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The applied research of simultaneous image acquisition of T2-weighted imaging(T2WI)and diffusion-weighted imaging(DWI)in the assessment of patients with prostate cancer

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Asian Journal of Andrology 2019年第2期21卷 177-182页

作者： Yi Liu Wei wang Xiu-Bo Qin Hui-Hui wang Ge Gao xiao-Dong Zhang xiao-ying wang Department of Radiology Peking University First HospitalBeijing 100034China

We aimed to evaluate the feasibility of simultaneous image acquisition of multiple instantaneous switchable scan(MISS)for prostate magnetic resonance imaging(MRI)on ***-three patients were scanned with MRI due to suspected prostate ***-eight of them got histological ***,two readers assessed the structure delineation and image quality based on images of conventional T2-weighted imaging(T2WI)and diffusion-weighted imaging(DWI)(CTD).Second,two readers identified the index lesion together,and then,reader one evaluated the contrast of index lesion on T2WI and signal ratio on apparent diffusion coefficient ***,they assigned Prostate Imaging Reporting and Data System(PI-RADS)score in consensus for the index *** 4 weeks,the images of MISS were reviewed by the same readers following the same ***,two readers gave preference for image interpretation,*** coefficient,Wilcoxon signed-rank test,paired-sample t-test,Bland-Altman analysis,and receiver operating characteristic(ROC)analysis were used for statistical *** acquisition time of CTD was 6 min and 10 st while the acquisition time of MISS was 4 min and 30 *** agreements for image evaluation were k=0.65 and k=0.80 for CTD and MISS,***-T2WI showed better delineation for seminal vesicles than CTD-T2WI(reader 1:P<0.001,reader 2:P=0.001).The index lesion demonstrated higher contrast in MISS-T2WI(P<0.001).The FI-RADS scores based on CTD and MISS exhibited high ability in predicting clinically significant cancer(area under curve[AUC]=0.828 vs 0.854).Readers preferred to use MISS in 41.5%-47.2%of *** showed comparable performance to conventional technique with less acquisition time.

关键词： diffusion-weighted imaging magnetic resonance imaging prostate cancer

Effect and mechanism of β-L-D4A on DNA polymerase α

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World Journal of Gastroenterology 2007年第46期13卷 6243-6248页

作者： Yan Li Ju-Sheng Lin ying-Hui Zhang xiao-Yan wang ying Chang Xing-Xing He Institute of Liver Diseases Tongji MedicalCollege Huazhong University of Science and Technology 1095Jiefang Street Wuhan 430030 Hubei Province China

AIM： To investigate the safety of β-L-D4A on DNA polymerase α.METHODS： Ion exchange chromatography was used to separate DNA polymerase cc from crude extract of human Hela cells. Detailed kinetic parameters were determined for β-L-D4A against DNA polymeraseα . RESULTS： DNA polymerase was purified with 4% yield and 31000 units/mg specific activity. The Michaelis constant （Km = 3.22 i^mol/L）, 50% inhibition concentration （IC50 = 178.49 μmol/L） and inhibition constant （Ki = 126 mol/L） of β-L-D4A were determined by kinetic analysis. CONCLUSION： β-L-D4A is a more safe nucleoside for hepatitis B virus （HBV） infection with a lower host toxicity.

关键词： Nucleoside β-L-D4A DNA polymeraseα Kinetic study Side effect Hepatitis B virus

GaAs pHEMT multi-band/multi-mode SP9T switch for quad-band GSM and UMTS handsets applications

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第4期12卷 317-322页

作者： xiao-ying wang Wen-ting GUO Yang-yang PENG Wen-quan SUI Zhejiang California International Nanosystems Institute (ZCNI) Zhejiang University Hangzhou 310029 China

A multi-band/multi-mode single-pole nine-throw (SP9T) switch for GSM/UMTS (global system for mobile communications/universal mobile telecommunication system) systems is *** switch consists of a GaAs 0.5μm pseudomorphic high-electron mobility transistor (pHEMT) radio frequency (RF) switches module and Si complementary metal-oxide-semiconductor (COMS) digital module with an encoder and a DC boost *** isolation and high linearity are achieved by a series-shunt switch structure and the DC boost circuit,*** switch shows a measured insertion loss of 0.4 dB at 0.8 GHz for GSM transmit arms,0.7 dB at 0.9 GHz and 0.9 dB at 1.8 GHz for GSM receive arms,and 0.6 dB at 1.8 GHz for UMTS *** switch introduces 2nd and 3rd harmonic suppression levels less than 64 dBc at 37 dBm input *** between transmit and receive terminals are more than 48 dB when one transmit arm is *** size of the RF switches module is 1.5 mm×1.1 mm,and the size of the digital module is 1.3 mm×0.63 mm with gold bonding wires connecting these two modules.

关键词： GSM UMTS Single-pole nine-throw (SP9T) pHEMT Encoder DC boost

Long-term follow-up study of elderly patients with covered stent implantation after coronary perforation

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Journal of Geriatric Cardiology 2014年第3期11卷 218-221页

作者： Geng wang Ya-Ling HAN Quan-Min JING xiao-Zeng wang ying-Yan MA Bin wang Department of Cardiology Shenyang Northern Hospital Shenyang 110016 Liaoning Province China

ObjectiveTo evaluate the long-term efficacy of covered stent implantation in the treatment of elderly patients with coronary perforation while undergoing percutaneous coronary intervention （PCI）.MethodsFrom June 2004 to June 2012, our center has followed ten elderly patients （age≥ 60 years） who sustained coronary perforation during PCI. The major adverse cardiac events （MACE） were observed as well. The patients were advised to take 75 mg/day Clopidogrel for two years, and indefinite use of 100 mg/day enteric-coated *** out of the 10 patients aged from 60 to 76 years old （mean 68.6 ± 5.2 years） were male, four were female. The average diameter of the implanted stents was 3.3 ± 0.3 mm, and the average length was 22.1 ± 3.7 mm. All the ruptures were successfully sealed without intra-procedural death. The follow-up duration ranged from 0.6 to 67 months （mean 31.7 ± 24.5 months）. One patient died of multiple organ failure due to lung infection in 19 days after PCI; one died of cardiac sudden death in 13 months after PCI; one had angina pectoris in 53 months after PCI; one underwent multi-slice CT examination in six months after PCI, and no in-stent restenosis was found. The other four patients received angiography follow-up, and the results showed that three patients had no intra-stent restenosis, while one had left anterior descending （LAD） restenosis in the covered stent in 67 months after PCI. The in-hospital mortality was 10% （1/10）. The MACE rate in 12 months after PCI was 10% （1/10）. During the entire followed-up period, the restenosis rate in target vessels was 20% （1/5）, mortality was 20% （2/10）, and the MACE rate was 40% （4/10）.ConclusionTreatment of coronary perforation by using covered stents can achieve favorable long-term results; a two-year dual antiplatelet therapy （DAPT） after PCI can effectively prevent intra-stent thrombosis.

关键词： Coronary perforation Percutaneous coronary intervention Covered stent

Preparation of high-strength Al-Mg-Si-Cu-Fe alloy via heat treatment and rolling

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International Journal of Minerals,Metallurgy and Materials 2014年第7期21卷 702-710页

作者： Chong-yu Liu Peng-fei Yu xiao-ying wang Ming-zhen Ma Ri-ping Liu State Key Laboratory of Metastable Materials Science and Technology Yanshan University Key Laboratory of New Processing Technology for Nonferrous Metal & Materials Ministry of EducationGuilin University of Technology College of Materials Science and Engineering Guilin University of Technology

An Al-Mg-Si-Cu-Fe alloy was solid-solution treated at 560℃ for 3 h and then cooled by water quenching or furnace cooling. The alloy samples which underwent cooling by these two methods were rolled at different temperatures. The microstructure and mechanical properties of the rolled alloys were investigated by optical microscopy, scanning electron microscopy, transmission electron microscopy, X-ray diffraction analysis, and tensile testing. For the water-quenched alloys, the peak tensile strength and elongation occurred at a rolling temperature of 180℃. For the furnace-cooled alloys, the tensile strength decreased initially, until the rolling temperature of 420℃, and then increased;the elongation increased consistently with increasing rolling temperature. The effects of grain boundary hardening and dislocation hardening on the mechanical properties of these rolled alloys decreased with increases in rolling temperature. The mechanical properties of the 180℃ rolling water-quenched alloy were also improved by the presence ofβ″phase. Above 420℃, the effect of solid-solution hardening on the mechanical properties of the rolled alloys increased with increases in rolling temperature.

关键词： aluminum alloys heat treatment rolling mechanical properties microstructure

NORMAL APPEARANCE OF LARGE FIELD DIFFUSION WEIGHTED IMAGING ON 3.0T MRI

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Chinese Medical Sciences Journal 2008年第3期23卷 158-161页

作者： Rong Rong Chun-yan Zhang xiao-ying wang Department of Radiology Peking University First Hospital Functional Imaging Center Advanced Academy of Interdisciplinary Sciences Peking University Beijing 100034

Objective To evaluate the normal appearance of large field diffusion weighted imaging (DWI) on 3.0T magnetic resonance imaging (MRI). Methods Twenty healthy volunteers and thirty patients with benign prostate hyperplasia were included in this study. All patients were examined with large field DWI on 3.0T MRI. Normal tissue appearance was analyzed and apparent diffusion coefficient (ADC) of normal tissue with high signal intensity was measured. The ADC values of bilateral symmetrical tissue were also compared. The ADC values of intervertebral disks of healthy people younger than 50 years and exceeding 50 years were compared. Results Salivary gland, spleen, kidney, gallbladder, bladder, prostate, seminal vesicle, testis, intervertebral disk, liquid in articular cavity and lymph node showed high signal intensity on large field DWI, while lung, liver and bone showed hypo-signal intensity. The mean ADC values of partial hyperintensity tissue were as followed: parotid gland (1.088 ± 0.114) ×10-3 mm2/s, submaxillary gland (1.309 ± 0.189) ×10-3 mm2/s, kidney (1.909 ± 0.143) ×10-3 mm2/s, seminal vesicle (1.669 ± 0.168) ×10-3 mm2/s, testis (1.028 ± 0.075) ×10-3 mm2/s, spleen (0.963 ± 0.108) ×10-3 mm2/s, bladder (2.898 ± 0.267) ×10-3 mm2/s, prostate (1.448 ± 0.132) ×10-3 mm2/s, intervertebral disks (1.360 ± 0.140) ×10-3 mm2/s. No statistical significance was found between the ADC values of bilateral symmetrical tissues. The difference of ADC values of intervertebral disks of healthy people younger than 50 years [(1.372 ± 0.142) ×10-3 mm2/s] and exceeding 50 years [(1.344 ± 0.134) ×10-3 mm2/s] showed statistical significance (P = 0.040). Conclusion Understanding the high signal intensity of normal tissue on large field DWI may help to differentiate the normal tissues and abnormal ones.

关键词： diffusion weighted imaging magnetic resonance imaging normal appearance

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Chinese Medical Sciences Journal 2008年第3期23卷 162-165页

作者： Chun-yan Zhang Rong Rong xiao-ying wang Department of Radiology Peking University First Hospital Functional Imaging Center Advanced Academy of Interdisciplinary Sciences Peking University Beijing 100034

Objective To investigate the signal intensity and apparent diffusion coefficient (ADC) of bone marrow of normal adult man on diffusion weighted imaging (DWI). Methods Fifteen healthy volunteers and thirty-eight patients with benign prostatic hyperplasia or normal prostate were enrolled in this study, with age range 28-82 years old (mean 55.26 ± 18.05 years). All people were examined with large field DWI on a 3.0T magnetic resonance scanner, which ranges from the top of head to the lower limb. The signal-to-noise ratio (SNR) on the DWI and ADC of lumber vertebra at renal hilum level, left ilium and superior segment of left femur were measured. The measured SNR and ADC value of the above sites were compared by one way analysis of variance and their correlations with age were investigated by Pearson's correlation analysis. Results The SNR of lumber vertebra, left ilium and left femur showed no significant difference (F = 0.271, P = 0.763). The SNR of lumber vertebra (r = 0.309, P = 0.024) and left ilium (r = 0.359, P = 0.008) showed positive correlation with age, while the SNR of left femur showed no correlation with age (r = -0.163, P = 0.283). The ADC of lumber vertebra [(0.617 ± 0.177) ×10-3 mm2/s] was significantly higher than that of left ilium [(0.404 ± 0.112) ×10-3 mm2/s, P < 0.001] and left femur [(0.362 ± 0.092) ×10-3 mm2/s, P < 0.001], while the ADC of left ilium and left femur had no significant difference. The ADC of lumber vertebra, left ilium and left femur showed no correlation with age. Conclusion Understanding of age-related changes of normal adult bone marrow on DWI is very important to differentiate the normal bone marrow and abnormal lesions.

关键词： diffusion weighted imaging magnetic resonance imaging bone marrow

Dicyclopentyl azodicarboxylate(DCpAD):A new alternative azo-reagent for the Mitsunobu reaction

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Chinese Chemical Letters 2011年第9期22卷 1047-1050页

作者： Jian Hai Yang Li Yan Dai xiao Zhong wang ying Qi Chen Department of Chemical and Biological Engineering Zhejiang University Hangzhou 310027 China

Dicyclopentyl azodicarboxylate is introduced as a new azo-reagent which can be conveniently prepared in two steps and be used in the Mitsunobu reaction. Though there are no distinct difference of reactivity between DC... 详细信息

关键词： Dicyclopentyl azodicarboxylatc Mitsunobu reaction Azo-reagent

Using CT imaging to delineate the prostatic apex for radiation treatment planning

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Chinese Journal of Cancer 2010年第11期29卷 914-922页

作者： xiao-Mei Li Xian-Shu Gao Xue-Mei Guo Ya-Gang Li xiao-ying wang Department of Radiation Oncology Peking University First Hospital Beijing 100034 P. R. China Department of Radiology Peking University First Hospital Beijing 100034 P. R. China

Background and Objective: In computed tomography (CT)-based radiotherapy planning for prostate cancer, it is difficult to precisely delineate the prostatic apex because of its relationship with the urogenital diaphragm and bulbospongiosus musculature. In this retrospective study, we analyzed the magnetic resonance imaging (MRI) and CT scans of the patients with prostate cancer to investigate the relationship between the prostatic apex and the anatomic structure visible on CT, and to provide evidence for localizing the prostatic apex in radiotherapy planning. Methods: MRI and CT scans of 108 patients with prostate cancer were analyzed to measure the distances between the prostatic apex and the bottom of ischial tuberosities, the bottom of obturator foramen, the bottom of pubic symphysis, and the bulb of the penis. The volume of the prostate was measured to analyze its relationship with the localization of the prostatic apex. Results: The prostatic apex was located (13.1 ± 3.3) mm above the bulb of the penis, (11.0 ± 5.4) mm above the bottom of the obturator foramen, (31.3 ± 5.5) mm above the ischial tuberosities, and (7.1 ± 4.7) mm above the bottom of the symphysis pubis. There was no correlation between the size of the prostate and the localization of the prostatic apex. Conclusions: The variance of the distance between the prostatic apex and the bulb of the penis is smaller than that of the distance between the apex and bony anatomy. Delineating the target to 6 mm above the bulb of the penis can cover the prostatic apex in 95% of the patients with prostate cancer, delineating to the bottom of obturator foramen can cover the prostatic apex in 100% of the patients.

关键词：前列腺癌 CT检查放射治疗断层扫描肌肉组织解剖结构磁共振成像扫描测量