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Multiple Uplift and Exhumation of the Southeastern Tibetan Plateau:Evidence from Low-Temperature Thermochronology

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 569-584页

作者： WU Limin PENG Touping FAN Weiming ZHAO Guochun GAO Jianfeng dong xiaohan PENG Shili MIN Kang Tin Aung MYINT State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China Chinese Academy of Sciences Center for Excellence in Deep Earth Science Guangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China Chinese Academy of Sciences Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China Department of Earth Sciences The University of Hong KongHong Kong 999077China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiGuangdong 519085China Department of Geology University of MandalayMandalay 05011Myanmar

Since the Cenozoic,the Tibetan Plateau has experienced large-scale uplift and outgrowth due to the India-Asia ***,the mechanism and timing of these tectonic processes still remain ***,using apatite fission track dating and inverse thermal modeling,we explore the mechanism of different phases of rapid cooling for different batholiths and intrusions in the southeastern Tibetan *** contrast to previous views,we find that the coeval granitic batholith exposed in the same tectonic zone experienced differential fast uplift in different sites,indicating that the present Tibetan Plateau was the result of differential uplift rather than the entire lithosphere uplift related to lithospheric collapse during Cenozoic *** addition,we also suggest that the 5-2 Ma mantle-related magmatism should be regarded as the critical trigger for the widely coeval cooling event in the southeastern Tibetan Plateau,because it led to the increase in atmospheric CO_(2)level and a hotter upper crust than before,which are efficient for suddenly fast rock weathering and ***,we propose that the current landform of the southeastern Tibetan Plateau was the combined influences of tectonic and climate.

关键词： apatite fission track rapid cooling differential uplift magmatism southeastern Tibetan Plateau

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含钛高炉渣制备复合吸附剂及其铬吸附性能

化工进展 2024年第3期43卷 1552-1564页

作者：董晓涵田月苏毅昆明理工大学化学工程学院云南昆明650000

Cr(Ⅵ)是一种有害污染物,既污染水环境,也会对人体造成伤害。本文以工业固废含钛高炉渣为原料,通过酸浸得到浸出渣基体,经壳聚糖改性,制备一种新型GLZ-jcz/CS复合吸附剂,用来去除废水中的Cr(Ⅵ)。研究了吸附温度、废水pH、吸附剂量、Cr(... 详细信息

Cr(Ⅵ)是一种有害污染物,既污染水环境,也会对人体造成伤害。本文以工业固废含钛高炉渣为原料,通过酸浸得到浸出渣基体,经壳聚糖改性,制备一种新型GLZ-jcz/CS复合吸附剂,用来去除废水中的Cr(Ⅵ)。研究了吸附温度、废水pH、吸附剂量、Cr(Ⅵ)初始浓度、吸附时间对Cr(Ⅵ)吸附性能的影响。以Cr(Ⅵ)吸附率为评价指标,确定最优实验条件,并研究了GLZ-jcz/CS复合吸附剂的再生性能。采用扫描电子显微镜、傅里叶红外变换光谱仪、X射线光电子能谱仪、BET比表面积测试仪对GLZ-jcz/CS复合吸附剂进行表征,结合吸附动力学模型和吸附等温线模型分析,确定吸附机理。实验结果表明:当吸附温度为70℃、废水pH=4、吸附剂用量为0.13g、Cr(Ⅵ)初始浓度为50mg/L、吸附时间为2h时,吸附率达到99.8%,吸附容量可以达到67mg/g,GLZ-jcz/CS复合吸附剂经过6次洗脱,吸附率仍可达到96%以上,吸附模型符合拟二级动力学模型和Langmuir吸附等温模型。

关键词：复合吸附剂 Cr(Ⅵ)吸附率动力学模型等温线模型含钛高炉渣壳聚糖改性

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预制青鱼干脂肪酶法脱脂工艺研究

核农学报 2024年第8期38卷 1523-1531页

作者：刘晓霞董晓涵陈康金仁耀浙江工商大学海洋食品研究院浙江杭州310012

为降低预制青鱼干鱼肉的腥味,改善青鱼干的口感,本研究采用碱性脂肪酶对青鱼干进行脱脂,通过响应面法获得最优工艺,并研究酶法工艺对青鱼干的影响。结果表明,pH值8.8、酶浓度27.6 U·mL^(-1)、料液比1∶2.9时的脱脂效率最高,鱼肉含脂率... 详细信息

为降低预制青鱼干鱼肉的腥味,改善青鱼干的口感,本研究采用碱性脂肪酶对青鱼干进行脱脂,通过响应面法获得最优工艺,并研究酶法工艺对青鱼干的影响。结果表明,pH值8.8、酶浓度27.6 U·mL^(-1)、料液比1∶2.9时的脱脂效率最高,鱼肉含脂率为5.29%;与皂化脱脂相比,脂肪酶法的脱脂效果更好,青鱼干的营养成分损失少,色泽亮黄,并且能够维持青鱼干独特的滋味。本试验结果为制备健康、营养的预制青鱼干提供了理论依据。

关键词：青鱼干酶法脱脂碱性脂肪酶含脂率

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miR-147a在宫颈癌Hela细胞中的表达及对Hela 细胞增殖、黏附及迁移的调控作用

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检验医学与临床 2024年第14期21卷 2047-2052页

作者：郭健曾友玲董晓寒华中科技大学同济医学院附属武汉儿童医院(武汉市妇幼保健院)妇产科湖北武汉430022

目的探讨微小核糖核酸-147a(miR-147a)在宫颈癌Hela细胞中的表达及对宫颈癌Hela细胞增殖、黏附及迁移的调控作用。方法在体外培养人宫颈癌Hela细胞,将对数期生长细胞分为对照组(不进行干预)、mimics NC组(转染mimics NC片段至Hela细胞)... 详细信息

目的探讨微小核糖核酸-147a(miR-147a)在宫颈癌Hela细胞中的表达及对宫颈癌Hela细胞增殖、黏附及迁移的调控作用。方法在体外培养人宫颈癌Hela细胞,将对数期生长细胞分为对照组(不进行干预)、mimics NC组(转染mimics NC片段至Hela细胞)、inhibitor NC组(转染inhibitor NC片段至Hela细胞)、miR-147a mimics组(转染miR-147a mimics片段至Hela细胞)及miR-147a inhibitor组(转染miR-147a inhibitor片段至Hela细胞),干预24 h。采用实时荧光定量聚合酶链反应检测Hela细胞中miR-147a表达水平;采用细胞计数试剂盒-8测定细胞活力;采用5-乙炔基-2′脱氧尿嘧啶核苷测定细胞的增殖率;采用细胞黏附实验测定细胞的黏附能力;采用Transwell小室法测定细胞的迁移能力;采用蛋白免疫印迹法测定细胞周期蛋白D1(cyclin D1)和核转录因子-κB(NF-κB)通路相关蛋白表达水平。结果miR-147a mimics组miR-147a表达水平明显高于mimics NC组(P<0.05),miR-147a inhibitor组miR-147a表达水平明显低于inhibitor NC组(P<0.05),miR-147a mimics、miR-147a inhibitor转染成功。与mimics NC组相比,miR-147a mimics组细胞活力、增殖率、黏附数、迁移数及cyclin D1、磷酸化(p)-NF-κB蛋白表达水平明显下降(P<0.05);与inhibitor NC组相比,miR-147a inhibitor组细胞活力、增殖率、黏附数、迁移数及cyclin D1、p-NF-κB蛋白表达水平明显升高(P<0.05)。结论过表达miR-147a通过调控NF-κB通路抑制宫颈癌细胞的增殖、黏附及迁移能力。

关键词：宫颈癌微小核糖核酸-147a 核转录因子-κB信号通路增殖黏附迁移

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不同温度下冻藏对青鱼品质的影响研究

核农学报 2024年第6期38卷 1108-1116页

作者：宋妍灵王士桢董晓涵陈康金仁耀浙江工商大学海洋食品研究院浙江杭州310012 浙江省水产品加工技术研究联合重点实验室浙江杭州310012

为研究不同温度下冻藏对青鱼品质的影响,本研究将新鲜青鱼在-18、-30、-60、-80℃下冻藏,分别取冻藏后0、7、15、30、60、90 d样品测定盐溶性蛋白含量、钙ATP酶(Ca^(2+)-ATPase)活性、总巯基含量、表面疏水性,并结合质构、色差、十二烷... 详细信息

为研究不同温度下冻藏对青鱼品质的影响,本研究将新鲜青鱼在-18、-30、-60、-80℃下冻藏,分别取冻藏后0、7、15、30、60、90 d样品测定盐溶性蛋白含量、钙ATP酶(Ca^(2+)-ATPase)活性、总巯基含量、表面疏水性,并结合质构、色差、十二烷基硫酸钠聚丙烯酰胺(SDS-PAGE)凝胶电泳、电镜观察,分析4个温度梯度下冻藏青鱼品质的变化。结果表明,随着冻藏时间的延长,4组青鱼鱼肉的品质均出现下降,以30 d内检测指标的变化较为突出,说明冻藏1月的青鱼可食用价值发生改变。相同冻藏时间下,-80℃组冻藏青鱼的各项指标均优于其余3组,-60℃组品质次之,-18与-30℃组品质无明显差异,说明超低温可降低青鱼组织蛋白质的变性速率,更好地保持鱼肉品质。本研究可为研发青鱼冻藏新方式及辅助存储技术提供理论依据。

关键词：青鱼鱼肉品质冻藏温度肌原纤维蛋白特性

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滇西剑川始新世粗面岩及其包体成因:印度-欧亚大陆碰撞过程的约束和大地构造意义

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大地构造与成矿学 2024年第4期48卷 820-843页

作者：董晓涵彭头平范蔚茗刘兵兵彭世利武利民中国科学院广州地球化学研究所同位素地球化学国家重点实验室广东广州510640 中国科学院大学北京100049 中国科学院深地科学卓越创新中心广东广州510640 中国科学院青藏高原研究所北京100101

新生代以来,印度-欧亚大陆碰撞导致青藏高原发生大规模隆升和岩石圈挤出,这一过程引发了金沙江-哀牢山-红河构造带等深大断裂带的大规模剪切走滑,并沿该构造带发生强烈的碱性岩浆作用。这些始新世碱性岩记录了印度-欧亚大陆的早期碰撞过... 详细信息

新生代以来,印度-欧亚大陆碰撞导致青藏高原发生大规模隆升和岩石圈挤出,这一过程引发了金沙江-哀牢山-红河构造带等深大断裂带的大规模剪切走滑,并沿该构造带发生强烈的碱性岩浆作用。这些始新世碱性岩记录了印度-欧亚大陆的早期碰撞过程,因而可以作为研究青藏高原早期隆升和岩石圈挤出过程及其深部动力学机制的重要“探针”。本文针对剑川盆地甸南地区始新世粗面岩及其二长岩包体和辉长岩包体开展了系统的锆石U-Pb年代学、Lu-Hf同位素和全岩主-微量元素和Sr-Nd同位素组成研究。锆石U-Pb定年结果显示,剑川盆地甸南粗面岩形成时代为36Ma;其内部包含的两件二长岩包体的形成年龄分别为41.6±3.4 Ma和35.7±0.3 Ma,一件辉长岩包体的形成时代为35.8±0.2 Ma。地球化学研究结果显示,粗面岩与二长岩包体K_(2)O含量均较高,属于钾玄质系列岩石,且富集轻稀土元素(LREE)和大离子亲石元素(LILE),亏损高场强元素(HFSE)。结合锆石Hf同位素和全岩Sr-Nd同位素组成,表明甸南地区寄主粗面岩和二长岩包体来自相同的交代富集岩石圈地幔的部分熔融,并经历了不同程度的橄榄石和辉石分离结晶作用。包体研究显示,~41Ma二长岩包体为寄主粗面岩岩浆上升过程中捕获自早期围岩,而~36Ma二长岩包体为同源岩浆房内与围岩接触淬冷的早期结晶产物,它们被寄主粗面岩岩浆裹挟而存在其内部。堆晶辉长岩包体较寄主粗面岩和二长岩包体具明显低的K2O、稀土和微量元素含量,其全岩Nd同位素组成与剑川盆地二龙山橄榄玄武岩相似,但高于寄主粗面岩,表明其源自弱富集地幔的部分熔融,并在壳-幔过渡带堆晶形成。此外,~41 Ma碱性岩包体和碱性岩内46~38 Ma捕获锆石年龄,以及剑川盆地内近源沉积岩内碎屑锆石的同期年龄记录,均表明金沙江-哀牢山-红河碱性岩带的岩浆作用并非存在从高原内部向东南方向的滇西地区逐渐变年轻的趋势,而是印度-欧亚大陆碰撞过程中,岩石圈向东南向挤出导致兰坪-思茅地块和印支地块旋转挤出的响应。

关键词：青藏高原金沙江-哀牢山-红河构造带粗面岩包体岩石圈挤出

并联电抗器中抽能绕组设计及匝数验证研究分析

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变压器 2024年第8期61卷 1-5页

作者：董景义董潇涵禹云长王冰陆建林吴江变压器有限公司江苏苏州215200 烟台大学机电汽车工程学院山东烟台264000

本文作者介绍了并联电抗器中抽能绕组的作用、设计要点和验证方法,指出抽能绕组在匝电势设计和验证时,不能简单照搬变压器的匝电势计算和半成品变比试验时的传统方法,应充分考虑各种边界条件的影响,为类似结构产品的设计、制造提供借鉴... 详细信息

本文作者介绍了并联电抗器中抽能绕组的作用、设计要点和验证方法,指出抽能绕组在匝电势设计和验证时,不能简单照搬变压器的匝电势计算和半成品变比试验时的传统方法,应充分考虑各种边界条件的影响,为类似结构产品的设计、制造提供借鉴参考。

关键词：单相并联电抗器抽能绕组匝数

Milk fat globule membrane supplementation protects againstβ-lactoglobul-ininduced food allergy in mice via upregulation of regulatory T cells and enhancement of intestinal barrier in a microbiota-derived short-chain fatty acids manner

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Food Science and Human Wellness 2024年第1期13卷 124-136页

作者： Han Gong Tiange Li dong Liang Jingxin Gao xiaohan Liu Xueying Mao Key Laboratory of Functional Dairy Ministry of EducationCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Henan Engineering Technology Research Center of Food Processing and Circulation Safety Control College of Food Science and TechnologyHenan Agricultural UniversityZhengzhou 450002China Applied Nutrition I China National Center for Food Safety Risk AssessmentBeijing 100022China

Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and *** aim of this study was to evaluate the protective effects and possible underlying mechanisms of MFGM on cow’s milk allergy(CMA)in aβ-lactoglobulin(BLG)-induced allergic mice *** was supplemented to allergic mice induced by BLG at a dose of 400 mg/kg body *** demonstrated that MFGM alleviated food allergy symptoms,decreased serum levels of lipopolysaccharide,pro-inflammatory cytokines,immunoglobulin(Ig)E,Ig G1,and Th2 cytokines including interleukin(IL)-4,while increased serum levels of Th1 cytokines including interferon-γand regulatory T cells(Tregs)cytokines including IL-10 and transforming growth factor-β.MFGM modulated gut microbiota and enhanced intestinal barrier of BLG-allergic mice,as evidenced by decreased relative abundance of Desulfobacterota,Rikenellaceae,Lachnospiraceae,and Desulfovibrionaceae,while increased relative abundance of Bacteroidetes,Lactobacillaceae and Muribaculaceae,and enhanced expressions of tight junction proteins including Occludin,Claudin-1 and zonula ***,MFGM increased fecal short-chain fatty acids(SCFAs)levels,which elevated G protein-coupled receptor(GPR)43 and GPR109A *** increased expressions of GPR43 and GPR109A induced CD103+dendritic cells accumulation and promoted Tregs differentiation in mesenteric lymph node to a certain *** summary,MFGM alleviated CMA in a BLG-induced allergic mice model through enhancing intestinal barrier and promoting Tregs differentiation,which may be correlated with SCFAs-mediated activation of *** findings suggest that MFGM may be useful as a promising functional ingredient against CMA.

关键词： Cow’s milk allergy Milk fat globule membrane Gut microbiota Short-chain fatty acid G protein-coupled receptor Regulatory T cell

Rapid and label-free classification of pathogens based on light scattering,reduced power spectral features and support vector machine

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Chinese Chemical Letters 2020年第12期31卷 3163-3167页

作者： Mubashir Hussain Zhen Chen Mu Lv Jingyi Xu xiaohan dong Jingzhou Zhao Song Li Yan Deng Nongyue He Zhiyang Li Bin Liu State Key Laboratory of Bioelectrontics School of Biological Science and Medical Engineering.Southeast UniversityNanjing 210096China Key laboratory of Clinical and Medical Engineering Department of Biomedical EngineeringSchool of Biomedical Engieering and lnformaticsNanjingMedical UniversiryNanjing 211166China Department of Clinical Laboratory The Affliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of TechnologyZhuzhou 412007China

The rapid identification of pathogens is crucial in controlling the food quality and *** proposed system for the rapid and label-free identification of pathogens is based on the principle of laser scattering from the bacterial *** clinical prototype consists of three parts:the laser beam,photodetectors,and the data acquisition *** bacterial testing sample was mixed with 10 mL distilled water and placed inside the machine *** the bacterial microbes pass by the laser beam,the scattering of light occurs due to variation in size,shape,and *** to this reason,different types of pathogens show their unique light scattering *** photo-detectors were arranged at the surroundings of the sample at different angles to collect the scattered *** photodetectors convert the scattered light intensity into a voltage *** waveform features were acquired by using the power spectral characteristics,and the dimensionality of extracted features was reduced by applying minimal-redundancy-maximal-relevance criterion(mRMR).A support vector machine(SVM)classifier was developed by training the selected power spectral features for the classification of three different bacterial *** resulting average identification accuracies of ***,*** and *** were 99%,87%,and 94%,*** ove rall experimental results yield a higher accuracy of 93.6%,indicating that the proposed device has the potential for label-free identification of pathogens with simplicity,rapidity,and cost-effectiveness.

关键词： Pathogens identification Laser light scattering Features reduction Support vector machines Waveform features extraction