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Involvement of interstitial cells of Cajal in experimental severe acute pancreatitis in rats

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World Journal of Gastroenterology 2013年第14期19卷 2179-2186页

作者： Liang-Liang Shi Ming-Dong Liu Min Chen xiao-ping zou Department of Gastroenterology Medical Schoolthe Affiliated Drum Tower Hospital of Nanjing University

AIM:To observe the changes in interstitial cells of Cajal(ICC) in rats with experimental severe acute pancreatitis(SAP).METHODS:A total of twenty-four SD rats were randomly divided into two groups(n = 12),namely the sham(S) group and the SAP group;the SAP rat model was established by retrograde injection of 5% sodium taurocholate(1.0 mL/kg) into the pancreatic ***-four hours later intestinal motility was assessed by testing small intestinal propulsion rate,and then the rats were *** pancreas and jejunum were resected and underwent routine pathologic *** staining was used to detect c-kit-positive cells in the *** of c-kit mRNA was detected by real-time polymerase chain reaction,and the expression of c-kit protein was evaluated by Western *** of ICC was evaluated by transmission electron ***:There was bleeding,necrosis and a largeamount of inflammatory cell infiltration in pancreatic tissue in the SAP group,while in jejunal tissue we observed a markedly denuded mucosal layer,loss of villous tissue and a slightly dilated muscular *** small intestinal propulsion rate was 68.66% ± 2.66% in the S group and 41.55% ± 3.85% in the SAP *** with the S group,the rate of the SAP group decreased *** density of c-kit-positive cells in the SAP group was significantly lower than in the S group;the respective mean densities were 88.47 ± 10.49 in the S group and 56.11 ± 7.09 in the SAP *** levels of c-kit protein and mRNA were 0.36 ± 0.04 and 1.29 ± 0.91 in the SAP group,respectively,which were significantly lower than those in the S group(0.53 ± 0.06,0.64 ± 0.33,respectively).In the SAP group,ICC profiles showed the same change tendency,such as vacuolation of mitochondria,irregular vacuoles and loosened desmosome-like ***:Decreased c-kit-positive cells and ultrastructural changes in ICC resulting from blockade of the c-kit signaling pathway

关键词： Severe acute pancreatitis c-kit Interstitial cells of Cajal Real-time polymerase chain reaction Ultrastructure

Endoscopic submucosal dissection vs endoscopic mucosal resection for superficial esophageal cancer

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World Journal of Gastroenterology 2014年第18期20卷 5540-5547页

作者： Hui-Min Guo xiao-Qi Zhang Min Chen Shu-Ling Huang xiao-ping zou Department of Gastroenterology the Affiliated Drum Tower Hospital of Nanjing University Medical School

AIM: To investigate the effectiveness of endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR) in treating superficial esophageal cancer (SEC).

关键词： Superficial esophageal cancer Endoscopic mucosal resection Endoscopic submucosal dissection Meta-analysis

Risk factors for post-endoscopic retrograde cholangiopancreatography(ERCP) abdominal pain in patients without post-ERCP pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2022年第3期21卷 285-292页

作者： Meng-Jie Chen Ru-Hua Zheng Jun Cao Yu-Ling Yao Lei Wang xiao-ping zou Department of Gastroenterology Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjingChina Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingChina

Background:Abdominal pain is often observed after endoscopic retrograde cholangiopancreatography(ERCP).Few studies have focused on the risk factors of post-ERCP abdominal pain without post-ERCP pancreatitis(PEP).This study aimed to identify risk factors of post-ERCP abdominal pain without PEP and investigate characteristics of the abdominal pain in non-PEP ***:Data from patients who underwent ERCP from August 2019 to January 2020 were retrospectively *** of the abdominal pain after ERCP were recorded and compared between PEP and non-PEP *** analysis was conducted to identify risk factors of non-PEP abdominal ***:A total of 1295 ERCP procedures were investigated in this study,among which 100(7.72%)patients presented post-ERCP abdominal pain without PEP and 63(4.86%)patients with *** analysis found 9 risk factors of non-PEP abdominal pain:age≤65 years[odds ratio(OR):1.971],primary ERCP(OR:2.442),dilated extrahepatic bile duct(OR:1.803),no papilla opening(OR:2.095),pancreatic guidewire passages(OR:2.258),white blood cells(WBC)≤6.0×10^(9)/L(OR:1.689),platelet(PLT)≤250×10^(9)/L(OR:2.505),serumγ-glutamyl transferase(γ-GT)≤35 U/L(OR:2.190),and albumin≥40 g/L(OR:1.762).The PEP group had later pain onset,higher pain frequency and longer hospital stay than those of the non-PEP pain group(P0.05).Conclusions:This study indicated that age≤65 years,primary ERCP,dilated extrahepatic bile duct,no papilla opening,pancreatic guidewire passages,lower WBC,lower PLT,normalγ-GT and elevated albumin were independent risk factors for post-ERCP abdominal pain without *** pain occurred earlier in non-PEP patients than in PEP patients.

关键词： Post-ERCP abdominal pain Cholangiopancreatography Endoscopic retrograde Pancreatitis Risk factor

Synthesis of ultralong Si_3N_4 nanowires by a simple thermal evaporation method

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Rare Metals 2013年第2期32卷 186-190页

作者： Wen-Qi Wang xiao-ping zou Nan-Jia Zhou Guang Zhu Gui-Ying Wang Zhen-Sheng Peng Anhui Key Laboratory of Spintronics and Nano-materials (Cultivating Base) Suzhou University Research Center for Sensor Technology Beijing Key Laboratory for SensorBeijing Information Science and Technology University Department of Materials Science and Engineering Northwestern University Structure Research Laboratory University of Science and Technology of China

Largescale vaporsolid synthesis of ultralong silicon nitride （Si3N4） nanowires was achieved by using simple thermal evaporation of mixture powders of active carbon and monoxide silicon. The products were charac terized by Xray diffraction, scanning electron microscopy, energydispersive Xray spectroscopy, and transmission electron microscopy. The results suggest that the silicon nitride nanowires have a smooth surface, with lengths of up to several hundreds of microns and diameters of 100300 nm. A detailed study of both the chemical and structural composition was performed. Such ultralong sil icon nitride nanowires demonstrate potential applications as materials for constructing nanoscale devices and as reinforcement in advanced composites.

关键词： Si3N4 nanowires Ultralong Thermal evaporation

Factors affecting occurrence of gastric varioliform lesions: A case-control study

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World Journal of Gastroenterology 2016年第22期22卷 5228-5236页

作者： Tian-Hui zou Ru-Hua Zheng Qin-Yan Gao Xuan Kong xiao-Yu Chen Zhi-Zheng Ge Ying-Xuan Chen xiao-ping zou Jing-Yuan Fang Division of Gastroenterology and Hepatology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Institute of Digestive Disease Division of Gastroenterology and Hepatology the Affiliated Drum Tower Hospital of Nanjing University Medical School

AIM: To investigate the factors influencing the occurrence of gastric varioliform lesions(GVLs) and their possible link with gastric ***: A 1:1 matched case-control study was performed to retrospectively analyze data from 1638 chronic gastritis patients who had undergone gastroscopy at one of two Chinese hospitals between 2009 and 2014. Patients with GVLs(cases) were compared to those without such lesions(controls). Endoscopic and pathological findings were recorded, along with interview information on Helicobacter pylori(H. pylori) infection, medical, drug and family histories, lifestyle and eating habits. The association between each factor and the occurrence of GVLs was estimated, and then multivariate conditional logistic regression was used to evaluate the independent ***: The frequency and severity of glandular atrophy, intestinal metaplasia(IM) and low-grade intraepithelial neoplasia were significantly increased in the GVL group(P < 0.01). Overall analysis showed that H. pylori infection [3.051(2.157, 4.317), P <0.001], allergic respiratory diseases [3.636(2.183, 6.055), P < 0.001], work-related stress [2.019(1.568, 2.600), P < 0.001], irregular meals [2.300(1.462, 3.619), P < 0.001], high intake of spicy food [1.754(1.227, 2.507), P = 0.002] and high intake of fresh fruit [0.231(0.101, 0.529), P = 0.001] were significantly correlated with the occurrence of GVLs(positively, except for the latter). Stratified analyses indicated that pickled food consumption in patients over 50 years old [7.224(2.360, 22.115), P = 0.001] and excessive smoking in men [2.013(1.282, 3.163), P = 0.002] were also positively correlated, and that, for antral GVLs, vegetable consumption [0.491(0.311, 0.776), P = 0.002] was negatively correlated. CONCLUSION: Seven risk factors and two protective factors are determined for GVLs, which were found to be associated with premalignant abnormalities.

关键词： Gastric cancer Gastric varioliform lesions Precancerous lesion Risk factor Varioliform gastritis

Big-data analysis: A clinical pathway on endoscopic retrograde cholangiopancreatography for common bile duct stones

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World Journal of Gastroenterology 2019年第8期25卷 1002-1011页

作者： Wei Zhang Bing-Yi Wang xiao-Yan Du Wei-Wei Fang Han Wu Lei Wang Yu-Zheng Zhuge xiao-ping zou Department of Gastroenterology The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina Medical Division Yidu Cloud(Beijing)Technology Co.Ltd.Beijing 100101China

BACKGROUND A clinical pathway(CP)is a standardized approach for disease ***,big data-based evidence is rarely involved in CP for related common bile duct(CBD)stones,let alone outcome comparisons before and after CP *** To investigate the value of CP implementation in patients with CBD stones undergoing endoscopic retrograde cholangiopancreatography(ERCP).METHODS This retrospective study was conducted at Nanjing Drum Tower Hospital in patients with CBD stones undergoing ERCP from January 2007 to December *** data and outcomes were compared by using univariate and multivariable regression/linear models between the patients who received conventional care(non-pathway group,n=467)and CP care(pathway group,n=2196).RESULTS At baseline,the main differences observed between the two groups were the percentage of patients with multiple stones(P<0.001)and incidence of cholangitis complication(P<0.05).The percentage of antibiotic use and complications in the CP group were significantly less than those in the nonpathway group[adjusted odds ratio(OR)=0.72,95%confidence interval(CI):0.55-0.93,P=0.012,adjusted OR=0.44,95%CI:0.33-0.59,P<0.001,respectively].Patients spent lower costs on hospitalization,operation,nursing,medication,and medical consumable materials(P<0.001 for all),and even experienced shorter length of hospital stay(LOHS)(P<0.001)after the CP *** significant differences in clinical outcomes,readmission rate,or secondary surgery rate were presented between the patients in the non-pathway and CP *** Implementing a CP for patients with CBD stones is a safe mode to reduce the LOHS,hospital costs,antibiotic use,and complication rate.

关键词： Common bile duct stones Endoscopic retrograde cholangiopancreatography Clinical pathway Outcomes Costs

CDH1 promoter polymorphism(-347G→GA) is a possible prognostic factor in sporadic colorectal cancer

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World Journal of Gastroenterology 2009年第42期15卷 5340-5345页

作者： xiao-ping zou Wei-Jie Dai Jun Cao Department of Gastroenterology The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing 210008 Jiangsu Province China Department of Internal Medicine Clinical Medical Colleges of Drum Tower Nanjing Medical University Nanjing 210029 Jiangsu Province China

AIM:To investigate the role of the-347G→GA polymorphism in the progression of colorectal cancer(CRC) .METHODS:We designed a case-control study based on a population of CRC patients in China and normal healthy controls with no history of tumors or inherited *** chain reaction-restriction fragment length polymorphism(PCR-RFLP) analyses were used to genotype the variants,and immunohistochemical staining was performed to measure the expression of E-cadherin in different allele cases among the CRC patients and normal ***:The GA-allele(G/GA heterozygous and GA/GA homozygous) did not increase the risk of CRC compared with the G-allele(OR = 1.232,95% CI = 0.898-1.691) .However,the frequencies of the GAallele were higher in poorly differentiated(P = 0.002) and proximal(P = 0.019) CRC patients than in normal *** also observed that E-cadherin expression was lower in poorly differentiated CRC patients than in well differentiated CRC patients(P = 0.001) .Furthermore,E-cadherin expression was lower for the GA-allele than for the G-allele(G/G heterozygous) in CRC patients(P = 0.018) .In contrast,there was no significant difference in E-cadherin expression for the G-allele and GA-allele in normal controls(P = 0.292) .CONCLUSION:The-347G→GA promoter polymorphism in E-cadherin gene is associated with specific CRC features,and may be a prognostic factor rather than a susceptibility factor during the progression of CRC.

关键词： Allele Colorectal cancer E-cadherin Polymorphism Prognosis

Lymphoepithelial cyst of the pancreas: a case report

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Hepatobiliary & Pancreatic Diseases International 2004年第1期3卷 155-157页

作者： xiao-ping zou Yu-Mei Li Zhao-Shen Li Guo-Ming Xu Department of Internal Medicine Changhai Hospital Second Military Medical University Shanghai 200433 China. zxpfcp@***

BACKGROUND: Lymphoepithelial cyst of the pancreas is a rare lesion of undetermined pathogenesis that had been documented almost exclusively in males. The literature on this entity is limited to reports of single or a small number of cases.METHODS: The case we described herein was compared with a total of 36 cases reported elsewhere.RESULTS: The 37 cases of lymphoepithelial cyst of the pancreas including our case were reviewed. Lymphoepithelial cysts have uniform and distinctive clinicopathologic features. Approximately 46% of the reported cases were asymptomatic with the lesions found incidentally, and their symptoms were non-specific.CONCLUSIONS: Lymphoepithelial cyst is a rare benign lesion of the pancreas. Fine-needle aspiration biopsy (FNAB) is a rapid and reliable technique that can be used as the first diagnostic step in cases of cystic lesions of the pancreas.

关键词： lymphoepithelial cyst pancreas

Risk factor analysis of post-ERCP cholangitis: A single-center experience

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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 55-58页

作者： Min Chen Lei Wang Yun Wang Wei Wei Yu-Ling Yao Ting-Sheng Ling Yong-Hua Shen xiao-ping zou Department of Gastroenterology The Affiliated Drum Tower Hospital of Nanjing University Medical School Department of Gastrointestinal Surgery The Second Affiliated Hospital of Nanjing Medical University

Background: Endoscopic retrograde cholangiopancreatography(ERCP) may have complications. Our study aimed to investigate the risk factors and prevention of post-ERCP ***: We retrospectively analyzed 4234 cases undergone ERCP in the Affiliated Drum Tower Hospital of Nanjing University Medical School from January 2008 to December 2013. Patient-related factors and procedure-related factors were analyzed to find the risk factors of post-ERCP cholangitis. The time point of post-ERCP cholangitis was also analyzed. Univariate and multivariate analyses were performed to define the independent risk factors of post-ERCP ***: The success rate of ERCP was 96.8%(4099/4234). The overall complication rate was 9.4%(399/4234). Post-ERCP cholangitis occurred in 102 cases(2.4%, 102/4234). The most dangerous time of post-ERCP cholangitis was from 24 h–48 h after ERCP(45.1%, 46/102). Univariate analysis revealed that age, hypertension, diabetes, previous ERCP history, biliary stent insertion, pancreatography, endoscopic sphincterotomy, balloon dilation and hilar obstruction were risk factors of post-ERCP cholangitis(P < 0.05). Multivariate analysis indicated that age, previous ERCP history and hilar obstruction were independent risk factors(P < 0.05). While endoscopic stone extraction was the potential protective ***: Many risk factors are involved in post-ERCP cholangitis. Among them, old age, previous ERCP history and hilar obstruction were independently related to this post-ERCP complication.

关键词： Cholangitis Endoscopic retrograde cholangiopancreatography Risk factors Logistic regression analysis