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绿藻对高温硫化硅橡胶材料憎水性能的影响

高电压技术 2017年第3期43卷 885-890页

作者：贾志东王也欧阳小刚张星海白欢陈洪波清华大学深圳研究生院深圳518055 国网四川省电力公司电力科学研究院成都610072

绝缘子上生长藻类的现象在国内外多有报道,但由于该领域缺乏试验标准,在各国学者的研究中,很少对藻种和藻量予以测定,这使得研究结果差异性大,对藻类问题的认识也未能统一。为此,探索了定量研究藻类问题的方法,利用该方法研究了藻类对... 详细信息

绝缘子上生长藻类的现象在国内外多有报道,但由于该领域缺乏试验标准,在各国学者的研究中,很少对藻种和藻量予以测定,这使得研究结果差异性大,对藻类问题的认识也未能统一。为此,探索了定量研究藻类问题的方法,利用该方法研究了藻类对高温硫化硅橡胶(HTV)憎水性能的影响。在四川省某变电站的长藻绝缘子上取得藻样,利用基因测序的方法确定其为单细胞绿藻,在实验室扩大培养,并利用血球计数板对其数量进行了定量测量。借鉴ASTM G29以及GB/T 24127的试验方法,研究了不同浓度的藻液对于硅橡胶憎水性的抑制情况,发现由藻细胞数密度为107 m L–1量级的藻液浸泡72 h就可以在HTV硅橡胶表面形成稳定的亲水层,自然干燥后测量其静态接触角4×104/cm2时,其对于憎水迁移性有明显抑制作用。

关键词：绿藻藻类定量测量憎水性藻细胞数密度憎水迁移

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330 kV输电线路鸟粪闪络仿真研究

高压电器 2018年第4期54卷 120-127页

作者：吴波吴旭涛刘世涛闫振华常彬贾志东姜金涛欧阳小刚国网宁夏电力公司电力科学研究院银川750002 清华大学深圳研究生院深圳518055

2011年以来宁夏地区330 kV线路先后多次发生鸟害故障跳闸,因此文中对330 kV输电线路复合绝缘子的鸟粪闪络展开了仿真研究。仿真了绝缘子I串和V串布置情况下鸟粪对绝缘子附近空间电场的影响,分析了鸟粪的长度、位置以及悬浮鸟粪的存在对... 详细信息

2011年以来宁夏地区330 kV线路先后多次发生鸟害故障跳闸,因此文中对330 kV输电线路复合绝缘子的鸟粪闪络展开了仿真研究。仿真了绝缘子I串和V串布置情况下鸟粪对绝缘子附近空间电场的影响,分析了鸟粪的长度、位置以及悬浮鸟粪的存在对电场的畸变效应,接着讨论了分裂导线以及屏蔽环对于电场的影响。结果表明,当鸟粪通道位于绝缘子附近时,电场畸变比较明显;悬浮鸟粪的存在会增加电场的不均匀度,更易引发闪络;分裂导线降低了电场的不均匀度,对鸟粪闪络具有抑制作用;屏蔽环缩短了高低压端之间的距离,增加了闪络的可能性。

关键词： 330 kV输电线路复合绝缘子鸟粪闪络空气击穿悬浮鸟粪

330 kV输电线路复合绝缘子鸟粪闪络特性研究

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高压电器 2018年第4期54卷 135-141页

作者：刘世涛吴波吴旭涛陈泓李秀广常彬贾志东徐笑然欧阳小刚李阳林国网宁夏电力公司电力科学研究院银川750002 国网宁夏电力公司银川750001 清华大学深圳研究生院深圳518055 国网江西省电力公司电力科学研究院南昌330096

2011年以来,宁夏地区330 kV线路多次发生鸟害故障跳闸,严重威胁了宁夏电网的安全稳定运行。目前国内外对于引起330 kV线路的鸟粪闪络机理及其影响因素仍缺乏研究。文中首先研究了低温环境下染污硅橡胶的憎水特性,然后基于鸟粪下落过程... 详细信息

2011年以来,宁夏地区330 kV线路多次发生鸟害故障跳闸,严重威胁了宁夏电网的安全稳定运行。目前国内外对于引起330 kV线路的鸟粪闪络机理及其影响因素仍缺乏研究。文中首先研究了低温环境下染污硅橡胶的憎水特性,然后基于鸟粪下落过程中最大连续长度与鸟粪参数的关系,试验研究了鸟粪下落方式、下落通道、电导率、粘度、体积、下落位置和相对湿度等对330 kV复合绝缘子闪络特性的影响。试验结果表明,330 kV复合绝缘子的鸟粪闪络概率随距离的减小、鸟粪长度的增加而增加;鸟粪脱离横担比未脱离横担下落时发生闪络的概率更低;带均压环比不带均压环时绝缘子更易发生闪络;当鸟粪体积、鸟粪电导率、空气相对湿度越大时,发生鸟粪闪络的概率越大。

关键词： 330 kV复合绝缘子鸟粪闪络下落方式电导率粘度相对湿度

“一站式”腔内治疗冠心病合并主动脉粥样硬化性疾病的探讨

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中国普通外科杂志 2016年第12期25卷 1683-1688页

作者：罗明尧唐熠达方坤陈祖君陈雷吕滨常谦孙晓刚欧阳晨曦舒畅中国医学科学院北京协和医学院国家心血管病中心阜外医院心血管疾病国家重点实验室北京100037 中南大学湘雅二医院血管外科湖南长沙410011

目的：探讨冠状动脉介入治疗（PCI）联合主动脉腔内修复术（EVAR）“一站式”治疗冠心病和主动脉粥样硬化性疾病的临床策略及其安全性。方法：回顾性分析2016年1月—2016年6月中国医学科学院阜外医院行腔内治疗的7例合并冠心病的主动... 详细信息

目的：探讨冠状动脉介入治疗（PCI）联合主动脉腔内修复术（EVAR）“一站式”治疗冠心病和主动脉粥样硬化性疾病的临床策略及其安全性。方法：回顾性分析2016年1月—2016年6月中国医学科学院阜外医院行腔内治疗的7例合并冠心病的主动脉粥样硬化性疾病患者资料，其中男6例，女1例，平均年龄76.2（64-86）岁，术前主动脉CT和冠脉CT确诊主动脉病变和冠脉病变并存，术中造影确认主动脉和冠脉病变均符合介入治疗指征后，实施“一站式”手术治疗。结果：手术成功率100%，无围术期死亡。术后并发症包括切口附近皮下瘀斑2例，其中合并血肿1例，后者因血色素下降予以输注浓缩红细胞2U治疗。1例主动脉弓降部溃疡患者以烟囱技术重建左锁骨下动脉，其左侧肱动脉穿刺点出现假性动脉瘤，予以外科修复。所有患者均获得门诊或电话随访，随访时间7（6-10）个月，所有患者临床症状消失或明显减轻，生活质量改善，无再次手术或死亡。结论：PCI联合EVAR“一站式”治疗冠心病和主动脉粥样硬化性疾病早中期疗效满意，切口或穿刺部位出血性并发症应予警惕。术后药物治疗方案严格按照冠心病的治疗原则进行。

关键词：动脉硬化主动脉冠心病血管内操作

Downward continuation of airborne gravimetry data based on Poisson integral iteration method

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Geodesy and Geodynamics 2017年第4期8卷 273-277页

作者： xiaogang Liu Zhongmiao Sun Kang Xu Mingda ouyang State Key Laboratory of Geo-Information Engineering Xi'an 710054 China Xi'an Research Institute of Surveying and Mapping Xi'an 710054 China State Key Laboratory of Geodesy and Earth's Dynamics Wuhan 430077 China Military Key Laboratory of Surveying Mapping and Navigation of Engineering Information Engineering University Zhengzhou 450052 China 61287 Unit of PLA Chengdu 610036 China Technical Division of Surveying and Mapping Xi'an 710054 China

The research and application of airborne gravimetry technology has become one of the hottest topics in gravity field in recent years. Downward continuation is one of the key steps in airborne gravimetry data processing, and the quality of continuation results directly influence the further application of surveying data. The Poisson integral iteration method is proposed in this paper, and the modified Poisson integral discretization formulae are also introduced in the downward continuation of airborne gravimerty data. For the test area in this paper, compared with traditional Poisson integral discretization formula, the continuation result of modified formulae is improved by 10.8 mGal, and the precision of Poisson integral iteration method is in the same amplitude as modified formulae. So the Poisson integral iteration method can reduce the discretization error of Poisson integral formula effectively. Therefore, the research achievements in this paper can be applied directly in the data processing of our country＇s airborne scalar and vector gravimetry.

关键词： Airborne gravimetry Downward continuation Poisson integral Gravity anomaly Discretization

High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients

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Cellular & Molecular Immunology 2020年第6期17卷 650-652页

作者： Wenjing Wang Bin Su Lijun Pang Luxin Qiao Yingmei Feng Yabo ouyang Xianghua Guo Hongbo Shi Feili Wei xiaogang Su Jiming Yin Ronghua Jin Dexi Chen Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University100069 BeijingChina Beijing Precision Medicine and Transformation Engineering Technology Research Center of Hepatitis and Liver Cancer 100069 BeijingChina Center for Infectious Diseases Beijing Youan HospitalCapital Medical University100069 BeijingChina

The outbreak of coronavirus disease 2019(COVID-19)caused by the new virus SARS-CoV-2 has been announced as a public health emergency of international concern.1–3 The clinical features of patients with COVID-19 range from common fever and cough to other rare symptoms,such as diarrhea and *** disease can progress quickly,and 2–3%of patients die within a short time,which is generally due to multiple organ failure.4–7 Clinically,COVID-19 patients are classified into mild,moderate,severe,and critical cases.5–7 The immune response against SARS-CoV-2 is probably linked to the severity of ***,Zheng et al.8 showed that elevated levels of T-cell exhaustion and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients;however,a more comprehensive understanding of the pathology of SARS-CoV-2 infection remains to be ***,we profiled immune cellular components using mass cytometry(CyTOF)to analyze the peripheral blood mononuclear cells(PBMCs)from patients with differences in disease progression by comparing with the PBMCs from healthy donors(HDs).

关键词： patients immunity elevated

Garlic-derived compound S-allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6/Wnt pathway

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Acta Pharmaceutica Sinica B 2018年第4期8卷 575-586页

作者： Jia Xiao Feiyue Xing Yingxia Liu Yi Lv xiaogang Wang Ming-Tat Ling Hao Gao Songying ouyang Min Yang Jiang Zhu Yu Xia Kwok-Fai So George L.Tipoe State Key Discipline of Infectious Diseases Shenzhen Third People's Hospital Department of Immunobiology Institute of Tissue Transplantation and ImmunologyJinan University School of Biomedical Sciences The University of Hong Kong Department of Cell Biology & Institute of Biomedicine Jinan University Australian Prostate Cancer Research Centre-Queensland and Institute of Health and Biomedical Innovation Queensland University of Technology Institute of Traditional Chinese Medicine and Natural Products College of PharmacyJinan University Biomedical Research Center of South China College of Life SciencesFujian Normal University JM Medical (Shenzhen) LLC GMH Institute of Central Nervous System Regeneration Jinan University

Whether and how garlic-derived S-allylmercaptocysteine(SAMC) inhibits hepatocellular carcinoma(HCC) is largely unknown. In the current study, the role of low-density lipoprotein receptor(LDLR)-related protein 6(LRP6) in HCC progression and the anti-HCC mechanism of SAMC was examined in clinical sample, cell model and xenograft/orthotopic mouse models. We demonstrated that SAMC inhibited cell proliferation and tumorigenesis, while induced apoptosis of human HCC cells without influencing normal hepatocytes. SAMC directly interacted with Wnt-pathway co-receptor LRP6 on the cell membrane. LRP6 was frequently over-expressed in the tumor tissue of human HCC patients(66.7% of 48 patients) and its overexpression only correlated with the over-expression of β-catenin, but not with age, gender, tumor size, stage and metastasis. Deficiency or over-expression of LRP6 in hepatoma cells could partly mimic or counteract the anti-tumor properties of SAMC, respectively. In vivo administration of SAMC significantly suppressed the growth of Huh-7 xenograft/orthotopic HCC tumor without causing undesirable side effects. In addition, stable down-regulation of LRP6 in Huh-7 facilitated the anti-HCC effects of SAMC. In conclusion, LRP6 can be a potential therapeutic target of HCC. SAMC is a promising specific anti-tumor agent for treating HCC subtypes with Wnt activation at the hepatoma cell surface.

关键词： S-allylmercaptocysteine HCC Wnt LRP6 Human Nude mice

Cross-sectional rainfall observation on the central-western Tibetan Plateau in the warm season:System design and preliminary results

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Science China Earth Sciences 2023年第5期66卷 1015-1030页

作者： Kun YANG Yingying CHEN Lazhu Changhui ZHAN Xiaoyan LING Xu ZHOU Yaozhi JIANG Xiangnan YAO Hui LU xiaogang MA Lin ouyang Weihao PAN Yanghang REN Changkun SHAO Jiaxin TIAN Yan WANG Hua YANG Siyu YUE Ke ZHANG Dingchi ZHAO Long ZHAO Jianhong ZHOU Mijun ZOU Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceInstitute for Global Change StudiesTsinghua UniversityBeijing100084China National Tibetan Plateau Data Center State Key Laboratory of Tibetan Plateau Earth System and Resource EnvironmentInstitute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing100101China Research Center for Ecology College of ScienceTibet UniversityLhasa850011China Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Science and Natural Resources ResearchChinese Academy of SciencesBeijing100101China Chongqing Jinfo Mountain Karst Ecosystem National Observation and Research Station School of Geographical SciencesSouthwest UniversityChongqing400715China

The central and western Tibetan Plateau(CWTP)is characterized by harsh environment and strong interactions among the spheres of earth as well as significant changes in climate and water cycles over the past four *** lack of precipitation observations is a bottleneck for the study of land surface processes in this *** the past six years,we have designed and established two observation transects across the south-north and the west-east in this region to obtain hourly rainfall data during the warm season(May-September).The south-north transect extends from Yadong Valley on the southern slope of the Himalayas to Shuanghu County in the hinterland of the plateau,with a total of 31stations;the west-east transect extends from Shiquanhe in the west to Naqu in the central TP,with a total of 22 *** observation dataset has been applied to clarify the spatiotemporal characteristics of precipitation in the CWTP,to evaluate the quality of typical gridded precipitation products,to support the development of regional climate models,and to reveal the processes of summertime lake-air *** observation dataset has been released in the National Tibetan Plateau Data Center.

关键词： Central and western Tibetan Plateau Rainfall observation transects Observation uncertainty Spatiotemporal characteristics of precipitation Precipitation data evaluation

武汉卓刀泉立交与地铁隧道施工的相互影响分析

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人民长江 2011年第20期42卷 86-88,92页

作者：郭晓刚欧阳院平长江勘测规划设计研究责任有限公司湖北武汉430010

武汉地铁2号线广虎区间下穿正在施工的卓刀泉立交桥,为了避免两工程在建设中的相互干扰,对地铁隧道与立交施工的相互影响进行数值模拟分析。计算结果表明,隧道开挖对立交桥桩的影响不大,但需要采取针对性工程措施以保障两个工程的安全... 详细信息

武汉地铁2号线广虎区间下穿正在施工的卓刀泉立交桥,为了避免两工程在建设中的相互干扰,对地铁隧道与立交施工的相互影响进行数值模拟分析。计算结果表明,隧道开挖对立交桥桩的影响不大,但需要采取针对性工程措施以保障两个工程的安全。提出在施工中加长靠近地铁一侧的桩身,加强桩周土体回填注浆,加强监测和进行桥墩结构复核等措施以提高桩周土体稳定性,并把隧道开挖的影响降到最低。完工后的监测数据显示,施工中采取的各项措施既有效保证了工程安全,又将相互影响降到最低。

关键词：地铁施工矿山法隧道卓刀泉立交数值计算相互影响