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Effects of surface roughness on overflow discharge of embankment weirs

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Journal of Hydrodynamics 2021年第4期33卷 773-781页

作者： Shang-tuo Qian Yan Zhang Hui Xu xiao-sheng wang Jian-gang Feng Zhi-xiang Li College of Agricultural Science and Engineering Hohai UniversityNanjing210098China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210098China Power China Huadong Engineering Corporation Limited Hangzhou311122China

A numerical study was performed on the embankment weir overflows with various surface roughness and tailwater submergence, to better understand the effects of weir roughness on discharge performances under the free and submerged conditions. The variation of flow regime is captured, from the free overflow, submerged hydraulic jump, to surface flow with increasing tailwater depth. A roughness factor is introduced to reflect the reduction in discharge caused by weir roughness. The roughness factor decreases with the roughness height, and it also depends on the tailwater depth, highlighting various relations of the roughness factor with the roughness height between different flow regimes, which is linear for the free overflow and submerged hydraulic jump while exponential for the surface flow. Accordingly, the effects of weir roughness on overflow discharge appear nonnegligible for the significant roughness height and the surface flow regime occurring under considerable tailwater submergence. The established empirical expressions of discharge coefficient and submergence and roughness factors make it possible to predict the discharge over embankment weirs considering both tailwater submergence and surface roughness.

关键词： Discharge embankment weir numerical simulation tailwater submergence surface roughness

Identification of genomic features associated with immunotherapy response in gastrointestinal cancers

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World Journal of Gastrointestinal Oncology 2019年第4期11卷 270-280页

作者： Yin He Zhi-Xian Liu Ze-Hang Jiang xiao-sheng wang Biomedical Informatics Research Lab School of Basic Medicine and Clinical Pharmacy Cancer Genomics Research Center School of Basic Medicine and Clinical Pharmacy Big Data Research Institute China Pharmaceutical University

Gastrointestinal(GI) cancers prevail and account for an extremely high number of cancer deaths worldwide. The traditional treatment strategies, including surgery, chemotherapy, radiotherapy, and targeted therapy, have a limited therapeutic effect for advanced GI cancers. Recently, immunotherapy has shown promise in treating various refractory malignancies, including the GI cancers with mismatch repair deficiency(dMMR) or microsatellite instability(MSI). Thus,immunotherapy could be a promising treatment approach for GI ***, only a small proportion of GI cancer patients currently respond to immunotherapy. Therefore, it is important to discover predictive biomarkers for stratifying GI cancer patients response to immunotherapy. Certain genomic features, such as dMMR/MSI, tumor mutation burden(TMB), and tumor aneuploidy have been associated with tumor immunity and im-munotherapy response and may serve as predictive biomarkers for cancer immunotherapy. In this review, we examined the correlations between tumor immunity and three genomic features: dMMR/MSI, TMB, and tumor aneuploidy. We also explored their correlations using The Cancer Genome Atlas data and confirmed that the dMMR/MSI status, high TMB, and low tumor aneuploidy are associated with elevated tumor immunity in GI cancers. To improve the immunotherapeutic potential in GI cancers, more genetic or genomic features associated with tumor immune response need to be identified. Furthermore, it is worth exploring the combination of different immunotherapeutic methods and the combination of immunotherapy with other therapeutic approaches for cancer therapy.

关键词： Gastrointestinal cancer Tumor immunity Tumor immunotherapy DNA mismatch repair Tumor mutation burden Tumor aneuploidy

Immunological classification of hepatitis B virus-positive hepatocellular carcinoma by transcriptome analysis

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World Journal of Hepatology 2022年第12期14卷 1997-2011页

作者： sheng-Wei Li Li-Fan Han Yin He xiao-sheng wang Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjing 211198Jiangsu ProvinceChina

BACKGROUND Hepatitis B virus(HBV)infection is a major factor responsible for HBV+hepatocellular carcinoma(HCC).AIM An immunological classification of HBV+HCC may provide both biological insights and clinical implications for this *** Based on the enrichment of 23 immune signatures,we identified two immunespecific subtypes(Imm-H and Imm-L)of HBV+HCC by unsupervised *** showed that this subtyping method was reproducible and predictable by analyzing three different *** Compared to Imm-L,Imm-H displayed stronger immunity,more stromal components,lower tumor purity,lower stemness and intratumor heterogeneity,lower-level copy number alterations,higher global methylation level,and better overall and disease-free survival *** immune-related pathways,stromal pathways(ECM receptor interaction,focal adhesion,and regulation of actin cytoskeleton)and neuro-related pathways(neuroactive ligand-receptor interaction,and prion diseases)were more highly enriched in Imm-H than in *** identified nine proteins differentially expressed between Imm-H and Imm-L,of which MYH11,PDCD4,Dvl3,and Syk were upregulated in Imm-H,while PCNA,Acetyl-a-Tubulin-Lys40,ER-α_pS118,Cyclin E2,andβ-Catenin were upregulated in *** Our data suggest that“hot”tumors have a better prognosis than“cold”tumors in HBV+HCC and that“hot”tumors respond better to immunotherapy.

关键词： Hepatitis B virus Hepatocellular carcinoma Immunological classification Transcriptomics Tumor immunity Cancer immunotherapy

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

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Infectious Diseases of Poverty 2020年第2期9卷 23-29页

作者： Meng-Yuan Li Lin Li Yue Zhang xiao-sheng wang Biomedical Informatics Research Lab School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 211198China Big Data Research Institute China Pharmaceutical UniversityNanjing 211198China Pinghu hospital of Shenzhen University Shenzhen 440307China Futian Hospital for Rheumatic Diseases Shenzhen 518000China Department of Rheumatology and Immunology The First Clinical College of Harbin Medical UniversityHarbin 150001China

Background:Since its discovery in December 2019,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has infected more than 2180000 people worldwide and has caused more than 150000 deaths as of April 16,***-CoV-2,which is the virus causing coronavirus disease 2019(COVID-19),uses the angiotensin-converting enzyme 2(ACE2)as a cell receptor to invade human ***,ACE2 is the key to understanding the mechanism of SARS-CoV-2 *** study is to investigate the ACE2 expression in various human tissues in order to provide insights into the mechanism of SARS-CoV-2 ***:We compared ACE2 expression levels across 31 normal human tissues between males and females and between younger(ages≤49 years)and older(ages>49 years)persons using two-sided Student's t *** also investigated the correlations between ACE2 expression and immune signatures in various tissues using Pearson's correlation ***:ACE2 expression levels were the highest in the small intestine,testis,kidneys,heart,thyroid,and adipose tissue,and were the lowest in the blood,spleen,bone marrow,brain,blood vessels,and ***2 showed medium expression levels in the lungs,colon,liver,bladder,and adrenal ***2 was not differentially expressed between males and females or between younger and older persons in any *** the skin,digestive system,brain,and blood vessels,ACE2 expression levels were positively associated with immune signatures in both males and *** the thyroid and lungs,ACE2 expression levels were positively and negatively associated with immune signatures in males and females,respectively,and in the lungs they had a positive and a negative correlation in the older and younger groups,***:Our data indicate that SARS-CoV-2 may infect other tissues aside from the lungs and infect persons with different sexes,ages,and races *** different host immune responses to SARS-CoV-2 infection may partially explain why males and femal

关键词： SARS-CoV-2 COVID-19 SARS-CoV-2 cell receptor Angiotensin-converting enzyme 2 Gene expression SARS-CoV-2 pandemic Immune signatures

Effects of adenovirus-mediated human cyclooxygenase-2 antisense RNA on the growth of hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第39期11卷 6110-6114页

作者： xiao-Hu wang sheng-Bao Li Qiang Tong Guo-Jian Xie Qing-Ming Wu Department of Gastroenterology Taihe Hospital Yunyang Medical College Shiyan 442000 Hubei Province China

AIM: To investigate the relation between the expression of cyclooxygenase-2 (COX-2) and liver cancer, to construct the recombinant adenovirus encoding human COX-2antisense RNA, and to explore its effects on liver cancer cell ***: We studied the expression of COX-2 in 34cases of hepatocellular carcinoma (HCC) and SMMC7402and SMMC7721 by immunohistochemical *** adenovirus Ad-AShcox-2 was constructed and transfected into human HCC cell lines SMMC7402and SMMC7721, and its effects on COX-2 expression, cell apoptosis and cell cycle were analyzed by flow *** proliferation was determined by colony-forming ***: We observed COX-2 expression in 82.4% of HCC and SMMC7402 cells, but no COX-2 expression in SMMC7721 cells. In addition, recombinant adenovirus encoding antisense COX-2 fragment Ad-AShcox-2 was obtained with the titer of 1.06× 1012 PFU/mL. Ad-AShcox-2 could reduce the expression of COX-2 and enhance the percentage of cells in G1/G0 phase in SMMC7402 cell *** difference of apoptotic index between the Ad-AShcox2 group and control group was statistically significant(tcontrol group= 32.62 and tAd-LacZ= 10.93, P＜0.001) in SMMC7402 but not in SMMC7721. Similarly, colony-forming rates of SMMC7402 and SMMC7721 cell lines, after the transfer of Ad-AShcox-2, were (2.7±0.94)% and(33.6±4.24)%, ***: Reduction in the expression of COX-2 can inhibit COX-2 expressing HCC cells.

关键词： Adenovirus Cyclooxygenase-2 Antisense RNA Hepatocellular carcinoma

Ginsenoside Rg1 inhibits proliferation of vascular smooth muscle cells stimulated by tumor necrosis factor-α

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Acta Pharmacologica Sinica 2006年第8期27卷 1000-1006页

作者： Zeng-chun MA Yue GAO~2 Yu-guang wang Hong-ling TAN Cheng-rong xiao sheng-qi wang Institute of Radiation Medicine Sciences,Academy of Military Medical Sciences,Beijing 100850,China Institute of Radiation Medicine Sciences Academy of Military Medical Sciences Beijing 100850 China

Aim:To investigate the proliferation of vascular smooth muscle cells(VSMC)affected by ginsenoside Rg1 and further explore the molecular mechanism ofginsenoside Rg1 using ***:The proliferation of VSMC wasmeasured by MTS assay kit and flow *** alterations were ana-lyzed using two-dimensional electrophoresis and peptide mass *** proteins found in proteomics were confirmed by ***:The proliferation of VSMC was enhanced significantly after tumor necrosis fac-tor-α(TNF-α)treatment,and ginsenoside Rg1 treatment inhibited proliferation ina dose-dependent *** analysis showed 24 protein spots werechanged,including 17 spots that were increased and 7 spots that were *** Rg1 could restore the expression levels of these proteins,at leastpartly,to basic levels of untreated *** expression of G-protein coupledreceptor kinase,protein kinase C(PKC)-ζ,N-ras protein were decreased,whilecycle related protein p21 was increased by ginsenoside Rgl in TNF-α ***:PKC-ζ and p21 pathway might be the mechanism for inhibi-tory effects of ginsenoside Rg1 on proliferation of VSMC.

关键词： cell cycle ginsenoside Rg1 proteomics tumor necrosis factor-α vascular smooth muscle cells

超高碱度连铸保护渣固渣膜凝固和结晶行为特性

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钢铁研究学报 2018年第1期30卷 21-25页

作者：龙潇何生平王谦重庆大学材料科学与工程学院

针对工业应用的超高碱度保护渣（二元碱度为1.74）,采用改进后的水冷铜探头浸入液渣,设置不同的探头浸入时间获取不同凝固阶段的渣膜。分析了固渣膜的生长速度、渣膜总体孔隙率、渣膜凝固结晶和渣膜内的脱玻璃化过程。结果表明,渣膜凝... 详细信息

针对工业应用的超高碱度保护渣（二元碱度为1.74）,采用改进后的水冷铜探头浸入液渣,设置不同的探头浸入时间获取不同凝固阶段的渣膜。分析了固渣膜的生长速度、渣膜总体孔隙率、渣膜凝固结晶和渣膜内的脱玻璃化过程。结果表明,渣膜凝固初期（0～15 s）玻璃层平均生长速度较快,为79.9μm/s。固渣膜脱玻璃化析出主要矿相为细小球状钠氟石（2CaO·SiO2·NaF）,固渣膜玻璃层脱玻璃化平均速度可达65μm/s。靠近液渣的外层渣膜矿相为板条状枪晶石（3CaO·2SiO2·CaF2）,该板条状枪晶石的凝固生长速度较慢,但使固渣膜的整体孔隙率在凝固后期维持在较高水平,相对降低了固渣膜的有效导热系数。

关键词：保护渣超高碱度脱玻璃化结晶孔隙率矿相

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包晶钢连铸保护渣固渣膜生长及成分偏析试验

钢铁 2017年第5期52卷 43-46,86页

作者：龙潇何生平王谦重庆大学材料科学与工程学院重庆400044

保护渣渣膜的形态及性能对提高连铸坯质量及稳定连铸生产起着至关重要的作用。采用改进型水冷铜探头冷凝获取不同探头浸入时间下的包晶钢保护渣固渣膜,通过光学显微镜及SEM观察方法检测及评价保护渣渣膜的内部结构特性,并结合SEM-EDX检... 详细信息

保护渣渣膜的形态及性能对提高连铸坯质量及稳定连铸生产起着至关重要的作用。采用改进型水冷铜探头冷凝获取不同探头浸入时间下的包晶钢保护渣固渣膜,通过光学显微镜及SEM观察方法检测及评价保护渣渣膜的内部结构特性,并结合SEM-EDX检测了渣膜不同部位各主要成分的偏析情况,分析了渣膜凝固过程中凝固前沿元素的偏聚规律。研究结果表明,本渣系及试验条件下,保护渣渣膜主要晶体为枪晶石与三斜霞石;枪晶石凝固析晶过程中凝固前沿成分变化促进了三斜霞石等高熔点相在渣膜凝固前沿与枪晶石混合析出,使得固渣膜厚度迅速增加。

关键词：保护渣固渣膜矿相成分偏析

拼接干涉技术在同步辐射领域的发展现状及趋势

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光学精密工程 2016年第10期24卷 2357-2369页

作者：刘丁枭盛伟繁王秋实李明中国科学院高能物理研究所北京同步辐射装置X射线光学与技术实验室北京100049

针对同步辐射领域光学元件的口径逐渐增大,其面形测量精度的要求已达到纳弧度级的问题,本文研究了该领域先进的面形测量方法——拼接干涉技术,以实现光学元件的高分辨率二维测量。介绍了拼接干涉技术的基本原理,综述了目前同步辐射光学... 详细信息

针对同步辐射领域光学元件的口径逐渐增大,其面形测量精度的要求已达到纳弧度级的问题,本文研究了该领域先进的面形测量方法——拼接干涉技术,以实现光学元件的高分辨率二维测量。介绍了拼接干涉技术的基本原理,综述了目前同步辐射光学领域常用的面形测量设备——激光光束长程面形仪、高精度自准直纳米测量仪,以及拼接干涉仪的发展历程和特点,比较了它们各自的缺点和优势。最后,分析了拼接干涉涉及的主要误差来源,指出该技术的应用和发展趋势主要有拼接算法的创新,干涉仪测量的快速化,拼接干涉仪的商业化,以及拼接干涉技术与其他科学技术的融合等。

关键词：光学元件面形检测拼接干涉术同步辐射综述