High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients
作者机构：Beijing Institute of HepatologyBeijing Youan HospitalCapital Medical University100069 BeijingChina Beijing Precision Medicine and Transformation Engineering Technology Research Center of Hepatitis and Liver Cancer100069 BeijingChina Center for Infectious DiseasesBeijing Youan HospitalCapital Medical University100069 BeijingChina
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2020年第17卷第6期
页 面：650-652页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
基 金：supported by the COVID-19 Key Technology Research and Development Funding of Beijing Hospital Authority,the National Natural Science Foundation of China(NSFC,81772165 and 81974303) the National 13th Five-Year Grand Program on Key Infectious Disease Control(2017ZX10202102-005-003)
主 题：patients immunity elevated
摘 要：The outbreak of coronavirus disease 2019(COVID-19)caused by the new virus SARS-CoV-2 has been announced as a public health emergency of international concern.1–3 The clinical features of patients with COVID-19 range from common fever and cough to other rare symptoms,such as diarrhea and *** disease can progress quickly,and 2–3%of patients die within a short time,which is generally due to multiple organ failure.4–7 Clinically,COVID-19 patients are classified into mild,moderate,severe,and critical cases.5–7 The immune response against SARS-CoV-2 is probably linked to the severity of ***,Zheng et al.8 showed that elevated levels of T-cell exhaustion and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients;however,a more comprehensive understanding of the pathology of SARS-CoV-2 infection remains to be ***,we profiled immune cellular components using mass cytometry(CyTOF)to analyze the peripheral blood mononuclear cells(PBMCs)from patients with differences in disease progression by comparing with the PBMCs from healthy donors(HDs).
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