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Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 795-807页

作者： Yongchun Pan Xiaowei Luan Fei Zeng Xuyuan Wang Shurong Qin Qianglan Lu Guanzhong He Yanfeng Gao xiaolian sun Xin Han Bangshun He Yujun Song Department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and PharmacovigilanceDepartment of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing 211198China School of Medicine&Holistic Integrative Medicine Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene ***,the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the biomarkers vary in a spatiotemporal-dependent manner with tumor ***,we propose a self-amplifying logic-gated gene editing strategy for gene/H_(2)O_(2)-mediated/starvation multimodal cancer *** this approach,a hypoxia-degradable covalent-organic framework(COF) is synthesized to coat a-ZIF-8 in which glucose oxidase(GOx) and CRISPR system are *** intensify intracellular redox dyshomeostasis,DNAzymes which can cleave catalase mRNA are loaded as *** the nano system gets into the tumor,the weakly acidic and hypoxic microenvironment degrades the ZIF-8@COF to activate GOx,which amplifies intracellular H^(+)and hypoxia,accelerating the nanocarrier degradation to guarantee available CRISPR plasmid and GOx release in target *** tandem reactions deplete glucose and oxygen,leading to logic-gated-triggered gene editing as well as synergistic gene/H_(2)O_(2)-mediated/starvation ***,this approach highlights the biocomputing-based CRISPR delivery and underscores the great potential of precise cancer therapy.

关键词： CRISPRdelivery Enzymeencapsulation Logic gate Hybridmaterial Hypoxia Gene editing Precise nanomedicine Multimodal therapy

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铜基催化剂用于一氧化碳电还原为多碳产品

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Science China Materials 2024年第6期67卷 1684-1705页

作者：赵雯刘娟王光滔王新天杨传举李剑王鋙葶孙晓莲林日琛左淦丞朱文磊 State Key Laboratory of Pollution Control and Resource Reuse Frontiers Science Center for Critical Earth Material CyclingState Key Laboratory of Pollution Control and Resource Reusethe Frontiers Science Center for Critical Earth Material CyclingSchool of the EnvironmentNanjing UniversityNanjing 210023China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and PharmacovigilanceSchool of PharmaceuticsChina Pharmaceutical UniversityNanjing 210009China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 211189China Jiangsu Engineering Lab of Water and Soil Eco-remediation School of EnvironmentNanjing Normal UniversityNanjing 210023China

电化学二氧化碳还原(ECO_(2)R)是一种将碳和可再生能源的能量储存在多碳产品(C_(2+))的化学键中的有效途径.然而,反应涉及的复杂步骤为CO_(2)直接转化为C_(2+)设置了巨大的障碍.一种利用CO作为“中转站”,通过串联ECO_(2)R和电化学CO还... 详细信息

电化学二氧化碳还原(ECO_(2)R)是一种将碳和可再生能源的能量储存在多碳产品(C_(2+))的化学键中的有效途径.然而,反应涉及的复杂步骤为CO_(2)直接转化为C_(2+)设置了巨大的障碍.一种利用CO作为“中转站”,通过串联ECO_(2)R和电化学CO还原(ECOR)以提高生产C_(2+)的选择性和反应速率的策略引起了人们的广泛关注.本文总结了铜基电催化剂在ECOR中催化特定C_(2+)生成的设计策略.其次,从各个方面总结了催化剂工程的代表性设计策略,并介绍了电解反应器改进方面的最新进展.最后,阐述了该研究领域面临的主要挑战和未来前景.这些见解和观点将为铜基电催化剂的设计提供有益指导.

关键词： CO electroreduction Cu-based catalysts multi-car-bon products

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Ferrous Oxide Nanoparticles Induced Abnormal Cardiac Development in Zebrafish Through Hypoxia and Ferroptosis

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Chemical Research in Chinese Universities 2023年第3期39卷 502-507页

作者： ZHENG Naying CHEN Xintan ZHAN Ruyu LIAO Tingting SHI Yiyue sun xiaolian CHEN Shuzhen ZUO Zhenghong State Key Laboratory of Cellular Stress Biology Xiang’an Hospital of Xiamen UniversitySchool of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen361102China Department of Microbiology and Immunology Fujian Provincial Key Laboratory of Functional and Clinical Translational MedicineXiamen Key Laboratory of Respiratory DiseasesXiamen Medical CollegeXiamen361023China Chest Pain Center Anxi County HospitalQuanzhou362400China State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and PharmacovigilanceDepartment of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing210009China

Ferrous oxide nanoparticles(nFeO)have potential applications in biomedicine,industrial processes,and waste water ***,the biocompatibility of nFeO remains *** this study,we synthesized rhombus-shaped nFeO and exposed them to zebrafish embryos to investigate the bio-safety of *** results showed that exposure to nFeO led to pericardial edema,heart bleeding,and enlarged ***,the content of dissolved oxygen ***^(2+)ions,which were released from the core of nFeO,were oxidized into Fe^(3+).This caused the overexpression of tfa and fpn genes,which carried Fe^(3+)into and out of the cell membrane,*** overload of Fe^(3+)caused ferroptosis in zebrafish larvae,which was evidenced by the overexpression of the marker gene ptgs2 and the marker production malondialdehyde(MDA)of ***,neither the ferrostatin-1(Fer-1)inhibitor nor deferoxiamine(DFO)could completely rescue the toxicity caused by *** found that co-treatment of nFeO with CaO_(2),a dissolved oxygen donor,and Fer-1 or DFO could totally rescue pericardial edema and heart *** results provide new knowledge that both hypoxia and ferroptosis play important roles in nFeO-induced zebrafish cardiac developmental toxicity,which is beneficial for the development and safe application of iron-based nanomaterials in the future.

关键词： Nanoparticle Biocompatibility Heart Zebrafish Iron

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Porous hollow palladium nanoplafform for imaging-guided trimodal chemo-, photothermal-, and radiotherapy

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Nano Research 2018年第5期11卷 2796-2808页

作者： Menglin Song Nian Liu Le He Gang Liu Daishun Ling Xinhui Su xiaolian sun State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361005 China Department of Pharmaceutical Analysis China Pharmaceutical University Nanjing 210009 China Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Soochow University Suzhou 215123 China Zhejiang Province Key Laboratory of Anti-Cancer Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China Department of Nuclear Medicine Zhongshan Hospital Xiamen University Xiamen 361004 China

Cancer is one of the major causes of human death. There are many types of cancer treatment including surgery, chemotherapy, radiotherapy, and photothermal therapy. Combining different therapies can synergistically enhance the therapeutic effect. We developed porous hollow palladium nanoparticles （PHPdNPs） to co-deliver ^131I （a radioisotope that is commonly used in radiotherapy） and doxorubicin （DOX; a chemotherapy drug）. Compared with other mesoporous nanocarriers, our PHPdNPs exhibited impressive photothermal conversion efficiency and stability. Drug loading is high and drug release is controllable by repeated laser irradiation and acidic pH in tumor microenvironments. Owing to the specific interaction between palladium and iodine, the PHPdNPs serve as effective ^131I delivery vehicles with excellent radiochemical stability. A single dose of [^131I]PHPdNPs-DOX has superior antitumor efficacy because it enables a combination of chemo-, photothermal-, and radio-therapy. Moreover, the nanocomplex has no obvious side-effects in mice. Therefore, we believe that PHPdNPs are excellent candidates for multimodal imaging-guided therapy.

关键词： porous hollo wnanopartides radiotherapy phototherrnal therapy chemotherapy

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Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles

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Nano Research 2013年第1期6卷 1-9页

作者： Ruijun Xing Ashwinkumar A. Bhirde Shouju Wang xiaolian sun Gang Liu Yanglong Hou Xiaoyuan Chen Laboratory of Molecular Imaging and Nanomedicine (LOMIN) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH) Bethesda MD 20892 USA Department of Materials Science and Engineering College of Engineering Peking University Beijing 100871 China Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361005 China

磁性的 nanoparticles 对很多个癌症房间被用作药交货车辆。大多数这些 theranostic 明确的表达使用了为两磁性的回声成像(MRI ) 和癌症治疗作为 nano 搬运人明确的表达与 chemotherapeutics 装载的稳固的氧化铁 nanoparticles (SIONP )... 详细信息

磁性的 nanoparticles 对很多个癌症房间被用作药交货车辆。大多数这些 theranostic 明确的表达使用了为两磁性的回声成像(MRI ) 和癌症治疗作为 nano 搬运人明确的表达与 chemotherapeutics 装载的稳固的氧化铁 nanoparticles (SIONP ) 。在这研究，我们使用了 dopamine-plus-human 浆液白朊(HSA ) 方法在 nano 搬运人的空多孔的结构以内修改空氧化铁 nanoparticles (HIONP ) 和 encapsuated doxorubicin (纪录影片) 。新交货系统能用一样的涂层策略比一样的核心尺寸的稳固的氧化铁 nanoparticles 装载更多的药。HIONPs 纪录影片明确的表达也有 pH 依赖的药版本行为。与免费纪录影片相比， HIONPs 纪录影片有效地是更多由 multidrug 的 uptaken 抵抗 OVCAR8-ADR 房间并且因而在杀死药的更多的有势力抵抗癌症房间。MRI 幽灵和房间研究也证明 HIONPs 纪录影片能减少当充当药交货车辆时， T 2 MRI 信号紧张和罐头被用作一个 MRI 对比代理人。第一次， chemo 药运输的双申请和用 HIONPs 纪录影片明确的表达的先生成像对纪录影片敏感、纪录影片抵抗的癌症房间被完成。

关键词：核磁共振成像铁纳米粒子化疗药物多药耐药氧化车辆交付空心

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Radioiodinated tyrosine based carbon dots with efficient renal clearance for single photon emission computed tomography of tumor

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Nano Research 2019年第12期12卷 3037-3043页

作者： Nian Liu Yiyue Shi Jingru Guo Hai Li Qiang Wang Menglin Song Zhiyuan Shi Le He Xinhui Su Jin Xie xiaolian sun State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and PharmacovigilanceDepartment of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing 210009China Institute of Biological and Medical Imaging Helmholtz Zentrum Miinchen and Technische Universitat MiinchenNeuherberg 85764Germany State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361005China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Department of Nuclear Medicine Zhongshan Hospital Xiamen UniversityXiamen 361004China Department of Chemistry Bio-Imaging Research CenterUniversity of GeorgiaAthensGeorgia 30602USA

Nan oparticles with effective tumor accumulation and efficient renal clearance have attracted significant interests for clinical *** 2.5 nm tyrosine based carbon dots(TCDs)with phenolic hydroxyl groups on the surface for directly 125I *** 125I labeledpolyethylene glycol(PEG)functionalized TCDs(125I-TCDPEGs)showed excellent radiochemical stability both in vitro and in *** to theenhanced permeability and retentio n effect,these 125I-TCDPEGs demonstrated a tumor accumulatio n around 4%-5%of the injected doseper gram(ID/g)for U87MG,4T1,HepG2 and MCF7 tumor-bearing mice at 1 h ***,the 125I-TCDPEGs also could befast renally excreted,with less than 0.6%ID/g left in the liver and spleen within 24 *** radioactive carb on dots not only can be used forcellular fluorescence imaging due to their intrinsic optical property,but are also effective single photon emission computed tomography(SPECT)imaging agents for *** with their excellent biocompatibility and stability,we anticipate these 125I-TCDPEGs of great potential for earlytumor diagnosis in *** more,our TCDPEGs are also proved to be feasible carriers for other iodine isotopes such as 127I and 131I fordifferent biomedical application.

关键词： radioiodination tyrosine based carbon dots single photon emissionrenal clearance

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风电场参与电网调频的多机协同控制策略

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发电技术 2024年第3期45卷 448-457页

作者：张小莲孙啊传郝思鹏许乐妍武启川南京工程学院电力工程学院江苏省南京市211167

【目的】考虑风电场中不同风况下风电机组参与一次调频能力的差异,在下垂控制和惯量控制策略的基础上,对机组的调频能力评估方法进行优化。【方法】提出了一种改进的多机组调频参考功率协同控制策略。【结果】引入多机组协同控制方法能... 详细信息

【目的】考虑风电场中不同风况下风电机组参与一次调频能力的差异,在下垂控制和惯量控制策略的基础上,对机组的调频能力评估方法进行优化。【方法】提出了一种改进的多机组调频参考功率协同控制策略。【结果】引入多机组协同控制方法能够有效改善机组之间调频参考功率的分配,从而有效调节各机组参与系统一次调频的程度。在惯量控制和下垂控制的基础上引入改进的协同控制策略,依据机组在实际风况下运行的状态,评估机组能够有效参与一次调频的参考功率。引入调频能力系数能够实现调频功率参考值在各机组之间按能分配。【结论】协同控制策略能够有效保护风电机组转速,同时能够有效改善电网频率响应。

关键词：风电场一次调频协同控制综合控制转速保护

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Color-tunable Gd-Zn-Cu-ln-S/ZnS quantum dots for dual modality magnetic resonance and fluorescence imaging

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Nano Research 2014年第11期7卷 1581-1591页

作者： Weisheng Guo Weitao Yang Yu Wang xiaolian sun Zhongyun Liu Bingbo Zhang Jin Chang Xiaoyuan Chen Institute of Nanobiotechnology School of Materials Science and Engineering Tianjin University and Tianjin Key Laboratory of Composites and Functional Materials Tianjin 300072 China Laboratory of Molecular Imaging and Nanomedicine National Institute of 8iomedical Imaging and Bioengineering National Institutes of Health Bethesda MD 20892 USA Shanghai East Hospital The Institute for 8iomedical Engineering & Nano Science Tongji University School of Medicine Shanghai 200120 China Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging Department of Radiology Zhongda Hospital Medical School of Southeast University Nanjing 210009 China

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高效磷氮硅防火涂层的制备与性能研究

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涂料工业 2024年第3期54卷 2-7,14页

作者：贾昊孙军张晓莲王军军谷晓昱张胜北京市水性聚合物合成和应用工程技术中心北京化工大学北京100029 海洋化工研究院有限公司山东青岛266071

为提高木材防火性能,采用六氯环三磷腈(HCCP)和三(2-羟乙基)异氰尿酸酯(THEIC)合成了新型磷腈枝化物(HT),HT与异氰酸酯基丙基三乙氧基硅烷(IPTS)制备了木材防火涂层。研究了涂层的透明性、热稳定性、硬度和防火性能。结果表明:涂层高度... 详细信息

为提高木材防火性能,采用六氯环三磷腈(HCCP)和三(2-羟乙基)异氰尿酸酯(THEIC)合成了新型磷腈枝化物(HT),HT与异氰酸酯基丙基三乙氧基硅烷(IPTS)制备了木材防火涂层。研究了涂层的透明性、热稳定性、硬度和防火性能。结果表明:涂层高度透明,铅笔硬度达3H,极限氧指数提高30%,垂直燃烧UL-94测试达V-0等级。锥形量热结果表明,与纯木材相比,涂层处理后的木材的最大热释放速率和总热释放量分别降低了25.5%和53.2%,同时涂层可以使生成的炭层更加致密、完整,可有效阻隔热量与可燃气体,使木材的防火性能得到提高。

关键词：磷腈支化物防火涂层木材透明性防火性

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无机纳米声敏剂在肿瘤声动力治疗中的应用进展

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药学进展 2018年第11期42卷 824-830页

作者：马静文孙晓莲中国药科大学药分系天然药物活性组分与药效国家重点实验室药物质量与安全预警教育部重点实验室

肿瘤声动力治疗(SDT)是利用超声波将声能聚集于深部组织,并激活声敏药物产生抗肿瘤效应。SDT能够克服目前肿瘤治疗中诸如穿透深度有限等弊端。无机纳米声敏剂具有体内稳定性高、物理化学性质可控以及易于实现多功能化等优点,在肿瘤治疗... 详细信息

肿瘤声动力治疗(SDT)是利用超声波将声能聚集于深部组织,并激活声敏药物产生抗肿瘤效应。SDT能够克服目前肿瘤治疗中诸如穿透深度有限等弊端。无机纳米声敏剂具有体内稳定性高、物理化学性质可控以及易于实现多功能化等优点,在肿瘤治疗方面具有广阔的应用前景。综述无机纳米声敏剂在SDT中的应用进展,并对其未来可能的研究方向进行展望。

关键词：超声声动力治疗活性氧自由基无机纳米声敏剂

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