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NbN superconducting nanowire single photon detector with efficiency over 90% at 1550 nm wavelength operational at compact cryocooler temperature

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Science China(Physics,Mechanics & Astronomy) 2017年第12期60卷 26-35页

作者： WeiJun Zhang LiXing You Hao Li Jia Huang ChaoLin Lv Lu Zhang xiaoyu liu JunJie Wu Zhen Wang XiaoMing Xie State Key Lab of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China CAS Center for Excellence in Superconducting Electronics Shanghai 200050 China

The rapid development of superconducting nanowire single-photon detectors over the past decade has led to numerous advances in quantum information technology. The record for the best system detection efficiency at an incident photon wavelength of 1550 nm is 93%. This performance was attained from a superconducting nanowire single-photon detector made of amorphous WSi; such detectors are usually operated at sub-Kelvin temperatures. In this study, we first demonstrate superconducting nanowire single-photon detectors made of polycrystalline NbN with system detection efficiency of 90.2% for 1550-nm-wavelength photons at2.1 K, accessible with a compact cryocooler. The system detection efficiency saturated at 92.1% when the temperature was lowered to 1.8 K. We expect the results lighten the practical and high performance superconducting nanowire single-photon detectors to quantum information and other high-end applications.

关键词： detection efficiency NbN superconducting nanowire single-photon detector(SNSPD) quantum information

Alloyed Pt-Sn nanoparticles on hierarchical nitrogen-doped carbon nanocages for advanced glycerol electrooxidation

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Nano Research 2024年第5期17卷 4055-4061页

作者： Jietao Jiang Liqi Zhou Fengfei Xu Guanghai Chen xiaoyu liu Zhen Shen Lijun Yang Qiang Wu Xizhang Wang Zheng Hu Key Laboratory of Mesoscopic Chemistry of MOE Jiangsu Provincial Laboratory for NanotechnologySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied Sciences and Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

Glycerol is an alternative sustainable fuel for fuel cells,and efficient electrocatalyst is crucial for glycerol oxidation reaction(GOR).The promising Pt catalysts are subject to the inadequate capability of C-C bond cleavage and the susceptibility to ***,Pt-Sn alloyed nanoparticles are immobilized on hierarchical nitrogen-doped carbon nanocages(hNCNCs)by convenient ethylene glycol reduction and subsequent thermal *** optimal Pt_(3)Sn/hNCNC catalyst exhibits excellent GOR performance with a high mass activity(5.9 A·mg_(Pt)^(-1)),which is 2.7 and 5.4 times higher than that of Pt/hNCNC and commercial Pt/C,*** an enhancement can be mainly ascribed to the increased anti-poisoning and C-C bond cleavage capability due to the Pt_(3)Sn alloying effect and Sn-enriched surface,the high dispersion of Pt_(3)Sn active species due to N-participation,as well as the high accessibility of Pt_(3)Sn active species due to the three-dimensional(3D)hierarchical architecture of *** study provides an effective GOR electrocatalyst and convenient approach for catalyst preparation.

关键词： Pt_(3)Sn alloy hierarchical nitrogen-doped carbon nanocages glycerol electrooxidation anti-poisoning C-C bond cleavage

Tandem organic solar cells with 20.6% efficiency enabled by reduced voltage losses

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National Science Review 2023年第6期10卷 215-225页

作者： Jianqiu Wang Zhong Zheng Pengqing Bi Zhihao Chen Yafei Wang xiaoyu liu Shaoqing Zhang Xiaotao Hao Maojie Zhang Yongfang Li Jianhui Hou State Key Laboratory of Polymer Physics and Chemistry Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Laboratory of Advanced Optoelectronic Materials Suzhou Key Laboratory of Novel Semiconductoroptoelectronics Materials and Devices College of Chemistry Chemical Engineering and Materials Science Soochow University School of Chemistry and Biology Engineering University of Science and Technology Beijing School of Physics State Key Laboratory of Crystal Materials Shandong University University of Chinese Academy of Sciences CAS Key Laboratory of Organic Solids Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences

Large voltage losses are the main obstacle for achieving high efficiency in organic solar cells(OSCs).Here we construct ternary OSCs by introducing an asymmetric small molecule acceptor AITC into PBDB-TCl:BTP-eC9 system and demonstrate the effectiveness in simultaneously decreasing energy disorder and non-radiative voltage *** is found that the introduction of AITC can modify domain size and increase the degree of crystallinity,which enhances open-circuit voltage and power conversion efficiency(19.1%,certified as 18.9%).Inspiringly,an output efficiency of 20.6% of the constructed tandem OSCs based on PBDB-TCl:AITC:BTP-eC9 ternary active layer output a recorded efficiency of 20.6%(certified as 20.3%),which is the highest value in OSCs field to *** work demonstrates that decreasing the voltage losses by ternary strategy and constructing of tandem architecture are effective approaches towards improving photovoltaic performance.

关键词： organic solar cells power conversion efficiency voltage losses tandem cells ternary strategy

Career Planning and Management of Healthcare Talent Based on Life Cycle Theory

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Modern General Practice

Modern General Practice 2024年第1期 23-26页

作者： liu xiaoyu The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou511300

This study aims to explore career planning and management strategies for healthcare talent based on life cycle theory,in order to enhance retention rates and job satisfaction among healthcare *** qualitative research methods combined with a case study of Liannan County Hospital,the study analyzes the needs and challenges faced by healthcare talent at different career *** findings reveal major issues confronted by healthcare talent during career planning,including compensation and benefits,career development opportunities,work environment,and organizational *** study proposes a series of targeted management strategies,such as individualized career development paths,continuous professional training,and support for work-life balance,to promote long-term retention and career growth of healthcare *** conclusion emphasizes that healthcare organizations should consider the life cycle needs of healthcare talent in career planning and management to achieve optimal talent allocation and sustainable hospital development.

关键词： healthcare talent,career planning,life cycle theory,retention rate,job satisfaction

Study on the Causes and Countermeasures of Medical Staff Turnover in County Public Hospitals from the Perspective of Developmental Psychology

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Modern General Practice

Modern General Practice 2024年第1期 12-15页

作者： liu xiaoyu The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou511300

This study aims to explore the causes of medical staff turnover in county public hospitals from the perspective of developmental psychology and put forward effective *** qualitative research method,a semi-structured in-depth interview was conducted with 23 medical staff in Liannan County Hospital to analyze the current situation and influencing factors of their *** study found that difficult working environment,lack of career development opportunities,poor sociocultural adaptation and inconsistency between personal values and organizational goals were the main reasons leading to the turnover of medical *** response to these problems,the research puts forward countermeasures and suggestions to improve the working environment,provide career development platform,strengthen social and cultural support,and promote the integration of individual values with organizational *** results of this study provide a new perspective for understanding and solving the problem of medical staff turnover in county public hospitals,and provide a reference for relevant policy formulation and hospital management practice.

关键词： Developmental Psychology The Loss of Medical Staff County Public Hospital Retention Strategy Medical Human Resource Management

He Grenville Orogenesis Recorded by Monazite from the Paragneiss of North Qaidam UHP Metamorphic Belt, Western China

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Acta Geologica Sinica(English Edition) 2016年第S1期90卷 224-226页

作者： liu xiaoyu ZHANG Cong YANG Jingsui LI Peng National Research Center for Geoanalysis Institute of Geology Chinese Academy of Geological Sciences

The poly-phase orogeny information included in one orogenic belt is the key for studying the regional tectonic evolution at different time *** also has important significance of understanding the rock association and

关键词： UHP Western China He Grenville Orogenesis Recorded by Monazite from the Paragneiss of North Qaidam UHP Metamorphic Belt

Local sustained release of PD-1 monoclonal antibody and lenvatinib by thermo-sensitive hydrogel for improving tumor immunotherapy

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Chinese Chemical Letters 2023年第8期34卷 241-247页

作者： Lin Zhai Yujie Shi Yi Yan An Lu xiaoyu liu Lei Lei Yi Sun Linxia Jiang Xiangyu Wang Honggang Qian Jiancheng Wang Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Pharmaceutical Analysis School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Hepato-Pancreato-Biliary SurgeryPeking University Cancer Hospital&InstituteBeijing 100142China

In clinic,the combination of intravenous pembrolizumab(PD-1 monoclonal antibody)with oral Lenvatinib(LEN)exhibited an enhanced synergistic benefit for cancer ***,the clinical outcomes were always limited by the problems of inconsistent pharmacokinetic profiles of two drugs,lower drug accumulation in tumor and obvious side effects during the combination ***,in situ-forming thermosensitive hydrogels based on PLGA-PEG-PLGA triblock copolymers were prepared for local administration of anti-PD1 and LEN(P&L@Gel)to improve therapeutic efficacy and *** peritumoral or surgical resection site injection,the significant increased concentrations of both drugs in tumor were observed with the local sustained release of P&L@*** comparison with the group of intraperitoneal anti-PD1 plus oral LEN(P-ip&L-po),significantly higher tumor inhibition efficiency on CT26 tumor models could be obtained in P&L@Gel group,even at the dose of one-eighth of the former,same tumorinhibition effects could be *** enhanced antitumor efficacy of P&L@Gel group was probably associated with the 2.2 folds of increased level of CD8+T cells and the polarization of tumor associated macrophage from M2 to M1 along with the increased drug ***,compared with the obvious side effects of P-ip&L-po group,no significant changes of PLT,ALT and UA in blood,as well as IL-1αand IL-1βin mice paws were observed between P&L@Gel group and untreated *** results suggested that local administration of anti-PD1 and LEN with thermosensitive hydrogel could offer a potential strategy for tumors or tumor postoperative adjuvant treatment.

关键词： Lenvatinib PD-1 antibody Thermosensitive hydrogels Topical administration Tumor immunotherapy

Ultra-thin Body Buried In0.35Ga0.65As Channel MOSFETs with Extremely Low Off-current on Si Substrates

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Chinese Journal of Electronics 2021年第6期30卷 1017-1021页

作者： WANG Bo DING Peng FENG Ruize WANG Yanfu liu xiaoyu SUN Tangyou CHEN Yonghe liu Xingpeng LI Qi LI Yue liu Yingbo YIN Yihui ZHAO Hao ZHANG Wei LI Haiou JIN Zhi Guangxi Key Laboratory of Precision Navigation Technology and Application Guilin University of Electronic Technology High-Frequency High-Voltage Device and Integrated Circuits Center Institute of MicroelectronicsChinese Academy of Sciences The 34th Research Institute of China Electronics Technology Group Corporation State Key Laboratory of ASIC & System Fudan University

In this paper, we investigated the electrical properties of the Metal-oxide-semiconductor gate stack of Ti/AlO/In P under different annealing conditions. A minimum interface trap density of 3×10cmeVis obtained without postmetallization annealing ***, utilizing Ti/AlO/In P MOS gate stack,we fabricated ultra-thin body buried In0.35 Ga0.65 As channel MOSFETs on Si substrates with optimized on/off trade-off. The 200 nm gate length device with extremely low off-current of 0.6 n A/μm, and on-off ratio of 3.3×10, is demonstrated by employing buried low indium(InGaAs) channel with In P barrier/spacer device structure, giving strong potential for future highperformance and low-power applications.

关键词： silicon gallium arsenide Si substrates size 200.0 nm minimum interface trap density III-V semiconductors As extremely low off-current postmetallization annealing treatment Si Ga In ultra-thin body optimized on-off trade-off MOSFET metal-oxide-semiconductor gate stack InP barrier-spacer device structure annealing elemental semiconductors O aluminium compounds different annealing conditions ultra-thin body buried channel MOSFET Ti-Al indium compounds interface states gate length device -InP

Ferritin-based nanomedicine for disease treatment

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Medical Review 2023年第1期3卷 49-74页

作者： Yuanjun Zhu Yuefeng Zhu Tianmiao Cao xiaoyu liu Xiaoyan liu Yi Yan Yujie Shi Jian-Cheng Wang Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijingChina Department of Molecular and Cellular Pharmacology School of Pharmaceutical SciencesPeking UniversityBeijingChina Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China Laboratory of Innovative Formulations and Pharmaceutical Excipients Ningbo Institute of Marine MedicinePeking UniversityNingbo 315832Zhejiang ProvinceChina

Ferritin is an endogenous protein which is selfassembled by 24 subunits into a highly uniform nanocage *** to the drug-encapsulating ability in the hollow inner cavity and abundant modification sites on the outer surface,ferritin nanocage has been demonstrated great potential to become a multi-functional nanomedicine *** good biocompatibility,low toxicity and immunogenicity,intrinsic tumor-targeting ability,high stability,low cost and massive production,together make ferritin nanocage stand out from other *** this review,we summarized ferritin-based nanomedicine in field of disease diagnosis,treatment and *** different types of drugs to be loaded in ferritin,as well as drug-loading methods were *** strategies for site-specific and non-specific functional modification of ferritin were investigated,then the application of ferritin for disease imaging,drug delivery and vaccine development were ***,the challenges restricting the clinical translation of ferritin-based nanomedicines were analyzed.

关键词： drug loading ferritin-based nanomedicine functional modiﬁcation tumor therapy vaccine