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Signaling pathways involved in ischemic stroke:molecular mechanisms and therapeutic interventions

Signal Transduction and Targeted Therapy 2022年第8期7卷 2733-2761页

作者： Chuan Qin Sheng Yang Yun-Hui Chu Hang Zhang xiao-wei pang Lian Chen Luo-Qi Zhou Man Chen Dai-Shi Tian wei Wang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Ischemic stroke is caused primarily by an interruption in cerebral blood flow,which induces severe neural injuries,and is one of the leading causes of death and disability ***,it is of great necessity to further detailly elucidate the mechanisms of ischemic stroke and find out new therapies against the *** recent years,efforts have been made to understand the pathophysiology of ischemic stroke,including cellular excitotoxicity,oxidative stress,cell death processes,and *** the meantime,a plethora of signaling pathways,either detrimental or neuroprotective,are also highly involved in the forementioned *** pathways are closely intertwined and form a complex signaling ***,these signaling pathways reveal therapeutic potential,as targeting these signaling pathways could possibly serve as therapeutic approaches against ischemic *** this review,we describe the signaling pathways involved in ischemic stroke and categorize them based on the pathophysiological processes they participate *** approaches targeting these signaling pathways,which are associated with the pathophysiology mentioned above,are also ***,clinical trials regarding ischemic stroke,which potentially target the pathophysiology and the signaling pathways involved,are summarized in ***,this review elucidated potential molecular mechanisms and related signaling pathways underlying ischemic stroke,and summarize the therapeutic approaches targeted various pathophysiology,with particular reference to clinical trials and future prospects for treating ischemic stroke.

关键词： therapeutic injuries protective

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Photocatalytic uranium extraction boosted by dual effective active sites of porphyrin metal-organic frameworks

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Nano Research 2024年第7期17卷 6713-6720页

作者： Jianming Pan Bentian xiao wei Zhu Yanan Yang Hongliang Huang Zichao Lian Tao Zhang Fengxian Qiu Songlin Xue Huan pang School of Chemistry and Chemical Engineering Jiangsu University301 Xuefu RoadZhenjiang 212013China Institute of Smart Liquid Crystal Technologies JITRI280 Huangpu Jiang RoadChangshu 215500China State key laboratory of Separation Membranes and Membrane Processes Tiangong UniversityTianjin 300387China School of Chemical Engineering and Technology Tiangong UniversityTianjin 300387China School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China School of Chemistry and Chemical Engineering Institute for Innovative Materials and EnergyYangzhou UniversityYangzhou 225002China

Porphyrinoid metal-organic frameworks(MOFs)with dual effective uranium uptake sites were synthesized through combined insitu and post-synthetic *** MOF10@5 demonstrates the uptake amount of uranium reaches 1476 mg/g under visiblelight *** PN-MOF10@5 with dual uranyl uptake sites yields the amount of extracting uranyl of 1590 mg/g under visible-light *** density functional theory(DFT)calculations reveal strong interaction between uranyl and dual uranyl effective active *** MOFs demonstrate a powerful synthesis strategy for uranium extraction materials with dual effective active sites.

关键词： photocatalytic uranium extraction metal-organic framework(MOF) dual active sites in-suit synthesis post-synthetic

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High-sensitivity formaldehyde gas sensor based on Ce-doped urchin-like SnO_(2) nanowires derived from calcination of Sn-MOFs

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Frontiers of Materials Science 2024年第1期18卷 29-43页

作者： wei xiao wei Yang Shantang Liu Hubei Key Lab of Novel Reactor&Green Chemical Technology School of Chemistry and Environmental EngineeringWuhan Institute of TechnologyWuhan 430073China Hubei Key Laboratory of Wudang Local Chinese Medicine Research Department of ChemistrySchool of Pharmaceutical SciencesHubei University of MedicineShiyan 442000China

Metal-organic frameworks(MOFs)have attracted widespread attention due to their regular structures,multiple material centers,and various *** are always considered as one kind of ideal templates for developing highly sensitive and selective gas *** this study,the advantages of MOFs with the high specific surface area(71.9891 m^(2)·g^(-1))and uniform morphology were fully utilized,and urchin-like SnO_(2) nanowires were obtained by the hydrothermal method followed by the calcination using Sn-MOFs consisting of the ligand of C_(9)H_(6)O_(6)(H_(3)BTC)and Sn/Ce center ions as sacrificial *** unique urchin-like nanowire structure facilitated gas diffusion and adsorption,resulting in superior gas sensitivity.A series of Ce-doped SnO_(2) nanowires with different doping ratios were synthesized,and their gas sensing properties towards formaldehyde were *** resulted Ce-SnO_(2) was revealed to have high sensitivity(201.2 at 250℃),rapid response(4 s),long-term stability,and good repeatability for formaldehyde sensing,and the gas sensing mechanism of Ce-SnO_(2) exposed to formaldehyde was also systematically discussed.

关键词： Ce-SnO_(2) SnO_(2) gas sensor formaldehyde Sn-MOF

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Impaired implicit emotion regulation in patients with panic disorder:An event-related potential study on affect labeling

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World Journal of Psychiatry 2024年第2期14卷 234-244页

作者： Hai-Yang Wang Li-Zhu Li Yi Chang xiao-Mei pang Bing-wei Zhang Department of Neurology Jining No.1 People's HospitalShandong First Medical UniversityJining 272000Shandong ProvinceChina Department of Neurology and Psychiatry First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina Department of Neurology Sixth Peoples'Hospital of ShenyangShenyang 110003Liaoning ProvinceChina

BACKGROUND Panic disorder(PD)involves emotion dysregulation,but its underlying mechanisms remain poorly *** research suggests that implicit emotion regulation may play a central role in PD-related emotion dysregulation and symptom ***,there is a lack of studies exploring the neural mechanisms of implicit emotion regulation in PD using neurophysiological *** To study the neural mechanisms of implicit emotion regulation in PD with eventrelated potentials(ERP).METHODS A total of 25 PD patients and 20 healthy controls(HC)underwent clinical *** study utilized a case-control design with random sampling,selecting participants for the case group from March to December *** performed an affect labeling task,using affect labeling as the experimental condition and gender labeling as the control *** and behavioral data were recorded to compare the late positive potential(LPP)within and between the *** Both PD and HC groups showed longer reaction times and decreased accuracy under the affect *** the HC group,late LPP amplitudes exhibited a dynamic pattern of initial increase followed by ***,a significant group×condition interaction effect was *** effect analysis revealed a reduction in the differences of late LPP amplitudes between the affect labeling and gender labeling conditions in the PD group compared to the HC ***,among PD patients under the affect labeling,the late LPP was negatively correlated with disease severity,symptom frequency,and *** PD patients demonstrate abnormalities in implicit emotion regulation,hampering their ability to mobilize cognitive resources for downregulating negative *** late LPP amplitude in response to affect labeling may serve as a potentially valuable clinical indicator of PD severity.

关键词： Panic disorder Implicit Emotion regulation Affect labeling Late positive potential

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Investigation of mechanical and electrical characteristics of selfsensing pneumatic torsional actuators

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Science China(Technological Sciences) 2024年第1期67卷 130-142页

作者： xiao wei HU DeAn HU GuoLiang xiao YiHua Key Laboratory of Conveyance and Equipment Ministry of EducationEast China Jiaotong UniversityNanchang 330013China Key Laboratory of Advanced Design and Simulation Techniques for Special Equipment Ministry of EducationHunan UniversityChangsha 410082China

Soft pneumatic actuators are one of the most promising actuation for soft robots,and great achievements have been *** it remains challenging to endow sensing capabilities to pneumatic actuators,especially for the sensing ability originating directly from the actuator ***,a self-sensing pneumatic torsional actuator(SPTA)is designed based on the electromagnetic induction effect and magnetically responsive *** SPTA can generate feedback voltage and current with the deformation,in which the sensing function comes from its inherent *** investigate the mechanical and electrical characteristics,an experimental platform and a finite element model are established,*** find that the torsion angle and output torque increase in nonlinear with the actuating *** maximum torsion angle is 66.35°,which is 84.34%of that for the actuator fabricated by pure *** maximum output torque(24.9 N mm)improves by 23.19%compared with the actuator made by pure *** regards the electrical characteristics,the maximum feedback voltage and current are 2.90μV and 29.50 nA when the SPTA is actuated by a pressure of−40 *** also demonstrate that the relationship between the torsion angle and the magnetic flux change is approximately ***,the number of turns of wires,magnetic powders contents,and magnetic direction on the feedback voltage and current are *** show that the feedback voltage and current can be enhanced by increasing the number of turns and magnetic powders *** envision that the SPTA would be promising for soft robots to realize their accuracy control and intelligentization.

关键词： pneumatic torsional actuators self-sensing feedback voltage finite element modeling soft robots

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Thermodynamic nature of black holes in coexistence region

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 27-32页

作者： Shao-Wen wei Yu-xiao Liu Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Provinceand Key Laboratory of Quantum Theory and Applications of Mo ELanzhou UniversityLanzhou 730000China Institute of Theoretical Physics&Research Center of Gravitation Lanzhou UniversityLanzhou 730000China

Studying the system state of coexistence regions will peek into to reveal microscopic interactions between different phases of a thermodynamic ***,there is no effective method to study thermodynamic nature of the coexistence black hole regions for the failure of the equation of *** at these coexistence states,in this work,we develop a general approach by introducing two new ratio *** first one is the ratio of the horizon radii of the saturated coexistence small and large black holes,and the second one measures that of the small black hole molecule number to the total molecule *** demonstrate that the first parameter can serve as an order parameter to characterize the first-order phase *** study also shows that the black hole state in the coexistence region is uniquely determined by these two introduced parameters bounded between 0 and *** results are quite significant in the analytical study of phase transition and the microscopic nature of black hole in the coexistence regions.

关键词： transition. state. thermodynamic

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A Numerical Calculation Algorithm of the Inclination Function Based on the Representation of SO(3) Group

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 137-148页

作者： Yu-xiao wei Wen-lin Tang Department of Geophysics School of Geology Engineering and GeomaticsChang’An UniversityXi’an710064China Key Laboratory of Electronics and Information Technology for Space Systems National Space Science CenterChinese Academy of SciencesBeijing100190China

In the determination of the Earth gravity field in satellite geodesy, the inclination functions represent the projection of data observed along the orbital plane of a satellite orbit into the sphere in the terrestial reference frame. The inclination functions in this work is studied from a group theoretical perspective. The inclination functions are proved to generate a representation of the SO(3) group. An orthogonal relation of the inclination functions is derived and some recurrence relations for the inclination functions are given, based on which an algorithm to calculate the inclination functions is proposed.

关键词： SO(3)group inclination function satellite geodesy representation of SO(3)

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Trace formula of the integro-differential operator on a quantum graph

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 311-318页

作者： wei Li-xiao YANG Chuan-fu School of Mathematics and Statistics Nanjing University of Science and TechnologyNanjing 210094China.

In this paper we study the eigenvalue problem for integro-differential operators on a lasso *** trace formula of the operator is established by applying the residual technique in complex analysis.

关键词： integro-differential operators eigenvalue trace formula

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Joint Sample Position Based Noise Filtering and Mean Shift Clustering for Imbalanced Classification Learning

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Tsinghua Science and Technology 2024年第1期29卷 216-231页

作者： Lilong Duan wei Xue Jun Huang xiao Zheng School of Computer Science and Technology Anhui University of TechnologyMaanshan 243032China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China

The problem of imbalanced data classification learning has received much *** classification algorithms are susceptible to data skew to favor majority samples and ignore minority *** weighted minority oversampling technique(MWMOTE)is an effective approach to solve this problem,however,it may suffer from the shortcomings of inadequate noise filtering and synthesizing the same samples as the original minority *** this end,we propose an improved MWMOTE method named joint sample position based noise filtering and mean shift clustering(SPMSC)to solve these ***,in order to effectively eliminate the effect of noisy samples,SPMsC uses a new noise filtering mechanism to determine whether a minority sample is noisy or not based on its position and distribution relative to the majority *** that MWMOTE may generate duplicate samples,we then employ the mean shift algorithm to cluster minority samples to reduce synthetic replicate ***,data cleaning is performed on the processed data to further eliminate class *** on extensive benchmark datasets demonstrate the effectiveness of SPMsC compared with other sampling methods.

关键词： imbalanced data classification oversampling noise filtering clustering

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Evolutionary game analysis of shared parking market diffusion under government management

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Transportation Safety and Environment 2024年第3期6卷 17-27页

作者： Qingqi wei Guomei xiao School of Economics and Management Chongqing Jiaotong UniversityChongqing 400074China

The imbalance between supply and demand in urban settings poses a significant barrier to the sustainable advancement of urban *** parking serves as a viable solution to mitigate these ***,for its sustained growth,a regulatory mechanism enforced by the government is *** promote shared parking market diffusion,we construct an evolutionary game model that incorporates the government,enterprises and parking *** explores stabilization strategies for these stakeholders and identifies multiple equilibrium states under different parameter *** results show that the rate and stability of these evolutionary strategies are constrained by the mutual benefits derived by the three ***,such stakeholders are reciprocally influenced by their willingness to engage in shared parking to varying *** subsidies serve as a determining factor for the strategic choices made by both enterprises and demanders,albeit at different evolutionary *** who have a higher value of time tend to park on-street,thereby influencing enterprise *** foster the long-term growth of the shared parking market,the government must enact appropriate subsidy policies,maintain consistent regulations and advocate for increased subsidies for parking demanders to reduce the effect of temporal heterogeneity on parking behavioural choices.

关键词： traffic management shared parking government management parking behaviour choice evolutionary game

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