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The circadian clock in enamel development

International Journal of Oral Science 2024年第3期16卷 371-380页

作者： Ke Wu xiaochan Li Yunyang Bai Boon Chin Heng Xuehui Zhang Xuliang Deng Department of Geriatric Dentistry Peking University School and Hospital of StomatologyBeijingChina 4th Division Peking University School and Hospital of StomatologyBeijingChina Department of Dental Materials&Dental Medical Devices Testing Center Peking University School and Hospital of StomatologyBeijingChina National Engineering Research Center of Oral Biomaterials and Digital Medical Devices NMPA Key Laboratory for Dental MaterialsBeijing Laboratory of Biomedical Materials&Beijing Key Laboratory of Digital StomatologyPeking University School and Hospital of StomatologyBeijingChina Oral Translational Medicine Research Center Joint Training base for Shanxi Provincial Key Laboratory in Oral and Maxillofacial Repair Reconstruction and Regeneration The First People’s Hospital of Jinzhong JinzhongChina

Circadian rhythms are self-sustaining oscillations within biological systems that play key roles in a diverse multitude of physiological *** circadian clock mechanisms in brain and peripheral tissues can oscillate independently or be synchronized/disrupted by external *** enamel is a type of mineralized tissue that forms the exterior surface of the tooth *** Retzius lines are readily observable microstructures of mature tooth enamel that indicate the regulation of amelogenesis by circadian *** enamel is formed by enamel-forming cells known as ameloblasts,which are regulated and orchestrated by the circadian clock during *** review will first examine the key roles of the circadian clock in regulating ameloblasts and *** physiological processes are involved,including gene expression,cell morphology,metabolic changes,matrix deposition,ion transportation,and ***,the potential detrimental effects of circadian rhythm disruption on enamel formation are *** rhythm disruption can directly lead to Enamel Hypoplasia,which might also be a potential causative mechanism of amelogenesis ***,future research trajectory in this field is *** is hoped that this review will inspire more intensive research efforts and provide relevant cues in formulating novel therapeutic strategies for preventing tooth enamel developmental abnormalities.

关键词： enamel crown exterior

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Fertilization strategy and application model using a centrifugal variable-rate fertilizer spreader

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International Journal of Agricultural and Biological Engineering 2018年第6期11卷 41-48页

作者： Yinyan Shi Zhichao Hu xiaochan Wang Morice O.Odhiambo Guoxiang Sun College of Engineering Nanjing Agricultural UniversityNanjing 210031China Nanjing Research Institute for Agricultural Mechanization Ministry of Agriculture and Rural AffairsNanjing 210014China Jiangsu Province Engineering Laboratory for Modern Facilities Agricultural Technology and Equipment Nanjing 210031China

With the sustainable development of precision agriculture and the steady progress of variable-rate fertilization technology,the centrifugal variable-rate fertilizer spreader has attracted research attention due to its lower incidence of crush damage,high efficiency,and low *** improve fertilization accuracy and uniformity,spreading performance tests were conducted using this spreader in accordance with the test methods specified in ISO 5690 and ASAE S341.2,in which particle mass was weighed in a two-dimensional matrix of collection *** effects of fertilization strategies that control the feed gate flow rate and the disc rotation speed on particle distribution,and application rate per unit area and effective swath width,were investigated.A variable-rate fertilization model was developed by analyzing the variation characteristics resulting from an increasing and decreasing application rate,and field experiments were conducted to verify its *** results indicated that when the feed gate flow rate was 300 g/s,the mean application rate was 26.47 g,the standard deviation is 2.81,and the coefficient of variation of particle distribution is at its minimum value of 14.25%.When the disc rotation speed was 600 r/min,the fertilizer was most evenly distributed with a coefficient of variation of 13.86%,and an average effective spreader swath width of 24.51 *** proposed variable-rate fertilization model showed a high fitting degree with an S-shaped function curve for both increasing and decreasing distribution rates and the yielding coefficients of determination were more than 0.82 and 0.71,*** average error between the model predictions and the test results was 9.47%,and the coefficients of determination for the increasing and decreasing distribution rates were 0.91 and 0.82,respectively,which confirmed the accuracy of the proposed variable-rate fertilization *** investigation provided a theoretical basis for traditional empirical fertiliza

关键词： variable-rate fertilization centrifugal spreader fertilization strategy application model

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Experiment and analysis on mechanical properties of Artemisia selengensis stalk

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International Journal of Agricultural and Biological Engineering 2017年第2期10卷 16-25页

作者： Shi Yinyan Chen Man Wang xiaochan Zhang Yongnian Morice O.Odhiambo College of Engineering Nanjing Agricultural UniversityNanjing210031China Nanjing Research Institute for Agricultural Mechanization Ministry of AgricultureNanjing 210014China

The technology used for the storage and transportation of Artemisia selengensis is becoming increasingly important with its increasing consumption and demand;moreover,the amounts of artificial planting contribute to the challenges in Artemisia selengensis ***,the mechanical property parameters of the Artemisia selengensis stalks were determined and researched to reduce the mechanical damage during harvesting,transportation,processing and *** Artemisia selengensis stalks were taken as the test object and a physical test method was adopted to study the impact of different positions,diameters,and directions on the mechanical properties by using the TMS-Pro texture analyzer;then,the relevant changing trends of the characteristic mechanical parameters were analyzed using statistical *** the compression test,the compression load-deformation curve was observed and the breaking force and deformation were obtained;then,the compressive strength,elastic modulus and compression energy were ***,the curve-fitting of the compressive strength and compression energy was carried *** the shear test,the shear stress-deformation curve was obtained and the shear force,deformation,shear strength,and shear work were ***,the regression fitting of the section area,peak shearing stress and shearing work was ***,in the last bending test,the bending stress-deformation curve,bending peak force,deformation,and bending work were *** the bending forces of other plants were tested,the results were compared and analyzed with the theoretical values,and finally the regression fittings were *** the analysis results showed that Artemisia selengensis stalks can be considered to be anisotropic *** results also showed that the compressive strength and elastic modulus decreased with the height of stalk position,while the deformation *** addition,with the increase in the stalk diameter,the bending

关键词： Artemisia selengensis stalks texture analyzer mechanical properties

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Image compression algorithm of floral canopy based on mask hybrid coding for ROI

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International Journal of Agricultural and Biological Engineering 2017年第5期10卷 166-176页

作者： Sun Guoxiang Wang xiaochan Ding Yongqian Li Yuhua Zhang Baohua Li Yongbo Zhang Yu College of Engineering Nanjing Agricultural UniversityNanjing 210095China

To achieve high-quality image compression of a floral canopy,a region of interest(ROI)mask of the wavelet domain was generated through the automatic identification of the canopy ROI and lifting the bit-plane of the ROI to obtain priority of coding for the ROI-set partitioning in hierarchical trees(ROI-SPIHT)*** embedded zerotree wavelet(EZW)coding was conducted for the background(BG)region of the image and a relatively more low-frequency wavelet coefficient was obtained using a relatively small amount of *** the weighing factor r of the ROI coding amount,the proportion of the ROI and BG coding amount was dynamically adjusted to generate embedded,truncatable bit *** the location of truncation,the image information and ROI mask information required by the decoder can be guaranteed to achieve high-quality compression and reconstruction of the image *** results indicated that under the same bit rate,the larger the r value is,the larger the peak-signal-to-noise ratio(PSNR)for the ROI reconstructed image and the smaller the PSNR for the BG reconstructed *** the range of 0.07-1.09 bpp,the PSNR of the ROI reconstructed image was 42.65%higher on average than that of the BG reconstructed image,43.95%higher on average than that of the composite image of the ROI and BG(ALL),and 16.84%higher on average than that of the standard SPIHT reconstructed ***,the mean square error of the quality evaluation index and similarity for the ROI reconstructed image were both better than those for the BG,ALL,and standard SPIHT reconstructed *** texture distortion of the ALL image was smaller than that of the SPIHT reconstructed image,indicating that the image compression algorithm based on the mask hybrid coding for ROI(ROI-MHC)is capable of improving the reconstruction quality of an ROI *** the weighing factor r is a fixed value,as the proportion of ROI(a)increases,the quality of ROI image reconstruction gradually ***

关键词： floral canopy ROI mask hybrid coding image compression algorithm wavelet transform

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Controlled synthesis of hierarchically-structured MnCo_2O_4 and its potential as a high performance anode material

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Science China Chemistry 2017年第9期60卷 1180-1186页

作者： Zixiao Wu Fuhai Li Yonggang Sun Deshan Bin Junyu Piao Xijie Lin xiaochan Liu Anmin Cao Li-Jun Wan CAS Key Laboratory of Molecular Nanostructure and Nanotechnology and CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

To satisfy the upsurging demand for energy storage in modern society,anode materials which can deliver high capacity have been intensively researched for the next generation lithium ion ***,the binary MnCo_2O_4 with a characteristic coupled metal cations showed promising potential due to its high theoretical capacity and low ***,by means of a well-designed synthesis control,we demonstrated a scalable process to achieve a hierarchical structure of MnCo_2O_4,which existed as uniform microspheres with embedded mesopores,showing favorable structural characters for high performance during a fast charge/discharge *** synthesis highlighted the importance of sodium salicylate as an essential additive to control the precipitation of the two involved metal *** was proved that a dual role was played sodium salicylate which cannot only facilitate the formation of microspheric shape,but also act as an effective precursor for the creation of inner *** confirmed that the hierarchically-structured MnCo_2O_4 showed outstanding performance when it was tested as an anode material in lithium ion batteries as revealed by its extraordinary cycling stability and high rate capability.

关键词： hierarchical structure anode materials MnCo2O4 lithium ion batteries porous structure

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Image segmentation algorithm for greenhouse cucumber canopy under various natural lighting conditions

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International Journal of Agricultural and Biological Engineering 2016年第3期9卷 130-138页

作者： Sun Guoxiang Li Yongbo Wang xiaochan Hu Guyue Wang Xuan Zhang Yu College of Engineering Nanjing Agricultural UniversityNanjing 210095China

In this study,machine vision technology was used to capture images of greenhouse cucumber canopy,and image segmentation was implemented under various natural lighting *** images were enhanced by multi-scale retinex with color restore(MSRCR),and the MSRCR images were segmented by four algorithms:normalized difference index(NDI),excess green(ExG),modified excess green(MExG),and modified excess green minus excess red(MExG-ExR).The results indicated that compared with the original images,under various lighting conditions,the average evaluation indexes of brightness,information entropy,average gradient and mean gray value of the MSRCR images were increased by 38.71%,8.04%,4.54%,and 37.81%,respectively,and only the contrast degree decreased by 12.13%.The MExG-ExR segmentation algorithm was used to segment the MSRCR images(fifty images under various lighting conditions in the test and it performed best among the four segmentation algorithms,average overlap ratios and recognition rates of were 99.28%and 98.91%,respectively,while 38.39%and 37.95%respectively for original *** results indicated that the MExG-ExR segmentation algorithm applied to a MSRCR canopy image produced the most stable results among the four *** using the MSRCR image enhancement algorithm,the interference of lighting on greenhouse cucumber canopy images was reduced and the foundation for achieving accurate segmentation of a canopy region was laid,which is of great significance for greenhouse cucumber phenotypic parameter measurements.

关键词： greenhouse cucumber canopy machine vision image segmentation illumination retinex

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Optimization and experiment on key structural parameters of no-tillage planter with straw-smashing and strip-mulching

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International Journal of Agricultural and Biological Engineering 2021年第3期14卷 103-111页

作者： Yinyan Shi xiaochan Wang Zhichao Hu Fengwei Gu Feng Wu Youqing Chen College of Engineering Nanjing Agricultural UniversityNanjing 210031China Nanjing Institute of Agricultural Mechanization Ministry of Agriculture and Rural AffairsNanjing 210014China

Accelerate the quality of smashed-straw laying and enhance the effect of seed-bed arranging for no-tillage planter with straw-smashing and strip-mulching in full stubble covered paddy have become imperative in implementing modern conservation *** the perfect operating performance(passability and stability)of the developed no-tillageplanter,this study intends to optimize the structure design of smashed-straw diversion device and strip-rotary tillage *** equations of smashed straw and kinematics models of rotary blades were established through theoretical analysis,and the principal factors that affecting straw strip-laying quality and seed-bed arranging effect were *** influence of out-enlarge angle(η)and slide-push angle(γ)of the diversion device on the coefficient of variation(ζ1)of cover-straw width,and the influence of rotary tillage-blade number(N)and configuration in a singlerotary plane on the broken rate(ζ2)of strip soil were completely *** then,based on the systematic analysis and integrated scheme,operating performance and field verification tests using the optimized no-tillage planter were thoroughly *** results of the performance tests indicated that the out-enlarge angle(η)had a highly significant influence on the coefficient of variation(ζ1),and the slide-push angle(γ)had a significant influence on(ζ1).The rotary tillage-blade number(N)had a highly significant influence on the broken rate(ζ2),and the slide-push angle(γ)had a significant influence on(ζ2).The obtained optimal combination of these key structure parameters through comprehensive analysis wasη=45°,γ=40°,and N=*** verification test results indicated that the optimized no-tillage planter achieved mean values of ζ1=10.47%and ζ2=90.95%,which satisfied the relevant operation quality and cultivation agricultural requirement of conservation tillage equipment,and provided technical references for developing the similar no-tillage planter of

关键词： no-tillage planter smashed-straw laying strip rotary tillage optimization test

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High-throughput first-principle prediction of collinear magnetic topological materials

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npj Computational Materials 2022年第1期8卷 2490-2497页

作者： Yunlong Su Jiayu Hu xiaochan Cai Wujun Shi Yunyouyou Xia Yuanfeng Xu Xuguang Xu Yulin Chen Gang Li School of Physical Science and Technology ShanghaiTech University201210ShanghaiChina Center for Transformative Science ShanghaiTech University201210ShanghaiChina Shanghai High Repetition Rate XFEL and Extreme Light Facility(SHINE) ShanghaiTech University201210ShanghaiChina ShanghaiTech Laboratory for Topological Physics ShanghaiTech University201210ShanghaiChina Center for Correlated Matter and School of Physics Zhejiang University310058HangzhouChina Department of Physics Princeton UniversityPrincetonNJUSA Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxfordOX13PUUK

The success of topological band theory and symmetry-based topological classification significantly advances our understanding of the Berry *** on the critical concept of topological obstruction,efficient theoretical frameworks,including topological quantum chemistry and symmetry indicator theory,were developed,making a massive characterization of real materials ***,the classification of magnetic materials often involves the complexity of their unknown magnetic structures,which are often hard to know from experiments,thus,hindering the topological *** this paper,we design a high-throughput workflow to classify magnetic topological materials by automating the search for collinear magnetic structures and the characterization of their topological *** computed 1049 chosen transition-metal compounds(TMCs)without oxygen and identified 64 topological insulators and 53 semimetals,which become 73 and 26 when U correction is further *** to the lack of magnetic structure information from experiments,our high-throughput predictions provide insightful reference results and make the step toward a complete diagnosis of magnetic topological materials.

关键词： materials topological symmetry

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Design and experiment of the components for soil flow direction control of hilling machine based on EDEM

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International Journal of Agricultural and Biological Engineering 2022年第3期15卷 122-131页

作者： Zhenwei Tong Lianhao Li Xiuli Zhang Yong Chen xiaochan Liu Peilin Zhou Yueqing Xia College of Mechanical and Electrical Engineering Henan Agricultural UniversityZhengzhou 450002China

Cultivation and hilling are important steps in crop field management and provide an important guarantee of crop quality and *** the aim of addressing how the soil flow direction of a traditional cultivation and hilling machine is difficult to control,and because it is difficult to achieve high ridge soil cultivation,among other issues,the components of the soil flow direction control of a hilling machine was *** components of the soil flow direction control consisted of a soil-feeding plough device,spiral knives and guide cover devices,*** design and analysis of the guiding parts for the two tools of the soil-feeding plough device and the spiral knife were performed to obtain an appropriate guide wall and helix *** guiding principle in the flow direction control components was *** design of the guide wall adopts the torsional columnar plough surface,and the elementary line angle changes from stable to *** analysis of spiral milling showed that when the spiral angle is large,the milling effect is *** to the discrete element method,the working part of the machine-soil interaction model was *** software was used to simulate the control components for the soil flow direction of the hilling machine for compound *** design method with a two-factor comprehensive test was used to study the linear velocity along the outer part of the spiral knife and the influence of the forward velocity of machine of the implement on the soil cultivation *** results of the discrete element simulation showed that both the linear velocity along the outer part of the spiral knife and the forward velocity of the machine have extremely significant effects on the transportation of particles to the ridge top and the hilling *** multiple comparisons of the average hilling thickness with different linear velocities along with the outer spiral knife and different forward velocities of the machine

关键词： compound cutting hilling machine flow direction control discrete element method design

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Electrical charge on ferroelectric nanocomposite membranes enhances SHED neural differentiation

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Bioactive Materials 2023年第2期20卷 81-92页

作者： xiaochan Li Boon Chin Heng Yunyang Bai Qianqian Wang Min Gao Ying He Xinwen Zhang Xuliang Deng Xuehui Zhang Department of Geriatric Dentistry Peking University School and Hospital of StomatologyBeijing100081PR China Department of Dental Materials&Dental Medical Devices Testing Center Peking University School and Hospital of StomatologyBeijing100081PR China Department of Prosthodontics Peking University School and Hospital of StomatologyBeijing100081PR China Central Laboratory Peking University School and Hospital of StomatologyBeijing100081PR China Center of Implant Dentistry School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseasesShenyang110002PR China National Engineering Research Center of Oral Biomaterials and Digital Medical Devices NMPA Key Laboratory for Dental MaterialsBeijing Laboratory of Biomedical MaterialsPeking University School and Hospital of StomatologyBeijing100081PR China

Stem cells from human exfoliated deciduous teeth(SHED)uniquely exhibit high proliferative and neurogenic *** biomaterials have been demonstrated to promote neural differentiation of stem cells,but the dose-response effect of electrical stimuli from these materials on neural differentiation of SHED remains to be ***,by utilizing different annealing temperatures prior to corona poling treatment,BaTiO_(3)/P(VDF-TrFE)ferroelectric nanocomposite membranes with varying charge polarization intensity(d_(33)≈0,4,12 and 19 pC N^(-1))were *** expression of neural markers,increased cell elongation and more prominent neurite outgrowths were observed with increasing surface charge of the nanocomposite membrane indicating a dose-response effect of surface electrical charge on SHED neural *** investigations of the underlying molecular mechanisms revealed that intracellular calcium influx,focal adhesion formation,FAK-ERK mechanosensing pathway and neurogenic-related ErbB signaling pathway were implicated in the enhancement of SHED neural differentiation by surface electrical ***,this study confirms the dose-response effect of biomaterial surface charge on SHED neural differentiation and provides preliminary insights into the molecular mechanisms and signaling pathways involved.

关键词： Surface charge Electric polarization Dose-response effect Electrical microenvironment Neurogenesis

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