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电刺激疗法在骨质疏松症中的应用

中国骨质疏松杂志 2024年第1期30卷 119-123页

作者：郑小花郑云燕郑启斌陈春花林超琴徐颖福建省妇幼保健院福建医科大学妇儿临床医学院福建福州350001 中国人民解放军联勤保障部队第九〇〇医院仓山院区妇产科福建福州350025 福建医科大学附属第一医院神经外科福建福州350001

目的总结电刺激疗法在骨质疏松症(osteoporosis,OP)中的应用,以期更好地指导临床。方法检索近年来电刺激疗法在OP中的相关研究,总结其治疗模式、具体参数选择、治疗部位及时间强度等。结果电刺激疗法在OP的应用基础研究报道较临床研究多... 详细信息

目的总结电刺激疗法在骨质疏松症(osteoporosis,OP)中的应用,以期更好地指导临床。方法检索近年来电刺激疗法在OP中的相关研究,总结其治疗模式、具体参数选择、治疗部位及时间强度等。结果电刺激疗法在OP的应用基础研究报道较临床研究多,常见的治疗模式包括脉冲电磁场、电针疗法、直流电、电容耦合、经皮神经电刺激等,目前没有固定的治疗参数方案,影响较大的为频率,最佳的频率仍具有争议性。治疗部位多集中在肌肉、神经、穴位等方面。治疗时间多为1个月(4周)、3个月,每周3~5次。结论电刺激在OP中的应用有效,但无固定的参数方案,需开展更多的基础及临床研究。

关键词：电刺激骨质疏松症频率部位

宫颈癌患者血清Hsa_circ_0089761的表达及其临床意义

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中国医师杂志 2024年第6期26卷 890-894页

作者：胡晓华张文颖刘峰何飞燕严晓春上海交通大学医学院附属第九人民医院肿瘤科上海201900 上海交通大学医学院附属第九人民医院妇产科上海201900

目的探讨宫颈癌患者血清Hsa_circ_0089761表达水平及其临床意义。方法选取2021年1月至2023年3月上海交通大学医学院附属第九人民医收治的宫颈癌患者107例、宫颈上皮内瘤变(CIN)患者80例和正常对照组60例进行分析。比较各组血清Hsa_circ_... 详细信息

目的探讨宫颈癌患者血清Hsa_circ_0089761表达水平及其临床意义。方法选取2021年1月至2023年3月上海交通大学医学院附属第九人民医收治的宫颈癌患者107例、宫颈上皮内瘤变(CIN)患者80例和正常对照组60例进行分析。比较各组血清Hsa_circ_0089761、鳞状上皮细胞癌抗原(SCCA)及癌胚抗原(CEA)水平,分析血清Hsa_circ_0089761表达水平与宫颈癌临床病理特征的关系。绘制受试者工作特征(ROC)曲线分析血清Hsa_circ_0089761、SCCA及CEA水平对宫颈癌的诊断价值。采用Pearson相关分析法评估宫颈癌患者血清Hsa_circ_0089761表达水平与SCCA及CEA的相关性。结果宫颈癌组血清Hsa_circ_0089761[(2.96±0.95)vs(1.83±0.74),(0.92±0.41)]、SCCA[(9.63±1.84)ng/ml vs(2.28±0.65)ng/ml,(1.30±0.27)ng/ml]及CEA[(6.47±2.20)ng/ml vs(1.61±0.57)ng/ml,(1.15±0.12)ng/ml]水平均明显高于CIN组和对照组(均P<0.001),CIN组血清Hsa_circ_0089761表达水平明显高于对照组(P<0.001)。Ⅲ~Ⅳ期、低分化、淋巴结转移、浸润深度≥1/2肌层、SCCA阳性以及CEA阳性的宫颈癌患者血清Hsa_circ_0089761表达水平明显更高(均P<0.05)。ROC曲线分析显示,Hsa_circ_0089761≥2.25诊断宫颈癌的特异度最高(85.00%),Hsa_circ_0089761联合SCCA诊断宫颈癌的ROC曲线下面积(AUC)最大(0.932,95%CI:0.874~0.993),准确度最高(89.30%),Hsa_circ_0089761+SCCA+CEA三项联合诊断宫颈癌的灵敏度最高(96.26%)。相关性分析结果显示,宫颈癌患者血清Hsa_circ_0089761表达水平与SCCA(r=0.775,P<0.001)及CEA(r=0.613,P<0.001)呈正相关。结论宫颈癌患者血清Hsa_circ_0089761表达水平明显升高,其升高与临床病理特征有关,Hsa_circ_0089761联合SCCA检测对宫颈癌诊断具有较高的价值。

关键词：宫颈肿瘤 RNA,环状 Hsa_circ_0089761

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药师对中医药信息化管理的需求与期望

中医药管理杂志 2024年第17期32卷 223-225页

作者：张小花夏方圆陈婷婷温州市中西医结合医院浙江温州325000

目的:通过对药师参与中医药信息化管理的需求、期望进行分析,揭示药师在中医药信息化管理中的地位和作用。方法:针对中医药信息化管理,于2023年12月1—7日对某院30名药师展开调查,调查药师对中医药信息化管理的需求和期望。结果:药师对... 详细信息

目的:通过对药师参与中医药信息化管理的需求、期望进行分析,揭示药师在中医药信息化管理中的地位和作用。方法:针对中医药信息化管理,于2023年12月1—7日对某院30名药师展开调查,调查药师对中医药信息化管理的需求和期望。结果:药师对中医药病例管理、中医药质量管理的需求率均为96.67%,对中医药知识库、中医药电子处方管理、中医药临床指南和规范的需求率均为93.33%,对中医药药物信息管理、中医药药物相互作用和不良反应监测的需求率均为90.00%,对中医药研究和教育资源的需求率为83.33%。药师对系统的完整性和准确性、操作的便捷性和高效性、数据的安全性和保密性的期望率为100.00%,对多样化的功能和应用、教育和培训资源的丰富性的期望率为96.67%,对及时的技术支持和更新的期望率为93.33%,对与其他系统的兼容性和互联互通的期望率为86.67%。结论:药师对中医药信息化管理的需求大,期望高,加强对药师的技术培训和支持,满足其需求和期望,对于推动中医药信息化管理的发展具有重要意义。

关键词：药师中医药信息化管理需求期望

实时心肌声学造影在心肌微循环障碍诊断中的应用价值

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中国超声医学杂志 2024年第3期40卷 297-300页

作者：茹翱范晓华潘丹丽姚家芳许海斌顾高杨湖州师范学院附属第一医院(湖州市第一人民医院)超声医学科湖州师范学院附属第一医院(湖州市第一人民医院)心血管内科

目的探讨实时心肌声学造影(RT-MCE)在心肌微循环障碍诊断中的应用价值。方法收集60例经皮冠状动脉介入治疗(PCI)术后疑似心肌微循环障碍患者，根据冠脉造影结果，将35例心肌微循环障碍的患者设为障碍组，25例无心肌微循环障碍或术后... 详细信息

目的探讨实时心肌声学造影(RT-MCE)在心肌微循环障碍诊断中的应用价值。方法收集60例经皮冠状动脉介入治疗(PCI)术后疑似心肌微循环障碍患者，根据冠脉造影结果，将35例心肌微循环障碍的患者设为障碍组，25例无心肌微循环障碍或术后未复发的患者设为对照组。比较两组超声造影图片与左心室心肌声学造影参数，采用受试者工作特征(ROC)曲线下面积(AUC)分析各参数的诊断价值，采用斯皮尔曼法分析其相关性。结果实时心肌造影影像中前降支、回旋支、室壁瘤区域显示较明显，清晰显示节段较多；障碍组心肌峰值声学强度(A)、曲线上升平台期平均斜率(β)、再充盈平均速度(K)、局部心肌血流量(MBF)值均低于对照组(P<0.05);A、K、MBF诊断心肌微循环障碍的AUC分别为0.796、0.795、0.799;心肌微循环障碍与A、K、MBF值呈负相关(P<0.05)。结论 RT-MCE对心肌微循环障碍可能有较好的诊断价值，心肌微循环障碍与A、K、MBF值可能呈负相关。

关键词：实时心肌声学造影经皮冠状动脉介入治疗心肌微循环障碍

Revisiting the dependence of thermocline-dwelling foraminiferal B/Ca on temperature and [CO32-], and its application in reconstruction of the subsurface carbonate system in the tropical western Pacific since 24 ka

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Acta Oceanologica Sinica 2019年第9期38卷 71-86页

作者： Jingteng Guo Tiegang Li Zhifang Xiong xiaohua Qiu Fengming Chang CAS Key Laboratory of Marine Geology and Environment Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China First Institute of Oceanography Ministry of Natural Resources Qingdao 266061 China University of Chinese Academy of Sciences Beijing 100049 China Laboratory for Marine Geology and Environment Pilot National Laboratory for Marine Science and Technology (Qingdao) Qingdao 266237 China No. 1 Institute of Geology and Mineral Resources of Shandong Province Jinan 250014 China

The B/Ca ratio of planktonic foraminifer shells has been used as a proxy for reconstructing past ocean carbonate chemistry. However, recent studies have revealed significant uncertainties associated with this proxy, such as whether seawater temperature or [CO^2-3 ] is the dominant control on the partition coefficient (KD) of planktonic foraminiferal B/Ca. To address these uncertainties and thus improve our understanding of the planktonic foraminiferal B/Ca proxy, we analysed B/Ca ratios in the tests of Neogloboquadrina dutertrei (300- 355 μm) and Pulleniatina obliquiloculata (355- 400 μm) in surface sediment samples from the tropical western Pacific and South China Sea. The relationship between these B/Ca ratios and bottom water calcite saturation states (Δ[CO^2-3 ]) is weak, thus suggesting only a small dissolution effect on the B/Ca of the two species. The correlation coefficients (R2) between the B/Ca ratios of N. dutertrei and P. obliquiloculata and environmental parameters (e.g., temperature, salinity, phosphate, DIC and ALK) in the tropical western Pacific and South China Sea are not high enough to justify using B/Ca ratios as a palaeoenvironmental proxy in the study areas. The significant correlation between KD values of N. dutertrei and P. obliquiloculata and carbonate system parameters (e.g.,[CO^2-3 ], DIC, ALK, pH and [HCO^-3 ]) in the study area reflect chemical links between the KD denominator and these variables. Based on our surface sediment calibration, an empirical relationship between the KD of N. dutertrei and temperature is proposed in the tropical western Pacific. We also generated a record of B/Ca ratios in N. dutertrei (300 -355 μm) from Core MD06-3052 in the tropical western Pacific over the past 24 ka to evaluate the application of the revised B/Ca proxy method. Based on the reconstructed empirical relationship for B/Ca and subsurface seawater ALK, we estimated subsurface seawater carbonate system parameters in the tropical western Pacific si

关键词： planktonic foraminifera B/Ca carbonate chemistry tropical western Pacific South China Sea

多学科协作下的阶段性康复训练对置入起搏器患者术后心功能的影响

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国际医药卫生导报 2024年第14期30卷 2332-2337页

作者：张博许岭平封琳李小花咸阳市中心医院心血管内科咸阳710500

目的探索多学科协作下的阶段性康复训练对置入起搏器患者术后心功能的影响。方法选取2020年1月至2022年12月期间咸阳市中心医院收治的98例起搏器置入患者。根据入院顺序分为试验组(49例)和对照组(49例)。试验组男25例,女24例,年龄(60.52... 详细信息

目的探索多学科协作下的阶段性康复训练对置入起搏器患者术后心功能的影响。方法选取2020年1月至2022年12月期间咸阳市中心医院收治的98例起搏器置入患者。根据入院顺序分为试验组(49例)和对照组(49例)。试验组男25例,女24例,年龄(60.52±7.21)岁,起搏器置入类型:单腔起搏器20例,双腔起搏器29例。对照组男26例,女23例,年龄(60.78±7.09)岁,起搏器置入类型:单腔起搏器21例,双腔起搏器28例。对照组术后接受常规护理,试验组在此基础上进行多学科协作下的阶段性康复训练。两组均干预至术后3个月。通过运动耐力(6 min步行距离)、心功能[N端前脑钠肽(NT-proBNP)和左心室射血分数(LVEF)]、上肢活动能力、并发症(出血、感染、肩关节疼痛、电极脱位)、舒适度[简化舒适状况量表(GCQ)评分]等指标评估干预效果。统计学方法使用独立样本t检验、χ^(2)检验。结果干预后,试验组6 min步行距离为(290.14±34.16)m,长于对照组(138.75±14.34)m,NT-proBNP水平为(262.11±68.12)ng/L,低于对照组(398.93±76.69)ng/L,LVEF水平为(69.82±4.73)%,高于对照组(52.53±5.44)%,差异均有统计学意义(t=28.604、9.337、16.789,均P<0.05)。术后3个月,试验组的内收、外展、前屈和后伸的活动度为(18.27±6.02)°、(52.67±10.33)°、(64.37±7.14)°、(22.78±3.96)°,高于对照组(12.78±5.39)°、(45.34±9.33)°、(51.36±6.93)°、(18.61±3.78)°,差异均有统计学意义(t=4.756、3.686、9.153、5.332,均P<0.05)。试验组的并发症发生率为4.08%(2/49),低于对照组的16.33%(8/49),差异有统计学意义(χ^(2)=4.009,P=0.045)。干预后,试验组GCQ评分中的环境、生理、社会文化、心理精神评分为(3.72±0.67)、(3.24±0.53)、(3.90±0.42)、(3.68±0.54)分,高于对照组(2.38±0.42)、(2.49±0.36)、(2.75±0.27)、(3.17±0.35)分,差异均有统计学意义(t=11.537、7.951、15.276、5.431,均P<0.05)。结论多学科协作下的阶段性康复训练对置入起搏器患者术后有积极影响,能够改善患者的运动耐力、心功能、上肢活动能力,减少并发症发生,增强患者舒适度和日常生活自理能力,具有重要的临床应用价值。

关键词：起搏器置入多学科协作阶段性康复训练运动耐力心功能上肢活动能力并发症舒适度自理能力

Oxygen vacancy-rich amorphous FeNi hydroxide nanoclusters as an efficient electrocatalyst for water oxidation

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Journal of Energy Chemistry 2022年第8期31卷 167-173,I0005页

作者： youhai Cao y.ng Su Liangliang Xu xiaohua y.ng Zhongkang Han Rui Cao Gao Li State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Institute of Quantum and Sustainable Technology(IQST) School of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiang 212013JiangsuChina Multidisciplinary Computational Laboratory Department of Electrical and Biomedical EngineeringHanyang UniversitySeoul 04763South Korea Center for Energy Science and Technology Skolkovo Institute of Science and TechnologySkolkovo Innovation CenterMoscow 143026Russia Stanford Synchrotron Radiation Lightsource SLAC National Accelerator LaboratoryMenlo ParkCA 94025USA

In this work,a one-pot strategy is presented to directly synthesize amorphous Fe_(x)Ni_(y) hydroxide nanoclusters(denoted as ANC-Fe_(x)Ni_(y),<2 nm)with oxygen vacancies induced by ionic *** ANC-Fe_(x)Ni_(y) catalyst ... 详细信息

In this work,a one-pot strategy is presented to directly synthesize amorphous Fe_(x)Ni_(y) hydroxide nanoclusters(denoted as ANC-Fe_(x)Ni_(y),ygen vacancies induced by ionic *** ANC-Fe_(x)Ni_(y) catalyst presents abundant catalytic sites and high intrinsic *** such,the optimized ANC-Fe_(1)Ni_(2) exhibits high activity in oxygen evolution reaction(OER)with a Tafel slope of 39 m V dec^(–1) and an overpotential of 266 m V at 10 m A cm^(-2).Notably,the optimized ANC-Fe_(1)Ni_(2) shows an extraordinarily large mass activity of 3028 Ag_(FeNi)^(–1) at the overpotential of 300 m V,which is~24-fold of commercial RuO_(2) *** superior activity of these Fe_(x)Ni_(y) hydroxide nanoclusters is ascribed to(i)the amorphous and distorted structure with abundant oxygen vacancies,and(ii)enhanced active site density by downsizing the *** strategy provides a novel route for enhancing OER electrocatalytic performance and highly encouraging for the future application of amorphous metal hydroxides in catalysis.

关键词： Oxygen evolution reaction Hydroxides Amorphous Ni-Fe based nanoclusters Ionic liquids Oxygen vacancies

Albumin-bound paclitaxel dimeric prodrug nanoparticles with tumor Qr redox heterogeneity-triggered drug release for synergistic photothermal/ chemotherapy

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Nano Research 2019年第4期12卷 877-887页

作者： Qing Pei Xiuli Hu xiaohua Zheng Rui Xia Shi Liu Zhigang Xie Xiabin Jing State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 I China University of Science and Technology of China Hefei 230026 China

In spired by the clinically approved albumin based PTX formulatio n(Abraxa ne)and high-drug-loading dimeric prodrug tactics,herein we report a theranostic HAbraxane-likeH prodrug formulation,which is comprised of human serum albumin(HSA),a paclitaxel(PTX)dimer bridged with thioether liner(PTX2-S),and photosensitizer IR780 ***(NPs)with PTX2-S and IR780 as the core and HSA as the stealth shell are *** with HSA-based PTX clinical formulation(Abraxane),the dimeric molecules not only constitute the bulk structure of the particles,but also act as crossi ng age nt,thus realizing drug loadi ng content in creasi ng from 6.6 wt.%to 48.7 wt.%with high loadi ng efficie ncy(>90%)and excellent stability in biological *** ntly,the thioether lin kage dually resp onds to the tumor redox heteroge neity and the NPs gradually releases the pare nt drug PTX for *** nwhile,PTX2-S facilitates the en capsulatio n of IR780 iodide due to their π-π stacki ng interaction and IR780 iodide gen erates spatio-temporal hyperthermia un der light irradiation to kill cancer cells for photothermal *** described craft integrates the biomimetic trait of HSA,high drug loading,tumor redox heterogeneity-initiated on-dema nd drug release,and combi nation therapy into one formulati on and the developed nan oparticles are promising for cancer treatment.

关键词： human serum albumin prodrug nanoparticles tumor redox heterogeneity-responsiveness controlled drug release synergistic cancer therapy

DIC imaging for identification of motor and sensory nerves

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Journal of Innovative Optical Health Sciences 2016年第5期9卷 1-7页

作者： Dayu Chen yuxiang Wu Tao Sui Shaoqun Zeng Xiaojian Cao xiaohua Lv Department of Neurosurgery Wuhan General Hospital of Guangzhou Military Command of PLA 627 Wuluo Road Wuhan 430070P.R.China Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 P.R.China School of Physical Education Jianghan University Wuhan 430056P.R.China First A±liated Hospital of Nanjing Medical University Nanjing 210029 P.R.China

Identification of motor and sensory nerves is important in applications such as nerve injury *** practice relies on time consuming staining methods for this ***,we use laser scanning infrared diferential interference contrast(IR-DIC)microscopy for label-free observation of the two types of *** and dorsal nerve roots of adult beagle dogs were collected and sections of different thicknesses were imaged with an IR-DIC *** texture patterns of the IR-DIC images of the motor and sensory nerve can be distinguished when the section thickness increases to 40 *** suggests that nerve fibers in motor and sensory nerves have different distribution *** result hints a potential new way for more rapid identification of nerve type in peripheral nerve repair surgery.

关键词： Differential interference microscopy nerve repair nerve root image pattern.