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Alzheimer's disease treated with combined therapy based on nourishing marrow and reinforcing Qi

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Journal of Traditional Chinese Medicine 2015年第3期35卷 255-259页

作者： Chen Songlin yao xiaoli Liang Yinying Mei Weiyi Liu Xiaoyun Zhang Changran Department of Neurology First Affiliated Hospital of Sun Yat-sen University Department of Cardiology First Affiliated Hospital of Sun Yat-sen University Department of Traditional Chinese Medicine First Affiliated Hospital of Sun Yat-sen University Department of Pneumology First Affiliated Hospital of Sun Yat-sen University

OBJECTIVE:To study the efficacy and safety of combined Traditional Chinese Medicine(TCM) therapy based on nourishing marrow to improve intellect and reinforcing Qi to activate bloodon mild to moderate Alzheimer's disease(AD).METHODS:Sixty-six patients with AD,whoseMini-Mental State Examination(MMSE) score were from 10-24,were randomized equally into an intervention group and a control *** control group was given Aricept(5 mg,once daily).The intervention group was further divided into Yang-Qi deficiency(n = 18) and of Yin-Qi deficiency(n = 15)*** in the Yang-Qi deficiency group were intravenously administered Shenfu injection,60 mL,and deproteinized calf blood injection(DCBl),1.2 g,once *** Yin-Qi deficiency group was given Shenmai injection,60 mL,and DCBl,1.2 g,once *** course lasted 21 ***:Compared with the control group and with pre-treatment in the same group,MMSE,clinical dementia rating,and activities of daily living scale scores in the intervention group were significantly improved(all P0.05).No adverse effects were observed in any group during ***:We found that combined TCM therapy is effective and safe for managing mild to moderate AD.

关键词： Alzheimer disease Combined modality therapy Donepezil Deproteinized calf blood injection

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腺垂体功能减退症合并系统性红斑狼疮1例

大连医科大学学报 2024年第3期46卷 274-276页

作者：高楚淇胡楠李永桂姚孝礼刘娟西安交通大学第一附属医院内分泌代谢科陕西西安710061 西安交通大学第一附属医院风湿免疫科陕西西安710061 青海省人民医院内分泌科1科青海西宁810001

1临床资料患者,女,30岁。因“乏力、纳差4月余”于2021年1月18日就诊于西安交通大学第一附属医院。4月余前曾因剖宫产子后出现大出血,术中出血量约600 mL,输悬浮红细胞4 U、血浆400 mL,其间无意识丧失,产后逐渐出现情绪低落、乏力、纳... 详细信息

1临床资料患者,女,30岁。因“乏力、纳差4月余”于2021年1月18日就诊于西安交通大学第一附属医院。4月余前曾因剖宫产子后出现大出血,术中出血量约600 mL,输悬浮红细胞4 U、血浆400 mL,其间无意识丧失,产后逐渐出现情绪低落、乏力、纳差、怕冷、嗜睡,哺乳1周因奶量少及用药等因素改为奶粉喂养,伴有闭经,毛发脱落,神情淡漠,易感冒。入院半月前查血浆白蛋白24.1(40~55)g/L,血红蛋白90(110~150)g/L,尿蛋白(2+)。

关键词：腺垂体功能减退症系统性红斑狼疮诊断

Chiral plasmonic nanostructure of twistedly stacked nanogaps

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Chinese Optics Letters 2021年第1期19卷 95-99页

作者： Jian Zhang Rui Tu Chao Huang xiaoli yao Xin Hu Haixiong Ge Xuefeng Zhang Institute of Advanced Magnetic Materials College of Materials&Environmental EngineeringHangzhou Dianzi UniversityHangzhou 310018China College of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China Department of Materials Science and Engineering College of Engineering and Applied SciencesNanjing UniversityNanjing 210093China

Nanogap plasmonic structures with strong coupling between separated components have different responses to orthogonal-polarized light, giving rise to giant optical chirality. Here, we proposed a three-dimensional(3D) nanostructure that consists of two vertically and twistedly aligned nanogaps, showing the hybridized charge distribution within 3D *** is discovered that the structure twisted by 60° exhibits plasmonic coupling behavior with/without gap modes for different circular-polarized plane waves, showing giant chiral response of 60% at the wavelength of 1550 nm. By controlling the disk radius and the insulator layer, the circular dichroism signal can be further tuned between 1538 and 1626 nm.

关键词： metal-insulator-metal structure nanogaps gap mode twisted stacking charge distribution chiral response

“金课”建设驱动“药物分析实验”课程教学改革探索

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云南化工 2024年第4期51卷 200-203页

作者：罗兰张素中罗爱勤刘盈姚小丽陈锐娥广州新华学院药学院广东广州510520

“金课”建设已成为深化高等教育教学改革,全面提升高等教育质量的关键之举。通过对标金课的“两性一度”,调整优化了“药物分析实验”课程的教学模式、教学内容和课程评价等,在课程实施的不同阶段运用“超星学习通”+虚拟仿真平台,开... 详细信息

“金课”建设已成为深化高等教育教学改革,全面提升高等教育质量的关键之举。通过对标金课的“两性一度”,调整优化了“药物分析实验”课程的教学模式、教学内容和课程评价等,在课程实施的不同阶段运用“超星学习通”+虚拟仿真平台,开展翻转课堂、混合式教学,力求符合新时代高等教育课程建设要求。结果表明,改革后的实验教学能有效激发学生的求知欲,提高自主学习能力、动手实践能力,解决问题能力以及创新思维能力,同时也提升了思政德育素养及职业素养,达到提高本科实践教学的效果。

关键词：金课两性一度药物分析实验教学改革思政

依托思政案例的天然药物化学课程教学设计--以醌类化合物章节为例

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广东化工 2024年第18期51卷 225-227,186页

作者：王有娣徐娟娟贺彦姚小丽陈静雯罗盈明广州新华学院药学院广东广州510520

专业课程开展课程思政教学的关键是要提前做好教学计划设计,在不额外占用有限的课堂教学时间的前提下,有机地将思政内容融入课程教学中。本文以醌类化合物章节为例,从明确章节教学目标、整合章节教学内容、设计章节教学过程、构建科学... 详细信息

专业课程开展课程思政教学的关键是要提前做好教学计划设计,在不额外占用有限的课堂教学时间的前提下,有机地将思政内容融入课程教学中。本文以醌类化合物章节为例,从明确章节教学目标、整合章节教学内容、设计章节教学过程、构建科学评价体系来阐述如何依托思政案例将科研精神、创新思维、文化自信、职业素养、生态文明等思政素养有机地融入天然药物化学课程的教学中,旨在提高天然药物化学课程思政教学质量,同时也为医药化工类专业课程实施课程思政提供参考。

关键词：天然药物化学思政案例课程思政醌类化合物教学设计

A multicenter,randomized,double blind,placebo-controlled clinical trial of DL-3-n-butylphthalide in treatment of amyotrophic lateral sclerosis

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Chinese Medical Journal 2023年第3期136卷 354-356页

作者： Mingsheng Liu xiaoli yao Xusheng Huang Huifang Shang Dongsheng Fan Jia He Liying Cui the Chinese ALS Study Group Department of Neurology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Neurology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510006China Department of Neurology Chinese PLA General HospitalBeijing 100853China Department of Neurology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Neurology Peking University Third HospitalBeijing 100191China Department of Health Statistics Faculty of Health ServiceNaval Medical UniversityShanghai 200433China 不详

To the Editor:DL-3-n-butylphthalide(NBP)is a synthetic drug based on a component extracted from seeds of Apium graveolens Linn.(Chinese celery).It reportedly has protective effects in amyotrophic lateral sclerosis(ALS)model mice.[1]A randomized,double-blind,placebocontrolled trial was performed at 19 ALS clinical centers of the Chinese ALS *** patients provided written informed *** Ethics Committee of Peking Union Medical College Hospital approved the study protocol(No.S621)and all patients signed informed *** centers followed the same research protocol.

关键词： clinical amyotrophic protective

The impact of nanoporous SiN_x interlayer growth position on high-quality GaN epitaxial films

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Chinese Science Bulletin 2011年第25期56卷 2739-2743页

作者： MA ZiGuang XING ZhiGang WANG xiaoli CHEN yao XU PeiQiang CUI YanXiang WANG Lu JIANG Yang JIA HaiQiang CHEN Hong Beijing National Laboratory of Condensed Matter Institute of Physics Chinese Academy of Sciences Beijing 100190 China

The impact of nanoporous SiN x interlayer growth position on high-quality GaN epitaxial film was elucidated from the behavior of dislocations. The best quality GaN film was achieved when a nanoporous SiN x interlayer was grown on a rough layer, with the high-resolution X-ray diffraction rocking curve full width at half maximum for ( 1102 ) reflection decreasing to 223 arcs, and the total dislocation density reduced to less than 1.0×10 8 cm 2 . GaN films were grown on sapphire substrates by metal organic chemical vapor deposition. The quality of these films was investigated with high-resolution X-ray diffraction, atomic force microscopy, and cross-sectional transmission electron microscopy. A preference for the formation of half-loops to reduce threading dislocations was observed when an SiN x interlayer was grown on a rough layer. A growth mechanism is proposed to explain this preference.

关键词：氮化硅外延片多孔层间氮化镓 GaN薄膜化学气相沉积法透射电子显微镜

大宁—吉县区块深层煤岩气赋存产气特征与储量估算方法指标探讨

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中国石油勘探 2024年第4期29卷 142-155页

作者：李明宅曹毅民丁蓉邓泽蒋轲李永洲姚晓莉侯淞译惠卉孙晓光伊伟孙潇逸曹昕欣中石油煤层气有限责任公司中国石油勘探开发研究院中联煤层气国家工程研究中心有限责任公司

深层煤岩气是煤层气勘探新领域,如何科学地估算深层煤岩气储量成为面临的新问题。从总结大宁—吉县区块深层煤岩气勘探开发成果出发,通过论证深层煤岩气的成藏特征、赋存模式、产气规律和生产特点,分析深层煤岩气独特的吸附气+游离气赋... 详细信息

深层煤岩气是煤层气勘探新领域,如何科学地估算深层煤岩气储量成为面临的新问题。从总结大宁—吉县区块深层煤岩气勘探开发成果出发,通过论证深层煤岩气的成藏特征、赋存模式、产气规律和生产特点,分析深层煤岩气独特的吸附气+游离气赋存特征、游离气→游离气+吸附气→吸附气的产气机制及其与浅—中浅层煤层气的明显差异,进而指出现行储量规范在估算方法、单元划分、估算参数、起算下限、资料录取等方面对估算深层煤岩气储量存在的不适应性。在上述研究的基础上,提出深层煤岩气储量估算建议:采用体积法和容积法两种方法估算储量,并根据游离气占比选择相应的估算方法;游离气需单独划分储量估算单元;夹矸起扣厚度为0.3~0.5m;R_(o)≤1.0%,煤层净厚度下限大于或等于1.0m;R_(o)>1.0%,煤层净厚度下限大于或等于0.8m;按深度段和井型分别确定单井产气量下限;勘探早期阶段,直井采收率为30%~45%,水平井采收率为35%~55%。研究为开展深层煤岩气勘探开发和储量估算提供了技术参考。

关键词：深层煤岩气地质特征吸附气游离气产气规律储量参数采收率

Dielectric Relaxation in Bi_2BaNb_2O_9 Ceramic

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Journal of Materials Science & Technology 1993年第6期9卷 461-463页

作者： xiaoli WANG Xi yao Electronic Materials Research Laboratory,Xi’an Jiaotong University,Xi’an,710049,China

A very strong dielectric relaxation was observed in Bi_2BaNb_2O_9 *** temperature difference between the maximum dielectric constant temperatures T_m measured at 1 kHz and 100 kHz is 65℃. which is about 2-4 times tha... 详细信息

关键词： dielectric relaxation ceramic temperature