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基于改进EMD方法与11/2谱的DEMON谱提取方法

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声学技术 2024年第2期43卷 260-267页

作者：高博超张群飞李岳珩崔晓东西北工业大学航海学院陕西西安710072 西北工业大学电子信息学院陕西西安710072

噪声的包络调制检测(Detection of Envelope Modulation on Noise,DEMON)谱分析技术已被广泛应用于特征提取领域,但经典DEMON谱提取中高频信号频段的选取会影响DEMON谱的提取效果。针对这一问题,文中首先运用经验模态分解(Empirical Mod... 详细信息

噪声的包络调制检测(Detection of Envelope Modulation on Noise,DEMON)谱分析技术已被广泛应用于特征提取领域,但经典DEMON谱提取中高频信号频段的选取会影响DEMON谱的提取效果。针对这一问题,文中首先运用经验模态分解(Empirical Mode Decomposition,EMD)方法获得一系列固有模态函数(Intrinsic Mode Function,IMF),依据各阶模态函数与原信号的相关程度,筛选出更具代表性的几阶固有模态函数进行解调,再对解调的结果运用11/2维谱分析方法进行谱分析以抑制高斯噪声,通过这种方法获得的DEMON谱信噪比优于传统方法。实测湖试数据分析结果表明,该改进方法可以有效地进行特征提取,结果优于经典DEMON谱分析方法;该改进方法具有一定的实用性,有利于进行后续目标分类识别。

关键词：特征提取经验模态分解(EMD) 固有模态函数 11/2维谱分析

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基于多尺度纹理特征的海底底质样本增强方法

海洋测绘 2024年第2期44卷 31-35页

作者：张少华胡海洋王朋程崔晓东王亚雪山东省第三地质矿产勘查院山东烟台264004 山东科技大学测绘与空间信息学院山东青岛266590

针对多波束海底底质分类模型构建受限于样本和特征对海底底质类型表征不足、模型稳定性差等问题,利用多尺度滑动窗口法提取声学纹理特征,结合K-均值聚类分析其精度,实现了多尺度纹理特征的优选,并利用多尺度纹理特征并辅以地形特征结合S... 详细信息

针对多波束海底底质分类模型构建受限于样本和特征对海底底质类型表征不足、模型稳定性差等问题,利用多尺度滑动窗口法提取声学纹理特征,结合K-均值聚类分析其精度,实现了多尺度纹理特征的优选,并利用多尺度纹理特征并辅以地形特征结合SLIC样本增强方法,实现了底质样本的有效扩充。同时,利用随机森林、BP神经网络、K最邻近、支持向量机等4种经典监督分类模型训练预测和评估所扩充的样本数据,最终总体分类精度均达到90%以上,kappa系数达到0.85以上。

关键词：海底底质分类反向散射强度多尺度纹理特征样本增强监督分类

Boosting tribo-catalytic conversion of H_(2)O and CO_(2)by Co_(3)O_(4)nanoparticles through metallic coatings in reactors

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Journal of Advanced Ceramics 2023年第10期12卷 1833-1843页

作者： Xuchao Jia Hongbo Wang Hua Lei Chenyue Mao xiaodong cui Yong Liu Yanmin Jia Wenqing Yao Wanping Chen School of Physics and Technology Wuhan UniversityWuhan 430072China School of Science Xi’an University of Posts and TelecommunicationsXi’an 710061China Department of Chemistry Tsinghua UniversityBeijing 100084China

In recent years,more and more metal oxides have been finding critical tribo-catalytic ***,we have explored the tribo-catalytic conversion of H_(2)O and CO_(2)using Co_(3)O_(4)nanoparticles and obtained some surprising *** an as-received 150 mL glass reactor enclosed with 10 mL of H_(2)O,0.10 g of Co_(3)O_(4)nanoparticles,1 atm of CO_(2),and a Teflon magnetic rotary disk,we observed the production of as much as 57.41μmol/L of H_(2),0.15μmol/L of CH_(4),and 0.21μmol/L of CO after 5 h of magnetic *** coatings of Cu,Ni,SUS316,Ti,Nb,Mo,and W were further introduced on reactor bottoms *** those coatings of Ni,SUS316,Ti,and Nb,the reduction of CO_(2)was dramatically enhanced,and C_(2+)products of C_(2)H_(6)and C_(2)H_(4)were *** for the Ti coating,the amounts of H_(2)and CH_(4)were increased by 2 and 26 times from those for the glass bottom,respectively,and the amounts of C_(2)H_(6)and C_(2)H_(4)were very *** Co_(3)O_(4)nanoparticles were proven chemically stable under magnetic stirring in water,and hydroxyl radicals and superoxide radicals have been detected for the Co_(3)O_(4)nanoparticles under magnetic stirring through fluorescence spectroscopy and electron paramagnetic resonance spectroscopy *** findings not only reveal outstanding capability of Co_(3)O_(4)to generate multicarbon products from H_(2)O and CO_(2)through tribo-catalysis but also highlight a promising potential of tribo-catalysis as a whole to harness mechanical energy for addressing energy shortages and environmental pollution.

关键词： tribo-catalysis water splitting CO_(2)reduction Co_(3)O_(4)

Micropeptides: origins, identification, and potential role in metabolism-related diseases

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第12期24卷 1106-1122页

作者： Yirui LU Yutong RAN Hong LI Jiao WEN xiaodong cui Xiaoyun ZHANG Xiumei GUAN Min CHENG School of Basic Medicine Sciences Weifang Medical UniversityWeifang 261053China

With the development of modern sequencing techniques and bioinformatics, genomes that were once thought to be noncoding have been found to encode abundant functional micropeptides(miPs), a kind of small polypeptides. Although miPs are difficult to analyze and identify, a number of studies have begun to focus on them. More and more miPs have been revealed as essential for energy metabolism homeostasis, immune regulation, and tumor growth and development. Many reports have shown that miPs are especially essential for regulating glucose and lipid metabolism and regulating mitochondrial *** are also involved in the progression of related diseases. This paper reviews the sources and identification of miPs, as well as the functional significance of miPs for metabolism-related diseases, with the aim of revealing their potential clinical applications.

关键词： Energy metabolism Micropeptides Mitochondria Noncoding RNA(ncRNA) Small open reading frame(sORF)

基于深度学习的冠状动脉CTA自动后处理技术诊断冠心病的价值研究

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同济大学学报（医学版） 2024年第1期45卷 66-74页

作者：罗月倪炯崔晓东吕礼胡琦王培军同济大学附属同济医院医学影像科上海200065 同济大学医学院医学影像人工智能研究所上海200065

目的探讨一种基于深度学习(deep learning,DL)的冠状动脉CT血管成像(coronary computed tomography angiography,CCTA)人工智能(artificial intelligence,AI)辅助诊断系统诊断冠心病(coronary artery disease,CAD)的临床价值。方法回顾性分析4周内先后完成CCTA和侵入性冠状动脉血管造影(coronary angiography,CAG)检查的69例患者,共462个冠状动脉近端血管节段。比较AI辅助诊断技术和CCTA人工分析影像数据所用时间。分别在患者水平、血管节段水平评估AI和CCTA对CAD的诊断效能;在各血管节段水平对AI、CCTA诊断结果进行误差分析。结果 AI耗时明显低于CCTA[(5.5±0.9) min vs(14.2±1.8) min]。在患者水平和总血管节段水平,AI识别显著狭窄(狭窄程度≥50%)的灵敏度分别为97.9%、79.6%,阴性预测值分别为90.9%、93.2%,准确性分别为82.6%、80.5%;CCTA识别显著狭窄的灵敏度分别为96.6%、85.9%,阴性预测值分别为81.8%、92.9%,准确性分别为94.2%、91.6%;CCTA识别显著狭窄的准确性较高,AUC分别为0.984(95%CI:0.959~1.000)、0.960(95%CI:0.942~0.977),与CAG差异无统计学意义(均P>0.05);AI识别显著狭窄有一定准确性,AUC分别为0.864(95%CI:0.748~0.979)、0.823(95%CI:0.780~0.865),与CAG差异有统计学意义(均P<0.05)。在各血管节段水平,AI检测显著狭窄的准确性分别为89.9%、78.3%、92.8%、69.6%、60.9%、88.4%、85.4%。对于钙化斑块、混合斑块、非钙化斑块、心肌桥及血管解剖异常,AI分别漏诊11、20、29、7、2段,误诊7、3、5、1、5段;CCTA分别漏诊2、5、6、2、2段,误诊9、3、4、4、2段。结论基于DL的CCTA自动后处理技术能高效完成CCTA数据分析,有较高的CAD诊断效能,具有成为临床诊断CAD辅助工具的潜力。而人机结合可能有望进一步提高CAD的诊断效能。

关键词：人工智能深度学习冠心病冠状动脉CT血管成像

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Valley excitons in two-dimensional semiconductors

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National Science Review 2015年第1期2卷 57-70页

作者： Hongyi Yu xiaodong cui xiaodong Xu Wang Yao Department of Physics The University of Hong Kong Center of Theoretical and Computational Physics The University of Hong Kong Department of Physics University of Washington Department of Material Science and Engineering University of Washington

Monolayer group-VIB transition-metal dichalcogenides have recently emerged as a new class of semiconductors in the two-dimensional limit. he atractive properties include the visible range direct band gap ideal for exploring optoelectronic applications; the intriguing physics associated with spin and valley pseudospin of carriers which implies potentials for novel electronics based on these internal degrees of freedom; the exceptionally strong Coulomb interaction due to the two-dimensional geometry and the large efective masses. he physics of excitons, the bound states of electrons and holes, has been one of the most actively studied topics on these two-dimensional semiconductors, where the excitons exhibit remarkably new features due to the strong Coulomb binding, the valley degeneracy of the band edges and the valley-dependent optical selection rules for interband transitions. Here, we give a brief overview of the experimental and theoretical indings on excitons in two-dimensional transition-metal dichalcogenides,with focus on the novel properties associated with their valley degrees of freedom.

关键词： exciton valley physics two-dimensional semiconductor transition metal dichalcogenides

基于生物信息学筛选影响胃癌患者预后的糖酵解相关基因

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临床荟萃 2024年第1期39卷 20-29页

作者：赵旭辉黄小敏达德转许焱崔晓东李红玲甘肃中医药大学第一临床医学院甘肃兰州730000 甘肃省人民医院肿瘤内科甘肃兰州730000

目的通过利用生物信息学开发糖酵解相关基因以预测胃癌(gastric cancer,GC)患者预后。方法使用癌症基因组图谱数据库中GC患者信使核糖核酸表达谱数据,通过进行基因集富集分析以鉴定GC组织和正常组织间显著差异的基因集。通过最小绝对... 详细信息

目的通过利用生物信息学开发糖酵解相关基因以预测胃癌(gastric cancer,GC)患者预后。方法使用癌症基因组图谱数据库中GC患者信使核糖核酸表达谱数据,通过进行基因集富集分析以鉴定GC组织和正常组织间显著差异的基因集。通过最小绝对收缩和选择算子回归分析构建糖酵解相关基因预测GC患者预后的模型,并使用Kaplan-Meier分析、受试者工作特征曲线、单因素及多因素Cox回归分析验证模型预测性能。采用基因集变异分析分析高低风险组间生物途径状态的差异。结果获得15个糖酵解相关基因(PFKFB2、UHRF1、ACYP1、CLDN9、STC1、EFNA3、NUP50、ADH4、ANGPTL4、PKP2、VCAN、HIF1A、LHX9、ANKZF1、ALDH3A2)与GC患者预后相关。根据15个基因特征风险评分,通过Cox回归分析将患者分为高风险组和低风险组。这15个基因标记是GC患者预后的独立生物标志物,低风险评分的GC患者预后更好。结合基因标记和临床预后因素的列线图可有效预测总生存期及无疾病生存期。结论建立的15个糖酵解相关基因标记可作为预测GC患者预后的可靠工具,可能为GC提供潜在的糖酵解治疗靶点。

关键词：胃肿瘤预后预测模型糖酵解

Holographic QSAR of environmental estrogens

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Science China Chemistry 2005年第2期48卷 156-161页

作者： WANG xiaodong XIAO Qianfen cui Shihai LIU Shushen YIN Daqiang WANG Liansheng State Key Laboratory of Pollution Control and Resources Reuse School of the Environment Nanjing University Nanjing 210093 China State Key Laboratory of Pollution Control and Resources ReuseSchool of the Environment Nanjing University Nanjing 210093 China State Key Laboratory of Pollution Control and Resources ReuseSchool of the Environment Nanjing University Nanjing 210093 China State Key Laboratory of Pollution Control and Resources ReuseSchool of the Environment Nanjing University Nanjing 210093 China State Key Laboratory of Pollution Control and Resources ReuseSchool of the Environment Nanjing University Nanjing 210093 China State Key Laboratory of Pollution Control and Resources ReuseSchool of the Environment Nanjing University Nanjing 210093 China

Experimental and epidemiological studies suggest that some man-made and natu- rally occurring chemicals related to the environment have the potential to interrupt normal func- tioning of the endocrine systems of humans and wildlife. These chemicals, termed EDCs (Endo- crine disrupting Chemicals), pose serious threats to the reproductive capability of humans and wildlife. Because of the structural diversity and various types, development of structure-based rapid screening methodologies is important and necessary for the assessment of the environ- mental pollutants. In this paper molecular hologram based QSAR models were developed with the combinatory application of partial least square (PLS) regression for a large diverse set of 105 environmental estrogens. Quantitatively predictive models were developed based on only mo- lecular structures, which can be used for the accurate prediction of estrogenicity to rapidly screen potential environmental endocrine disrupting chemicals.

关键词： EDCs, RBA, molecular hologram, QSAR, CoMFA.

Enzyme-free photothermally amplified fluorescent immunosorbent assay(PAFISA)for sensitive cytokine quantification

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Aggregate

Aggregate 2023年第6期4卷 137-145页

作者： Dian Li Wei He Xuyan Lin xiaodong cui Stefan Nagl Angela Ruohao Wu Ryan T.K.Kwok Renhua Wu Ben Zhong Tang Department of Medical Imaging The 2nd Affiliated HospitalMedical CollegeShantou UniversityShantouP.R.China Department of Physics Shantou UniversityShantouP.R.China Department of Physics University of Hong KongHong Kong SARP.R.China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyKowloonP.R.China Division of Life Science The Hong Kong University of Science and TechnologyKowloonP.R.China HKUST Fok Ying Tung Research Institute GuangzhouP.R.China Department of Chemistry The Hong Kong University of Science and TechnologyKowloonP.R.China Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyKowloonP.R.China School of Science and Engineering Shenzhen Key Laboratory of Functional Aggregate MaterialsThe Chinese University of Hong KongShenzhenP.R.China

Cytokine monitoring has attracted great attention due to its significance in the diagnosis and treatment of many diseases,such as tumors,microbial infections,and immunological ***-linked immunosorbent assay(ELISA)is one of the most popular methods in cytokine detection,ascribing to the lavish signal amplification methods in the ELISA *** addition to classical enzymes,other signal amplifiers such as fluorescent probes,artificial nano-enzymes,and photothermal reagents have been applied to reduce the detection limit and produce more sensitive ELISA *** to the accumulative effect of heat,photothermal reagents are promising materials in the signal amplification of ***,the lack of efficient photothermal generation material at an aggregate scale may delay the further development of this *** this contribution,based on an efficient organic photothermal aggregate material,an enzyme-free photothermally amplified fluorescent immunosorbent assay system consisting of an assay microfluidic chip and detecting platform was *** photothermal nanoparticles with highly efficient photothermal conversion by harvesting energy via excited-state intramolecular motions and enlarging molar absorptivity were successfully *** detection concentration at 50 pg/mL of interleukin-2 was achieved,realizing a signal improvement of detection limits by 20-fold compared to that of previously reported photothermal *** microscopic imaging integrated with plane sweeping technology provided high spatial resolution and precision,indicating the potential of achieving high throughput profiling at the ***,as an alternative excitation source,light-emitting diode not only provided a more affordable and miniaturized detection system but also revealed the great feasibility of intramolecular motion-induced photothermy nanoparticles for biological analyses.

关键词： cytokine quantitation enzyme free fluorescence intensity ratio metric interleukin-2 microchip microscopic mapping photothermally amplified fluorescent immunosorbent assay