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Research progress of Chinese herbal medicine compounds and their bioactivities:Fruitful 2020

Chinese Herbal Medicines 2022年第2期14卷 171-186页

作者： xiaojie Gu Dacheng Hao peigen xiao Biotechnology Institute School of Environment and Chemical EngineeringDalian Jiaotong UniversityDalian 116028China Institute of Medicinal Plant Development Chinese Academy of Medical SciencesBeijing 100193China

Traditional Chinese medicines(TCMs)have continued to be a treasure *** study of chemodiversity and versatility of bioactivities has always been an important content of *** is amazing progress in the discovery and research of natural components with novel structures and significant bioactivities in *** this paper we review 271 valuable natural products,including terpenoids,steroids,flavonoids,phenylpropanoids,phenolics,nitrogen containing compounds and essential oil,etc.,isolated and identified from TCMs published in journals of Chinese Traditional and Herbal Drugs(Zhong Cao Yao)and Chinese Herbal Medicines(CHMs),and focus on their structures,source organisms,and relevant bioactivities,paying special attention to structural characteristics of novel compounds and newly revealed pharmacological properties of known *** is worth noting that natural products with antitumor activity still constitute the primary object of *** the reported compounds,two new triterpenoids,i.e.,ursolic acid 3-O-β-cis-caffeate and mollugoside E,display remarkable cytotoxicity against PC-9 and HL-60 cell lines,*** known phenolic compounds,i.e.,pyoluteorin,4-hydroxy-3-methoxy cinnamaldehyde and 3,7-dimethoxy-5-hydroxy-1,4-phenanthrenequinone,exhibit significant cytotoxicity against multiple cell *** studies on the free radical scavenging activity of reported compounds are currently *** vitro,three known phenolic compounds,i.e.,3,4-Odicaffeoylquinic acid methyl ester,3,4,5-O-tricaffeoylquinic acid methyl ester and arbutin,had more considerable antioxidant activities than vitamin *** anti-inflammatory,anti-diabetic,hypolipidemic,neuroprotective and antimicrobial activities of isolated compounds are also *** structural characteristics and bioactivities of TCM compounds highlighted here reflect the enormous progress of CHM research in 2020 and will play a positive role in the future drug discovery and de

关键词： chemical constituents medicinal plants natural products pharmacological activities traditional Chinese medicine

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Research progress in the phytochemistry and biology of Ilex pharmaceutical resources

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Acta Pharmaceutica Sinica B 2013年第1期3卷 8-19页

作者： Dacheng Hao xiaojie gua.peigen xiao Zhanguo Liang Lijia Xu Yong Peng Biotechnology Institute School of Environmental and Chemical EngineeringDalian Jiaotong UniversityDalian 116028China Department of Metabolic Biology John Innes CentreNorwich Research ParkNorwich NR47UHUK Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine of Ministry of Education Institute of Medicinal Plant DevelopmentChinese Academy of Medical SciencesBeijing 100193China

Ilex is a botanical source for various health-promoting and pharmaceutically active compounds that have been used in traditional Chinese medicine and food for thousands of *** interest in Ilex pharmaceutical and food resources has led to additional discoveries of terpenoids,saponins,polyphenols(especially flavonoids),glycosides,and many other compounds in various Ilex species,and to investigation of their chemotaxonomy,molecular phylogeny and *** continuation of our studies on Ilex pharmacology and phylogeny,we review the phytochemistry,chemotaxonomy,molecular biology and phylogeny of Ilex species and their relevance to health-promotion and therapeutic *** similarity and dissimilarity between Ilex paraguariensis,the source plant of mate tea,and the source plants of large-leaved K udingcha(e.g.,Ilex kudingcha and Ilex latifolia)are *** is essential to utilize emerging technologies in non-Camellia tea studies to promote the sustainable utilization of Ilex resources and the identification and development of novel compounds with potential health and clinical *** biology and "-omics"technologies will play an increasingly important role in pharmaceutical and food research on the bioactive compounds of Ilex species.

关键词： Ilex Chemical components Pharmacology Chemotaxonomy Phylogeny Pharmaceutical and food resource

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Anemone medicinal plants:ethnopharmacology,phytochemistry and biology

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Acta Pharmaceutica Sinica B 2017年第2期7卷 146-158页

作者： Da-Cheng Hao xiaojie Gu peigen xiao Biotechnology Institute School of Environment and Chemical EngineeringDalian Jiaotong UniversityDalian 116028China Institute of Medicinal Plant Development Chinese Academy of Medical SciencesBeijing 100193China

The Ranunculaceae genus Anemone(order Ranunculales),comprising more than 150 species,mostly herbs,has long been used in folk medicine and worldwide *** medicinal compounds have been found in Anemone plants,especially triterpenoid saponins,some of which have shown anti-cancer *** Anemone compounds and extracts display immunomodulatory,antiinflammatory,antioxidant,and antimicrobial *** than 50 species have ethnopharmacological uses,which provide clues for modern drug *** compounds exert anticancer and other bioactivities via multiple ***,a comprehensive review of the Anemone medicinal resources is *** here summarize the ethnomedical knowledge and recent progress on the chemical and pharmacological diversity of Anemone medicinal plants,as well as the emerging molecular mechanisms and functions of these medicinal *** phylogenetic relationships of Anemone species were reconstructed based on nuclear ITS and chloroplast *** molecular phylogeny is largely congruent with the morphology-based *** used medicinal herbs are distributed in each subgenus and section,and chemical and biological studies of more unexplored taxa are *** expression profiling and relevant "omics" platforms could reveal differential effects of ***,transcriptomics,proteomics,and metabolomics should be highlighted in deciphering novel therapeutic mechanisms and utilities of Anemone phytometabolites.

关键词： Anemone Ethnomedicine Chemodiversity Bioactivity Molecular mechanism Pharmacophylogeny

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Chemical and biological research of Clematis medicinal resources

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Chinese Science Bulletin 2013年第10期58卷 1120-1129页

作者： HAO DaCheng GU xiaojie xiao peigen PENG Yong Biotechnology Institute School of EnvironmentDalian Jiaotong University Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine of Ministry of Education Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences

Clematis is a botanical source for various pharmaceutically active components,which has long been used in conventional medicine since the beginning of Chinese *** interest in Clematis medicinal resources has led to additional discoveries of triterpenoid saponins,flavonoids,coumarins,alkaloids and many other compounds in various Clematis species,and to investigations on their chemotaxonomy,molecular phylogeny and *** continuation with our studies on Clematis chemistry and biology,we review the chemistry,chemotaxonomy,molecular biology and phylogeny of Clematis and their relevance to drug efficacy and drug *** databases and technology have been used in literature search in order to characterize the global scientific *** is essential to study more species for both the sustainable utilization of Clematis medicinal resources and finding novel compounds with potential clinical *** biology and omics technologies will play an increasingly important role in future medicinal research involving bioactive compounds of Clematis.

关键词：化学分类学分子生物学药用资源威灵仙生物活性化合物传统医学检索技术分子系统学

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