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Colorectal cancer’s burden attributable to a diet high in processed meat in the Belt and Road Initiative countries

World Journal of Gastrointestinal Oncology 2024年第1期16卷 182-196页

作者： Gu liu Chang-Min li Fei Xie Qi-Lai li liang-Yan liao Wen-Jun Jiang xiao-pan li Guan-Ming Lu Department of Gastrointestinal Surgery The First Affiliated HospitalJinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Gastrointestinal Surgery Chenzhou Third People’s HospitalChenzhou 423000Hunan ProvinceChina Department of Gastrointestinal Surgery Chenzhou First People’s Hospital and the First Affiliated Hospital of Xiangnan UniversityChenzhou423000 Hunan ProvinceChina Department of Breast and Thyroid Surgery the Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Health Management Center Zhongshan HospitalShanghai Medical College of Fudan UniversityShanghai 200032China

BACKGROUND Colorectal cancer(CRC)plays a significant role in morbidity,mortality,and economic cost in the Belt and Road Initiative(“B and R”)*** addition,these countries have a substantial consumption of processed ***,the burden and trend of CRC in relation to the consumption of a diet high in processed meat(DHPM-CRC)in these“B and R”countries remain *** To analyze the burden and trend of DHPM-CRC in the“B and R”countries from 1990 to *** We used the 2019 Global Burden of Disease Study to collate information regarding the burden of *** and age-standardized rates(ASRs)of deaths along with the disability-adjusted life years(DALYs)were determined among the“B and R”countries in 1990 and *** joinpoint regression analysis,the average annual percent change(AAPC)was used to analyze the temporal trends of age-standardized DALYs rate(ASDALR)from 1990 to 2019 and in the final decade(2010–2019).RESULTS We found geographical differences in the burden of DHPM-CRC among“B and R”countries,with the three highest-ranking countries being the Russian Federation,China,and Ukraine in 1990,and China,the Russian Federation,and Poland in *** burden of DHPM-CRC generally increased in most member countries from 1990 to 2019(all Pline was observed in Kyrgyzstan,Central Asia,with an AAPC value of-2.05%(95%CI:-2.37%to-1.73%).A substantial upward trend in ASR of mortality,years lived with disability,years of life lost,and DALYs from DHPM-CRC changes in 1990-2019 and the final de

关键词： Belt and Road Initiative countries Colorectal cancer Burden of disease Dietary risk factors Processed meat Disability-adjusted life years Trend analysis

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接枝处理对芳纶纤维/炭黑/丁苯橡胶复合材料性能的影响

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塑料科技 2024年第3期52卷 67-71页

作者：李杨肖臻史才雯潘小丽王姿懿贵州理工学院材料与能源工程学院贵州贵阳550003 通标标准技术服务(青岛)有限公司山东青岛266000

文章通过超临界CO_(2)辅助溶液浸渍法,以聚酰胺酸(PAA)和缩水甘油多面体倍半硅氧烷(POSS)改性芳纶纤维,以改性芳纶纤维制备芳纶纤维/炭黑/丁苯橡胶复合材料(AF/CB/SBR=2/50/100),测试改性芳纶纤维对复合材料加工性能的影响,并研究两种... 详细信息

文章通过超临界CO_(2)辅助溶液浸渍法,以聚酰胺酸(PAA)和缩水甘油多面体倍半硅氧烷(POSS)改性芳纶纤维,以改性芳纶纤维制备芳纶纤维/炭黑/丁苯橡胶复合材料(AF/CB/SBR=2/50/100),测试改性芳纶纤维对复合材料加工性能的影响,并研究两种表面接枝处理剂对AF/CB/SBR复合材料性能的影响。结果表明:超临界CO_(2)辅助POSS、PAA改性处理后,复合材料的交联密度增加明显,延迟了橡胶的硫化过程,正硫化时间增加。两种改性均能提升改性纤维与橡胶间的界面黏结,超临界CO_(2)辅助POSS改性后复合材料的拉伸强度、100%定伸分别提升10.77%、19.58%,而超临界CO_(2)辅助PAA改性后复合材料的拉伸强度、100%定伸分别提升15.13%、25.77%。相应地,超临界CO_(2)辅助POSS、PAA改性后,改性芳纶纤维与丁苯橡胶界面滑脱能数值分别为5.76、6.94,分别增加17.6%和41.6%,相比较而言,经大分子PAA接枝改性后芳纶纤维对橡胶复合材料综合性能的提升较为有利。

关键词：芳纶纤维接枝处理超临界CO_(2) 丁苯橡胶界面黏合

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不同道地产区黄芩的主要成分和抗氧化活性的比较研究

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天然产物研究与开发 2024年第6期36卷 919-929页

作者：刘雨然郭梦佳杨立新瞿燕潘晓丽杨滨李化成都中医药大学药学院成都611137 中国中医科学院中药研究所北京100700

探究山东莱芜与河北承德两个道地产区黄芩的黄酮特征指纹图谱及其抗氧化能力的谱-效关系。在构建黄芩超高效液相色谱(ultra-performance liquid chromatography,UPLC)指纹图谱的基础上,采用体外抗氧化法测定25批不同道地产区黄芩对DPPH... 详细信息

探究山东莱芜与河北承德两个道地产区黄芩的黄酮特征指纹图谱及其抗氧化能力的谱-效关系。在构建黄芩超高效液相色谱(ultra-performance liquid chromatography,UPLC)指纹图谱的基础上,采用体外抗氧化法测定25批不同道地产区黄芩对DPPH、ABTS、O_(2)^(-)自由基的清除能力,计算其半数抑制浓度(half maximal inhibitory concentration,IC_(50));运用正交偏最小二乘判别(orthogonal partial least-squares discrimination analysis,OPLS-DA)法和双变量相关性分析构建化学成分和抗氧化活性的谱-效关系。25批样品的指纹图谱相似度均大于0.983,确定了16个共有峰,采用超高效液相色谱串联四级杆飞行时间质谱联用法(ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry,UPLC-Q-TOF-MS)确认了12个化合物。两个道地产区的黄芩均具有较强的清除DPPH、ABTS和O_(2)^(-)自由基能力,其中山东莱芜黄芩的抗氧化能力优于河北承德黄芩。OPLS-DA所建的两个模型,均可成功区分两个道地产区的黄芩,且黄芩苷、黄芩素和千层纸素A-7-O-β-D-葡萄糖醛酸苷是二者的差异性标志成分。谱效分析发现,黄芩药材中黄酮类成分相互间可能对DPPH、ABTS、O_(2)^(-)自由基的清除能力具有协同增效作用。本研究建立了基于化学成分和抗氧化活性的黄芩谱效评价模式,可用于不同道地产区黄芩品质的评价,可为中药材的道地性研究提供帮助。

关键词：黄芩超高效液相色谱抗氧化指纹图谱谱效关系道地

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PI3K/AKT/mTOR信号通路在骨关节炎中的研究进展

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风湿病与关节炎 2024年第3期13卷 74-80页

作者：肖娟张平潘小丽田梅遵义医科大学贵州遵义563006 贵州茅台医院贵州遵义564501 遵义医科大学附属医院贵州遵义563099

骨关节炎是临床常见退行性关节疾病,是世界范围内疼痛和残疾的重要原因之一,发病机制复杂,目前尚无根治药物,深入研究骨关节炎的发病机制显得尤为重要。已有研究证实,PI3K/AKT/mTOR信号通路在细胞内广泛存在,参与细胞增殖、存活、侵袭... 详细信息

骨关节炎是临床常见退行性关节疾病,是世界范围内疼痛和残疾的重要原因之一,发病机制复杂,目前尚无根治药物,深入研究骨关节炎的发病机制显得尤为重要。已有研究证实,PI3K/AKT/mTOR信号通路在细胞内广泛存在,参与细胞增殖、存活、侵袭、迁移、凋亡、代谢,及DNA修复,在骨关节炎的病理过程中发挥重要作用。近年来,miRNA被证明参与骨关节炎软骨细胞的合成和分解代谢平衡。就PI3K/AKT/mTOR信号通路对骨关节炎的关节软骨、软骨下骨、滑膜等影响的分子机制及该通路与miRNA相关的研究进展进行综述,以期为今后骨关节炎的治疗提供新的思路和研究方向。

关键词：骨关节炎 PI3K/AKT/mTOR 关节软骨软骨下骨滑膜 miRNA 研究进展综述

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Understanding the discrepancy between the quality and yield in the synthesis of carbon nanotubes

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Nano Research 2015年第1期8卷 296-302页

作者： xiao Zhang pan li Hongbo Zhang Jie liu Department of Chemistry Duke University Durham North Carolina 27708 United States

High-quality carbon nanotubes （CNTs） are promising materials in many applications. However, current chemical vapor deposition （CVD） methods for CNT synthesis suffer from the discrepancy between the quality and yield of CNTs： Low-quality CNTs can be synthesized with high yield, while high-quality CNTs can only be synthesized with low yield. Here a CVD method has been designed to synthesize both high-quality and low-quality CNTs using the same combination of catalyst and precursor. As a result, we were able to understand the reasons for the low yield in high-quality CNT synthesis and a method was derived to improve their yield. This understanding is an important step towards high- yield synthesis of high-quality CNTs.

关键词： carbon nanotubes chemical vapor deposition high quality high yield catalyst lifetime

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Modeling and Optimization for Piercing Energy Consumption

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Journal of Iron and Steel Research International 2009年第2期16卷 40-44页

作者： xiao Dong pan xiao-li YUAN Yong MAO Zhi-zhong WANG Fu-li Key Laboratory of Process Industry Automation of Ministry of Education and liaoning Province NortheasternUniversity Shenyang 110004 Liaoning China BaoSteel Corporation Shanghai 201900 China

Energy consumption is an important quality index in the production of seamless tubes. The complex factors affecting energy consumption make it difficult to build its mechanism model, and optimization is also very difficult, if not impossible. The piercing process was divided into three parts based on the production process, and an energy consumption prediction model was proposed based on the step mean value staged multiway partial least square meth- od. On the basis of the batch process prediction model, a genetic algorithm was adopted to calculate the optimum mean value of each process parameter and the minimum piercing energy consumption. Simulation proves that the op- timization method based on the energy consumption prediction model can obtain the optimum process parameters effectively and also provide reliable evidences for practical production.

关键词： seamless tube piercing energy consumption mean value staged multiway partial least square method genetic algorithm

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USP10 Alleviates Palmitic Acid-induced Steatosis through Autophagy in HepG2 Cells

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Journal of Clinical and Translational Hepatology 2023年第1期11卷 45-57页

作者： Sheng-liang Xin xiao-li pan xiao-Yuan Xu Yan-Yan Yu Department of Infectious Diseases Peking University First HospitalBeijingChina Division of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Background and Aims:Nonalcoholic fatty liver disease(NAFLD)is a common chronic liver disease caused by *** autophagy is closely related to NAFLD ***,ubiquitin-specific peptidase-10(USP10)was reported to ameliorate hepatic steatosis,but the underlying mechanism is still *** view of the potential effects of USP10 on autophagy,we investigated whether USP10 alleviated steatosis through ***:HepG2 cells were treated with palmitic acid(PA)to model NAFLD in *** was used to regulate USP10 level in *** regulators were used to autophagic progression in *** blotting,real-time fluorescence quantitative polymerase chain reaction,lipid drop staining and immunofluorescent staining were performed to determine the effect of USP10 on lipid ***’s t-test and Tukey’s post hoc test were used to compare the means among ***:PA induced cellular steatosis with dependance on ***10 overexpression alleviated PA-induced steatosis,restored autophagic activity,promoted autophagic flux,including synthesis and degradation of autophagosomes,and lipid-targeted *** the presence of autophagy inhibitors,the protective effectiveness of USP10 on steatosis ***,the specific inhibitor to C-jun N-terminal protein kinase-1(JNK1),DB07268,abolished USP10-induced ***,during early stage inhibition of JNK1,compensatory expression of tuberous sclerosis complex-2(TSC2)maintained *** degree of TSC2-to-JNK1 compensation was positively associated with USP10 ***,JNK1 and TSC2 were involved in the lipid-lowering effect of ***:USP10 alleviated hepatocellular steatosis in autophagy-dependent ***1/TSC2 signaling pathways were required for USP10-induced autophagy.

关键词： Autophagy Nonalcoholic fatty liver disease Steatosis Ubiquitinspecific peptidase-10 C-jun N-terminal protein kinase-1 Tuberous sclerosis complex-2

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Benfotiamine prevents increased β-amyloid production in HEK cells induced by high glucose

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Neuroscience Bulletin 2012年第5期28卷 561-566页

作者： xiao-Jing Sun Lei Zhao Na Zhao xiao-li pan Guo-Qiang Fei li-Rong Jin Chun-Jiu Zhong Department of Neurology Zhongshan Hospital & Shanghai Medical College Fudan University Shanghai 200032 China State Key Laboratory of Medical Neurobiology Institute of Brain Science Fudan University Shanghai 200032 China

Objective To determine whether high glucose enhances β-amyloid （Aβ） production in HEK293 Swedish mutant （APPsw） cells with Aβ precursor protein （APP） overexpression, and whether under this condition benfotiamine reduces the increased Aβ production. Methods HEK293 APPsw cells were cultured with different concentrations of glucose for different times. TheAβ content in the supernatant was determined by EliSA. To investigate the mechanism by which benfotiamine reduced Aβ production, glycogen synthase kinase-3 （GSK-3） activity and expression were measured after the cells were cultured with 5.5 g/L glucose for 12 h. Results With 1.0, 3.0, 4.5, 5.5, 6.5, 7.5, 8.5, or 10.5 g/L glucose, Aβ production by HEK293 APPsw cells was highest in the presence of 5.5 g/L glucose for 6 and 12 h. The difference in Aβ content between 5.5 and 1.0 g/L was most marked after incubation for 12 h. Benfotiamine at 20 and 40 μg/mL significantly reduced Aβ production in cells incubated with 5.5 g/L glucose for 12 h. Moreover, 40 μg/mL benfotiamine significantly enhanced the ratio of phosphorylated GSK-3 to total GSK-3, together with consistent down-regulation of GSK-3 activity. Conclusion High glucose increases Aβ production by HEK293 APPsw cells while benfotiamine prevents this increase. This is correlated with the modulation of GSK-3 activity.

关键词： Alzheimer’s disease β-amyloid high glucose benfotiamine glycogen synthase kinase

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A Generalized MSST Algorithm for Counting Points of Elliptic Curves over F_(p)^(n)

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Journal of Systems Science & Complexity 2024年第4期37卷 1738-1754页

作者： li xiao LV Chang pan Zhizhong Key Laboratory of Cyberspace Security Defense Institute of Information EngineeringChinese Academy of SciencesBeijing 100085China School of Cyber Security University of Chinese Academy of SciencesBeijing 100085China Huawei Technologies Co. Ltd.Shenzhen 518129China

Elliptic curve cryptography is an important part of nowaday's public key *** points of elliptic curves over finite fields is of great significance to the selection of safety *** present,there are many p-adic algorithms,such as SST algorithm,generalized AGM algorithm,Kedlaya algorithm,etc.,which can deal with the situation of finite fields of small *** this paper,the authors generalize the MSST algorithm of characteristic 2 to general fields of odd characteristic,and propose the generalized MSST *** generalized MSST algorithm is achieved by combining the advantages of the SST algorithm and the generalized AGM *** the time complexity of the multiplication of two n-bit numbers is denoted as O((n)^(μ)),then the time complexity of the generalized MSST algorithm is O(n^(2μ+1/1+μ)),which is the same as the improved SST *** practical experiments,the running time of the generalized MSST algorithm is less than that of the improved SST algorithm.

关键词： Elliptic curve generalized AGM algorithm generalized MSST algorithm SST algorithm

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沙南凹陷新生代断裂发育特征及控藏作用

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科学技术与工程 2024年第10期24卷 4056-4069页

作者：张正涛王兴艳潘晓丽殷亮亮张国坤中国石油长庆油田公司勘探开发研究院西安710018 低渗透油气田勘探开发国家工程实验室西安710018 中国石油长庆工程设计有限公司西安710001 中国石油长庆油田公司第一采气厂西安710021 中海石油(中国)有限公司天津分公司天津300452

为明确沙南凹陷新生代断裂活动特征以及对油气富集的控制作用,利用高精度三维地震资料及钻井资料,对研究区主要断裂的几何学特征、运动学特征开展研究,并对断裂活动对烃源岩、储层、圈闭及油气运移的控制作用进行了探讨。结果认为:研究... 详细信息

为明确沙南凹陷新生代断裂活动特征以及对油气富集的控制作用,利用高精度三维地震资料及钻井资料,对研究区主要断裂的几何学特征、运动学特征开展研究,并对断裂活动对烃源岩、储层、圈闭及油气运移的控制作用进行了探讨。结果认为:研究区断裂可划分为三级及上、下两套断裂系统,孔店组~沙三段沉积期、东营组沉积期是断裂活动高峰期;高活动速率主要同沉积断层下降盘为优质烃源岩发育区,凹陷北侧不同类型断层边界决定了多种类型砂体发育模式,断裂作用控制了构造及岩性圈闭的形成,断裂及断裂砂体耦合是研究区主要的油气运移通道;发育凹陷内部中央隆起区南北两侧“断控”双通道近源成藏、凹陷北侧陡坡带“断-砂耦合”阶梯状网毯输导远源成藏、凹陷斜坡下部“断控”前缘砂体源内成藏3种断裂控藏模式;凹陷北侧深层岩性圈闭、凹陷北侧陡坡带中浅部构造圈闭是后续有利勘探方向。

关键词：断裂特征断裂体系断裂控藏新生代沙南凹陷

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