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我国新版婴幼儿配方食品标准与欧盟标准的对比分析

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中国乳业 2024年第7期 83-87页

作者：周密马娇么赛于晓瑾史娜郑跃郭蕊耿健强北京市食品检验研究院(北京市食品安全监控和风险评估中心) 国家市场监管重点实验室(食品安全重大综合保障关键技术)北京100094

2021年我国颁布新版婴幼儿配方食品系列标准,2023年2月22日起已正式实施。欧盟标准是制定婴幼儿配方食品标准的重要参考标准。本文对比新版婴幼儿配方食品系列标准与欧盟标准中不同类型项目限量差异,分析可能导致差异原因。通过对比分析... 详细信息

2021年我国颁布新版婴幼儿配方食品系列标准,2023年2月22日起已正式实施。欧盟标准是制定婴幼儿配方食品标准的重要参考标准。本文对比新版婴幼儿配方食品系列标准与欧盟标准中不同类型项目限量差异,分析可能导致差异原因。通过对比分析,能更直观了解新版婴幼儿配方食品系列标准与欧盟标准差异,为后续研究和标准持续修订提供参考。

关键词：婴幼儿配方食品标准欧盟标准比较

研究生激光医学课程思政建设路径的思考与实践

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组织工程与重建外科 2024年第2期20卷 270-272页

作者：马刚吴晓瑾陆雯丽商颖林晓曦吴品茹上海交通大学医学院附属第九人民医院激光美容科上海市200011 上海交通大学医学院附属第九人民医院整复外科上海市200011 上海交通大学医学院附属第九人民医院皮肤科上海市200011

将思政建设融入医学课程是培养医学生职业道德和职业精神的重要途径。激光医学是一门新兴的交叉学科,在激光医学的教学实践中,要深入挖掘课程中的思政要素,提升课程思政建设水平,加强医学研究生的人文素质,同时也要重视教师的思政教育... 详细信息

将思政建设融入医学课程是培养医学生职业道德和职业精神的重要途径。激光医学是一门新兴的交叉学科,在激光医学的教学实践中,要深入挖掘课程中的思政要素,提升课程思政建设水平,加强医学研究生的人文素质,同时也要重视教师的思政教育能力培养,提高激光医学教学质量,从而为国家培养更多德才兼备的激光医学人才。

关键词：激光医学研究生思政建设

高山探险目的地形象对体育旅游参与者行为意向的影响研究——以风险感知和情绪为中介

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山东体育学院学报 2024年第5期40卷 116-126页

作者：宋恒义马腾山东体育学院研究生教育学院山东济南250102 山东体育学院运动休闲学院山东济南250102

目的:立足于情绪评价理论,以风险感知和情绪作为中介变量,探究高山探险目的地形象对体育旅游参与者行为意向的影响机制。方法:选取四川省小金县四姑娘山区域为调研采样地,以371名体育旅游参与者为样本,基于结构方程模型的多重中介效应,... 详细信息

目的:立足于情绪评价理论,以风险感知和情绪作为中介变量,探究高山探险目的地形象对体育旅游参与者行为意向的影响机制。方法:选取四川省小金县四姑娘山区域为调研采样地,以371名体育旅游参与者为样本,基于结构方程模型的多重中介效应,运用SPSS 26.0和Amos 24.0软件对数据进行统计分析。结果:(1)目的地形象对风险感知具有显著的负向影响,对情绪和行为意向具有显著的正向影响;(2)风险感知对情绪和行为意向具有显著的负向影响;(3)风险感知和情绪在目的地形象对行为意向的影响过程中发挥着显著的双中介作用。结论:体育旅游参与者行为意向的生成受多重要素驱动,为充分发挥目的地形象的直接效应及风险感知、情绪的双重中介作用,应塑造积极的高山探险旅游目的地形象,注重体育旅游参与者的情绪管理和风险管理,构建综合治理框架,为高山探险旅游消费业态健康发展提供理论支撑与现实指导。

关键词：高山探险体育旅游目的地形象行为意向风险感知情绪

王子瑜教授从“血瘀”论治子宫内膜异位性疾病经验

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中国医药导报 2024年第16期21卷 152-154页

作者：李娜甘小金阙绮莹李晓颖孙凌逸陈艳马秀丽北京中医药大学东直门医院妇科北京100700

介绍王子瑜教授从“血瘀”论治子宫内膜异位性疾病的经验。王子瑜教授认为此类疾病的病机为离经之瘀血阻滞胞宫冲任。根本治则是活血化瘀消癥,并研制院内制剂乌丹丸、妇科痛经丸、桂苓消癥丸,临床使用30余年,效果显著。总结瘀血之气滞... 详细信息

介绍王子瑜教授从“血瘀”论治子宫内膜异位性疾病的经验。王子瑜教授认为此类疾病的病机为离经之瘀血阻滞胞宫冲任。根本治则是活血化瘀消癥,并研制院内制剂乌丹丸、妇科痛经丸、桂苓消癥丸,临床使用30余年,效果显著。总结瘀血之气滞、寒凝、热郁、痰凝、湿热、气虚、阳虚、肾虚八大成因并提出化瘀八法。王子瑜教授的治疗特色:化瘀为主,标本、虚实、寒热兼顾;按周期规律分期论治;汤剂与丸剂相结合并善于运用粉剂;药性平和、寒温适宜,药味精简、善用小方药对。附病案1则,以资佐证。

关键词：子宫内膜异位性疾病血瘀名医经验王子瑜乌丹丸

Dendritic cell-derived IL-27 p28 regulates T cell program in pathogenicity and alleviates acute graft-versus-host disease

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3955-3966页

作者： Huanle Gong Shoubao ma Jia Chen Bingyu Yang Shuangzhu Liu Xin Liu Jingjing Han xiaojin.Wu Lei Lei Zhinan Yin Hongjian Sun Di Yu Haiyan Liu Yang Xu Depei Wu The First Affiliated Hospital of Soochow University National Clinical Research Center for Hematologic DiseasesJiangsu Institute of HematologyInstitute of Blood and Marrow TransplantationSoochow UniversitySuzhou 215123China Collaborative Innovation Center of Hematology Soochow UniversitySuzhou 215123China Department of Hematology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Zhuhai Precision Medical Center Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Jinan UniversityZhuhai 519000 GuangdongChina The Biomedical Translational Research Institute Faculty of Medical ScienceJinan UniversityGuangzhou 510632 GuangdongChina Shandong Artificial Intelligence Institute Qilu University of Technology(Shandong Academy of Sciences)Jinan 250200China The University of Queensland Diamantina Institute Faculty of MedicineThe University of QueenslandBrisbaneQLD 4072Australia Immunology Programme Life Sciences InstituteImmunology Translational Research Program and Department of Microbiology and ImmunologyYong Loo Lin School of MedicineNational University of SingaporeSingapore 117456Singapore

Interleukin 27(IL-27),a heterodimeric cytokine composed of Epstein-Barr virus-induced 3 and p28,is a pleiotropic cytokine with both pro-and anti-inflammatory ***,the precise role of IL-27 in acute graft-versus-host disease is not yet fully *** this study,utilizing mice with IL-27 p28 deficiency in dendritic cells(DCs),we demonstrated that IL-27 p28 deficiency resulted in impaired Treg cell function and enhanced effector T cell responses,corresponding to aggravated aGVHD in *** addition,using single-cell RNA sequencing,we found that loss of IL-27 p28 impaired Treg cell generation and promoted IL1R2^(+)TIGIT^(+)pathogenic CD4+T cells in the thymus at a steady ***,IL-27 p28 deficiency promoted STAT1 phosphorylation and Th1 cell responses,leading to the inhibition of Treg cell differentiation and ***,patients with high levels of IL-27 p28 in serum showed a substantially decreased occurrence of grade II-IV aGVHD and more favorable overall survival than those with low levels of IL-27 ***,our results suggest a protective role of DC-derived IL-27 p28 in the pathogenesis of aGVHD through modulation of the Treg/Teff cell balance during thymic ***-27 p28 may be a valuable marker for predicting aGVHD development after transplantation in humans.

关键词： impaired protective graft

网织红细胞、血清铁蛋白、VitB_(12)联合检测在MDS与ma鉴别诊断中的应用价值

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中国医学创新 2024年第27期21卷 148-152页

作者：徐小津丁益群刘苏琴杨子东吉安市中心人民医院核医学科江西吉安343000 吉安市中心人民医院输血科江西吉安343000 吉安市中心人民医院检验科江西吉安343000

目的:探讨网织红细胞、血清铁蛋白(SF)、维生素B_(12)(VitB_(12))联合检测在骨髓增生异常综合征(MDS)与巨幼细胞贫血(ma)鉴别诊断中的应用价值。方法:选取2020年7月—2023年11月吉安市中心人民医院收治的MDS患者43例纳入MDS组,ma患者43... 详细信息

目的:探讨网织红细胞、血清铁蛋白(SF)、维生素B_(12)(VitB_(12))联合检测在骨髓增生异常综合征(MDS)与巨幼细胞贫血(ma)鉴别诊断中的应用价值。方法:选取2020年7月—2023年11月吉安市中心人民医院收治的MDS患者43例纳入MDS组,ma患者43例纳入ma组,另选取于本院体检的健康体检者43例纳入对照组,比较三组血浆网织红细胞、SF及血清VitB_(12)水平,通过受试者操作特征(ROC)曲线分析三项指标单独或联合检测对MDS的诊断效能。结果:MDS组、ma组网织红细胞血红蛋白(Ret-He)、未成熟网织红细胞指数(IRF)、中荧光强度网织红细胞比率(MFR)、高荧光强度网织红细胞比率(HFR)水平均高于对照组,差异均有统计学意义(Pma组的低荧光强度网织红细胞比率(LFR)均低于对照组(P0.05);MDS组Ret-He水平低于ma组,差异有统计学意义(Pma组SF水平均高于对照组,差异均有统计学意义(Pma组血清VitB_(12)水平低于对照组,差异均有统计学意义(Pma组,差异均有统计学意义(Pma,Ret-He低于ma,可作为临床疾病鉴别的重要参考指标。

关键词：骨髓增生异常综合征再生障碍性贫血网织红细胞血清铁蛋白维生素B_(12)

The kinase OsSK41/OsGSK5 negatively regulates amylose content in rice endosperm by affecting the interaction between OsEBP89 and OsBP5

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Journal of Integrative Plant Biology 2023年第7期65卷 1782-1793页

作者： Zejun Hu Fuan Niu Peiwen Yan Kai Wang Lixia Zhang Ying Yan Yu Zhu Shiqing Dong Fuying ma Dengyong Lan Siwen Liu Xiaoyun Xin Ying Wang Jinshui Yang Liming Cao Shujun Wu xiaojin.Luo Key Laboratory of Germplasm Innovation and Genetic Improvement of Grain and Oil Crops(Co‐construction by Ministry and Province) Ministry of Agriculture and Rural AffairsCrop Breeding and Cultivation Research InstituteShanghai Academy of Agricultural SciencesShanghai 201403China State Key Laboratory of Genetic Engineering and MOE Engineering Research Center of Gene Technology School of Life SciencesFudan UniversityShanghai 200438China MOE Key Laboratory of Crop Physiology Ecology and Genetic Breeding College of AgronomyJiangxi Agricultural UniversityNanchang 330045China

Amylose content(AC) is the main factor determining the palatability, viscosity, transparency, and digestibility of rice(Oryza sativa)grains. AC in rice grains is mainly controlled by different alleles of the Waxy(Wx) gene. The AP2/EREBP transcription factor OsEBP89 interacts with the MYC-like protein OsBP5 to synergistically regulate the expression of ***, we determined that the GLYCOGEN SYNTHASE KINASE 5(OsGSK5, also named SHAGGY-like kinase 41 [OsSK41]) inhibits the transcriptional activation activity of OsEBP89 in rice grains during amylose biosynthesis. The loss of OsSK41 function enhanced Wx expression and increased AC in rice grains. By contrast, the loss of function of OsEBP89 reduced Wx expression and decreased AC in rice grains. OsSK41 interacts with OsEBP89 and phosphorylates four of its sites(Thr-28,Thr-30, Ser-238, and Thr-257), which makes OsEBP89 unstable and attenuates its interaction with OsBP5. Wx promoter activity was relatively weak when regulated by the phosphomimicvariantOsEBP89E–OsBP5but relatively strong when regulated by the nonphosphorylatable variant OsEBP89A–***, OsSK41-mediated phosphorylation of OsEBP89 represents an additional layer of complexity in the regulation of amylose biosynthesis during rice grain development. In addition, our findings provide four possible sites for regulating rice grain AC via precise gene editing.

关键词： AP2/EREBP transcription factor endosperm amylose content GSK3-like family protein MYC-like protein OsSK41/OsGSK5 OsEBP89 OsBP5 rice grain

Global trends and regional differences in non-transport unintentional injuries mortality among children and adolescents, 1990 to 2019: results from the Global Burden of Disease 2019 study

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Chinese Medical Journal 2022年第17期135卷 2056-2065页

作者： Yunfei Liu Yanhui Dong xiaojin.Yan Ning ma Jiajia Dang Jingshu Zhang Panliang Zhong Luo Li Zhiyong Zou Yi Song Jun ma Institute of Child and Adolescent Health School of Public HealthPeking UniversityBeijing 100191China The University of Melbourne Melbourne School of Population and Global HealthParkvileVIC 3010Australia

Background::Non-transport unintentional injuries(NTUIs)are major public concerns,especially among children and adolescents in low-and middle-income *** environmental and cognitive changes,a recent systematic description of global trends and regional differences concerning NTUIs is urgently needed for the global agenda of relevant policy-making and intervention target ***::We used mortality,population,and socio-demographic-index(SDI)data from Global Burden of Disease 2019 to analyze the trends of NTUIs *** applied the slope index of inequality(SII)and relative index of inequality(RII)to measure the absolute and relative inequality between countries and *** concentration curve and concentration index(CI)were also used to measure the *** conducted a sensitivity analysis to make our findings ***::In 2019,there were 205,000 deaths due to NTUIs among children and adolescents aged 5 to 24 years,which decreased from 375,000 in *** 2019,the age-standardized mortality rate(ASMR)was 8.13 per 100,000,ranging from the lowest in the Netherlands(0.90 per 100,000)to the highest in the Solomon Islands(29.34 per 100,000).The low-middle SDI group had the highest ASMR of NTUIs,while the low SDI group had the slowest *** excluding the death caused by"exposure to forces of nature"and"other unintentional injuries",drowning accounted for the most deaths in almost every SDI group,gender,and age group,but the major causes of death varied in different *** example,animal contact was a major cause in low and low-middle SDI groups but less in high SDI groups,while high and high-middle SDI groups had a higher proportion of deaths for foreign body and *** SII showed a declining trend,but the RII and CI did not,which might indicate that inequality was *** results were found in the sensitivity ***::Despite the declining trend of the mortality rate and the narrowing

关键词： Children and adolescents Non-transport unintentional injuries Socio-demographic-index Inequality analysis Foreign body Poisoning Global Burden of Disease Cause of death Developing countries Drowning

基于PI3K/Akt/FoxO1通路探讨脂肝清方对非酒精性脂肪性肝病小鼠胰岛素抵抗及糖异生的影响

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国际中医中药杂志 2024年第10期46卷 1295-1302页

作者：申明宇王静雅徐文轩王硕马雷雷胡佳豪李超喇孝瑾李继安华北理工大学中医学院唐山063210 华北理工大学公共卫生学院唐山063210

目的观察脂肝清方对高脂饲料诱导的非酒精性脂肪性肝病(NAFLD)C57BL/6J小鼠肝脏的保护作用及对PI3K/Akt/叉头盒转录因子1(FoxO1)信号通路、胰岛素抵抗(IR)、糖异生的影响。方法将48只8周龄雄性C57BL/6J小鼠按随机数字表法分为正常组(n=8... 详细信息

目的观察脂肝清方对高脂饲料诱导的非酒精性脂肪性肝病(NAFLD)C57BL/6J小鼠肝脏的保护作用及对PI3K/Akt/叉头盒转录因子1(FoxO1)信号通路、胰岛素抵抗(IR)、糖异生的影响。方法将48只8周龄雄性C57BL/6J小鼠按随机数字表法分为正常组(n=8)和造模组(n=40)。正常组普通饲料喂养,造模组饲喂高脂饲料8周建立NAFLD模型。将造模组小鼠按随机数字表法分为模型组、吡格列酮组及脂肝清方低、中、高剂量组,每组8只,相应药物干预8周。给药期间定期称重,分别于给药0、8周测定空腹血糖(FBG)水平,并进行口服葡萄糖耐量试验(OGTT)。实验结束后,检测血清GPT、GOT、TC、TG、LDL-C、HDL-C、胰岛素(FINS)、C肽(C-P)水平,并计算胰岛素抵抗指数(HOma-IR);采用HE和过碘酸-雪夫(PAS)染色观察肝组织病理形态;免疫组化染色检测PI3K、p-Akt蛋白表达;Western blot检测PI3K、Akt、p-Akt、FoxO1、p-FoxO1、葡萄糖-6-磷酸酶(G6PC)、磷酸烯醇丙酮酸羧激酶(PCK1)蛋白表达。结果与模型组比较,给药第4、6、8周,各给药组小鼠体重下降(Pma-IR降低(P<0.05或P<0.01);各给药组FINS、C-P水平升高(P<0.05或P<0.01),肝组织PI3K蛋白表达及p-Akt/Akt、p-FoxO1/FoxO1升高(P<0.05或P<0.01),G6PC、PCK1蛋白表达降低(P<0.05或P<0.01)。结论脂肝清方可有效控制NAFLD小鼠体重、血糖、肝功能及血脂水平,改善IR及糖异生,其作用机制可能与激活PI3K/Akt/FoxO1信号通路有关。

关键词：非酒精性脂肪肝脂肝清方 PI3K/Akt/FoxO1信号通路胰岛素抵抗糖异生小鼠