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Spatiotemporal Characteristics of Drought in the Heihe River Basin Based on the Extreme-Point Symmetric Mode Decomposition Method

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International Journal of Disaster Risk Science 2019年第4期10卷 591-603页

作者： Kai Feng xiaoling su College of Water Resources and Architectural Engineering Northwest A&F UniversityYangling 712100China Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid Areas Ministry of EducationNorthwest A&F UniversityYangling 712100China

Assessment of spatiotemporal characteristics of drought under climate change is significant for drought mitigation.In this study,the standardized precipitation evapotranspiration index(SPEI)calculated at different timescales was adopted to describe the drought conditions in the Heihe River Basin(HRB)from 1961 to 2014.The period characteristics and spatiotemporal distribution of drought were analyzed by using the extreme-point symmetric mode decomposition(ESMD)and inverse distance weight interpolation methods.Four main results were obtained.(1)The SPEI series of the upper reaches of the HRB at different timescales showed an upward trend(not significant)during 1961–2014.In the middle and lower reaches,the SPEI series exhibited significant downward trends.(2)The annual SPEI series of the lower reaches was decomposed through the ESMD method and exhibited a fluctuating downward trend as a whole.The oscillation showed quasi-3.4-year and quasi-4.5-year periods in the interannual variation,while a quasi-13.5-year period occurred in the interdecadal variation.The interannual period plays a leading role in drought variation across the HRB.(3)The entire research period was divided into three subperiods by the Bernaola–Galvan segmentation algorithm:1961–1966,1967–1996,and 1997–2014.The spring drought frequency and autumn drought intensity arrived at their maxima in the lower reaches during 1997–2014,with values of 72.22%and 1.56,respectively.The high frequency and intensity areas of spring,summer,and autumn drought moved from the middle-upper reaches to the middle-lower reaches of the HRB during 1961–2014.(4)Compared to the wavelet transform,the ESMD method has self-adaptability for signal decomposition and is more accurate for drought period analysis.Extreme-point symmetric mode decomposition is a more efficient decomposition method for nonlinear and nonstationary time series and has important significance for revealing the complicated change features of climate systems.

关键词： China Drought Heihe River Basin Spatiotemporal drought analysis

Potential of Antibody-Dependent Cellular Cytotoxicity in Acute and Recovery Phases of SARS-CoV-2 Infection

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Infectious Diseases & Immunity 2022年第2期2卷 74-82页

作者： Tingting Cui Mingzhu Huang xiaoling su Zhengfang Lin Jiaying Zhong Xiaoyun Yang Zhongfang Wang The State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510180China

Background:Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has caused a global pandemic that has resulted in millions of casualties.Although researchers have reported the existence of neutralizing antibodies and viral T cell immunity against SARS-CoV-2,little is known about the presence of antibody-dependent cellular cytotoxicity(ADCC)and its role in combating SARS-CoV-2 infection.Methods:Nineteen acute COVID-19 patients at the First Affiliated Hospital of Guangzhou Medical University from January to February,2020 and 55 recovery COVID-19 patients at the Second Peoples Hospital of Changde City from February,2020 to February,2021 were recruited in this study.Longitudinal plasma samples were collected.A virus-specific ADCC assay was performed to study the COVID-19 plasma samples.The correlations between ADCC and total IgG titer,including anti-RBD,anti-N,and neutralizing antibody titer were analyzed.Results:A high level of ADCC with 0.86%of IFN-g+CD107a+NK cells induced by anti RBD antibodies and with 0.54%of IFN-g+CD107a+NK cells induced by anti N antibodies was observed.This activity peaked at 3 weeks after disease onset with 1.16%and 0.63%of IFN-g+CD107a+NK cells induced by anti RBD and anti N antibodies respectively,declined to 0.32%and 0.32%of IFN-g+CD107a+NK cells respectively after more than 2 months,and persisted for 12 months after disease onset.The ADCC did not aggravate the severity of COVID-19 in terms of sequential organ failure assessment,although ADCC decreased with the age of COVID-19 patients.Interestingly,ADCC response is not correlated with neutralizing antibody titer or total IgG titers against S protein RBD and N protein in acute patients.ADCC in recovered patients showed a significant correlation with anti RBD IgG titer(R2=0.33,Psults provide evidence that vaccination should not only focus on neutralizing antibodies but also binding a

关键词： Antibody-dependent cell cytotoxicity Aged immunity Anti-viral immunity SARS-CoV-2 Severity

SARS-CoV-2-specific CD4^(+)T cells are associated with long-term persistence of neutralizing antibodies

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1773-1782页

作者： Zhongfang Wang Xiaoyun Yang Xinyue Mei Yumin Zhou Zhiqiang Tang Guichang Li Jiaying Zhong Mengqiu Yu Mingzhu Huang xiaoling su Bijia Lin Pengxing Cao Ji Yang Pixin Ran State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina The Second People’s Hospital of Changde HunanChina School of mathematics and Statistics University of MelbourneMelbourneVICAustralia

Understanding the decay and maintenance of long-term SARS-CoV-2 neutralizing antibodies in infected or vaccinated people and how vaccines protect against other SARS-CoV-2 variants is critical for assessing public vaccination plans.Here,we measured different plasm antibody levels 2 and 12 months after disease onset,including anti-RBD,anti-N,total neutralizing antibodies,and two neutralizing-antibody clusters.We found that total neutralizing antibodies declined more slowly than total anti-RBD and anti-N IgG.

关键词： antibodies neutral assessing

基于生态系统恢复力的干旱区植被生态需水阈值计算方法与应用

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湖泊科学 2024年第2期36卷 645-656页

作者：雷逸甦粟晓玲褚江东张特刘雨翰西北农林科技大学旱区农业水土工程教育部重点实验室杨凌712100 西北农林科技大学水利与建筑工程学院杨凌712100

本文以石羊河流域中下游为研究区,采用考虑生态系统恢复力(latitude of ecosystem resilience,LER)的月尺度生态需水评估方法计算19822020年植被月适宜生态需水量、最小生态需水量以及相应的生态缺水量,并与土壤水分特征值法(characteri... 详细信息

本文以石羊河流域中下游为研究区,采用考虑生态系统恢复力(latitude of ecosystem resilience,LER)的月尺度生态需水评估方法计算19822020年植被月适宜生态需水量、最小生态需水量以及相应的生态缺水量,并与土壤水分特征值法(characteristic value of soil water,CVSW)进行比较,分析不同类型植被生长期的水分盈亏关系。结果表明:LER法和CVSW法计算结果相近,但LER法具有更大的生态需水阈值区间;天然降水基本可以满足植被的基本生存,但无法满足正常生长需求;LER法的适宜需水条件下,各植被生长期总体处于缺水状态,缺水严重程度排序为灌木林>其他林地>疏林地>高覆盖度草地>中覆盖度草地>有林地,全部植被生长期总适宜生态需水量为3.7×10^(8)m^(3),亏缺水量为1.2×10^(8)m^(3),同一植被亏缺水量基本符合春秋多、夏季少的规律;最小需水条件下,只有其他林地存在生长期缺水情况,全部植被生长期总最小生态需水量为0.8×10^(8)m^(3);在缺乏土壤水分数据的干旱地区,LER法具有良好的适用性。研究结果可为石羊河流域水资源高效利用和干旱区生态系统的恢复与重建提供理论参考。

关键词：生态需水生态系统恢复力干旱区植被石羊河流域 Penman-Monteith公式

Cropping pattern optimization considering uncertainty of water availability and water saving potential

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International Journal of Agricultural and Biological Engineering 2018年第1期11卷 178-186页

作者： Lina Hao xiaoling su Vijay P.Singh College of Water Resources and Architectural Engineering Northwest A&F UniversityYangling 712100ShaanxiChina Department of Biological&Agricultural Engineering and Zachry Department of Civil Engineering Texas A&M UniversityCollege StationTX 77843-2117USA

In arid and semi-arid areas,the profitability of irrigated agriculture mainly depends on the availability of water resources and optimal cropping patterns of irrigation districts.In this study,an integrated agricultural cropping pattern optimization model was developed with considering the uncertainty of water availability and water saving potential in the future,aiming to maximize agricultural net benefit per unit of irrigation water.The available water which was based on the uncertainty of runoff was divided into five scenarios.The irrigation water-saving potential in the future was quantified by assuming an increase in the rate irrigation water-saving of 10% and 20%.The model was applied to the middle reaches of Heihe River basin,in Gansu Province,China.Results showed that if the irrigation water-saving rate was assumed to increase by 10%,then the net water-saving quantity would increase by 21.5-22.5 million m3 and the gross water-saving quantity would increase by 275.7-303.0 million m3.Similarly,if the irrigation water-saving rate increased by 20%,then the net water-saving quantity would increase by 43.0-45.1 million m3 and the gross water-saving quantity would increase by 331.7-383.2 million m3.If the agricultural cropping pattern was optimized,the optimal water and cultivated area allocation for maize would be greater than those for other crops.Under the premise that similar volume of irrigation water quantity was available in different scenarios,results showed differences in system benefit and net benefit per unit of irrigation water,for the distribution of available irrigation water was diverse in different irrigation districts.

关键词： cropping pattern optimization irrigation water-saving potential different scenarios water availability water use efficiency particle swarm optimization(PSO)

HIV-2 Seroepidemiological Evidence in Hunan Province—China,2003–2020

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China CDC weekly 2021年第38期3卷 811-812页

作者： Jinyu Peng Jianmei He Jun Zheng Xiaobai Zou Yang Jiang xiaoling su Xi Chen Hunan Provincial Center for Disease Control and Prevention ChangshaHunanChina Xiangtan Center for Disease Control and Prevention XiangtanHunanChina

The human immunodeficiency viruses-2(HIV-2)is endemic in West Africa and is a rarely imported infectious disease in China due to the small number of cases having had a history of living abroad(1–3).In 2007,through routine HIV surveillance,2 HIV-2 infected individuals were confirmed by serology and nucleic acid testing,becoming the first report of HIV-2 in China.Epidemiological case investigation showed that the two infected individuals had sexual contact.

关键词： Hunan becoming routine

Mass Spectrometry Analysis of SARS-CoV-2 Nucleocapsid Protein Reveals Camouflaging Glycans and Unique Post-Translational Modifications

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Infectious Microbes & Diseases 2021年第3期3卷 149-157页

作者： Zeyu sun Xiaoqin Zheng Feiyang Ji Menghao Zhou xiaoling su Keyi Ren Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina

The devastating coronavirus disease 2019(COVID-19)pandemic has prompted worldwide efforts to study structural biological traits of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its viral components.Compared to the Spike protein,which is the primary target for currently available vaccines or antibodies,knowledge about other virion structural components is incomplete.Using high-resolution mass spectrometry,we report a comprehensive post-translational modification(PTM)analysis of nucleocapsid phosphoprotein(NCP),the most abundant structural component of the SARS-CoV-2 virion.In addition to phosphoryl groups,we show that the SARS-CoV-2 NCP is decorated with a variety of PTMs,including N-glycans and ubiquitin.Based on newly identified PTMs,refined protein structural models of SARS-CoV-2 NCP were proposed and potential immune recognition epitopes of NCP were aligned with PTMs.These data can facilitate the design of novel vaccines or therapeutics targeting NCP,as valuable alternatives to the current vaccination and treatment paradigm that is under threat of the ever-mutating SARS-CoV-2 Spike protein.

关键词： glycosylation mass spectrometry nucleocapsid protein post-translational modification SARS-CoV-2

计及能源自洽率和共享氢储能的电-氢-交通耦合配电网低碳经济运行

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高电压技术 2024年第6期50卷 2424-2432页

作者：苏小玲陈来军赵超凡曹博文刘立泽青海大学新能源电力系统智慧运行教育部重点实验室西宁810016

新型储能的多元化发展为能源资源的优化配置和就地高水平消纳奠定了基础,为此提出了一种计及能源自洽率和共享氢储能(shared hydrogenstorage,SHS)的能源网低碳经济调度方法。设计了包含电负荷-氢负荷的氢燃料电池车(hydrogen fuel cell... 详细信息

新型储能的多元化发展为能源资源的优化配置和就地高水平消纳奠定了基础,为此提出了一种计及能源自洽率和共享氢储能(shared hydrogenstorage,SHS)的能源网低碳经济调度方法。设计了包含电负荷-氢负荷的氢燃料电池车(hydrogen fuel cell vehicle,HFCV)交通网与新能源配电网双向耦合架构。在此基础上,以提高能源自洽率、降低碳排放成本为目标,综合考虑配电网、交通网、氢储能系统的运行约束条件以及短期氢储能(short-term hydrogenstorage,STHS)和SHS服务,建立了电-氢-交通耦合配电网的低碳经济优化调度模型,并给出了基于精英遗传算法(elitist strategy genetic algorithm,ESGA)的求解方法。算例分析证明,提出的方法可有效提升电-氢-交通耦合网络能源自洽率、降低整体系统碳排放成本。

关键词：能源自洽率电-氢-交通耦合新型储能共享氢储能短期氢储能

考虑水转化过程的干旱区内陆河流域适宜灌溉规模

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农业工程学报 2024年第6期40卷 228-236页

作者：胡雪雪粟晓玲朱兴宇褚江东张特吴海江西北农林科技大学旱区农业水土工程教育部重点实验室杨凌712100 西北农林科技大学水利与建筑工程学院杨凌712100

农业适水发展是保障干旱区水土资源高效利用和生态健康的关键,其核心在于如何科学确定灌溉规模,进而控制农业灌溉用水量。该研究以石羊河流域为研究区,在明确非灌溉需水量的基础上,基于水均衡模型计算考虑水转化过程的不同水文年农业灌... 详细信息

农业适水发展是保障干旱区水土资源高效利用和生态健康的关键,其核心在于如何科学确定灌溉规模,进而控制农业灌溉用水量。该研究以石羊河流域为研究区,在明确非灌溉需水量的基础上,基于水均衡模型计算考虑水转化过程的不同水文年农业灌溉可用水量,并构建多目标种植结构优化模型对作物种植结构进行调整,最后改进水热平衡模型构建考虑水转化过程的旱区适宜灌溉规模计算模型,分析流域不同情景下的适宜灌溉规模。结果表明:地表水地下水联合调控下,石羊河流域丰、平、枯水年的灌溉可用水量分别为18.97亿~21.57亿、14.75亿~17.51亿、12.31亿~14.95亿m^(3);优化作物种植结构后能够以减少2.94%的经济效益实现14.13%的灌溉节水;构建的适宜灌溉规模计算模型在干旱区内陆河流域具有较好的适用性,采用该方法得到现状条件下石羊河流域丰、平、枯水年的适宜灌溉规模分别为27.73万~31.66万、21.55万~25.76万、18.01万~22.03万hm^(2),提高节水水平、调整种植结构后,流域的适宜灌溉规模有所增加。现状2020年(平水年)的实际灌溉面积高于当地水资源能够承载的临界适宜灌溉规模,需压减2.13万~6.34万hm^(2)。研究结果可在宏观层面上为决策者制定适水农业发展方案提供理论依据。

关键词：水资源灌溉模型水转化适宜规模种植结构优化石羊河流域