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X80管线钢自动焊焊缝冲击能量分配研究

压力容器 2024年第6期41卷 30-35页

作者：韩涛温晓峰刘宇尹长华王金环中国石油天然气管道科学研究院有限公司河北廊坊065000 国家管网集团北方管道有限责任公司河北廊坊065000

针对X80管线钢实心焊丝自动焊的焊缝金属,采用仪器化冲击试验方法,研究了焊缝金属冲击能量分配和温度敏感性。结果表明,工程常用测试温度(-10℃)条件下,X80管道实心焊丝自动焊的焊缝金属冲击韧性(128~195 J)良好;总冲击吸收能量数据波... 详细信息

针对X80管线钢实心焊丝自动焊的焊缝金属,采用仪器化冲击试验方法,研究了焊缝金属冲击能量分配和温度敏感性。结果表明,工程常用测试温度(-10℃)条件下,X80管道实心焊丝自动焊的焊缝金属冲击韧性(128~195 J)良好;总冲击吸收能量数据波动显著大于裂纹形成能量,主要原因是裂纹扩展过程吸收能量波动较大引起的;系列温度冲击试验的总吸收能量和裂纹形成能量均具有上平台特征,但裂纹形成能量数据曲线的上平台温度范围(-40~20℃)更大,且随着试验温度升高,裂纹形成能量占比表现出非线性降低特性。长输管道工程设计温度范围(-40~20℃)内,焊缝金属裂纹形成能量测试结果具有温度无关性特征,依据上平台温度试验结果制定验收指标,可能不利于对焊缝金属裂纹萌生的控制,建议进一步开展相关研究,制定焊缝金属起裂韧性指标,从根本上控制焊缝金属裂纹的萌生。

关键词： X80管线钢实芯焊丝自动焊焊缝金属仪器化冲击试验能量分配

加热与常温输送在役原油管道对调运行投产技术

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油气储运 2024年第2期43卷 232-239页

作者：孙勇吕全马宁刁宇温晓峰刘慧勇姚志强邓梁国家管网集团北方管道有限责任公司河北省廊坊市065000 国家管网集团建设项目管理分公司国家管网集团科学技术研究总院分公司

【目的】原油管道Q_(1)线与Q_(2)线对调运行是中国首例加热与常温输送在役原油管道对调运行工程,其采用“一边改造,一边运行”不停输方式进行对调运行,涉及工艺流程复杂、工程实施难度大、分输与注入用户多等众多因素制约。【方法】开... 详细信息

【目的】原油管道Q_(1)线与Q_(2)线对调运行是中国首例加热与常温输送在役原油管道对调运行工程,其采用“一边改造,一边运行”不停输方式进行对调运行,涉及工艺流程复杂、工程实施难度大、分输与注入用户多等众多因素制约。【方法】开展加热与常温输送管道水力、热力系统改造研究,分析对调运行投产期间影响常温管道预热、热油管道温降的各项因素及不同对调运行置换方式的优缺点,确定合理的改造及对调方式,以减少其对正常生产运行带来的影响;校核Q_(2)线常温输送管道改造为加热输送后预热模拟计算的准确性,并通过实际工程数据验证模拟结果是否满足工程实际需求,同时积累Q_(1)线热油管道改造为常温输送后油品置换的现场实践经验,并针对对调运行期间的关键节点提出合理建议。【结果】在役常温输油管道改造为加热输送,其预热方式要结合现场实际情况来选择,以Q_(2)线为例,其采用“提前加热管输俄油+高温俄油预热”的方式,可使管道满足庆油输送要求。由加热输送方式改为常温输送方式应考虑采取相应措施使站间油品温度逐渐降低,如采用按批次定量输送温度逐渐降低的油品的方式;沿线各加热站对不同批次油品加热,以确保各站间油品温度逐步降低。【结论】研究结果可为在役原油管道运行方式变更的投产提供参考依据。

关键词：原油管道常温输送加热输送投产对调运行

Fabrication-Technology Research of New Type Silicon Magnetic-Sensitive Transistor

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稀有金属材料与工程 2006年第A3期35卷 492-494页

作者： xiaofeng Zhao Dianzhong wen Major Laboratories of Integrated Circuits Heilongjiang University Harbin 150080 China

This paper mainly describes a research of fabrication-technology of silicon magnetic-sensitive transistor (SMST) with rectangle-plank-cubic structure fabricated on silicon wafer by MEMS *** experiment research on basic characteristic of the silicon magnetic-sensitive transistor was *** etching and reliable technique project were provided and applied in order to fabricate SMST with rectangle-plank-cubic *** means that a new kind of fabrication technology for silicon magnetic-sensitive transistor was *** result shows that the technique can be not only compatible with IC technology but also integrated easily,and has a wide application field.

关键词： silicon magnetic-sensitive transistor(SMST) MEMS anisotropic etching of silicon IC technology

Efficient and fair PPO-based integrated scheduling method for multiple tasks of SATech-01 satellite

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Chinese Journal of Aeronautics 2024年第2期37卷 417-430页

作者： Qi SHI Lu LI Ziruo FANG Xingzi BI Huaqiu LIU xiaofeng ZHANG wen CHEN Jinpei YU Shanghai Satellite Network Research Institute CO. LTDShanghai 201210China Innovation Academy for Microsatellites of Chinese Academy of Sciences Shanghai 201306China University of Chinese Academy of Sciences Beijing 100039China

SATech-01 is an experimental satellite for space science exploration and on-orbit demonstration of advanced *** satellite is equipped with 16 experimental payloads and supports multiple working modes to meet the observation requirements of various *** to the limitation of platform power supply and data storage systems,proposing reasonable mission planning schemes to improve scientific revenue of the payloads becomes a critical *** this article,we formulate the integrated task scheduling of SATech-01 as a multi-objective optimization problem and propose a novel Fair Integrated Scheduling with Proximal Policy Optimization(FIS-PPO)algorithm to solve *** use multiple decision heads to generate decisions for each task and design the action mask to ensure the schedule meeting the platform *** results show that FIS-PPO could push the capability of the platform to the limit and improve the overall observation efficiency by 31.5%compared to rule-based plans currently ***,fairness is considered in the reward design and our method achieves much better performance in terms of equal task *** of its low computational complexity,our task scheduling algorithm has the potential to be directly deployed on board for real-time task scheduling in future space projects.

关键词： Satellite observatories SATech-01 Multi-modes platform Scheduling algorithms Reinforcement learning Proximal Policy Optimization(PPO)

Wheel-legged In-pipe Robot with a Bioinspired Hook and Dry Adhesive Attachment Device

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Journal of Bionic Engineering 2024年第3期21卷 1208-1222页

作者： Yahong Liu Yi Sun Kai Cao Shutao Wu xiaofeng Xu Qingfei Han Shikun wen Huan Shen Guangming Chen Jiajun Xu Zhiwei Yu Aihong Ji Lab of Locomotion Bioinspiration and Intelligent Robots College of Mechanical and Electrical EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In-pipe robots have been widely used in pipes-with smooth inner ***,current in-pipe robots face challenges in terms of moving past obstacles and climbing in marine-vessel pipeline systems,which are affected by marine biofouling and electrochemical *** paper takes inspiration from the dual-hook structure of Trypoxylus dichotomus’s feet and gecko‑like dry adhesives,proposing an in-pipe robot that is capable of climbing on rough and smooth pipe *** combination of the bioinspired hook and dry adhesives allows the robot to stably attach to rough or smooth pipe inwalls,while the wheel-leg hybrid mechanism provides better conditions for obstacle *** paper explores the attachment and obstacle-surmounting mechanisms of the ***,motion strategies for the robot are devised based on different pipe structural *** experiments showed that this robot can adapt to both smooth and rough pipe environments simultaneously,and its motion performance is superior to conventional driving *** robot’s active turning actuators also enable it to navigate through horizontally or vertically oriented 90°bends.

关键词： In-pipe robot Bioinspired attachment device Wheel-legged robot Mechanical design

Comparison of clinical features and outcomes of proliferative,fibrotic,and mixed subtypes of IgG4-related disease:A retrospective cohort study

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Chinese Medical Journal 2024年第3期137卷 303-311页

作者： Linyi Peng Xinlu Zhang Jiaxin Zhou Jieqiong Li Zheng Liu Hui Lu Yu Peng Yunyun Fei Yan Zhao xiaofeng Zeng wen Zhang Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalNational Clinical Research Center for Dermatologic and Immunologic DiseasesState Key Laboratory of Complex Severe and Rare DiseasesThe Ministry of Education Key LaboratoryBeijing 100730China Institute of Clinical Medicine Peking Union Medical College Hospital(PUMCH)Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Background:Immunoglobulin G4-related disease(IgG4-RD)is a recently recognized immune-mediated disorder that can affect almost any organ in the human ***4-RD can be categorized into proliferative and fibrotic subtypes based on patients’clinicopathological *** study aimed to compare the clinical manifestations,laboratory findings,and treatment outcomes of IgG4-RD among different ***:We prospectively enrolled 622 patients with newly diagnosed IgG4-RD at Peking Union Medical College Hospital from March 2011 to August *** patients were divided into three groups according to their clinicopathological characteristics:proliferative,fibrotic,and mixed *** compared demographic features,clinical manifestations,organ involvement,laboratory tests,and treatment agents across three *** then assessed the differences in treatment outcomes among 448 patients receiving glucocorticoids alone or in combination with ***,risk factors of relapse were revealed by applying the univariate and multivariate Cox regression ***:We classified the 622 patients into three groups consisting of 470 proliferative patients,55 fibrotic patients,and 97 mixed patients,*** found that gender distribution,age,disease duration,and frequency of allergy history were significantly different among *** terms of organ involvement,submandibular and lacrimal glands were frequently involved in the proliferative subtype,while retroperitoneum was the most commonly involved site in both fibrotic subtype and mixed *** comparison of laboratory tests revealed that eosinophils(P=0.010),total IgE(P=0.006),high-sensitivity C-reactive protein(P<0.001),erythrocyte sedimentation rate(P<0.001),complement C4(P<0.001),IgG(P=0.001),IgG1(P<0.001),IgG4(P<0.001),and IgA(P<0.001),at baseline were significantly different among three *** with proliferative and mixed subtypes,the fibrotic subtype showed the

关键词： IgG4-related disease Proliferative subtype Fibrotic subtype Clinical features Treatment outcome

96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 649-660页

作者： Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao xiaofeng wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group Department of Infectious Diseases and Hepatology Unit Institutes of Liver Diseases Research of Guangdong ProvinceNan-fang HospitalSouthern Medical UniversityGuangzhouGuangdongChina The First Hospital of Jilin University Chang-chunJilinChina The First Affiliated Hospital of Xinjiang Medical University UrumqiXinjiangChina The Second Xiangya Hospital of Central South University ChangshaHunanChina Chongqing University Three Gorges Hospital ChongqingChina Mengchao Hepatobiliary Hospital of Fujian Medical University FuzhouFujianChina Liuzhou People’s Hospital LiuzhouGuangxiChina The Third Affiliated Hospital of Zhongshan University GuangzhouGuangdongChina Xiangya Hospital of Central South University ChangshaHunanChina The First Affiliated Hospital of Xinxiang Medical University XinxiangHenanChina West China Hospital of Sichuan University ChengduSichuanChina The Southwest Hospi-tal of AMU ChongqingChina Affiliated Hospital of Zunyi Medical University ZunyiGuizhouChina Henan Provincial People’s Hospital ZhengzhouHenanChina The Third Xiangya Hospital of Central South University ChangshaHunanChina The Fourth Affiliated Hospital of Harbin Medical University HarbinHeilongjiangChina The First Affiliated Hospi-tal of Anhui Medical University HefeiAnhuiChina Tianjin Third Central Hospital TianjinChina The Second Affiliated Hospital of Chongqing Medical University ChongqingChina Jiangsu Hansoh Pharmaceutical Group Co. LtdLianyungangJiangsuChina Members listed in the Supplementary File 1

Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of ***,we update 96-week comparison ***:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 *** virological suppression was defined as HBV DNA levels<20 IU/mL at week *** was evaluated thoroughly with focusing on bone,renal,and metabolic ***:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative *** efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at ***-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving *** addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite ***:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796).

关键词： Hepatitis B Liver function tests Viral hepatitis Liver Osteoporosis

Bacteroides ovatus-mediated CD27^(−)MAIT cell activation is associated with obesity-related T2D progression

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Cellular & Molecular Immunology 2022年第7期19卷 791-804页

作者： Yue Li Yi Yang Jin Wang Peihong Cai Mei Li Xixiang Tang Ying Tan Yuchan Wang Fan Zhang xiaofeng wen Qiaoxing Liang Yuanpeng Nie Tufeng Chen Xiang Peng Xuemin He Yanhua Zhu Guojun Shi Wai WCheung Lai Wei Yanming Chen Yan Lu Department of Endocrinology&Metabolism Guangdong Provincial Key Laboratory of DiabetologyThe Third Affliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Clinical Immunology The Third Affliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China VIP Medical Service Center The Third Affliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Department of Gastrointestinal Surgery The Third Affliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Rheumatology The Sixth Affliated Hospital of Guangzhou Medical UniversityQingyuan People's HospitalQingyuan 511518China Division of Pediatric Nephrology Rady Children's HospitalUniversity of CaliforniaSan DiegoCA 92093-0831USA

Type 2 diabetes(T2D)is highly associated with ***,the factors that drive the transition from excessive weight gain to glucose metabolism disruption are still uncertain and seem to revolve around systemic immune ***-associated invariant T(MAIT)cells,which are innate-like T cells that recognize bacterial metabolites,have been reported to be altered in obese people and to lead to metabolic dysfunction during *** studying the immunophenotypes of blood MAIT cells from a cross-sectional cohort of obese participants with/without T2D,we found an elevation in CD27^(-)negative(CD27−)MAIT cells producing a high level of IL-17 under T2D obese conditions,which could be positively correlated with impaired glucose metabolism in obese *** further explored microbial translocation caused by gut barrier dysfunction in obese people as a triggering factor of MAIT cell ***,accumulation of the bacterial strain Bacteroides ovatus in the peripheral blood drove IL-17^(-)producing CD27−MAIT cell expansion and could be associated with T2D risk in obese ***,these results suggest that an aberrant gut microbiota–immune axis in obese people may drive or exacerbate ***,CD27−MAIT cell subsets and Bacteroides ovatus could represent targets for novel interventional *** findings extend current knowledge regarding the clinical relevance of body mass index(BMI)-associated variation in circulating MAIT cells to reveal the role of these cells in obesity-related T2D progression and the underlying cellular mechanisms.

关键词： type 2 diabetes obesity MAIT cells Bacteroides ovatus bacterial translocation

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen wen Bo Zeng xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke