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Construction and validation of a risk-prediction model for anastomotic leakage after radical gastrectomy: A cohort study in China

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第1期7卷 34-43页

作者： Jinrui Wang xiaolin Liu Hongying Pan Yihong xu Mizhi Wu Xiuping Li Yang Gao Meijuan Wang Mengya Yan Nursing Department Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China School of Nursing Zhejiang Chinese Medical UniversityHangzhou 310053China

Objectives:Anastomotic leakage(AL)stands out as a prevalent and severe complication following gastric cancer *** frequently precipitates additional serious complications,significantly influencing the overall survival time of *** study aims to enhance the risk-assessment strategy for AL following gastrectomy for gastric ***:This study included a derivation cohort and validation *** derivation cohort included patients who underwent radical gastrectomy at Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,from January 1,2015 to December 31,*** evidence-based predictor questionnaire was crafted through extensive literature review and panel *** on the questionnaire,inpatient data were collected to form a model-derivation *** cohort underwent both univariate and multivariate analyses to identify factors associated with AL events,and a logistic regression model with stepwise regression was developed.A 5-fold cross-validation ensured model *** validation cohort included patients from August 1,2021 to December 31,2021 at the same *** the same imputation method,we organized the validation-queue *** then employed the risk-prediction model constructed in the earlier phase of the study to predict the risk of AL in the subjects included in the validation *** compared the predictions with the actual occurrence,and evaluated the external validation performance of the model using model-evaluation indicators such as the area under the receiver operating characteristic curve(AUROC),Brier score,and calibration ***:The derivation cohort included 1377 patients,and the validation cohort included 131 *** independent predictors of AL after radical gastrectomy included age65 y,preoperative albumin<35 g/L,resection extent,operative time240 min,and intraoperative blood loss90 *** predictive model exhibited a solid AUROC of 0.750(95%CI:0.694e0.806;p<0.001)with a Br

关键词： Stomach neoplasms Anastomotic leak Risk factors Prediction model Risk assessment

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Serum interleukin-10 levels and adverse events in patients with acute coronary syndrome： a systematic review and meta-analysis

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Chinese Medical Journal 2014年第1期127卷 150-156页

作者： Liu Jun Jia Yanjun Li xiaolin xu Ruixia Zhu Chenggang Guo Yuanlin Wu Naqiong Li Jianjun Division of Dyslipidemia Cardiovascular Medicine Fu Wai HospitalState Key Laboratory of Cardiovascular Disease National Centerfor Cardiovascular Diseases Chinese Academy of Medical SciencesPeking Union Medical College Beijing 100037 China

Background Several studies investigating the prognostic utility of interleukin-10 （IL-10） in patients with acute coronary syndrome （ACS） have provided conflicting *** aim of the study was to assess the existing evidence regarding association between serum IL-10 levels and adverse *** Literature search was performed in PubMed,EMBASE,and Cochrane Trials Register databases from their inception to September 30,*** addition,reference lists of the included articles and their related citations in PubMed were also reviewed for additional pertinent *** A total of 12 eligible studies comprising a total of 5882 patients were *** pooled relative risks for both studies reporting the risk estimates by IL-10 categories and studies reporting the risk estimates by unit IL-10 indicated an association between high IL-10 levels and adverse *** and subgroup analysis indicated that the results obtained in IL-10 categories were not *** Data from our meta-analysis supported the existence of a relationship between high serum IL-10 levels and adverse events in patients with *** study with longer follow-up is needed to confirm the findings.

关键词： interleukins acute coronary syndrome cardiovascular event meta-analysis

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High-Resolution Mesoscale Analysis Data from the South China Heavy Rainfall Experiment （SCHeREX）： Data Generation and Quality Evaluation

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Acta meteorologica Sinica 2011年第4期25卷 478-493页

作者： NI Yunqi CUI Chunguang LI Hongli PENG Juxiang QIU xuexing ZHANG Yanxia xu xiaolin GAO Mei JIE Lianshu ZHANG Wenhua Chinese Academy of Meteorological Sciences China Meteorological Administration （CMA） Beijing 100081 Wuhan Institute of Heavy Rain CMA Wuhan 430074 Guangzhou Institute of Tropical and Marine Meteorology CMA Guangzhou 510080 Anhui Meteorological Observatory Hefei 230031 Shanghai Typhoon Institute CMA Shanghai 230030

In this study, the observational data acquired in the South China Heavy Rainfall Experiment （SCHeREX） from May to July 2008 and 2009 were integrated and assimilated with the US National Oceanic and Atmospheric Administration＇s （NOAA） Local Analysis and Prediction System （LAPS; information available online at http：//***）. A high-resolution mesoscale analysis dataset was then generated at a spatial resolution of 5 km and a temporal resolution of 3 h in four observational areas： South China, Central China, Jianghuai area, and Yangtze River Delta area. The quality of this dataset was evaluated as follows. First, the dataset was qualitatively compared with radar reflectivity and TBB image for specific heavy rainfall events so as to examine its capability in reproduction of mesoscale systems. The results show that the SCHeREX analysis dataset has a strong capability in capturing severe mesoscale convective systems. Second, the mean deviation and root mean square error of the SCHeREX mesoscale analysis fields were analyzed and compared with radiosonde data. The results reveal that the errors of geopotential height, temperature, relative humidity, and wind of the SCHeREX analysis were within the acceptable range of observation errors. In particular, the average error was 45 m for geopotential height between 700 and 925 hPa, 1.0-1.1°C for temperature, less than 20% for relative humidity, 1.5-2.0 m s-1 for wind speed, and 20-25° for wind direction. The above results clearly indicate that the SCHeREX mesoscale analysis dataset is of high quality and sufficient reliability, and it is applicable to refined mesoscale weather studies.

关键词： diagnostic analysis integration and assimilation applicability quality evaluation

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中国科技安全图景:成果、问题和未来

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科研管理 2022年第1期43卷 22-31页

作者：黄广平徐晓林华中科技大学公共管理学院湖北武汉430074 湖南农业大学公共管理与法学学院湖南长沙410128

科技安全是新时代科技工作的重大任务之一。现有研究数量较少,又缺乏国外经验借鉴,使得维护国家科技安全成为一个"无人区",跨过"无人区"需要方向指引。本文研读了与科技安全相关的所有文献,分析了研究的总体情况,归纳整理了研究的具体成... 详细信息

科技安全是新时代科技工作的重大任务之一。现有研究数量较少,又缺乏国外经验借鉴,使得维护国家科技安全成为一个"无人区",跨过"无人区"需要方向指引。本文研读了与科技安全相关的所有文献,分析了研究的总体情况,归纳整理了研究的具体成果,结合其他信息,对研究及实践的现状及存在的问题进行了总结,展望了中国科技安全研究及实践需解决的关键问题。本研究呈现的中国科技安全研究及实践图景,可为认识中国科技安全研究的历史、研究及实践的现状和未来方向设置提供参考。

关键词：科技安全科技安全研究科技安全实践

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Rational design of a single-component mRNA vaccine against orthopoxvirus and SARS-CoV-2

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Science China(Life Sciences) 2024年第6期67卷 1311-1313页

作者： Yilong Yang Xiaofan Zhao Yu Li Xiaodong Zai Xinyi Wang Yue Zhang xiaolin Wang Peng Lv Jun Zhang Lihua Hou Junjie xu Wei Chen Laboratory of Advanced Biotechnology Beijing Institute of BiotechnologyAcademy of Military Medical SciencesBeijing 100071China

Dear Editor,In the era of COVID-19,the prevalence of viruses from other families poses new threats to *** the eradication of smallpox in 1980,the global outbreak of monkeypox in 2022(Lum et al.,2022;Nuzzo et al.,2022)alerted that the re-emerging orthopoxvirus(OPXV)remained a persistent threat to global *** includes a number of viruses with a broad host range,including variola virus(VARV),monkeypox virus(MPXV),vaccinia virus(VACV).

关键词： vaccine Rational

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Novel circular RNA expression profile of uveal melanoma revealed by microarray

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Chinese Journal of Cancer Research 2018年第6期30卷 656-668页

作者： xuan Yang Yang Li Yueming Liu xiaolin xu Yingzhi Wang Yanni Yan Wenjia Zhou Jingyan Yang Wenbin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology & Visual Sciences Key LabBeijing Tongren HospitalCapital Medical University Beijing Institute of Ophthalmology Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology & Visual Sciences Key Laboratory

Objective: The present study aimed to investigate circular RNA(circRNA) expression in uveal melanoma(UM).Methods: First,we used microarray to compare the expression profiles of circRNA in five UM samples and five normal uvea ***,bioinformatics analyses,including gene ontology(GO) analysis and pathway analysis,were applied to study these differentially expressed circRNAs to predict pathogenic pathways that may be *** real-time polymerase chain reaction(qRT-PCR) in 20 UM samples and 20 normal uvea samples was used to confirm the circRNA expression profiles obtained from the microarray ***,we analyzed the interaction between validated circRNAs and their potential cancer-associated miRNA ***: In total,50,579 circRNAs [fold change(FC) ≥2.0; P<0.05],including 20,654 up-regulated and 29,925 down-regulated circRNAs,were identified as differentially expressed between UM tissues and normal uvea *** used qRT-PCR to verify seven dysregulated circRNAs indicated by the microarray data,including hsacirc0119873,hsacirc0128533,hsacirc0047924,hsacirc0103232,hsa-circRNA10628-6,hsacirc0032148 and hsacirc0133460,which may be promising candidates to study future molecular ***: This study explored,for the first time,the abnormal expression of circRNAs in UM and described the expression profile of circRNAs,providing a new potential target for the mechanism of UM and future treatment of UM.

关键词： Uveal melanoma circular RNA microarray noncoding RNA

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一种车辆多源信息故障诊断方法

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国外电子测量技术 2022年第8期41卷 68-75页

作者：徐晓林赵毅栋郑州科技学院郑州450064 宇通客车股份有限公司郑州450000

无人驾驶作为一门综合性技术,其高度的可靠性及安全性是其发展过程中的必备属性;且自动驾驶程度越高涉及的各软、硬组件故障种类越多、故障监控、检测、处理越复杂,导致故障率越高、安全性越低。设计一种多源信息故障诊断系统,在ward聚... 详细信息

无人驾驶作为一门综合性技术,其高度的可靠性及安全性是其发展过程中的必备属性;且自动驾驶程度越高涉及的各软、硬组件故障种类越多、故障监控、检测、处理越复杂,导致故障率越高、安全性越低。设计一种多源信息故障诊断系统,在ward聚类方法基础上提出一种先分离再凝聚的混合聚类方法来搭建自动驾驶多源信息故障诊断模型,并采用分布式消息中间件ZMQ搭建各故障信息模块的并行异步消息框架,将车端各故障信息基于ZMQ进行统一发布订阅;以此建立多源故障信息的车端全故障码统计诊断库供不同模块共享使用;最后通过一种诊断分析工具实现各故障的在线诊断实时分析及离线下载保存,为自动驾驶提供全面、准确、实时的故障诊断方法,保证自动驾驶系统在复杂环境中的可靠、稳定工作。

关键词：无人驾驶多源信息故障混合聚类统计 ZMQ 诊断库诊断分析工具

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早期脊柱融合对早发性脊柱侧凸患者肺功能及胸廓发育的影响

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中华骨科杂志 2022年第6期42卷 382-387页

作者：许晓林王升儒仉建国北京协和医院外科北京100730 北京协和医院骨科北京100730

早发性脊柱侧凸(early-onset scoliosis,EOS)指10岁之前因任何原因发病的脊柱侧凸,如伴严重侧凸往往需要早期手术干预,但过早的脊柱融合又会对其胸廓及肺功能产生影响。依据发病原因,EOS可分为先天性、神经肌肉型、综合征相关型及特发... 详细信息

早发性脊柱侧凸(early-onset scoliosis,EOS)指10岁之前因任何原因发病的脊柱侧凸,如伴严重侧凸往往需要早期手术干预,但过早的脊柱融合又会对其胸廓及肺功能产生影响。依据发病原因,EOS可分为先天性、神经肌肉型、综合征相关型及特发性脊柱侧凸,治疗目标为控制侧凸进展的同时允许脊柱及胸廓尽可能地生长,以促进正常的肺泡及肺功能的发育,具体方式包括理疗、石膏及支具矫形、手术。由于患者年龄较小,处于胸廓及肺部发育的关键时期,且EOS的临床不一致性及复杂性,一些合并严重胸廓畸形的EOS还可能导致严重的心肺功能不全及相关并发症,威胁患儿的生命。但侧凸本身带来的胸廓解剖上的变化会限制胸壁运动、降低肺的顺应性,造成胸廓径线改变以及容积变小,导致限制性通气功能障碍。且脊柱融合术作为治疗EOS的主要干预手段,可矫正侧凸并控制进展,仍为一些严重的EOS主要外科选择。但过早的脊柱融合在限制胸廓高度及生长速度的同时甚至会导致肺组织受压变形、肺泡萎陷及发育异常,阻碍患儿的循环系统,导致呼吸功能障碍。其原因可能包括脊柱生长受限、曲轴现象以及肺泡增殖减少。针对早期脊柱融合对于EOS患者肺功能及胸廓发育的影响进行回顾和总结,并探讨其中可能存在的机制,以期更好地指导临床。

关键词：脊柱融合术心肺功能不全肺泡萎陷呼吸功能障碍胸廓畸形发育异常神经肌肉脊柱侧凸

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Clinical treatment and prognostic observation for different pathological infiltrations in 537 patients with unilateral retinoblastoma

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Chinese Medical Journal 2014年第20期127卷 3581-3586页

作者： Wang Yizhuo Huang Dongsheng Shi Jitong Ma Jianmin Zhao Junyang Li Bin xu xiaolin Hu Huimin Zhou Yan Sun Yongchang Department of Pediatrics BeijingTongren Hospital Capital Medical University Beijing 100730 China Department of Ophthalmology BeijingTongren Hospital Capital Medical University Beijing 100730 China Department of Respiratory Medicine BeijingTongren Hospital Capital Medical University Beijing 100730 China

Background The use of post-enucleation adjuvant therapy to decrease the extraocular relapse rate is frequently considered, but there is much controversy about the indications for adjuvant therapy. The aim of this retrospective study was to observe the treatment and prognosis for different degrees of invasion of eye tissue in retinoblastoma （RB） and identify the indications for post-enucleation adjuvant therapy. Methods We recruited 537 children who had been diagnosed with unilateral RB and had received enucleation from January 2006 to December 2012 in our hospital, and divided them into three groups according to their number of histopathologic risk factors： 0 factor, 1 factor, or 〉2 factors. Histopathologic high-risk factors included invasion of the optic nerve posterior to the ethmoid plate （including optic nerve stumps） and extensive invasions of the choroid, sclera, anterior chamber, iris, and ciliary body. Treatment was delivered accordingly, and the prognosis of different degrees of histopathologic invasion was observed. The subjects were followed up for 6 months to 7 years （average follow-up time： 35 months）. Statistical analysis was analyzed using X2 test. P 〈0.05 was considered significant. Results Of the 537 RB patients who received enucleation, 25 died （overall survival： 95.3%）. Of the 369 （68.7%） with no histopathologic risk factors, 1 died of recurrence, with a mortality rate of 0.3%, whereas of the 168 （31.3%） with histopathologic risk factors, 26 had recurrences and 24 died （mortality rate： 14.3%; P=0.000）. Of the 93 patients （17.3%）, each of whom had a single risk factor, nine had recurrences, 16 died （8.6%）. Of the 75 patients （14%） with two or more high-risk factors, 16 died （21.3%）. These differences were statistically significant between the three （P=0.000）. Conclusion Chemotherapy is recommended for patients with histopathologic risk factors, especially those with two or more histopathologic risk factors.

关键词： retinoblastoma histopathologic, high risk factors prognosis

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Nano-sized Sn/MWNTs and MWNTs Served as the Anode of Lithium Ion Battery

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Journal of Wuhan University of Technology(Materials Science) 2006年第4期21卷 60-63页

作者：林克芝 Department of Chemical Engineering Tsinghua University Beijing 100084 China

A chemical deposition was supposed to be an effwient method in preparation of nano-sized Sn/ MWNTs. The nanoconmposites of MWNTs and Sn/ MWNTs were both used as anodes of lithium ion battery. The special capacities and coulomb efficiencies of Snl MWNTs were studied by means of electrochemical methods. The coating of Sn on MWNTs observed by TEM was amorphous and nano-sized. The reversible capacity of Sn/ MWNTs , which was much larger than that of MWNTs , was 824 mAh/ g in the 1 st charge and discharge cycle. The coulomb efficiency of Sn/ MWNTs in the 1 st cycle was increased by 16% compared with that of MWNTs. The additional Sn, which was 37wt% of total Sn/ MWNTs＇ weight, introduced the additional reversible lithiation capacity at least 250 mAh/ g in the 40 charge and discharge cycles. The dispersing degree of Sn on MWNTs was the main reason for the influence of the electrochemical perfomance of the Sn/ MWNTs . Sn/ MWNTs is proved to be a promising candidate as an anode of lithium ion battery.

关键词： multi-walled carbon nanotubes ( MWNTs ) deposition nanocomposites lithium ion battery tinbased materials

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