Signaling pathways involved in ischemic stroke:molecular mechanisms and therapeutic interventions
作者机构：Department of NeurologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2022年第7卷第8期
页 面：2733-2761页
核心收录：
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
基 金：funded by National Natural Science Foundation of China(Grants:82071380,81873743,81801223) Tongji Hospital(HUST)Foundation for Excellent Young Scientist(Grant No.2020YQ06)
主 题：therapeutic injuries protective
摘 要：Ischemic stroke is caused primarily by an interruption in cerebral blood flow,which induces severe neural injuries,and is one of the leading causes of death and disability ***,it is of great necessity to further detailly elucidate the mechanisms of ischemic stroke and find out new therapies against the *** recent years,efforts have been made to understand the pathophysiology of ischemic stroke,including cellular excitotoxicity,oxidative stress,cell death processes,and *** the meantime,a plethora of signaling pathways,either detrimental or neuroprotective,are also highly involved in the forementioned *** pathways are closely intertwined and form a complex signaling ***,these signaling pathways reveal therapeutic potential,as targeting these signaling pathways could possibly serve as therapeutic approaches against ischemic *** this review,we describe the signaling pathways involved in ischemic stroke and categorize them based on the pathophysiological processes they participate *** approaches targeting these signaling pathways,which are associated with the pathophysiology mentioned above,are also ***,clinical trials regarding ischemic stroke,which potentially target the pathophysiology and the signaling pathways involved,are summarized in ***,this review elucidated potential molecular mechanisms and related signaling pathways underlying ischemic stroke,and summarize the therapeutic approaches targeted various pathophysiology,with particular reference to clinical trials and future prospects for treating ischemic stroke.
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