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Chinese Medical Journal 2024年第10期137卷 1231-1233页

作者： Cong Li Zuoqian Jing Jianbo Shen Shunming Liu Lei Liu xiaohong yang Honghua Yu Department of Ophthalmology Guangdong Eye InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong 510080China School of Medicine South China University of Technology Guangzhou 510006China Department of Ophthalmology The First Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Neurosurgery Jincheng People’s HospitalJinchengShanxi 048026China Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application Guangzhou 510080China

To the Editor:Blindness and vision loss(BVL)constitute a growing concern affecting an ever-expanding global population.[1]Globally,approximately 40%of the population relies on burning solid fuels for both cooking and *** air pollution(HAP)predominantly arises from the incomplete combustion of solid fuels used for ***,the adverse effects of HAP on eye health in human have ascended as a salient concern for environmental,ophthalmic,and public health.[2]Gaining a comprehensive understanding of the burden and temporal trends of BVL due to HAP is the essential basis for health program planning.

关键词： pollution cooking prediction

EZH2 is a prognostic factor associated with tumor stemness and immune infiltration in skull base chordoma

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Genes & Diseases 2024年第5期11卷 85-87页

作者： Qian Liu Mingxuan Li Yujia Xiong Yutao Shen Tianshun Ma Tianhao Zhang xiaohong R.yang Yazhuo Zhang Jiwei Bai Beijing Neurosurgical Institute Capital Medical UniversityBeijing 100070China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Division of Cancer Epidemiology and Genetics National Cancer InstituteNIHDHHSBethesdaMD 20892USA

Enhancer of zeste homolog 2(EZH2),an epigenetic regulator that inhibits transcription primarily through trimethylation of Lys-27 in histone 3(H3K27me3),has been reported to play an important role in the regulation of cell cycle,autophagy,and apoptosis,and DNA damage repair.1 EZH2 is highly expressed in a variety of cancers including prostate cancer,breast cancer,and renal clear cell carcinoma,and is associated with adverse prognosis.1 Moreover,it has been reported that EZH2 might increase tumor stemness and metastasis capacity and inhibit antitumor immunity by affecting T cells,NK cells,macrophages,and immune checkpoints.2,3 However,the prognostic value and the mechanism of EZH2 have not been investigated in *** this study,RNA sequencing and whole genome sequencing data based on 48 skull base chordomas as well as immunohistochemistry of paraffin sections were analyzed to elucidate the role of EZH2 in skull base *** found copy number gain mediated high EZH2 expression is associated with tumor stemness,M2 macrophage infiltration,and adverse prognosis in ***,we demonstrated that EZH2 promotes the proliferation,migration,and invasion of chordoma cells in in vitro cell experiments.

关键词： EZH2 immunity invasion

The light and hypoxia induced gene ZmPORB1 determines tocopherol content in the maize kernel

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Science China(Life Sciences) 2024年第3期67卷 435-448页

作者： Nannan Liu Yuanhao Du Shijuan Yan Wei Chen Min Deng Shutu Xu Hong Wang Wei Zhan Wenjie Huang Yan Yin xiaohong yang Qiao Zhao Alisdair R.Fernie Jianbing Yan National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China Agro-biological Gene Research Center Guangdong Academy of Agricultural SciencesGuangzhou 510640China College of Agronomy Hunan Agricultural UniversityChangsha 410128China College of Agronomy Northwest A&F UniversityXi'an 710000China State Key Laboratory of North China Crop Improvement and Regulation Hebei Sub-center of National Maize Improvement Center of ChinaCollege of AgronomyHebei Agricultural UniversityBaoding 071001China College of Life Sciences South-Central Minzu UniversityWuhan 430070China Plant Science Facility of the Institute of Botany Chinese Academy of SciencesBeijing 100093China National Maize Improvement Center of China Beijing Key Laboratory of Crop Genetic ImprovementChina Agricultural UniversityBeijing 100093China Shenzhen Key Laboratory of Synthetic Genomics Guangdong Provincial Key Laboratory of Synthetic GenomicsShenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Max Planck Institute of Molecular Plant Physiology Potsdam-Golm 14476Germany

Tocopherol is an important lipid-soluble antioxidant beneficial for both human health and plant growth. Here, we fine mapped a major QTLqVE1 affecting γ-tocopherol content in maize kernel, positionally cloned and confirmed the underlying gene ZmPORB1(por1), as a protochlorophyllide oxidoreductase. A 13.7 kb insertion reduced the tocopherol and chlorophyll content, and the photosynthetic activity by repressing ZmPORB1 expression in embryos of NIL-K22, but did not affect the levels of the tocopherol precursors HGA(homogentisic acid)and PMP(phytyl monophosphate). Furthermore, ZmPORB1 is inducible by low oxygen and light, thereby involved in the hypoxia response in developing embryos. Concurrent with natural hypoxia in embryos, the redox state has been changed with NO increasing and H_(2)O_(2) decreasing, which lowered γ-tocopherol content via scavenging reactive nitrogen species. In conclusion, we proposed that the lower lightharvesting chlorophyll content weakened embryo photosynthesis, leading to fewer oxygen supplies and consequently diverse hypoxic responses including an elevated γ-tocopherol consumption. Our findings shed light on the mechanism for fine-tuning endogenous oxygen concentration in the maize embryo through a novel feedback pathway involving the light and low oxygen regulation of ZmPORB1 expression and chlorophyll content.

关键词： maize tocopherol hypoxia photosynthesis ZmPORB1

Genetic variation in a heat shock transcription factor modulates cold tolerance in maize

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MOLECULAR PLANT 2024年第9期17卷 1423-1438页

作者： Gao, Lei Pan, Lingling Shi, Yiting Zeng, Rong Li, Zhuoyang Zhang, Xuan Zhao, Xiaoming Gong, Xinru Huang, Wei yang, xiaohong Lai, Jinsheng Zuo, Jianru Gong, Zhizhong Wang, Xiqing Jin, Weiwei Dong, Zhaobin yang, Shuhua China Agr Univ Frontiers Sci Ctr Mol Design Breeding Ctr Crop Funct Genom & Mol Breeding State Key Lab Plant Environm ResilienceColl Biol Beijing 100193 Peoples R China China Agr Univ Natl Maize Improvement Ctr Frontiers Sci Ctr Mol Design Breeding Dept Plant Genet & BreedingState Key Lab Maize Bi Beijing Peoples R China Chinese Acad Sci State Key Lab Plant Genom Inst Genet & Dev Biol Beijing 100101 Peoples R China Chinese Acad Sci Inst Genet & Dev Biol Natl Plant Gene Res Ctr Beijing 100101 Peoples R China

Understanding how maize (Zea mays) responds to cold stress is crucial for facilitating breeding programs of cold-tolerant varieties. Despite extensive utilization of the genome-wide association study (GWAS) approach for exploring favorable natural alleles associated with maize cold tolerance, few studies have successfully identified candidate genes that contribute to maize cold tolerance. In this study, we used a diverse panel of inbred maize lines collected from different germplasm sources to perform a GWAS on variations in the relative injured area of maize true leaves during cold stress-a trait very closely correlated with maize cold tolerance. We identified HSF21, which encodes a B-class heat shock transcription factor (HSF) that positively regulates cold tolerance at both the seedling and germination stages. Natural variations in the promoter of the cold-tolerant HSF21(Hap1) allele led to increased HSF21 expression under cold stress by inhibiting binding of the basic leucine zipper bZIP68 transcription factor, a negative regulator of cold tolerance. By integrating transcriptome deep sequencing, DNA affinity purification sequencing, and targeted lipidomic analysis, we revealed the function of HSF21 in regulating lipid metabolism homeostasis to modulate cold tolerance in maize. In addition, we found that HSF21 confers maize cold tolerance without incurring yield penalties. Collectively, this study establishes HSF21 as a key regulator that enhances cold tolerance in maize, providing valuable genetic resources for breeding of cold-tolerant maize varieties.

关键词： heat shock factor HSF21 cold tolerance natural variation bZIP68 lipid metabolism maize QUANTITATIVE TRAIT LOCI CHILLING TOLERANCE FREEZING TOLERANCE LIPID CHANGES STRESS MEMBRANE ARCHITECTURE IMPACTS PLANTS YIELD

非遗活态传承视阈下浙川地方戏曲表演人才培养探究

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四川戏剧 2024年第4期 119-122页

作者：杨晓浤浙江艺术职业学院

地方戏曲是中国非物质文化遗产的地域性代表,表演人才的培养关乎地方戏曲的活态传承与剧种的兴衰存亡。当下,浙江、四川两省地方戏曲表演人才的培养在专业招生、培养模式、文化基因传承等方面面临困境,可通过形成地方戏曲发展高质量生... 详细信息

地方戏曲是中国非物质文化遗产的地域性代表,表演人才的培养关乎地方戏曲的活态传承与剧种的兴衰存亡。当下,浙江、四川两省地方戏曲表演人才的培养在专业招生、培养模式、文化基因传承等方面面临困境,可通过形成地方戏曲发展高质量生态群、实现戏曲人才培养模式现代化转型、建立地方戏曲剧种艺术基因库等举措促进地方戏曲表演人才的培养,推动地方戏曲在当代的活态传承。

关键词：地方戏曲表演人才培养非遗活态传承越剧川剧

重庆市尘肺病患者门诊服务利用情况及影响因素分析

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中华劳动卫生职业病杂志 2024年第6期42卷 426-432页

作者：杨小红杨婷婷罗东程淑群重庆医科大学公共卫生学院重庆401331 重庆市职业病防治院职业卫生与中毒应急办公室重庆400060

目的:了解重庆市尘肺病患者两周内门诊服务利用情况及特点,并分析其影响因素,为相关政策制定提供参考依据。方法:于2020年10月至2022年10月,采用多阶段分层随机整群抽样,选取1771名符合纳入标准的尘肺病患者为研究对象,对其基本情况、... 详细信息

目的:了解重庆市尘肺病患者两周内门诊服务利用情况及特点,并分析其影响因素,为相关政策制定提供参考依据。方法:于2020年10月至2022年10月,采用多阶段分层随机整群抽样,选取1771名符合纳入标准的尘肺病患者为研究对象,对其基本情况、两周内门诊服务利用情况、因尘肺病相关症状治疗情况、医疗服务机构选择情况等进行问卷调查,用χ^(2)检验和logistic回归进行数据统计分析。结果:1771例尘肺病患者均为男性,平均年龄(56.1±10.19)岁,两周内门诊就诊尘肺病患者中,年龄41~50岁患者占40.0%(204/510);农村患者占87.8%(448/510);矽肺患者占65.1%(332/510),贰期患者占37.5%(191/510),诊断尘肺后未继续从事接尘工作患者占75.1%(383/510),工作时从来没有工伤保险患者占57.1%(291/510)。获得尘肺相关救助和有低保患者两周内门诊率分别为17.6%(90/510)和12.5%(64/510),患者自我健康评分为3分(41~60/中等)者占59.1%(301/510),有并发症、有尘肺病相关症状加重和一年内有住院史的患者分别占97.8%(499/510)、78.8%(402/510)和76.5%(390/510)。患者自我健康评分平均得分(52.9±16.2)分;28.2%的患者购买过工伤保险;两周内进行治疗患者1204例,门诊就诊者42.2%,住院治疗者20.7%,自己买药者36.9%,患者不同治疗方式间差异有统计学意义(χ^(2)=27.53,P<0.01);不同居住地患者选择到不同医疗机构就诊的差异有统计学意义(χ^(2)=13.97,P<0.05);患者尘肺病期别、有无并发症、有无工伤保险、自我健康评分、近一年是否住过院等是影响尘肺病患者门诊就诊的重要因素。结论:尘肺病患者门诊利用情况受人口社会学、社会支持、疾病特征多因素的影响,应加强基层卫生机构的职业病医疗服务质量,让尘肺病患者能获得便利有效的治疗;建立更完善的社会保障支持体系,减轻尘肺病患者疾病负担。

关键词：尘肺病就医行为门诊率

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“互联网+支教”助推义务教育优质均衡发展——基于多元主体协同发展策略构建的行动研究

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中国远程教育 2024年第9期 65-77页

作者：杨晓宏马娟杨建东李策西北师范大学教育技术学院兰州730070 陇南师范高等专科学校陇南742500

“互联网+支教”是2019年甘肃省率先在全国发起的教育精准扶贫项目,项目的持续深入实施促进了甘肃师范教育与义务教育的有效衔接,助推了甘肃义务教育优质均衡发展。文章以一所高等师范院校(L校)及结对的两个县区(Z县和W区)的“互联网+... 详细信息

“互联网+支教”是2019年甘肃省率先在全国发起的教育精准扶贫项目,项目的持续深入实施促进了甘肃师范教育与义务教育的有效衔接,助推了甘肃义务教育优质均衡发展。文章以一所高等师范院校(L校)及结对的两个县区(Z县和W区)的“互联网+支教”行动为样本,以“互联网+支教”机构及个体实践层面的多元主体为研究对象,以构建学习共同体为行动导向,以解决问题为协同起点,开展了行动研究。通过长周期追踪的实证研究,构建了以“互联网+支教”为载体,促进以“师范生—乡村学生—乡村教师”为核心的多元主体协同发展的有效策略体系,分析了“互联网+支教”助推甘肃义务教育优质均衡发展的具体成效。文章详细描述了四年四轮行动研究中“计划→行动→观察→反思”各个环节的循环迭代过程,全面刻画了立足行动研究不断深化实践的发展脉络。

关键词： “互联网+支教” 教育均衡学习共同体行动研究

基于数字孪生与k-近邻算法的车间设备运行状态预测研究

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制造技术与机床 2024年第3期 193-199页

作者：和征李忠鹏杨小红西安工程大学管理学院陕西西安710048

由于传统车间设备运行状态预测不能有效利用历史数据进行学习,实时响应能力有限,难以在复杂调度环境中取得良好效果,因此文章提出一种数字孪生与k-近邻算法相结合的车间设备运行状态预测模型。构建车间设备实体在信息空间的数字孪生模型... 详细信息

由于传统车间设备运行状态预测不能有效利用历史数据进行学习,实时响应能力有限,难以在复杂调度环境中取得良好效果,因此文章提出一种数字孪生与k-近邻算法相结合的车间设备运行状态预测模型。构建车间设备实体在信息空间的数字孪生模型,并建立设备实体与模型之间的映射关系,从而获取实时特征数据,即设备的运行状态特征数据。运用k-近邻算法计算实时特征数据与历史数据之间的欧几里得距离,即计算设备当前运行状态与历史已知状态的相似度,最终通过前k个距离所对应的设备历史运行状态数据,预测设备的当前运行状态。该模型的本质是通过数字孪生的实时数据采集,获取指定设备运行状态特征数据,运用k-近邻算法预测设备的实时运行状态。相较以往研究,本研究贡献在于提高设备实时运行状态预测的准确率。如果将数字孪生、k-近邻算法与具备自我学习能力的相关算法相结合,模型的预测效果会更好。

关键词： k-近邻算法机器学习数字孪生车间设备运行状态预测

面向《教师数字素养》标准的师范生数字素养框架与培养路径

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电化教育研究 2024年第5期45卷 83-89页

作者：杨晓宏孟宝兴王丹华西北师范大学教育技术学院甘肃兰州730070 衡阳师范学院教育科学学院湖南衡阳421000

《教师数字素养》行业标准的发布,为师范生数字素养的培养指明了方向。面向教师数字素养框架,开展师范生数字素养框架构建与培养路径设计,能够为推动师范生数字素养理论研究与实践创新提供支持。研究对标教师数字素养框架,参照师范生核... 详细信息

《教师数字素养》行业标准的发布,为师范生数字素养的培养指明了方向。面向教师数字素养框架,开展师范生数字素养框架构建与培养路径设计,能够为推动师范生数字素养理论研究与实践创新提供支持。研究对标教师数字素养框架,参照师范生核心素养相关标准,运用内容分析和对比分析法,构建了包括5个一级维度,13个二级维度,28个三级维度的师范生数字素养框架。在框架构建的基础上,提出了师范生数字素养培养路径:推动师范教育的全面数字化转型,筑牢培养底座;构建以“第一课堂为主,第二课堂为辅”主辅并行的培养体系;组建“校内教师+校际教师”两个共同体支撑的师资队伍;建设“课程资源+实践资源”两个资源库;形成“混合必修+网络选修”两种课程模式;建立师范生数字素养智能测评系统等。

关键词：师范生数字素养框架构建培养路径教师数字素养

应用差分进化-神经网络模型的杀爆弹瞄准点分配方法

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北京理工大学学报 2024年第2期44卷 146-155页

作者：徐豫新贾志远杨晓红索非张益荣北京理工大学爆炸科学与技术国家重点实验室北京100081 北京理工大学重庆创新中心重庆401120 中国人民解放军63961部队北京100012

为在不增加计算时耗的前提下提升多枚杀爆弹对面目标打击毁伤效能,建立融入动爆威力计算的多瞄准点规划方法.对面目标采用结构化网格划分方法实现多枚杀爆弹对目标毁伤区域的精确计算,并进行计算结果验证,基于多次计算结果采用神经网络... 详细信息

为在不增加计算时耗的前提下提升多枚杀爆弹对面目标打击毁伤效能,建立融入动爆威力计算的多瞄准点规划方法.对面目标采用结构化网格划分方法实现多枚杀爆弹对目标毁伤区域的精确计算,并进行计算结果验证,基于多次计算结果采用神经网络方法建立单枚弹药对面目标毁伤区域的计算代理模型,在同样计算条件下,比非代理模型计算时间缩短1000倍;据此,通过差分进化算法实现多枚杀爆弹对面目标打击瞄准点及末端弹道参数的规划.通过实例对比分析表明:该瞄准点规划方法形成的打击方案比传统以毁伤半径为输入的方法毁伤效果大幅提升,最低提升25.5%,且单次规划时间不超过3 s,解决了瞄准点规划中毁伤效能模型复杂度与计算耗时之间的矛盾.

关键词：杀爆弹动爆威力瞄准点规划毁伤幅员神经网络差分进化算法