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Genetic Prion Disease:Insight from the Features and Experience of China National Surveillance for Creutzfeldt-Jakob Disease

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Neuroscience Bulletin 2021年第11期37卷 1570-1582页

作者： Qi Shi Cao Chen Kang xiao Wei Zhou Li-ping Gao dong-dong Chen Yue-Zhang Wu Yuan Wang Chao Hu Chen Gao xiao-ping dong State Key Laboratory for Infectious Disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases(Zhejiang University)National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing102206China Center for Global Public Health Chinese Center for Disease Control and PreventionBeijing102206China Center for Biosafety Mega-Science Chinese Academy of SciencesWuhan430064China China Academy of Chinese Medical Sciences Beijing100700China

Human genetic prion diseases(gPrDs)are directly associated with mutations and insertions in the PRNP(Prion Protein)*** collected and analyzed the data of 218 Chinese gPrD patients identified between Jan 2006 and June *** different subtypes were identified and gPrDs accounted for 10.9%of all diagnosed PrDs within the same *** subtypes of gPrDs showed a degree of geographic *** age at onset of Chinese gPrDs peaked in the 50–59 year ***–Sträussler–Scheinker syndrome(GSS)and fatal familial insomnia(FFI)cases usually displayed clinical symptoms earlier than genetic Creutzfeldt–Jakob disease(gCJD)patients with point mutations.A family history was more frequently recalled in P105L GSS and D178N FFI patients than T188K and E200K *** of the E196A gCJD patients reported a family *** gCJD cases with point mutations always developed clinical manifestations typical of sporadic CJD(sCJD).EEG examination was not sensitive for ***-associated abnormalities on MRI were found in high proportions of GSS and gCJD *** 14-3-3 positivity was frequently detected in gCJD *** CSF tau was found in more than half of FFI and T188K gCJD cases,and an even higher proportion of E196A and E200K gCJD patients.63.6%of P105L GSS cases showed a positive reaction in cerebrospinal fluid *** and FFI cases had longer durations than most subtypes of *** is one of the largest studies of gPrDs in East Asians,and the illness profile of Chinese gPrDs is clearly *** high proportions of T188K and E196A occur among Chinese gPrDs;these mutations are rarely reported in Caucasians and Japanese.

关键词： Genetic prion disease Mutation Surveillance Creutzfeldt-Jakob disease Gerstmann-Sträussler-Scheinker syndrome Fatal familial insomnia

Asymmetric aza-Henry reaction with α-substituted nitroacetates catalyzed by a bifunctional thiourea-guanidine catalyst

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Chinese Chemical Letters 2011年第8期22卷 923-926页

作者： Bo Han Wei Huang Zhen Rui Xu xiao ping dong State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu 611137 China State Key Laboratory of Oral Diseases Department of Orthodontics West China College of Stomatolgy Sichuan University Chengda 610041 China

The asymmetric aza-Henry reaction of α-substituted nitroacetates and N-Boc imines was achieved with a new-type thioureaguanidine bifunctional *** novel transformations exhibited high diastereoselectivities,and the adducts bearing adjacent quaternary and tertiary chiral centers were generally obtained in moderate to good enantioselectivities（up to 88%ee）.

关键词： Aza-Henry reaction Thiourea Guanidine Nitroacetate Organocatalysis

Effect of Spark Plasma Sintering Temperature on Electrochemical Properties of La_(0. 82)Mg_(0. 18)Ni_(3. 50)Co_(0. 15) Alloy

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Journal of Iron and Steel Research International 2016年第5期23卷 459-465页

作者： xiao-ping dong Yan-rong PANG Li-ying YANG Qing WANG Zhi-yuan LI Department of Mechanics Hebei University

Electrochemical properties of La_（0. 82）Mg_（0. 18）Ni_（3. 50）Co_（0. 15） alloys synthesized by spark plasma sintering（ SPS） were investigated based on the electrochemical measurements,physical parameters and microstructure observation. The sintering behavior of La_（0. 82）Mg_（0. 18）Ni_（3. 50）Co_（0. 15） alloys at the temperatures of 900,950 and 1 000 ℃ is characterized by four stages,i. e.,initial slight shrinkage,expansion,abrupt shrinkage and slight expansion. The maximum shrinkage displacement increases with increasing sintering temperature. All of the alloys consist of（ La,Mg）_2（ Ni,Co）_7 phase; additionally,temperatures of 900 and 950 ℃ are beneficial to the formation of（ La,Mg）（ Ni,Co）_3 phase,whereas the LaNi_5 phase is easy to form in the alloy synthesized by SPS at 1 000 ℃. The electrochemical measurements indicate an evident change of the electrochemical performance of the alloys associated with increasing the sintering temperature. The discharge capacity of the alloys first increases and then decreases as sintering temperature rises,whereas their cycle stability clearly grows all the ***,the charging-discharging potential difference and discharging efficiency both demonstrate that the electrochemical properties of the alloy electrodes first augment and then decline with increasing sintering temperature.

关键词： spark plasma sintering La-Mg-Ni system microstructure electrochemical property

Teleportation for an Unknown Entangled State Without Any Joint Measurement via Josephson Charge Qubits

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Communications in Theoretical Physics 2008年第5期49卷 1195-1198页

作者： LI Da-Chuang ZHENG xiao-Hu dong ping CAO Zhuo-Liang Key Laboratory of Opto-electronic Information Acquisition and Manipulation Ministry of Education School of Physics＆ Material Science Anhui University Hefei 230039 China

An experimentally feasible scheme for teleportation of an arbitrary unknown entangled state is proposed. Our scheme is based on Josephson charge qubits, where we do not need any joint measurement. Moreover the successful probability and fidelity of the teleportation can both reach 1.0. The current scheme can be realized within the current experimental technology.

关键词： quantum teleportation Bell-state measurement Josephson charge qubits

Structure and electrochemical performances of as-milled LaMg12-type alloy-Ni composites

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Journal of Iron and Steel Research International 2019年第1期26卷 59-68页

作者： Wen-gang Bi Wei Zhang Jin-liang Gao Yan Qi dong-liang Zhao xiao-ping dong Yang-huan Zhang Department of Functional Material Research Central Iron and Steel Research InstituteBeijing 100081China Key Laboratory of Integrated Exploitation of Baiyun Obo Multi-Metal Resources Inner Mongolia University of Science and TechnologyBaotou 014010Inner MongoliaChina Weishan Cisri-Eare Earth Materials Co. LtdJining 277600ShandongChina Department of Mechanical Engineering Hebei UniversityBaoding 071002HebeiChina

LaMg11Ni+x wt.%Ni(x=100,200)alloys were prepared by ball milling and researched by various methods to study their structure and electrochemical hydrogen storage *** outcomes reveal that increasing Ni content contributes to improving its electrochemical ***,the discharge capacity of as-milled(40 h)alloy will be increased from 157.3 to 1053.5 mAh/g through enhancing Ni percentage from 100 to 200 wt.%when discharging at 60 mAh/*** milling obviously affects the electrochemical performanee of *** milling duration prolonging,the discharge capacity of x=100 alloy keeps increasing,while that of the x=200 alloy has a maximum *** time also affects the cycle stability of experimental *** ng milli ng duration clearly decreases the cycle stability of x=100 alloy but weakens that of the x=200 alloy at first and strengthens it *** addition,prolonging milling time makes the milling prepared x=100 and 200 alloys get the maximal values of high rate discharge ability of 81.60%and 84.52%,respectively.

关键词： LaMg12 alloy Mechanical milling Ni content Microstructure Hydrogen storage performance

Migration of harmful elements in municipal sludge under hightemperature oxidation conditions

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Journal of Iron and Steel Research International 2023年第9期30卷 1701-1713页

作者： xiao-dong ping Hai-feng Wang Feng Wang Xin-yu Wan Zhi-wei An Jian-lei Pan State Key Laboratory of Advanced Steel Processes and Products Central Iron and Steel Research Institute Co.Ltd.Beijing 100081China Department of Science and Technology Development China Iron and Steel Research Institute Group Co.Ltd.Beijing 100081China Production and Equipment Department Chengde Jianlong Special Steel Co.Ltd.Chengde 067200HebeiChina Technology Department Chengde Jianlong Special Steel Co.Ltd.Chengde 067200HebeiChina

Municipal sludge is produced in large amounts and is difficult to *** is the most direct and thorough treatment *** order to study the feasibility of sintering for municipal sludge treatment,the municipal sludge reforming process was studied under high-temperature oxidation *** results showed that the sludge reforming process could be divided into four stages:the precipitation and evaporation of adsorbed water,the precipitation and combustion of the volatile,the combustion of the residual volatile and solid carbon,and the decomposition of salts and the melting of *** increase in the heating rate resulted in more intense sludge combustion and improved the sludge reaction capacity and combustion *** burning at 1300℃,Si,Ca,Mg,Al,K,Na,and Cu formed new phases and entered the slag.75%of P remained in the slag.80%of the S formed SO_(2) and entered the flue *** formed gaseous chlorides like HCl upon combustion and entered the flue *** sintering is a feasible method for treating municipal sludge,care must be taken to limit the amount of P that ends up in the ore.

关键词： Municipal sludge Oxidizing atmosphere Mini-sintering Reforming process Element migration

Strongly screened electron capture rates of chromium isotopes in presupernova evolution

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Research in Astronomy and Astrophysics 2017年第10期17卷 91-96页

作者： Jing-Jing Liu Qiu-He Peng Liang-Huan Hao xiao-ping Kang dong-Mei Liu College of Marine Science and Technology Hainan Tropical Ocean University Department of Astronomy Nanjing University

Taking into account the effect of electron screening on electron energy and electron capture threshold energy, by using the method of Shell-Model Monte Carlo and random phase approximation theory, we investigate the capture rates of chromium isotopes with strong electron screening according to the linear response theory screening model. Strong screening rates can decrease by about 40.43% （e.g., for 6Cr at T9 = 3.44, Ye = 0.43）. Our conclusions may be helpful to researches on supernova explosions and related numerical simulation methods.

关键词： nuclear reactions -- electron capture -- supernovae

Regulated polarization degree of upconversion luminescence and multiple anti-counterfeit applications

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Rare Metals 2024年第5期43卷 2172-2183页

作者： dong-ping Wen ping Chen Yi Liang xiao-Ming Mo Cao-Feng Pan Center On Nanoenergy Research Guangxi Key Laboratory for Relativistic AstrophysicsSchool of Physical Science and TechnologyGuangxi UniversityNanning 530004China Key Laboratory of Micronano Energy and Sensor CAS Center for Excellence in NanoscienceBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100140China

Polarization upconversion luminescence(PUCL)of lanthanide ions(Ln^(3+))has been widely used in single particle tracking,microfluidics detection,three-dimensional displays,and so ***,no effective strategy has been developed for modulating *** we report a strategy to regulate PUCL in Ho^(3+)-doped NaYF4single nanorods based on the number of upconversion *** constructing a multiphoton upconversion system for Ho^(3+),we regulate the degree of polarization(DOP)of PUCL from 0.590 for two-photon luminescence to 0.929 for three-photon upconversion luminescence(UCL).Furthermore,our strategy is verified from cross-relaxation between Ho^(3+)and Yb^(3+),excitation wavelength,excitation power density,and local site *** this regulation strategy of PUCL has also been achieved in Tm^(3+),with the DOP ranging from 0.233 for two-photon luminescence to 0.925 for four-photon UCL Besides,multi-dimensional anti-counterfeiting display has been explored with *** work provides an effective strategy for regulating PUCL and also provides more opportunities for the development of polarization display optical encoding,anti-counterfeiting,and integrated optical devices.

关键词： Polarization upconversion luminescence Degree of polarization Population density of excited state Number of upconversion photons Polarization anti-counterfeitingdisplay

Improved hydrogen storage performance of as-milled Sm-Mg-Ni alloy by adding CeO2

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Journal of Iron and Steel Research International 2018年第12期25卷 1255-1264页

作者： Yang-huan Zhang Kai-feng Zhang Ze-ming Yuan Ya-qin Li Hong-wei Shang Yan Qi xiao-ping dong dong-liang Zhao Key Laboratory of Integrated Exploitation of Baiyun Obo Multi-Metal Resources Inner Mongolia University of Science and TechnologyBaotou 014010Inner Mongolia China Department of Functional Material Research Central Iron and Steel Research InstituteBeijing 100081China Department of Mechanical Engineering Hebei University Baoding 071002HebeiChina

To investigate the influence of adding CeO2 on the hydrogen storage characteristics of Sm-Mg-Ni-based SmMg11Ni-type alloy,mechanical milling was utilized to synthesize SrnMg11Ni and SmMg11Ni +5 wt.%CeO2 (named SmMg11Ni- 5CeO2)*** microstructure of as-castand as-milled samples was measured via X-ray diffractometer and transmission electron *** device was utilized to measure the isothermal hydriding and dehydriding kinetics. The non-isothermal dehydrogenation performance was explored by thermogravimetry and differential scanning *** hydrogen desorption activation energy of the compound metal hydride can be computed by both Arrhenius and Kissinger *** related data show that adding CeO2 can engender a very slight influence on the hydrogen storage thermodynamics,but it can result in an obvious reduction in hydrogen absorption and desorption ***,the hydrogen desorption performance of experimental alloys is conspicuously ameliorated by the addition of CeO2,*** the initial hydrogen desorption temperature and enhancing hydrogen desorption *** hydrogen desorpfion activation energies with and without CeO2 addition are 84.28 and 100.31 kJ/mol,respectively,with an obvious decrease of 16.03 kJ/*** is thought to be responsible for the ameliorated hydrogen desorption kinetics by adding CeO2.

关键词： Mg-based alloy Mechanical milling Activation energy Catalysis Hydrogen storage kinetics