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国际心脏研究会（ISHR）中国分会第十届暨中国病理生理学会心血管专业委员会第十三届学术会议

作者： LIAO Duan-Fang YUAN Hao-Yu YU Wei-Xia LIANG Lei ZHU Bing-Yang Tuo Qin-Hui LEI xiao-Yong zheng xing CHEN Lin-Xi The State Key Lab of Pharmacoproteomics,Institute of Pharmacy and Pharmacology,University of South China,Hengyang 421001

The main aim of this study is to investigate the effects of ezetimibe on cellular cholesterol accumulation in RAW264.7 cells induced by oxidized low density lipoprotein (oxLDL).Cellular lipid level,lipid droplets and DiI- oxLDL uptake were measured by HPLC,Oil red O staining,DiI lipophilic tracer *** protein expres- sion of Niemann-Pick type C1 Like-1 (NPC1L1),Scavenger receptor class B typeⅠ(SR-BI) and Sterol regulatory element binding protein 1(SREBP-1) was analyzed by Western *** mRNA level of SREBP-1 and SR-BI was determined by Real-time *** results showed that RAW264.7 cells exposure to 50 mg/L ox-LDL or DiI- oxLDL for 24 h significantly resulted in cellular cholesterol *** of ezetimibe at different concentrations (3,10,and 30μmol/L) for 24 h or 30μmol/L ezetimibe for different time (0,6,12 and 24 h) obviously diminished cellular cholesterol accumulation by a decreased cellular cholesterol level,reduced number and area of cellular lipid *** oxLDL uptake and Dil-oxLDL uptake in 30μmol/L ezetimibe group were decreased by (47+0.1)% and (59+4.5)% respectively comparing with oxLDL or DiI-oxLDL ***, 30μmol/L ezetimibe inhibited the protein and mRNA expression of SR-BI by (12+ 1.5)% and (80+6.3)% respectively. Ezetimibe treatment also dramatically decreased mRNA expressions of SREBP-1 and NPC1L1 by (22+2.7)% and (23+6.2)%.Both SR-BI inhibitor fenofibrate and SREBP-1 inhibitor oleic acid showed a similar effect as ezetimibe on cellular cholesterol accumulation in oxLDL-treated RAW264.7 *** of SRB 1 and SREBP-1 could block the effects of ezetimibe,indicating ezetimibe inhibits cellular cholesterol accumulation in RAW264.7 cells by regulating the SREBP-1/SR-BI pathway and the expression of NPC1L1.

关键词： ezetimibe scavenger receptor B-I sterol regulatory element binding protein 1 macrophage cholesterol

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In Superdeformed Bands ΔI=2 Staggering

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Chinese Physics Letters 1996年第12期13卷 893-895页

作者： xing zheng WANG xiao-chun CHEN xing-qu Department of Modern Physics Lanzhou UniversityLanzhou 730000

By using triaxial-particle-rotor model with a perturbation term,ΔI=2 staggering effects in the γ-transition energies of superdeformed bands built upon j_(15/2) orbitals are *** general features of ΔI=2 staggering which have been observed are obtained in the *** model provides a possibility to fit the calculated values to the experimental data.

关键词： bands perturbation transition

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湖北省全民健康信息化建设标准及规范研究

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中国医院管理 2018年第7期38卷 42-45页

作者：肖兴政孙俊菲陈敏邱杰巴才国郭雪清肖树发湖北省卫生计生信息中心湖北武汉430079 中国人民解放军武汉总医院湖北武汉430070 华中科技大学同济医学院医药卫生管理学院湖北武汉430030

在遵循国家和行业相关标准、规范的基础上,依据湖北省全民健康信息化建设与管理需求,研究建立全省统一的全民健康信息化标准体系,包括基础类标准、数据类标准、技术类标准和管理类标准4大类,共42个标准规范,从基础代码、数据集、技术规... 详细信息

在遵循国家和行业相关标准、规范的基础上,依据湖北省全民健康信息化建设与管理需求,研究建立全省统一的全民健康信息化标准体系,包括基础类标准、数据类标准、技术类标准和管理类标准4大类,共42个标准规范,从基础代码、数据集、技术规范、功能应用等方面为全省全民健康信息化建设提供标准化技术支撑。

关键词：全民健康信息标准标准化规范湖北省

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盐酸纳洛酮鼻腔喷雾剂的制备及评价

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国际药学研究杂志 2017年第6期44卷 616-621页

作者：杨鹏李琬晴李迎孙建绪张慧高静印晓星郑爱萍徐州医科大学徐州221004 军事医学科学院毒物药物研究所药物制剂室抗毒药物与毒理学国家重点实验室北京100850 北京中医药大学基础医学院北京100029

目的制备盐酸纳洛酮鼻腔喷雾剂并考察制剂的纤毛毒性和体内药代动力学行为。方法考察盐酸纳洛酮在不同pH溶液中的稳定性,不同吸收促进剂对盐酸纳洛酮的促渗透效果,筛选出适宜的处方;以离体蟾蜍上颚黏膜表面纤毛的相对运动百分率评价盐... 详细信息

目的制备盐酸纳洛酮鼻腔喷雾剂并考察制剂的纤毛毒性和体内药代动力学行为。方法考察盐酸纳洛酮在不同pH溶液中的稳定性,不同吸收促进剂对盐酸纳洛酮的促渗透效果,筛选出适宜的处方;以离体蟾蜍上颚黏膜表面纤毛的相对运动百分率评价盐酸纳洛酮鼻腔喷雾剂的纤毛毒性;考察盐酸纳洛酮鼻腔喷雾剂在大鼠体内的药代动力学行为。结果盐酸纳洛酮溶液在pH3.5~5.5范围内稳定,0.2%乙二胺四乙酸二钠(EDTA-2Na)促渗透效果最好;盐酸纳洛酮鼻腔喷雾剂的纤毛毒性小且可恢复;盐酸纳洛酮鼻腔喷雾剂起效快,在大鼠体内的生物利用度与肌肉注射相当。结论本文制备的鼻腔喷雾剂体外性质稳定可控,纤毛毒性小,起效快,生物利用度高,具有较好的应用前景。

关键词：盐酸纳洛酮鼻腔喷雾剂吸收促进剂纤毛毒性药代动力学

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电子束辐照降解玉米中黄曲霉毒素B_1及对玉米品质的影响

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食品与机械 2016年第10期32卷 111-114,193页

作者：罗小虎齐丽君房文苗潘丽红王韧王莉余晓斌陈正行江南大学食品科学与技术国家重点实验室江苏无锡214122 粮食发酵工艺与技术国家工程实验室江苏无锡214122 江南大学食品学院江苏无锡214122 江南大学生物工程学院江苏无锡214122

为考察电子束辐照对玉米中黄曲霉毒素B1（aflatoxinB1，AFB1）的降解效果及对玉米品质的影响，试验选取AFB1污染的玉米为原料，研究0-50kGy剂量辐照下玉米中AFB1的降解效果，并考察电子束辐照对玉米理化性质，包括脂肪酸值、黏度值和色... 详细信息

为考察电子束辐照对玉米中黄曲霉毒素B1（aflatoxinB1，AFB1）的降解效果及对玉米品质的影响，试验选取AFB1污染的玉米为原料，研究0-50kGy剂量辐照下玉米中AFB1的降解效果，并考察电子束辐照对玉米理化性质，包括脂肪酸值、黏度值和色度的影响。结果表明，随着电子束辐照剂量的升高（5-50kGy），玉米中AFB1含量显著降低（P〈0．05）；当电子束辐照剂量大于15kGy时，玉米理化性质变化较明显，其中脂肪酸值显著升高（P〈0．05），黏度值显著下降（P〈0．05），L＊值无显著变化（P〉0．05），a＊，b＊值显著下降（P〈0．05）。

关键词：黄曲霉毒素B1 玉米电子束辐照降解品质

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基于SVM增量学习的用户适应性研究

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计算机科学 2003年第3期30卷 75-79页

作者：彭彬彬金翔宇徐晓刚孙正兴南京大学软件新技术国家重点实验室计算机科学与技术系南京210093 南京大学软件新技术国家重点实验室计算机科学与技术系南京210093

User adaptation is a critical and important problem. For users' specialization, such as Handwriting, Voice,Drawing Styles, the system is hard to adapt to all users. SVM-based incremental learning can find the most basic fea-ture of different users and cast away the special user's character, so this method can adapt the different users withoutover fitting. In this paper, the repetitive learning strategy and other two incremental learning algorithms are presentedfor comparison. Based on theoretical analysis and experimental results, we draw the conclusion that SVM-based incre-mental learning can solve the user conflict problem.

关键词： SVM 增量学习用户适应性图形识别人机交互支持向量机机器学习

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A revised rotation curve of the Milky Way with maser astrometry

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Research in Astronomy and Astrophysics 2013年第7期13卷 849-861页

作者： xiao-Sheng Xin xing-Wu zheng School of Astronomy and Space Science Nanjing University

We reconstruct the rotation curve of the Milky Way using the new trigono-metric parallax and proper motion data for masers in 43 high-mass star-forming re-gions obtained by VLBI, as well as the existing data from the literature, based on a new set of galactic constants （R0, -0） = （8.4 kpc, 254 km s^-1） measured by Reid et al. The revised rotation curve of the Milky Way is almost fiat or slightly rising in the region from about 6 to 15 kpc. The rotation velocities within 5 kpc of the Galactic center, as determined by VLBI, differ from those obtained by measurement of the HI-and CO-line tangent velocities. We fitted the revised rotation curve arising from three mass components： the bulge, disk and dark matter halo. The total mass of the Milky Way is found to be 2.3× 10^11 M⊙ （20 kpc）. This is about 10% larger than that from Sofue et al, and is comparable with the mass of M31, 3.4× 10^11 M⊙ （35 kpc）, given by Carignan et al. The limited accurate observational data, especially the VLBI data, do not permit a fully satisfactory fit to the rotation curve. The extensive par-allax and proper motion data that will be produced by the Bar and Spiral Structure Legacy Survey project in the next few years should lead to considerable progress in understanding the rotation curve and dark matter halo of the Milky Way.

关键词： Galaxy: structure - Galaxy: bulge - Galaxy: disk - Galaxy: halo-dark matter - masers

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“数据结构”虚拟课堂的设计与实现

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计算机教育 2009年第22期 32-35页

作者：肖正兴徐人凤赵志亮深圳职业技术学院广东深圳518055

"数据结构"是软件专业课程中难教、难学的一门课程,本文针对高职学生特点,设计实现了用于辅助教学的虚拟课堂,重点探讨了Authorware动画的实现、Agent的加入和Java中的多线程技术。

关键词：数据结构虚拟课堂 Agent 多线程

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Heavy metal removal from aqueous solutions by chitosan-based magnetic composite flocculants

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Journal of Environmental Sciences 2021年第10期33卷 22-32页

作者： Xuefeng xiao Yuanyuan Yu Yongjun Sun xing zheng Aowen Chen College of Urban Construction Nanjing Tech UniversityNanjing 211800China Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China

In this study,three magnetic flocculants with different chelating groups,namely,carboxymethyl chitosan-modified Fe_(3)O_(4)flocculant(MC),acrylamide-grafted magnetic carboxymethyl chitosan flocculant(MCM),and 2-acrylamide-2-methylpropanesulfonic acid copolyacrylamide-grafted magnetic carboxymethyl chitosan flocculant(MCAA)were prepared,synthesized,and characterized by photopolymerization *** were applied to the flocculation removal of Cr(Ⅲ),Co(Ⅱ),and Pb(Ⅱ).The effect of flocculation condition on the removal performance of Cr(Ⅲ),Co(Ⅱ),and Pb(Ⅱ)was *** results show that the three magnetic carboxymethyl chitosan-based flocculants have been successfully prepared with good magnetic induction *** results show that the removal rates of MC,MCM,and MCAA on Cr(Ⅲ)are 51.79%,82.33%,and 91.42%,respectively,under the conditions of 80 mg/L flocculant,pH value of 6,reaction time of 1.5 hr,G value of 200 s^(-1),and precipitation magnetic field strength of 120 *** removal rates of Co(Ⅱ)by MC,MCM,and MCAA are 54.33%,84.99%,and 90.49%,*** removal rates of Pb(Ⅱ)by MC,MCM,and MCAA are 61.54%,91.32%,and 95.74%,*** shows good flocculation performance in composite heavy metal-simulated *** magnetic carboxymethyl chitosan-based flocculant shows excellent flocculation performance in removing soluble heavy *** research provides guidance and ideas for the development of efficient and low-cost flocculation technology to remove heavy metals in wastewater.

关键词： Flocculant Carboxymethyl chitosan Magnetic flocculants Heavy metal Flocculation

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Numerical and experimental study on the falling film flow characteristics with the effect of co-current gas flow in hydrogen liquefaction process

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Petroleum Science 2024年第2期21卷 1369-1384页

作者： Chong-zheng Sun Yu-xing Li Hui Han xiao-Yi Geng xiao Lu College of Energy Storage Technology Shandong University of Science and TechnologyQingdao 266590ShandongChina College of Pipeline and Civil Engineering/Shandong Provincial Key Laboratory of Oil&Gas Storage and Transportation Safety China University of PetroleumQingdao 266580ShandongChina

Liquid hydrogen storage and transportation is an effective method for large-scale transportation and utilization of hydrogen energy. Revealing the flow mechanism of cryogenic working fluid is the key to optimize heat exchanger structure and hydrogen liquefaction process(LH2). The methods of cryogenic visualization experiment, theoretical analysis and numerical simulation are conducted to study the falling film flow characteristics with the effect of co-current gas flow in LH2spiral wound heat *** results show that the flow rate of mixed refrigerant has a great influence on liquid film spreading process, falling film flow pattern and heat transfer performance. The liquid film of LH2mixed refrigerant with column flow pattern can not uniformly and completely cover the tube wall surface. As liquid flow rate increases, the falling film flow pattern evolves into sheet-column flow and sheet flow, and liquid film completely covers the surface of tube wall. With the increase of shear effect of gas-phase mixed refrigerant in the same direction, the liquid film gradually becomes unstable, and the flow pattern eventually evolves into a mist flow.

关键词： Hydrogen liquefaction Spiral wound heat exchanger Flow pattern transition Falling film flow

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