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c-myb is involved in CML progression and is a therapeutic target in the zebrafish CML model

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Animal Models and Experimental Medicine 2024年第2期7卷 136-144页

作者： Yin Ye xiaojun yang Feifei Li Wei Liu Wenqing Zhang Zhibin Huang Division of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhouChina

Background:Despite the success of tyrosine kinase inhibitors in chronic myeloid leukemia(CML)therapy,CML still faces the challenges of drug resistance and progression to blast ***-five percent of patients have imatinib resistance and treatment difficulties due to heterogeneity after progression,but little is known about the mechanism.A key transcription factor in hematopoiesis,MYB,has been reported to increase abnormally in several types of aggressive blood disorders including ***:This study used a zebrafish model to explore the relationship between BCR/ABL1 and c-myb in CML progression.A CML zebrafish model was crossed with a c-myb hyperactivity transgenic ***:It was found that both exogenous BCR/ABL1 and c-myb could up-regulate the expression of neutrophil-related *** seriously,neutrophil accumulation was observed when BCR/ABL1 was combined with c-myb *** studies showed that c-myb may be one of the downstream targets of BCR/ABL1 and the effect of BCR/ABL1 on neutrophils was c-myb *** advantage of this inheritable in vivo model,it was shown that a combination of imatinib and flavopiridol,a cyclin-dependent kinase inhibitor targeting MYB,could more effectively alleviate the aggressive phenotype of the double transgene ***:In summary,this study suggests that c-myb acts downstream of BCR/ABL1 and is involved in CML progression and is therefore a risk factor and a valuable target for the treatment of CML *** model used in the study could be helpful in high-throughput drug screening in CML transformation.

关键词： chronic myeloid leukemia c-myb flavopiridol zebrafish model

Research and Application of Log Defect Detection and Visualization System Based on Dry Coupling Ultrasonic Method

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Journal of Renewable Materials 2023年第11期11卷 3917-3932页

作者： Yongning Yuan Dong Zhang Usama Sayed Hao Zhu Jun Wang xiaojun yang Zheng Wang College of Mechanical and Electronic Engineering Nanjing Forestry UniversityNanjing210037China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing210037China College of Civil Engineering Nanjing Forestry UniversityNanjing210037China College of Information Science and Technology Nanjing Forestry UniversityNanjing210037China

In order to optimize the wood internal quality detection and evaluation system and improve the comprehensive utilization rate of wood,this paper invented a set of log internal defect detection and visualization system by using the ultrasonic dry coupling agent *** detection and visualization analysis of internal log defects were realized through log specimen *** main conclusions show that the accuracy,reliability and practicability of the system for detecting the internal defects of log specimens have been effectively *** system can make the edge of the detected image smooth by interpolation algorithm,and the edge detection algorithm can be used to detect and reflect the location of internal defects of logs *** content mentioned above has good application value for meeting the requirement of increasing demand for wood resources and improving the automation level of wood nondestructive testing instruments.

关键词： Ultrasonic method log defect detection visualization system dry coupling B-scan pulse transmission method bilinear image interpolation algorithm edge detection algorithm

Dietary vitamin D_(3) deprivation suppresses fibroblast growth factor 23 signals by reducing serum phosphorus levels in laying hens

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Animal Nutrition 2022年第2期9卷 23-30页

作者： Jiakun Yan Chong Pan Yanli Liu Xujie Liao Jionghao Chen Yufei Zhu Xinhuo Huang xiaojun yang Zhouzheng Ren College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxiChina Nano Vitamin Engineering Research Center of Shaanxi Province Xi'anChina

The present study was carried out to evaluate the effect of dietary supplemental vitamin D_(3) on fibroblast growth factor 23(FGF23)signals as well as phosphorus homeostasis and metabolism in laying *** 40-week-old Hy-Line Brown layers were randomly assigned into 2 treatments:1)vitamin D_(3) restriction group(n=7)fed 0 IU/kg vitamin D_(3) diet,and 2)regular vitamin D_(3) group(n=7)fed 1,600 IU/kg vitamin D_(3) *** study lasted for 21 *** parameters,phosphorus and calcium excretion status,and tissue expressions of type II sodium-phosphate co-transporters(NPt2),FGF23 signals and vitamin D_(3) metabolic regulators were *** fed the vitamin D_(3) restricted diet had decreased serum phosphorus levels(by 31.3%,P=0.028)when compared to those fed regular vitamin D_(3) *** response to the decreased serum phosphorus,the vitamin D_(3) restricted laying hens exhibited:1)suppressed kidney expressions of 25-hydroxyvitamin D 1-a-hydroxylase(CYP27B1,by 52.8%,P=0.036)and 1,25-dihydroxyvitamin D 24-hydroxylase(CYP24A1,by 99.4%,P=0.032);2)suppressed serum levels of FGF23(by 14.6%,P=0.048)and increased serum alkaline phosphatase level(by 414.1%,P=0.012);3)decreased calvaria mRNA expressions of fibroblast growth factor receptors(FGFR1,by 85.2%,P=0.003,FGFR2,by 89.4%,P=0.014,FGFR3,by 88.8%,P=0.017,FGFR4,by 89.6%,P=0.030);4)decreased kidney mRNA expressions of FGFR1(by 65.5%,P=0.021),FGFR4(by 66.0%,P=0.050)and KLOTHO(by 68.8%,P=0.038);5)decreased kidney protein expression of type 2a sodium-phosphorus co-transporters(by 54.3%,P=0.039);and 6)increased percent excreta calcium(by 26.9%,P=0.002).In conclusion,the deprivation of dietary vitamin D_(3) decreased FGF23 signals in laying hens by reducing serum FGF23 level and suppressing calvaria and kidney mRNA expressions of FGF23 receptors.

关键词： Dietary vitamin D_(3) Fibroblast growth factor 23 Fibroblast growth factor receptor KLOTHO Laying hen

Numerical simulation of spatial distributions of mining-induced stress and fracture fields for three coal mining layouts

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第5期10卷 907-913页

作者： Shengwei Li Mingzhong Gao xiaojun yang Ru Zhang Li Ren Zhaopeng Zhang Guo Li Zetian Zhang Jing Xie State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and Hydropower Sichuan University State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and Technology MOE Laboratory of Deep Underground Science and Engineering College of Architecture and Environment Sichuan University China Three Gorges Projects Development Co. Ltd.

In this study, the spatial distributions of stress and fracture fields for three typical underground coal mining layouts, Le, non-pillar mining （NM）, top-coal caving mining （TCM） and protective coal-seam mining （PCM）, are modeled using discrete element software UDEC, The numerical results show that different mining layouts can lead to different mining-induced stress fields, resulting in diverse fracture fields, For the PCM, the mining influenced area in front of the mining faces is the largest, and the stress concentration factor in front of the mining faces is the lowest, The spatial shapes of the mining-induced fracture fields under NM, TCM and PCM differ, and they are characterized by trapezoidal, triangular and tower shapes, respectively, The fractal dimensions of mining-induced fractures of the three mining layouts decrease in the order of PCM, TCM and NM, It is also shown that the PCM can result in a better gas control effect in coal mines with high outburst potential, The numerical results are expected to provide a basis for understanding of mining-induced gas seepage fields and provide a reference for high- efficiency coal mining,

关键词： Coal mining Mining layouts Mining-induced stress field Mining-induced fracture field Numerical simulation

A simple daily dynamic feeding regimen for reducing phosphorus consumption and excretion in laying hens

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Animal Nutrition 2022年第4期11卷 132-141页

作者： Xujie Liao Jiakun Yan Jionghao Chen Zhenyu Huang Tianshuai Xiao Changqing Li Chong Pan Xin yang Yanli Liu Thomas D.Crenshaw xiaojun yang Zhouzheng Ren College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxi 712100China Department of Animal Sciences University of Wisconsin-MadisonMadisonWI 53706USA

Phosphorus metabolism in laying hens is a highly dynamic process over the course of the 24 h egg-laying *** the phosphorus feeding regimen according to the daily egg-laying cycle may help to improve phosphorus utilization ***-Line Brown layers(n=120;70 wk old)were offered 4different phosphorus daily regimens:(1)RR,fed regular phosphorus at both 09:00 and 17:00;(2)RL,fed regular phosphorus at 09:00 and low phosphorus at 17:00;(3)LR,fed low phosphorus at 09:00 and regular phosphorus at 17:00;(4)LL,fed low phosphorus at both 09:00 and 17:*** regular and low phosphorus diets contained 0.32% and 0.14% non-phytate phosphorus,*** feeding trial lasted for 12 *** a result,layers on the RL regimen had decreased laying rate(P0.05);(2)decreased phosphorus excretion(P<0.05)during the period of09:00 to 17:00;(3)increased jejunal calbindin D28k protein expression(P<0.05)2 h after feeding in the morning;(4)decreased serum fibroblast growth factor 23 and calcitriol levels(P<0.05),decreased jejunal type Ⅲ sodium-phosphate cotransporter 2 gene and protein expression(P<0.05),and decreased renal type Ⅲ sodium-phosphate cotransporter 1 protein expression(P<0.05),2 h after feeding in the *** summary,when dietary phosphorus was supplemented in accordance with daily serum phosphorus rhythms(i.e.,the LR regimen),laying performance and egg quality were well supported whilst significantly decreasing phosphorus consumption and ***,serum phosphorus rhythms will need to be carefully maintained when developing dietar

关键词： Phosphorus-calcium homeostasis Dynamic feeding regimen Egg production Laying hen Phosphorus excretion

Negative magnetoresistance in Weyl semimetals NbAs and NbP： Intrinsic chiral anomaly and extrinsic effects

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Frontiers of physics 2017年第3期12卷 19-28页

作者： Yupeng Li Zhen Wang Pengshan Li xiaojun yang Zhixuan Shen Feng Sheng Xiaodong Li Yunhao Lu Yi Zheng Zhu-An Xu Department of Physics Zhejiang University Hangzhou 310027 China State Key Lab of Silicon Materials Zhejiang University Hangzhou 310027 China Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Zhejiang California International NanoSystems Institute Zhejiang University Hangzhou 310058 China Collaborative Innovation Centre of Advanced Microstructures Nanjing 210093 China

Chiral anomaly-induced negative magnetoresistance （NMR） has been widely used as critical transport evidence for the existence of Weyl fermions in topological semimetals. In this mini-review, we discuss the general observation of NMR phenomena in non-centrosymmetric NbP and NbAs. We show that NMR can arise from the intrinsic chiral anomaly of Weyl fermions and/or extrinsic effects, such as the superimposition of Hall signals; field-dependent inhomogeneous current flow in the bulk, i.e., current jetting; and weak localization （WL） of coexistent trivial carriers. The WLmcontrolled NMR is heavily dependent on sample quality and is characterized by a pronounced crossover from positive to negative MR growth at elevated temperatures, resulting from the competition between the phase coherence time and the spin-orbital scattering constant of the bulk trivial pockets. Thus, the correlation between the NMR and the chiral anomaly need to be scrutinized without the support of complimentary techniques. Because of the lifting of spin degeneracy, the spin orientations of Weyl fermions are either parallel or antiparallel to the momentum, which is a unique physical property known as helicity. The conservation of helicity provides strong protection for the transport of Weyl fermions, which can only be effectively scattered by magnetic impurities. Chemical doping with magnetic and non-magnetic impurities is thus more convincing than the NMR method for detecting the existence of Weyl fermions.

关键词： Weyl semimetals chiral anomaly negative magnetoresistance extrinsic effects

Nonlinear spectral cleaning effect in cross-polarized wave generation

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Chinese Physics B 2018年第5期27卷 281-286页

作者： Linpeng Yu Yi Xu Fenxiang Wu xiaojun yang Zongxin Zhang Yuanfeng Wu Yuxin Leng Zhizhan Xu State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 China University of Chinese Academy of Sciences Beijing 100049 China

The underlying mechanism of the spectral cleaning effect of the cross-polarized wave（XPW） generation process was theoretically investigated. This study shows that the spectral noise of an input spectrum can be removed in the XPW generation process and that the spectral cleaning effect depends on the characteristics of the input pulses, such as the chirp and Fourier-transform-limited duration of the initial pulse, and the modulation amplitude and frequency of the spectral noise. Though these factors codetermine the output spectrum of the XPW generation process, the spectral cleaning effect is mainly affected by the initial pulse chirp. The smoothing of the spectrum in the XPW generation process leads to a significant enhancement of the coherent contrast.

关键词： nonlinear optics cross-polarized wave generation spectral cleaning effect

Photonic crystal rod-based high-performance ultrafast fiber laser system

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High Power Laser Science and Engineering 2020年第4期8卷 84-90页

作者： Zhiguo Lv Zhi yang Qianglong Li Feng Li Yishan Wang Wei Zhao xiaojun yang School of Physical Science and Technology Inner Mongolia Key Laboratory of Nanoscience and NanotechnologyInner Mongolia UniversityHohhot 010021China State Key Laboratory of Transient Optics and Photonics Xi’an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi'an 710119China

In this paper,we innovatively conduct a Porro prism-based beam pointing stability promotion technique research and realize a high-performance rod-type photonic crystal fiber-based chirped pulse amplification(CPA)system,mainly including a frequency-reduced all-fiber pre-amplification stage,photonic crystal rod-based main amplification stage,and 1600 lines/mm transmission grating-pair *** output with average power of 50 W,repetition rates of500 kHz,pulse energy of 100μJ,pulse duration of 830 fs,beam quality of M2<1.3,power fluctuation of 0.55%root mean square,and beam pointing drift of 19μrad/?C over 8 h is *** high-performance laser system has an enormous application potential in fundamental research and precision manufacturing fields.

关键词： chirped pulse amplification ultrashort pulses high performance laser system

武周时期从长安到敦煌的佛舍利崇拜——以莫高窟第332窟为中心

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考古与文物 2019年第4期 99-105页

作者：杨效俊陕西历史博物馆

开凿于武周圣历元年(698年)的莫高窟第332窟是武周时期新出现的'原创性'洞窟,其建筑与图像程序为从佛祖寂灭到佛法永恒,其主题是武周时期兴盛的佛舍利崇拜,是在长安佛舍利崇拜制度影响下形成的敦煌地区独特的佛舍利崇拜形式。

关键词：莫高窟第332窟 “原创性”洞窟佛舍利崇拜长安敦煌