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Neutrophil extracellular traps induced by interleukin 8 via CXCR1/2 promote the progression of gastric carcinoma through transcription factor IIB-related factor 1 and cyclin

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Genes & Diseases 2024年第2期11卷 575-578页

作者： Qianling Wang Yiyin Zhang Wenxi Ding Cheng Feng Yuyan Wang xiaoli Wei Ziting qu Hui Wang Xiaoying Liu Hua Wang Kangsheng Gu Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China School of Life Sciences Anhui Medical UniversityHefeiAnhui 230032China

Neutrophils constitute a significant portion of the immune cells present within the tumor microenvironment.Evidence generated by our group has confirmed neutrophils to be an adverse independent prognostic factor affecting the disease-free survival of gastric carcinoma(GC)patients.1 Neutrophil extracellular traps(NETs),protein-covered DNA webs that interact with tumor cells in the tumor microenvironment,were detected in GC tissues and found to clinically associated with disease progression in our previous study.2 NETosis could be mediated by a series of agonists,such as interleukin 8(IL-8).3 However,the mechanism of IL-8 in the progression of GC occurs via NETs remains unclear.In this study,we identified that IL-8-mediated NETosis can promote the proliferation,migration,and invasion of GC cells in vitro,which can be abrogated by NET degradation through deoxyribonucleaseI(DNase I)or IL-8 suppression through neutralizing antibodies.Disruption of NETs by DNase I or blockade of the IL-8-CXC chemokine receptor 2(CXCR2)axis could result in growth retardation in mouse models.We also confirmed that NETs may influence the biological behavior of GC cells by up-regulating the expression of transcription factor IB-related factor 1(BRF1)and cyclin p21/p27.

关键词： invasion gastric progression

Fucosyltransferase 8 regulates adult neurogenesis and cognition of mice by modulating the Itga6-PI3K/Akt signaling pathway

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Science China(Life Sciences) 2024年第7期67卷 1427-1440页

作者： Hongfeng Guo Qihang Sun xiaoli Huang Xiaohao Wang Feng Zhang Wenzheng qu Jinling Liu Xuejun Cheng Qiang Zhu Wen Yi Qiang Shu Xuekun Li The Children’s Hospital National Clinical Research Center for Child HealthSchool of MedicineZhejiang UniversityHangzhou 310052China The Institute of Translational Medicine School of MedicineZhejiang UniversityHangzhou 310029China College of Life Sciences Zhejiang UniversityHangzhou 310058China Binjiang Institute of Zhejiang University Hangzhou 310053China Zhejiang University Cancer Center Zhejiang UniversityHangzhou 310029China

Fucosyltransferase 8(Fut8)and core fucosylation play critical roles in regulating various biological processes,including immune response,signal transduction,proteasomal degradation,and energy metabolism.However,the function and underlying mechanism of Fut8 and core fucosylation in regulating adult neurogenesis remains unknown.We have shown that Fut8 and core fucosylation display dynamic features during the differentiation of adult neural stem/progenitor cells(aNSPCs)and postnatal brain development.Fut8 depletion reduces the proliferation of a NSPCs and inhibits neuronal differentiation of aNSPCs in vitro and in vivo,respectively.Additionally,Fut8 deficiency impairs learning and memory in mice.Mechanistically,Fut8 directly interacts with integrinα6(Itga6),an upstream regulator of the PI3kAkt signaling pathway,and catalyzes core fucosylation of Itga6.Deletion of Fut8 enhances the ubiquitination of Itga6 by promoting the binding of ubiquitin ligase Trim21 to Itga6.Low levels of Itga6 inhibit the activity of the PI3K/Akt signaling pathway.Moreover,the Akt agonist SC79 can rescue neurogenic and behavioral deficits caused by Fut8 deficiency.In summary,our study uncovers an essential function of Fut8 and core fucosylation in regulating adult neurogenesis and sheds light on the underlying mechanisms.

关键词： Fut8 adult neural stem/progenitor cells neurogenesis Itga6 PI3K/Akt

A hybrid guidance law of LOS acceleration feedback for missile against maneuvering targets

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Journal of Control and Decision 2017年第3期4卷 168-178页

作者： Xiangbin Liu xiaoli qu School of electronic information engineering Beijing Jiaotong universityBeijingChina Electrical engineering College Henan science and technology of universityluoyangChina

A quantised backstepping robust guidance law of three-dimension(3-D)space for compound control of reaction control jets and aerodynamic surfaces is proposed to attenuate the unknown target manoeuvre in this paper.The presented guidance law guarantees that the rates of line of sight converge to a residual circle centred at the origin whose radius is depended on the target manoeuvres,quantised length and guidance law gains.The simulations are given to illustrate the effectiveness of the proposed guidance law.

关键词： Guidance law target manoeuvre compound control reaction trust and aerodynamic surface missile interception

Asymptotic attenuation of a class of nonlinear systems with unknown sinusoidal disturbances

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控制理论与应用（英文版） 2010年第4期8卷 509-514页

作者： xiaoli qu Xiangbin LIU Mingxuan SUN Electronic Information Engineering College Henan University of Science & Technology Luoyang Henan 471003 China Advanced Control Systems Laboratory School of Electronics and Information Engineering Beijing Jiaotong University Beijing 100044 China College of Information Engineering Zhejiang University of Technology Hangzhou Zhejiang 310032 China

In this paper,nonlinear observers are incorporated into the adaptive control to synthesize controllers for a class of uncertain nonlinear systems with unknown sinusoidal disturbances which are presented in matched and unmatched forms.In addition to magnitudes and phases,frequencies of the sinusoidal disturbances need not be known as well,so long as the overall order is known.Nonlinear observers are constructed to eliminate the effect of unknown sinusoidal disturbances to improve the steady-state output tracking performance-asymptotic output tracking is achieved.The adaptation law is used to obtain the estimate of all unknown parameters.The presented disturbance decoupling algorithms can deal with matched and unmatched unknown sinusoidal disturbances.

关键词： Adaptive control Nonlinear systems Backstepping Disturbance attenuation

Multiple virus sorting based on aptamer-modified microspheres in a TSAW device

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微系统与纳米工程(英文) 2023年第3期9卷 309-318页

作者： Xianglian Liu Xuan Chen Yangchao Dong Chuanyu Zhang xiaoli qu Yingfeng Lei Zhuangde Jiang Xueyong Wei State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710049China Department of Microbiology the Fourth Military Medical UniversityXi’an 710032China

Due to the overlapping epidemiology and clinical manifestations of flaviviruses,differential diagnosis of these viral diseases is complicated,and the results are unreliable.There is perpetual demand for a simplified,sensitive,rapid and inexpensive assay with less cross-reactivity.The ability to sort distinct virus particles from a mixture of biological samples is crucial for improving the sensitivity of diagnoses.Therefore,we developed a sorting system for the subsequent differential diagnosis of dengue and tick-borne encephalitis in the early stage.We employed aptamer-modified polystyrene(PS)microspheres with different diameters to specifically capture dengue virus(DENV)and tick-borne encephalitis virus(TBEV),and utilized a traveling surface acoustic wave(TSAW)device to accomplish microsphere sorting according to particle size.The captured viruses were then characterized by laser scanning confocal microscopy(LSCM),field emission scanning electron microscopy(FE-SEM)and reverse transcription-polymerase chain reaction(RT‒PCR).The characterization results indicated that the acoustic sorting process was effective and damage-free for subsequent analysis.Furthermore,the strategy can be utilized for sample pretreatment in the differential diagnosis of viral diseases.

关键词： diagnosis epidemiology sorting

基于模糊C均值聚类和概率神经网络的PEMFC故障诊断方法研究

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太阳能学报 2024年第1期45卷 475-483页

作者：黄赵军苏建徽解宝施永黄诚瞿晓丽合肥工业大学光伏系统教育部工程研究中心合肥230009 合肥综合性国家科学中心能源研究院合肥230071

为解决质子交换膜燃料电池电堆的故障分类问题,提出一种基于模糊C均值聚类和概率神经网络的故障诊断新方法。首先基于修正后的燃料电池电堆Fouquet等效电路模型,并结合电堆阻抗谱实验数据,得到电堆的正常、水淹、膜干和氧饥饿4种工作状... 详细信息

为解决质子交换膜燃料电池电堆的故障分类问题,提出一种基于模糊C均值聚类和概率神经网络的故障诊断新方法。首先基于修正后的燃料电池电堆Fouquet等效电路模型,并结合电堆阻抗谱实验数据,得到电堆的正常、水淹、膜干和氧饥饿4种工作状态与电路模型参数的对应关系,进而提取合适的故障特征量作为聚类算法的特征输入。然后,利用模糊C均值聚类算法对故障样本进行聚类,形成标准聚类中心,并在此基础上,采用概率神经网络算法对故障样本实现多故障分类,有效剔除奇异数据并提高模型分类的正确率。最后,对200组实验数据进行实例分析,并与支持向量机和K最邻近方法进行对比,结果表明所提方法能对4种电堆工作状态进行快速识别,分类准确率达98.33%,验证了所提算法的有效性。

关键词：质子交换膜燃料电池聚类算法神经网络故障诊断故障特征量

基于天气分型的水平面总辐射及散射辐射建模分析

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太阳能学报 2024年第4期45卷 560-568页

作者：李芬刘楚琦于淏屈爱芳毛玲陈小莉上海电力大学电气工程学院上海200090 上海师范大学数理学院上海200234 中国水利水电科学研究院北京100038

为获得无太阳辐射观测地区的水平面总辐射及散射辐射量提出一种组合模型。首先通过日照百分率将天气情况分成3类,在此基础上,探究总云量、气溶胶等气象环境因子对水平面总辐射的影响,构建水平面总辐射线性模型;其次,考虑不同天气类型下... 详细信息

为获得无太阳辐射观测地区的水平面总辐射及散射辐射量提出一种组合模型。首先通过日照百分率将天气情况分成3类,在此基础上,探究总云量、气溶胶等气象环境因子对水平面总辐射的影响,构建水平面总辐射线性模型;其次,考虑不同天气类型下气象环境因子的特征,建立基于高斯过程回归(GPR)的散射比和散射系数模型,进而获得散射辐射量;最后,得到每种天气类型下最优水平面总辐射模型与散射辐射模型构成的组合模型。结果表明,所提组合模型可有效提高水平面总辐射与散射辐射的预测精度。

关键词：太阳辐射天气分型机器学习散射辐射气象环境因子

International standard of Traditional Chinese Medicine Techniques: Traditional Chinese Medicine guidelines for acute primary headache(2022)

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Journal of Traditional Chinese Medicine 2024年第4期 839-850页

作者： YAO Yuning CAO Kegang ZHANG Genming LIU Jianping CHEN Wei CAO Junling YANG Wenming YAN Yongmei GENG Chang JU Yi ZHAO Dexi qu Miao LI xiaoli SUN Li HAN Zhenyun HE Liyun CUI Fangyuan FU Caihong ZHOU Bo LIAO Shuqin Department of Geriatrics Jilin Academy of Traditional Chinese Medicine Department of Neurology Shenzhen Hospital of Beijing University of Chinese Medicine Institute of Basic Research in Clinical Medicine China Academy Of Chinese Medical Sciences Department of Rehabilitation Shunyi HospitalBeijing Traditional Chinese Medicine Hospital Department of Neurology Xiyuan Hospital of China Academy of Chinese Medical Sciences Department of Neurology Dongzhimen Hospital of Beijing University of Chinese Medicine Centre for Evidence-Based Chinese Medicine Beijing University of Chinese Medicine Encephalopathy center First Affiliated Hospital of Anhui University of Chinese Medicine Department of Neurology Affiliated Hospital of Shaanxi University of Chinese Medicine Department of Neurology Beijing Changping District Hospital of Traditional Chinese Medicine Neurology center Beijing Tiantan HospitalCapital Medical University Department of Neurology Affiliated Hospital of Changchun University of Chinese Medicine Department of Neurology Xuanwu HospitalCapital Medical University Department of Neurology Beijing University of Chinese Medicine Third Affiliated Hospital

OBJECTIVE: To summarize the evidence from Traditional Chinese Medicine(TCM) practice in the treatment of acute primary headache and provide clinical practice guidance. METHODS: The guidelines were developed in accordance with the World Health Organization guideline development manual. After the establishment of steering committee, panel and the registration and protocol formulation, the evidence on TCM for acute primary headache from published guidelines, clinical evidence, and expert experience and consensus were collected. The grading of recommendations assessment, development and evaluation method was used to grade the evidence and make the recommendations. RESULTS: Based on the available evidence, the guidelines recommended three TCM herbal decoctions, six Chinese patent medicines, and two kinds of external application of Chinese herbal medicines. Diagnostic recommendations based on the expert experience and consensus were also included in the guidelines. CONCLUSION: TCM diagnosis and treatment of decoction, Chinese patent medicine and external application for treating acute primary headache were recommended. We hope these guidelines will be helpful in standardize the TCM acute treatment of primary headache.

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夏季日峰降温电力负荷预测灰色模型及其应用

气象 2024年第1期50卷 95-102页

作者：王洁曲晓黎尤琦杨琳晗时珉张金满中国气象局雄安大气边界层重点开放实验室河北雄安071800 河北省气象与生态环境重点实验室石家庄050021 河北省气象服务中心石家庄050021 国网河北省电力有限公司石家庄050011

基于2017—2020年石家庄市逐15分钟电力负荷及同期气象资料,计算人体舒适度指标有效温度和温湿指数,考虑基准负荷存在周期性和增长性,提出采用灰色模型GM(1,1)并结合滤波法、相关分析等方法,建立日峰降温电力负荷与人体舒适度指标分段... 详细信息

基于2017—2020年石家庄市逐15分钟电力负荷及同期气象资料,计算人体舒适度指标有效温度和温湿指数,考虑基准负荷存在周期性和增长性,提出采用灰色模型GM(1,1)并结合滤波法、相关分析等方法,建立日峰降温电力负荷与人体舒适度指标分段回归模型。结果表明:石家庄电力负荷具有明显的逐年增长趋势;剥离出的日降温负荷曲线呈“W”型分布;分别对模型进行一次、二次和分段函数拟合,对3种预测模型进行检验发现分段函数预测精度较高,平均相对误差在4.8%~5.2%,有效温度和温湿指数的分段函数误差在-10%~10%所占比例分别为88.1%和90.5%;考虑了温度、湿度和风速的有效温度较温湿指数的夏季日峰降温电力负荷预测模型预测准确率更高,回归模型分段点为26.2℃,对电网“迎峰度夏”时期电力调度具有参考价值。

关键词：降温负荷灰色模型滤波法相关性分析分段回归