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加强第三方机构服务创新助推建筑领域绿色低碳发展

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质量与认证 2024年第6期 72-74页

作者：宋小婧中国质量认证中心深圳分中心

早在2017年,国家认监委就与住房城乡建设部签署《全面推进住房城乡建设领域认证认可发展的战略合作协议》,支持推动住房城乡建设领域认证认可制度创新发展。本文介绍了建筑领域认证认可的发展基础,阐明了认证认可服务创新对于建筑领域... 详细信息

早在2017年,国家认监委就与住房城乡建设部签署《全面推进住房城乡建设领域认证认可发展的战略合作协议》,支持推动住房城乡建设领域认证认可制度创新发展。本文介绍了建筑领域认证认可的发展基础,阐明了认证认可服务创新对于建筑领域实现“双碳”目标的重要作用,围绕建筑领域降碳路径,介绍了建筑领域绿色化、产业化和智能化等绿色低碳发展转型过程中涉及到的各类第三方创新服务。最后,对于建筑领域第三方服务创新提出了相关建议。

关键词：第三方机构认证认可建筑双碳创新

二氧化乙烯基环己烯致大鼠早发性卵巢功能不全模型的给药剂量探讨

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中国实验方剂学杂志 2024年第18期30卷 72-79页

作者：黎蔚欣杜鹏飞朱瑶瑶苏晨晨许焕芳杨莉宋晓晶房繄恭中国中医科学院针灸研究所北京100700

目的:通过比较二氧化乙烯基环己烯(VCD)不同剂量和不同停药时间对雌性大鼠生殖内分泌水平的影响,以探索VCD构建早发性卵巢功能不全(POI)大鼠模型有效、稳定及安全的给药剂量。方法:将动情周期规律的SD大鼠随机分为3组,分别为空白组、VC... 详细信息

目的:通过比较二氧化乙烯基环己烯(VCD)不同剂量和不同停药时间对雌性大鼠生殖内分泌水平的影响,以探索VCD构建早发性卵巢功能不全(POI)大鼠模型有效、稳定及安全的给药剂量。方法:将动情周期规律的SD大鼠随机分为3组,分别为空白组、VCD低、高剂量组(80、160 mg·kg^(-1)·d^(-1)),每组24只。药物干预后,分别于干预后第15天和第45天取材,检测大鼠的一般情况、动情周期紊乱率、血清激素水平、卵巢组织形态学、卵泡计数、妊娠结局、转化生长因子-β(TGF-β)和Smad2/3蛋白及mRNA表达。结果:与空白组比较,VCD低剂量组大鼠动情周期紊乱率、血清促卵泡激素(FSH)、促黄体生成激素(LH)、雌二醇(E_(2))水平差异无统计学意义;卵巢组织受损,原始卵泡和初级卵泡在第15天显著减少(P<0.01),在第45天进一步出现次级卵泡(P<0.01)和窦卵泡(P<0.05)数量明显减少;产崽数在第15天明显减少(P<0.05),但在第45天差异无统计学意义;TGF-β蛋白水平在第15天(P<0.05)和第45天(P<0.01)升高;Smad2/3在第45天显著升高(P<0.01);TGF-β和Smad2/3mRNA水平在第45天升高(P<0.05)。与空白组比较,VCD高剂量组大鼠动情周期紊乱率在第45天升高(P<0.01);血清FSH、LH明显升高,E_(2)明显下降(P<0.05,P<0.01);卵巢组织受损,各级卵泡下降趋势同VCD低剂量组;产崽数在第15天和第45天均明显下降;TGF-β和Smad2/3蛋白水平升高(P<0.05,P<0.01),TGF-β mRNA在第45天明显升高(P<0.05)。结论:VCD高剂量是VCD构建POI大鼠模型的理想剂量,具有有效性、稳定性和安全性。

关键词：二氧化乙烯基环己烯早发性卵巢功能不全动物模型剂量研究妊娠结局

Prevalence of echocardiographic abnormalities in HIV-infected adults on long-term combination antiretroviral therapy

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中华医学杂志(英文版) 2024年第19期

作者： Luo Ling Li Xiaodi song xiaojing Lyu Wei Liu Zhengyin Wang Huanling Han Yang Li Xiaoxia Li Yanling Chen Tielong Xiong Yong He Yun Li Huiqin Ye Hanhui Cao Wei Li Taisheng Department of Infectious Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China Department of Infectious Diseases Zhongnan Hospital of Wuhan University Wuhan Hubei China National Clinical Research Center for Infectious Diseases HKU AIDS Institute Shenzhen Research Laboratory The Third People’s Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology Shenzhen Guangdong China Department of HIV/AIDS Clinical Research Yunnan Provincial Hospital of Infectious Disease AIDS Care Center (YNACC) Kunming Yunnan China Department of infection Mengchao Hepatobiliary Hospital of Fujian Medical University Fuzhou Fujian China Department of Basic Medical Sciences School of Medicine Tsinghua University Beijing China Tsinghua-Peking Center for Life Sciences Beijing China State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China

中国人类免疫缺陷病毒感染者的肺动脉高压发生情况及危险因素分析

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中华传染病杂志 2024年第3期42卷 141-146页

作者：罗玲宋晓璟吕玮刘正印王焕玲李雁凌李晓霞曹玮李太生中国医学科学院北京协和医学院北京协和医院感染内科北京100730

目的评估中国长期行抗反转录病毒治疗(ART)与未接受过ART的人类免疫缺陷病毒(HIV)感染者的肺动脉高压(PH)发生情况,并分析HIV感染者发生PH的危险因素,为我国HIV感染者的心血管疾病监测和管理提供依据。方法长期行ART的HIV感染者来自NCT0... 详细信息

目的评估中国长期行抗反转录病毒治疗(ART)与未接受过ART的人类免疫缺陷病毒(HIV)感染者的肺动脉高压(PH)发生情况,并分析HIV感染者发生PH的危险因素,为我国HIV感染者的心血管疾病监测和管理提供依据。方法长期行ART的HIV感染者来自NCT04463810研究队列。另外,采用倾向性评分匹配方法,从NCT00872417与NCT01844297研究中选取性别匹配、未接受过ART的HIV感染者作为对照。本研究为回顾性、观察性临床研究。收集纳入HIV感染者的基本资料和临床访视资料,以及心脏彩色多普勒超声检查数据,以分析HIV感染者的PH发生率及发生PH的危险因素。统计学方法采用χ^(2)检验和多因素logistic回归分析。结果318例HIV感染者中,长期行ART和未接受过ART的患者各159例,分别为长期治疗组和未治疗组。318例HIV感染者中发生PH者30例(9.4%),其中临界性PH 23例(7.2%),轻度PH 6例(1.9%),中度PH 1例(0.3%),无重度PH。长期治疗组PH发生率为5.0%(8/159),低于未治疗组的13.8%(22/159),差异有统计学意义(χ^(2)=7.21,P=0.012)。多因素分析显示,年龄大[比值比(OR)=1.064,95%可信区间(CI)1.019~1.111,P=0.016]和病毒未被抑制(OR=2.660,95%CI 1.041~6.797,P=0.041)是HIV感染者发生PH的独立危险因素。结论长期行ART的HIV感染者的PH发生率低于未接受过ART的HIV感染者。年龄大、病毒未被抑制是HIV感染者发生PH的独立危险因素。心脏彩色多普勒超声检查有助于HIV感染者早期筛查PH,对于HIV感染者,应积极行ART以减少PH的发生。

关键词： HIV 肺动脉高压心脏彩色多普勒超声抗逆转录病毒治疗

A Message-Level Security Model Consisting of Multiple Security-Tokens Mechanism

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Wuhan University Journal of Natural Sciences 2007年第1期12卷 1-4页

作者： LIU Zhenpeng song xiaojing TANG Wansheng CHANG Xiaomeng ZHOU Dongdong Institute of System Engineering Tianjin UniversityTianjin 300072 China School of Mathematics and Computer Hebei UniversityBaoding 071002 Hebei China

Current Web services architectures are confronted with a few stubborn problems, and the security problem becomes one of the bottlenecks that restrict the extensive application of Web service. After compared transport level with message level security, the limitation of transport level security became clearly. And then on the basis of the analysis message level security, especially WS-Security, XML security protocol was adopted to guarantee message level security. Because WS-Security is a new protocol jointly developed by Microsoft and IBM among these XML security protocols, and a security-token mechanism of WS-Security mechanism was improved, added a table with security-token types. And a new model consisting of multiple security-token is put forward to guarantee the security of message transmission.

关键词： Web service message level security WS-Security security-token

Genetic relationship between formation,accumulation and migration and dispersion of peat materials in Paleogene——Take the Qiongdongnan Basin as an example

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Acta Oceanologica Sinica 2024年第4期43卷 80-91页

作者： xiaojing Li Zengxue Li Dongdong Wang Guangzeng song Pingli Wang Haiyan Liu Key Laboratory of Sedimentary Mineralization and Sedimentary Minerals in Shandong Province Qingdao 266590China Shandong University of Science and Technology Qingdao 266590China School of Water Conservancy and Environment University of JinanJinan 250022China

Coal-type source rocks include both coal and terrigenous marine source *** studying the distribution of secondary depressions,uplifts,as well as the characteristics of peat formation and accumulation in the northern marginal sea basin of the South China Sea,and combining them with coal formation characteristics observed in other basins,five genetic theories on the relationship between peat accumulation and dispersed organic matter accumulation are *** northern marginal sea basin of the South China Sea is characterized by“disadvantageous coals formation and favorable terrigenous marine source rocks formation.”This paper provides a distribution map of coal seams and terrigenous marine source rocks in the Qiongdongnan Basin and determines their distribution *** shows that the migration of sedimentary facies in the basins and inner depressions led to the formation and migration of the peat accumulation *** addition,the vertical migration of the peat accumulation centers led to planar migration,which is actually a type of coupling *** research results have revealed that the formation of coal-type source rock is *** marginal sea basin is composed of several fault-depression basins,with each basin developing a second order of depression and *** is no unified basin center or depositional center to be *** a result,the concentration centers of coal-forming materials also vary *** on the distribution characteristics of coal-type source rocks in different basins within the marginal sea basins of the South China Sea,the research results have practical significance and provide guidance for exploring coal-type oil and gas reservoirs in this area.

关键词： Coal-type source rock marginal sea basins migration of peat aggregation centers terrigenous marine source rock Qiongdongnan Basin

小型猪四肢间质通道的三维可视化及与人体经脉的比较

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中国科学：生命科学 2024年第8期54卷 1466-1487页

作者：熊枫宋晓晶黄江伟贾术永王广军王淑友刘琪申耀华涂娜降雨强张维波中国中医科学院针灸研究所北京100700 中国科学院遗传与发育生物学研究所北京100101 天津中医药大学针灸推拿学院天津301617 北京中医药大学针灸推拿学院北京100029

经络是中医理论的核心概念.以往大量的研究表明,间质中存在长程流动的组织液,可能与经络相关.本团队前期通过在小型猪四肢的循经低电阻点注射一种亲组织液的小分子荧光物质,在体表观察到部分循经迁移的荧光轨迹,解剖发现迁移轨迹主体位... 详细信息

经络是中医理论的核心概念.以往大量的研究表明,间质中存在长程流动的组织液,可能与经络相关.本团队前期通过在小型猪四肢的循经低电阻点注射一种亲组织液的小分子荧光物质,在体表观察到部分循经迁移的荧光轨迹,解剖发现迁移轨迹主体位于深层间质组织.为比较深层迁移的循经间质通道和人体经脉的关系,本研究首先用经络定位仪测定8只健康小型猪四肢的低电阻点,其中6只小型猪分别进行12条循经低电阻线注射(1条/腿), 1只小型猪作非经的对照注射,最后1只小型猪按照人体骨度分寸标记用作横切面位置定位.在低电阻点及旁开高电阻点注射微量荧光素钠后,小型猪注射过量麻药并冷冻肢体.取下四肢经冷冻、包埋后进行整体横切,用装有窄带滤色镜的数码相机与蓝激光照明切换采集横切面的明场与荧光图像,观察荧光信号在横切面的分布特征.从横切面上荧光信号区域组织取材做新鲜组织冰冻切片观察其微观结构.连续横切面图像进行数字化三维重建.结果发现,四肢的低电阻点注射荧光素钠后在横切面上观察到可重复的12条循经迁移轨迹,除前肢三条与人体上肢三阴经类似的循经间质通道向近心端迁移逐渐汇聚成一处外,其余通道相互独立,位置固定.而在旁开非经注射后仅出现接近椭球体的局部扩散,或者扩散到附近的间质通道后继续循经迁移.横切面上的荧光信号位置与传统中医描述的经络循行接近,与针刺的针尖位置基本一致,其微观结构为结缔组织中充满网格状纤维的间隙结构.本研究发现生物体内存在着一种长程连续的间质通道,是中医经络的科学内涵之一.

关键词：经络间质通道三维可视化荧光素钠整体横切穴位针刺小型猪

Atmospheric nitrogen deposition affects forest plant and soil system carbon:nitrogen:phosphorus stoichiometric flexibility:A meta-analysis

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Forest Ecosystems 2024年第3期11卷 307-317页

作者： Xiyan Jiang xiaojing Wang Yaqi Qiao Yi Cao Yan Jiao An Yang Mengzhou Liu Lei Ma Mengya song Shenglei Fu Key Laboratory of Geospatial Technology for the Middle and Lower Yellow River Regions College of Geography and Environmental ScienceHenan UniversityKaifeng475004China Henan Key Laboratory of Integrated Air Pollution Control and Ecological Security College of Geography and Environmental ScienceHenan UniversityKaifeng475004China Henan Dabieshan National Field Observation and Research Station of Forest Ecosystem Henan UniversityZhengzhou450046China

Background:Nitrogen(N)deposition affects forest stoichiometric flexibility through changing soil nutrient availability to influence plant ***,the effect of N deposition on the flexibility of carbon(C),N,and phosphorus(P)in forest plant-soil-microbe systems remains ***:We conducted a meta-analysis based on 751 pairs of observations to evaluate the responses of plant,soil and microbial biomass C,N and P nutrients and stoichiometry to N addition in different N intensity(050,50–100,>100 kg·ha^(-1)·year^(-1)of N),duration(0–5,>5 year),method(understory,canopy),and matter(ammonium N,nitrate N,organic N,mixed N).Results:N addition significantly increased plant N:P(leaf:14.98%,root:13.29%),plant C:P(leaf:6.8%,root:25.44%),soil N:P(13.94%),soil C:P(10.86%),microbial biomass N:P(23.58%),microbial biomass C:P(12.62%),but reduced plant C:N(leaf:6.49%,root:9.02%).Furthermore,plant C:N:P stoichiometry changed significantly under short-term N inputs,while soil and microorganisms changed drastically under high N *** N addition primarily affected plant C:N:P stoichiometry through altering plant N content,while understory N inputs altered more by influencing soil C and P *** N significantly influenced plant and soil C:N and C:P,while ammonia N changed plant N:*** C:P and soil C:N were strongly correlated with mean annual precipitation(MAT),and the C:N:P stoichiometric flexibility in soil and plant under N addition connected with soil ***,N addition decoupled the correlations between soil microorganisms and the ***:N addition significantly increased the C:P and N:P in soil,plant,and microbial biomass,reducing plant C:N,and aggravated forest P ***,these impacts were contingent on climate types,soil layers,and N input *** findings enhance our comprehension of the plant-soil system nutrient cycling mechanisms in forest ecosystems and plant strategy responses to N deposition.

关键词： C:N:P stoichiometry Meta-analysis Forest ecosystem Nitrogen addition form Nutrient cycles

On Stability Analysis of Active Disturbance Rejection Disturbance Control for General MIMO Motion Control Systems

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On Stability Analysis of Active Disturbance Rejection Distur...