaccinated people and how vaccines protect against other SARS-CoV-2 variants is critical for assessing public vaccination ***,we measured different plasm antibody levels 2 and 12 months after disease onset,including anti-RBD,anti-N,total neutralizing antibodies,and two neutralizing-antibody *** found that total neutralizing antibodies declined more slowly than total anti-RBD and anti-N IgG.

关键词： antibodies neutral assessing

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