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Rituximab induction therapy in highly sensitized kidney transplant recipients

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Chinese Medical Journal 2011年第13期124卷 1928-1932页

作者： YIN Hang WAN Hao HU xiao-peng LI xiao-bei wang wei LIU Hang REN Liang ZHANG xiao-dong Kidney Transplantation Program Department of Urology BeijingChao-Yang Hospital Capital Medical University Beijing 100020China

Background The number of highly sensitized patients is rising, The present study aimed to investigate the safety and efficacy of rituximab in highly sensitized kidney transplant recipients. and sensitization can lead to renal transplant failure. renal transplantation following induction therapy with Methods Seven highly sensitized kidney transplant recipients who underwent rituximab therapy from December 2008 to December 2009 were retrospectively analyzed. There were 3 men and 4 women, with a mean age of 38.5 years （range, 21-47 years）. The duration of hemodialysis was 3-12 months, with a mean duration of 11 months. For 4 patients, this was the second transplant; the previous graft survival time was 2-11 years, with a mean survival time of 5.8 years. All the female recipients had history of multiple pregnancies, and all patients had previously received blood transfusions. All donors were men, with a mean age of 32.5 years （range, 25-37 years）. In 2 of the 7 patients, both class I and class II of panel reactive antibody were high; the remaining 5 patients showed either high in class I or in class II of panel reactive antibody. The mean panel reactive antibody value was 31% for class I and 51% for class II respectively. The donors and the recipients had the same blood type, with low lymphocyte cytotoxicity ranging from 2% to 5%. The human leukocyte antigen （HLA） mismatch numbers were from 2 to 4. All patients received tacrolimus （0.1 ***^-1 .d^-1） and mycophenolate mofetil （750 mg twice per day） orally 3 days prior to surgery. All patients received a single dose of 600 mg rituximab （375 mg/m^2） infusion on the day before surgery and polyclonal antibody （antithymocyte globulin） on the day of surgery. Postoperative creatinine, creatinine clearance rate, and occurrence of rejection by pathological biopsy confirmation were monitored. Results No patient had delayed graft function after surgery. Two patients had acute rejection, one on day 7 and the other on day 13 post-s

关键词： kidney transplant highly sensitized rituximab

The transcriptional regulator JAZ8 interacts with the C2 protein from geminiviruses and limits the geminiviral infection in Arabidopsis

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Journal of Integrative Plant Biology 2023年第7期65卷 1826-1840页

作者： Tabata Rosas-Diaz Pepe Cana-Quijada Mengshi Wu Du Hui Gemma Fernandez-Barbero Alberto PMacho Roberto Solano Araceli GCastillo xiao-wei wang Rosa Lozano-Duran Eduardo R.Bejarano Departamento de Biología Celular Genética y FisiologíaFacultad de CienciasInstituto de Hortofruticultura Subtropical y Mediterránea“La Mayora”(IHSM‐UMA‐CSIC)Universidad de MálagaMálagaSpain Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China Institute of Insect Sciences Zhejiang UniversityHangzhou 310058China Departamento de Genética Molecular de Plantas Centro Nacional de Biotecnología‐Consejo Superior de Investigaciones CientíficasMadrid 28049Spain Department of Plant Biochemistry Centre for Plant Molecular BiologyEberhard Karls UniversityTübingen D‐72076Germany

Jasmonates(JAs) are phytohormones that finely regulate critical biological processes, including plant development and defense. JASMONATE ZIM-DOMAIN(JAZ) proteins are crucial transcriptional regulators that keep JA-responsive genes in a repressed state. In the presence of JA-Ile, JAZ repressors are ubiquitinated and targeted for degradation by the ubiquitin/proteasome system,allowing the activation of downstream transcription factors and, consequently, the induction of JA-responsive genes. A growing body of evidence has shown that JA signaling is crucial in defending against plant viruses and their insect vectors. Here, we describe the interaction of C2proteins from two tomato-infecting geminiviruses from the genus Begomovirus, tomato yellow leaf curl virus(TYLCV) and tomato yellow curl Sardinia virus(TYLCSaV), with the transcriptional repressor JAZ8 from Arabidopsis thaliana and its closest orthologue in tomato, SlJAZ9. Both JAZ and C2proteins colocalize in the nucleus, forming discrete nuclear speckles. Overexpression of JAZ8did not lead to altered responses to TYLCV infection in Arabidopsis;however, knock-down of JAZ8 favors geminiviral infection. Low levels of JAZ8 likely affect the viral infection specifically,since JAZ8-silenced plants neither display obvious developmental phenotypes nor present differences in their interaction with the viral insect vector. In summary, our results show that the geminivirus-encoded C2 interacts with JAZ8 in the nucleus, and suggest that this plant protein exerts an anti-geminiviral effect.

关键词： C2 protein geminivirus jasmonates JAZ8 transcriptional repressor TYLCV

Tetra-n-butylammonium Hydroxide:an Efficient Catalyst for N-Alkylation of Pyrimidines and Purines

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Chemical Research in Chinese Universities 2006年第4期22卷 451-454页

作者： ZHANG Zhi-li~ , ZHOU Shou-xin, wang xiao-wei, wang Hong-tao, CHEN Yan-li and LIU Jun-yi Department of Chemical Biology, School of Pharmaceutical Sciences State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, P. R. China Department of Chemical Biology School of Pharmaceutical Sciences State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100083 P. R. China

An efficient procedure for N-alkylation of pyrimidines and purines in the presence of tetra-n-butylammonium hydroxide（TBAH） is described. The method is very practical and the alkylation can occur at room temperature... 详细信息

关键词： Tetra-n-butylammonium hydroxide N-Alkylation Purine Pyrimidine

Traditional Chinese medicine integrated with chemotherapy for stage Ⅳ non-surgical gastric cancer: a retrospective clinical analysis

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Journal of Integrative Medicine 2017年第6期15卷 469-475页

作者： xuan liu li-juan xiu jian-peng jiao jing zhao ying zhao ye lu jun shi yong-jin li min ye yu-fang gu xiao-wei wang jing-yu xu ci-an zhang yong-ying liu yun luo xiao-qiang yue department of traditional chinese medicine changzheng hospitalsecond military medical universityShanghai 200003China

OBJECTIVE： Traditional Chinese medicine （TCM） is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer patients, the authors performed a retrospective study to report the result of the integrated treatment of TCM with chemotherapy for stage IV non-surgical gastric cancer. METHODS： In this study, 182 patients with stage IV and non-surgical gastric cancer were retrospectively analyzed to evaluate the effects of TCM integrated with chemotherapy. Among the 182 cases, 88 cases received integrated therapy consisting of TCM and chemotherapy, while 94 cases received chemotherapy alone. The overall survival and Karnofsky performance status （KPS） score were measured as the main outcome. RESULTS： The median overall survival of the integrated therapy group and chemotherapy group were 16.9 and 10.5 months, respectively. The 1-, 3- and 5-year survival rates of integrated therapy group vs. chemotherapy group were 70% vs. 32%, 18% vs. 4%, and 11% vs. 0%, respectively. There was a significant difference between the two groups （x2 = 42.244, P 〈 0.001 ）. After six-month treatment, KPS scores of the integrated therapy group and the chemotherapy group were 75.00 ± 14.78 and 60.64 ± 21.39, respectively （P 〈 0.001）. The Cox regression analysis showed that TCM treatment is a protective factor for patients＇ overall survival. CONCLUSION： This study demonstrated that TCM integrated with chemotherapy may prolong overal survival and improve survival rate and life quality of patients with stage IV non-surgical gastric cancer

关键词： stomach neoplasms drug therapy, combination medicine, Chinese traditional integrativemedicine plants, medicinal

CATALYTIC COLOR REACTION OF THE SYSTEM OF MIMETIC PEROXIDASE(Fe-T(3MPy)P)-LEUCO CRYSTAL VIOLET-HYDROGEN PEROXIDE

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Chinese Chemical Letters 1992年第12期3卷 993-996页

作者： Shu Sheng SUN xiao wei WU An wang Yun Xiang CI Department of Chemistry,Peking University,Beijing,100871

The mimetic peroxidase iron-tetrakis(3-N-methylpyridyl)- porphyrin (Fe-T(3MPy)P)can be used as a catalyst in the spectrophoto- metric determination of H_2O_2 and *** method is based on the formation of crystal violet from leuco crystal *** glucose in human serum is determined by this reaction combined with catalytic reaction of glucose oxidase.

关键词： Fe-T CATALYTIC COLOR REACTION OF THE SYSTEM OF MIMETIC PEROXIDASE LEUCO CRYSTAL VIOLET-HYDROGEN PEROXIDE

时效Ag-7wt.%Cu合金的微观组织、电阻率和硬度

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物理学报 2017年第2期66卷 311-321页

作者：李蕊左小伟王恩刚东北大学材料电磁过程研究教育部重点实验室沈阳110819 东北大学材料科学与工程学院沈阳110819 东北大学冶金学院沈阳110819

采用差示扫描量热法、X射线衍射及透射电子显微镜研究了固溶和固溶一冷轧Ag-7wt.%Cu合金在时效过程中富Cu相的析出动力学和形貌特征,同时结合电阻率和显微硬度的测量,定量对比了固溶和固溶一冷轧Ag-7wt.%Cu合金时效过程中富Cu相对电阻... 详细信息

采用差示扫描量热法、X射线衍射及透射电子显微镜研究了固溶和固溶一冷轧Ag-7wt.%Cu合金在时效过程中富Cu相的析出动力学和形貌特征,同时结合电阻率和显微硬度的测量,定量对比了固溶和固溶一冷轧Ag-7wt.%Cu合金时效过程中富Cu相对电阻率和硬度的影响及其机理.研究结果表明:固溶样品中富Cu相反应温度为300℃-350℃,析出激活能为(111±1.6)kJ/mol;而固溶一冷轧样品中由于形变能的存在,富Cu相温度降低为290℃-330℃,析出激活能升高为(128±12)kJ/***结果证实富Cu相的析出过程与时效温度有关.固溶和固溶一冷轧合金在450℃时效后均能观察到球状的富Cu相,富Cu相的析出和溶解过程对电阻率和显微硬度有显著影响.当时效温度低于450℃时,随时效温度的提高,固溶一时效样品的电阻率降低,显微硬度增加:而固溶一冷轧一时效样品的电阻率和显微硬度均逐渐降低.显微硬度除了受富Cu相的影响外,还受到位错和形变孪晶的影响.当时效温度高于450℃时,两种样品的电阻率增大,而显微硬度降低.

关键词： Ag-Cu合金显微组织电阻率显微硬度

Regioselective Opening Reaction of Epoxides with Diphenyl Diselenides

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有机化学 2003年第Z1期23卷 308-308页

作者： WU xiao-wei wang Jin-Xian Department of Chemical Engineering Dalian Nationalities College Dalian 116600 Department of Chemical Engineering Dalian Nationalities College Dalian 116600

　　The oxirane ring opening[1] with various nuclephiles is an important synthetic transformation to allow easy ac cess to a large number of functionalized intermediates that are required during the synthesis of natural products. [2]The reaction of epoxides with phenylselenolate ion gave the organic selenides[3] which were formed via trans opening of the epoxides with the selenolate ion. However, many of methods suffer from lack of generality, poor regioselectivity and low temperature ( - 78 ℃ ). [4]……

关键词： natural products low temperature ring opening

Modeling Study of Hydrogen/Oxygen and n-alkane/Oxygen Counterflow Diffusion Flames

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Chinese Journal of Chemical Physics 2011年第2期24卷 231-238,I0004页

作者：汪小卫蔡国飙 Vigor Yang 北京航空航天大学宇航学院北京100191 美国佐治亚理工学院航空航天系佐治亚州30332

A comprehensive analysis of hydrogen/oxygen and hydrocarbon/oxygen counterflow diffusion flames has been conducted using corresponding detailed reaction mechanisms. The hydrocarbon fuels contain n-alkanes from CH4 to C16H34. The basic diffusion flame structures are demonstrated, analyzed, and compared. The effects of pressure, and strain rate on the flame behavior and energy-release rate for each fuel are examined systematically. The detailed chemical kinetic reaction mechanisms from Lawrence Livermore National Laboratory （LLNL） are employed, and the largest one of them contains 2115 species and 8157 reversible reactions. The results indicate for all of the fuels the flame thickness and heat release rate correlate well with the square root of the pressure multiplied by the strain rate. Under the condition of any strain rate and pressure, H2 has thicker flame than hydrocarbons, while the hydrocarbons have the similar temperature and main products distributions and almost have the same flame thickness and heat release rate. The result indicates that the fuels composed with these hydrocarbons will still have the same flame properties as any pure n-alkane fuel.

关键词： Counterflow Combustion Hydrogen Hydrocarbon Flame

Relationships Between Seasonal Variation and Idiopathic Congenital Talipes Equinovarus in Northwest China

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Proceedings of Anticancer Research 2020年第2期4卷 18-23页

作者： Yi-Jun Yang xiao-wei wang Jun-Hu Mao Kai-Hua Gou Department of Orthopedics The Affiliated Children’s Hospital of Xi’an Jiaotong UniversityXi’an CityShaanxi ProvinceChina

Background:The purpose of this study was to determine whether the occurrence of neonatal idiopathic congenital talipes equinovarus(ICTEV)in Northwest China followed a seasonal pattern and to speculate the potential etiology of ***:We collected data from 221 children with ICTEV who were born in Northwest China to investigate seasonal *** also analyzed seasonal variations in the month of birth and ***:Among male infants with ICTEV,the constituent ratio of children born in May and October was statistically different from that of normal children(OR=1.674,95%CI,1.003-2.795,P=0.049;OR=0.041,95%CI,0.450-0.968,P=0.041).The months distribution of unilateral and bilateral limb was different(P=0.025).The constituent ratio of bilateral limb in March was higher than that in the other months(P=0.003).Conclusions:This study does not support an in-utero enterovirus infection as the etiology of ***,the current research provides strong evidence in support of an unidentified environmental factor influencing the occurrence of ICTEV in the Northwest Chinese population.

关键词： Equinovarus Seasonal variation Blood folate level