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Three rare anti-inflammatory sesquiterpene lactones from Magnolia grandiflora

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Chinese Journal of Natural Medicines 2024年第3期22卷 265-272页

作者： XU Shuangyu ZHANG Feng TAO Linlan JIANG Yangming huANG Tao LI Yanan hu Zhanxing YANG Jue HAO xiaojiang YUAN Chunmao State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang 550025China Natural Products Research Center of Guizhou Province Guiyang 550014China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China

Four new sesquiterpene lactones(SLs)(1–4),along with a biosynthetically related SL(5),have been isolated from the leaves of Magnolia *** A(1)is notable as the first C18 homogemarane type SL,featuring a unique 1,7-dioxaspiro[4.4]nonan-6-one *** 2 and 3,representing the first instances of chlorine-substituted gemarane-type SL analogs in natural products,were also *** structures of these isolates were elucidated through a combination of spectroscopic data analysis,electronic circular dichroism calculations,and X-ray single-crystal diffraction *** isolates demonstrated anti-inflammatory activity in lipopolysaccharide-stimulated RAW264.7 ***,3–5 showed a significant inhibitory effect on nitric oxide production,with IC50 values ranging from 0.79 to 4.73μmol·L^(−1).Additionally,4 and 5 exhibited moderate cytotoxic activities against three cancer cell lines,with IC50 values between 3.09 and 11.23μmol·L^(−1).

关键词： Magnolia grandiflora Sesquiterpene lactones Isolation and identification Anti-inflammatory activity

TGF-β-induced CD4+FoxP3+regulatory T cell-derived extracellular vesicles modulate Notch1 signaling through miR-449a and prevent collagen-induced arthritis in a murine model

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Cellular & Molecular Immunology 2021年第11期18卷 2516-2529页

作者： Jingrong Chen Feng huang Yuluan Hou Xiaorong Lin Rongzhen Liang xiaojiang hu Jun Zhao Julie Wang Nancy Olsen Song Guo Zheng Department of Clinical Immunology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Internal Medicine Division of RheumatologyThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Division of Rheumatology Department of MedicinePenn State University Hershey Medical CenterHersheyPAUSA

CD4^(+)FOXP3^(+)Treg cells are central to the maintenance of self-tolerance and can be defective in *** autoimmune rheumatic diseases,dysfunctional self-tolerance,is to a large extent,caused by insufficient Treg-cell *** nTregs have therapeutic effects in vivo,their relative scarcity and slow rate of in vitro expansion hinder the application of nTreg *** was previously reported that EVs contribute significantly to the suppressive function of FOXP3^(+)Treg *** that the stability and plasticity of nTregs remain major challenges in vivo,we established EVs derived from in vitro TGF-β-induced Treg cells(iTreg-EVs)and assessed their functions in a murine model of autoimmune *** results demonstrated that iTreg-EVs preferentially homed to the pathological joint and efficiently prevented the imbalance in Th17/Treg cells in arthritic ***,we found that miR-449a-5p mediated Notch1 expression modulation and that miR-449a-5p knockdown abolished the effects of iTreg-EVs on effector T cells and regulatory T cells in vitro and in *** together,our results show that iTreg-EVs control the inflammatory responses of recipient T cells through miR-449a-5p-dependent modulation of Notch1 and ameliorate the development and severity of arthritis,which may provide a potential cell-free strategy based on manipulating iTreg-EVs to prevent autoimmune arthritis.

关键词： EVs iTreg Arthritis Th17 MicroRNA Notch1

High salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2082-2094页

作者： Ze Xiu Xiao xiaojiang hu Ximei Zhang Zhigang Chen Julie Wang Ke Jin Feng Lin Cao Baoqing Sun Joseph A.Bellanti Nancy Olsen Song Guo Zheng Department of Clinical Immunology The Third Affiliated Hospital at Sun Yat-sen University510630 GuangzhouChina Department of Internal Medicine Ohio State University College of Medicine and Wexner Medical CenterColumbusOH 43210USA Department of Medicine Penn State College of MedicineHersheyPA 17033USA Laboratory of human Diseases and Immunotherapy West China HospitalSichuan UniversityChengduChina Department of Internal Medicine The First Hospital of Harbin Medical UniversityHarbinChina Department of Allergy and Clinical Immunology The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Pediatrics and Microbiology-Immunology Georgetown University Medical CenterWashingtonDCUSA

The increased incidence of systemic lupus erythematosus(SLE)in recent decades might be related to changes in modern dietary *** sodium chloride(NaCl)promotes pathogenic T cell responses,we hypothesize that excessive salt intake contributes to the increased incidence of autoimmune diseases,including *** the importance of dendritic cells(DCs)in the pathogenesis of SLE,we explored the influence of an excessive sodium chloride diet on DCs in a murine SLE *** used an induced lupus model in which bone marrow-derived dendritic cells(BMDCs)were incubated with activated lymphocyte-derived DNA(ALD-DNA)and transferred into C57BL/6 recipient *** observed that a high-salt diet(HSD)markedly exacerbated lupus progression,which was accompanied by increased DC *** treatment also stimulated the maturation,activation and antigenpresenting ability of DCs in *** of BMDCs with NaCl also exacerbated BMDC-ALD-DNA-induced *** mice had increased production of autoantibodies and proinflammatory cytokines,more pronounced splenomegaly and lymphadenopathy,and enhanced pathological renal *** p38 MAPK–STAT1 pathway played an important role in NaClinduced DC immune *** together,our results demonstrate that HSD intake promotes immune activation of DCs through the p38 MAPK–STAT1 signaling pathway and exacerbates the features of ***,changes in diet may provide a novel strategy for the prevention or amelioration of lupus or other autoimmune diseases.

关键词： STAT1 lupus prevention

区域技术创新体系动态演进一般性规律分析——基于三螺旋理论的视角

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科技管理研究 2009年第12期29卷 14-16页

作者：胡小江浙江经贸职业技术学院浙江杭州310018

区域技术创新体系是区域创新活动的基础体系,其中结构以制度基础和产业基础为支撑,并包含技术创新主体、资源结构和经济要素结构等三个结构维度。在其演化过程中,三个结构维度呈现出不同的演进规律,而制度基础和产业基础又制约着三个结... 详细信息

区域技术创新体系是区域创新活动的基础体系,其中结构以制度基础和产业基础为支撑,并包含技术创新主体、资源结构和经济要素结构等三个结构维度。在其演化过程中,三个结构维度呈现出不同的演进规律,而制度基础和产业基础又制约着三个结构维度的演进,并规范着它们的演进方向和路径。发现区域技术创新体系呈现三维结构螺旋发展的形式从低水平向高水平演进,这其中制度基础与演进过程相适应。

关键词：技术创新体系动态演进三螺旋理论

高职公共卫生管理专业发展现况及问题探讨——以江苏卫生健康职业学院为例

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医药高职教育与现代护理 2022年第6期5卷 478-480页

作者：胡晓江吕广梅江苏卫生健康职业学院卫生管理与基础学院江苏南京210018

我国高等职业院校专科层次的公共卫生管理专业创办于2004年,作者以江苏卫生健康职业学院历时12年的公共卫生管理专业人才培养情况为切入点,探讨现阶段高职公共卫生管理专业的发展现况、存在问题及建议,为现代高等职业教育公共卫生管理... 详细信息

我国高等职业院校专科层次的公共卫生管理专业创办于2004年,作者以江苏卫生健康职业学院历时12年的公共卫生管理专业人才培养情况为切入点,探讨现阶段高职公共卫生管理专业的发展现况、存在问题及建议,为现代高等职业教育公共卫生管理专业人才培养提供参考。

关键词：公共卫生管理医药高职教育专业建设

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中国植物学家胡先骕(一)

生物学教学 2023年第8期48卷 90-93页

作者：胡晓江马金双北京师范大学社会学院北京100875 国家植物园北园北京100093

胡先骕是一位传奇式的中国近代科学家,是中国传统文化的捍卫者、大学校长、古体诗人,更是具有铮铮铁骨的真知识分子,具有博大的爱国情怀。他对中国植物科学事业的发展做出过杰出贡献。作为思政教育及生涯教育素材,本文基于《胡先骕全集... 详细信息

胡先骕是一位传奇式的中国近代科学家,是中国传统文化的捍卫者、大学校长、古体诗人,更是具有铮铮铁骨的真知识分子,具有博大的爱国情怀。他对中国植物科学事业的发展做出过杰出贡献。作为思政教育及生涯教育素材,本文基于《胡先骕全集》的编纂心得,详细介绍其人其事。本文为第一部分。

关键词：胡先骕植物学家人物传记

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数字化协同在机场运行保障的应用研究

民航学报 2024年第2期8卷 52-56页

作者：李小将户航民航机场成都电子工程设计有限责任公司河南省机场集团工程建设指挥部

本文将以数字化转型为契机、在给各大机场咨询及建设经验的基础上，提出机场数字化协同理念，涵盖数据共享、业务协同、流程协同、服务协同、管理协同等多个方面，通过数字化技术实现机场内部和外部资源的共享和协同，提高机场的运营效... 详细信息

本文将以数字化转型为契机、在给各大机场咨询及建设经验的基础上，提出机场数字化协同理念，涵盖数据共享、业务协同、流程协同、服务协同、管理协同等多个方面，通过数字化技术实现机场内部和外部资源的共享和协同，提高机场的运营效率和服务质量。最后，通过机场运行中典型协同场景来阐述数字化协同应用价值。

关键词：智慧机场数字化协同数字化

职业教育对新生代农民工社会能力影响研究--基于全国5省市的实证分析

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职业技术教育 2015年第25期36卷 63-68页

作者：郭元凯胡晓江北京师范大学北京100875

针对当前农民工职业教育存在的重"生存"轻"生活"现象,通过对全国5省4588位80后新生代农民工的调研发现,职业教育与新生代农民工的社会能力之间具有显著相关性,并且具有正向影响;新生代农民工群体内部,接受过职业教育的群体比没有接受过... 详细信息

针对当前农民工职业教育存在的重"生存"轻"生活"现象,通过对全国5省4588位80后新生代农民工的调研发现,职业教育与新生代农民工的社会能力之间具有显著相关性,并且具有正向影响;新生代农民工群体内部,接受过职业教育的群体比没有接受过职业教育的群体,在社会能力上具有显著性差异。建议在针对新生代农民工的职业教育中,要坚持全人教育理念,同时职业院校要调整课程设置,关注对新生代农民工社会能力的教育。

关键词：新生代农民工社会能力社会融合职业教育

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灰色系统理论在齿轮故障诊断中的应用

通用机械 2007年第9期 59-61页

作者：胡小江济南钢铁集团总公司热连轧厂山东250101

针对难以获取大量样本的齿轮故障诊断,应用灰色系统理论,可以简洁、准确地判断出齿轮运行状态,为此类故障诊断提供一种方法。

关键词：灰色系统理论灰色关联度故障诊断齿轮