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Small-Cell Carcinoma of Prostate:A Case Report and Literature Review

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Chinese Journal of Cancer Research 2010年第3期22卷 231-234页

作者： Feng Sun Chun-lin Chen Rong-jian Chen Ai-e Liu Ling Ding xiao-zhe cao Department of Pathology The People＇s Hospital of Shangyu Shangyu 312300 China Department of Pathology The 2nd People＇s Hospital of Zhuhai Zhuhai 519020 China

One case of small-cell carcinoma（SCC） of prostate was identified at Shangyu people＇s *** 70-year-old male had a prior diagnosis of prostatic adenocarcinoma when he was first admitted to the hospital and received anti-androgen treatment.9 months later,he was readmitted to the hospital and was diagnosed as SCC through *** article was written to evaluate the clinical and pathological characteristics and treatment of SCC of prostate.

关键词： Small-cell carcinoma Prostatic neoplasms

Perivascular epithelioid cell tumor of male pelvic cavity:a case report and literature review

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Chinese Journal of Cancer Research 2012年第4期24卷 399-402页

作者： Feng Sun Chun-Lin Chen Rong-Jian Chen Ling Ding Shi-Tao Xing xiao-zhe cao Department of Pathology the People's Hospital of Shangyu Department of Pathology Shangyu hospital of traditional Chinese medicine Department of Pathology the 2nd People's Hospital of Zhuhai

Perivascular epithelioid cell tumors （PEComas） are a family of rare mesenchymal neoplasms. The PEComas, composed of epithelioid and spindle cells, have the same cellular and immtmohistocherrtical features but are found in different visceral and soft tissue sites. Here, we report the histological and immunohistochemical features of one case of PEComa restricted in the pelvic visceral peritoneum of a male patient. The patient was treated with radical surgery, and was well and on follow-up visits without tumor recurrence.

关键词： Perivascular epithelioid cell tumor pelvic cavity surgical resection treatment

宫颈癌组织中人乳头瘤病毒16E6基因突变分析

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癌症 2009年第5期28卷 478-482页

作者：孙峰哈小琴吕同德邢传平刘斌曹晓哲兰州军区兰州总医院病理科甘肃兰州730050 兰州军区兰州总医院医学科学实验中心甘肃兰州730050 珠海市第二人民医院病理科广东珠海519020

背景与目的:高危型人乳头瘤病毒(human papillomavirus,HPV)以16型最为常见,HPV16 E6是宫颈癌主要的致癌基因之一,特定的E6突变是宫颈癌发生的主要因素之一。本研究主要观察兰州地区宫颈癌组织中是否存在E6突变,并探讨了突变与宫颈癌发... 详细信息

背景与目的:高危型人乳头瘤病毒(human papillomavirus,HPV)以16型最为常见,HPV16 E6是宫颈癌主要的致癌基因之一,特定的E6突变是宫颈癌发生的主要因素之一。本研究主要观察兰州地区宫颈癌组织中是否存在E6突变,并探讨了突变与宫颈癌发生的关系。方法:以23例宫颈癌手术切除标本及5例正常宫颈组织的DNA作为模板,PCR扩增HPV-16 E6基因201-523位,PCR产物直接测序,分析其HPV16E6基因的突变规律。结果:PCR扩增结果表明5例正常宫颈组织中HPV16 E6阳性率为0%(0/5),宫颈癌组织中HPV16 E6阳性率为82.61%(19/23),对18例样本PCR产物的测序和序列分析结果表明,6例(33.33%)E6基因与原型相同,12例(66.67%)E6基因发生突变,其中11例(61.11%)发生了350G突变。同时,在1例样本(5.56%)发现了249G突变。结论:兰州地区宫颈癌组织中存在着非常高的HPV感染率,且多数HPV16 E6发生了突变。

关键词：宫颈肿瘤人乳头瘤病毒 E6基因突变

Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu Chen Tong Zhou zhe-Yi Han Jun xiao Jian-Feng Ma Wen Ma Peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan cao Younghye Moon Chen Chen Nai-Kui Liu xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu xiao Feng Xing Yang zheheng Song Yuhang Song Jingyu Chen Yingcun Liu Chong Gao Yong Du zhe Sun Weilin Xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

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高考数学试题情境的价值、质量与考态分析

教学与管理 2025年第1期 63-66页

作者：曹翛骛陕西省西安市昆仑中学西安710043

鉴于试题情境影响测评目的的实现,首先探讨试题情境的测评价值和质量特征,并建构质量特征的分层评价标准。其次,以2024年高考全国卷和地方卷为研究单元,以上述评价标准为研究工具,研究得出高考数学试题情境综合质量的相对排序为:北京卷... 详细信息

鉴于试题情境影响测评目的的实现,首先探讨试题情境的测评价值和质量特征,并建构质量特征的分层评价标准。其次,以2024年高考全国卷和地方卷为研究单元,以上述评价标准为研究工具,研究得出高考数学试题情境综合质量的相对排序为:北京卷≈上海卷>新高考I卷>新高考II卷≈甲卷(理科)≈天津卷;虽然高考数学试题的情境存在差异性,但具有以下共性:试题情境主要承载单一的工具或发展价值;真实性与新颖性的水平较低;融合性水平较高。最后,提出重视情境教育、引导学生深度学习的教学建议。

关键词：高考数学试题情境 2024年高考数学试卷情境呈现

Deep Reinforcement Learning Based Approach for Optimal Power Flow of Distribution Networks Embedded with Renewable Energy and Storage Devices

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Journal of Modern Power Systems and Clean Energy 2021年第5期9卷 1101-1110页

作者： Di cao Weihao Hu xiao Xu Qiuwei Wu Qi Huang zhe Chen Frede Blaabjerg School of Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengduChina Department of Electrical Engineering Technical University of DenmarkKgs.Lyngby 2800Denmark Department of Energy Technology Aalborg UniversityAalborgDenmark

This study proposes a deep reinforcement learning(DRL)based approach to analyze the optimal power flow(OPF)of distribution networks(DNs)embedded with renewable energy and storage ***,the OPF of the DN is formulated as a stochastic nonlinear programming ***,the multi-period nonlinear programming decision problem is formulated as a Markov decision process(MDP),which is composed of multiple single-time-step ***,the state-of-the-art DRL algorithm,i.e.,proximal policy optimization(PPO),is used to solve the MDP sequentially considering the impact on the *** networks are used to extract operation knowledge from historical data offline and provide online decisions according to the real-time state of the *** proposed approach fully exploits the historical data and reduces the influence of the prediction error on the optimization *** proposed real-time control strategy can provide more flexible decisions and achieve better performance than the pre-determined *** results demonstrate the effectiveness of the proposed approach.

关键词： Deep reinforcement learning(DRL) optimal power flow(OPF) wind turbine distribution network

Particles attrition of binary mixtures in the coal-fueled chemical looping system based on fluidized bed

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Particuology 2024年第3期86卷 281-290页

作者： Heyu Li zhe Sun Yan cao Guangzhou Institute of Energy Conversion Chinese Academy of SciencesGuangzhou 510640China University of Chinese Academy of Sciences Bejing 100049China CAS Key Laboratory of Renewable Energy Guangzhou 510640China Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development Guangzhou 510640China College of Chemistry and Chemical Engineering Anhui UniversityHefei230601China

In this work,a reactive air jet attrition device with auto-recording and collection of elutriated fines was *** established insights into the physiochemical interaction and further correlated attrition behaviors between char and oxygen carriers under various operation *** attrition rate increased by over 110% upon the introduced CO_(2),which brought in the significant effect of thermo-chemical stress,similarly in effects of the increased char addition ratio and the decreased sizes of char or hematite in different *** the char-hematite co-attrition process,the elutriated carbon loss of char with poor mechanical strength was found to be over 10%,while the reactive iron loss of hematite was found to be 6.3%,and was enriched in elutriated *** reaction-derived thermochemical stress and the collision-derived mechanical stress jointly controls the particle attrition during the cyclic transformation of oxygen carrier particles in coal-fueled chemical looping fluidization,especially sig-nificant in its reduction stage.

关键词： Attrition Binary species Chemical looping Oxygen carrier CO_(2)capture